Oral nanoparticle polypeptide composition tablets and preparation method thereof
A polypeptide composition and nanoparticle technology, which is applied in the direction of drug combination, cyclic peptide composition, pill delivery, etc., can solve the problems of low bioavailability, difficult route of administration, and little clinical value
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Embodiment 1
[0020] Weigh 20 g of thymopentin and 10 g of sodium glycocholate in water to obtain the internal water phase; weigh 160 g of polylactic acid and dissolve in dichloromethane to obtain the oil phase. First move the internal water phase solution into the oil phase solution, and place it on an emulsifying disperser at room temperature at high speed (30000rpm) for 30 seconds to obtain a W / O emulsion; then transfer the W / O emulsion to 50ml of 5% polymer Place the vinyl alcohol solution in an emulsifying disperser at 5000 rpm and homogenize the milk for 1 minute to obtain W / O / W double emulsion. Stir magnetically at room temperature and rotate at 500 rpm for 2 hours. Remove the organic phase, centrifuge and collect The obtained nanoparticles precipitate, washed with distilled water several times, and then collected by centrifugation, add 10g sorbitol, freeze-dry to obtain nanoparticles, then add 10g corn starch, 10g cross-linked polyvinylpyrrolidone, 10g starch, 10g magnesium stearate, ...
Embodiment 2
[0023] Weigh 30 g of thymopentin and 15 g of camostat mesylate dissolved in water to obtain the internal water phase; weigh 200 g of polyglycolic acid and dissolve in dichloromethane to obtain the oil phase. First move the internal water phase solution into the oil phase solution, and place it on an emulsifying disperser at room temperature at high speed (30000rpm) for 30 seconds to obtain a W / O emulsion; then transfer the W / O emulsion to 50ml of 5% polymer In the vinyl alcohol solution, place it on an emulsifying disperser at 5000 rpm and homogenize for 1 minute to obtain a W / O / W double emulsion. Stir magnetically at room temperature and stir at 500 rpm for 2 hours at low speed. Remove organic solvents and centrifuge. Collect the obtained nanoparticle precipitate, wash it with distilled water several times, and then collect it by centrifugation, add 15g mannitol, freeze-dry, freeze-dry to obtain nanoparticles, then add 15g dextrin, 15g croscarmellose sodium, 15g carboxypropyl ...
Embodiment 3
[0026] Weigh 40 g of thymopentin and 15 g of bacitracin to dissolve in water to obtain an internal aqueous phase; weigh out 180 g of polylactic acid-glycolic acid copolymer and dissolve in dichloromethane to obtain an oil phase. First move the internal water phase solution into the oil phase solution, and place it on an emulsifying disperser at room temperature at high speed (30000rpm) for 30 seconds to obtain a W / O emulsion; then transfer the W / O emulsion to 50ml of 5% polymer Place the vinyl alcohol solution in an emulsifying disperser at 5000 rpm and homogenize the emulsion for 1 minute to obtain W / O / W double emulsion, magnetically stir at room temperature, stir at 500 rpm at low speed for 2 hours, centrifuge, and collect the resulting nanoparticle precipitate , Washed with distilled water for several times, then collected by centrifugation, added 10g of sucrose, freeze-dried to obtain nanoparticles, then added 10g of microcrystalline cellulose, 10g of cross-linked polyvinylp...
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