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A Halcinonide Cream

A technology of hacinide and cream, applied in the field of external medicine composition of sinide, can solve the problems of blood calcium reduction, convulsions, death and the like

Active Publication Date: 2017-05-10
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, it should be pointed out that patients with lead poisoning who should be treated with edetate calcium and sodium, especially children, may cause serious decrease in blood calcium, convulsions and even death due to misuse of edetate disodium

Method used

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  • A Halcinonide Cream
  • A Halcinonide Cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0032] Halcinonide 1g, dimethyl sulfoxide 30g, white petrolatum 100g, stearyl alcohol 90g, liquid paraffin 50g,

[0033] Sodium Lauryl Sulfate 50g, Glycerin 50g, Ethyl p-hydroxybenzoate 1g,

[0034] Add edetate disodium 0.1g to 1000g with water for injection,

[0035] Accurately weighed according to the above ratio, the cream preparation process is as follows:

[0036] 1) Mix sodium lauryl sulfate, edetate, ethyl p-hydroxybenzoate, glycerin and distilled water and heat to 70°C;

[0037] 2) The prescribed amount of halcinonide is dissolved in the prescribed amount of dimethyl sulfoxide;

[0038] 3) Heat stearyl alcohol, white petrolatum, and liquid paraffin in the prescribed amount to 80°C, slowly add the mixture obtained in step 1) and stir quickly, then add the halcinonide dimethyl sulfoxide solution in step 3), mix well, and condense into paste. Cream Halcinonide 0.1%

Embodiment 1-2

[0040] According to the recipe and process of Example 1-1, the amount of disodium edetate was changed to 0.25g.

Embodiment 1-3

[0042] According to the recipe and process of Example 1-1, the amount of edetate disodium was changed to 1 g.

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Abstract

Halcinonide cream is provided. The halcinonide cream comprises halcinonide adopted as the active component, solid in oil-phase components, a consistency modifier, a humectant, an emulsifier, an aseptic and water, and is characterized by also comprising edetate calcium disodium.

Description

technical field [0001] The invention relates to a pharmaceutical composition for external use of halcinonide. Background technique [0002] Halcinonide, (halcinonide, CAS: 3093-35-4) adrenal cortex hormone drugs, external use can shrink dermal capillaries, inhibit epidermal cell proliferation or regeneration, inhibit fibroblast regeneration in connective tissue, and stabilize intracellular lysozyme Body membrane, preventing tissue damage caused by the release of lysosomal enzymes, has strong anti-inflammatory and anti-allergic effects. For allergic dermatitis, atopic dermatitis, contact dermatitis, seborrheic dermatitis, eczema, pruritus, psoriasis, neurodermatitis, etc. However, long-term or large-scale application can cause skin atrophy and telangiectasia, acne-like dermatitis, folliculitis, perioral dermatitis, and increased susceptibility to infection. Even can cause allergic contact dermatitis. More importantly, long-term use can also cause pigmentation, that is, ski...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/58A61K47/18A61P17/00
Inventor 陈松赵琳孙亮
Owner TIANJIN JINYAO GRP
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