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122 results about "Thymopentin" patented technology

Thymopentin is an immunostimulant. As such, it has been used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985). Thymopentin helped to improve immunological condition in several patients for a brief time under specific treatments.

Fmoc-strategy solid-phase synthesis method of thymopentin

The invention discloses an Fmoc-strategy solid-phase synthesis method of thymopentin. The method comprises the following steps: taking Fmoc protected amino acids as the monomers and sequentially connecting the amino acids to a resin, wherein while synthesizing pentapeptide, the solvent of the added amido acid Fmoc-Arg(Pbf)-OH solution is the mixed solution of DMF (Dimethyl Formamide) and THF (Tetrahydrofuran); depriving all Fmoc protecting groups by using a piperazine solution, and finally, removing the resin and the side chain protecting groups to obtain the thymopentin. According to the invention, the piperazine is taken as the deprotection agent for depriving Fmoc in stead of the traditional pyridine, and the piperazine is a substance unregulated as the dangerous chemical and the poison-making chemical, and is cheap and easy to get, and also stable in chemical properties; the piperazine is in the form of white acicular crystals at the normal temperature, while piperidine is a liquid at the normal temperature, and therefore, the piperazine is more convenient to transport and store; under the same concentration, the Fmoc depriving efficiency of the piperazine is higher than that of piperidine; and obviously, the piperazine has many advantageous in the synthesis of the thymopentin, and also has great stimulative significance in production and study of polypeptides.
Owner:HAINAN UNIVERSITY

Thymopentin oral microsphere preparation and preparation method thereof

The invention discloses a thymopentin oral microsphere preparation and a preparation method thereof. The oral microsphere preparation comprises the following raw materials: thymopentin, gelatin, a lactide-glycolide copolymer, dichloromethane, polyvinylalcohol-124, an aprotinin or trypsin inhibitor, and sodium glycyl-cholate or deoxysodium cholate or sodium caprate. The thymopentin oral microsphere preparation has high bioavailability, can replace injection administration without reducing clinical curative effects and overcomes a lot of pains and inconvenience of patients caused by frequent injections.
Owner:北京博恩特药业有限公司
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