Medicinal composition for treating skin disease and its preparing method

A composition and technology for skin diseases, applied in the field of pharmaceutical compositions for treating skin diseases, can solve problems such as ineffective treatment, achieve satisfactory curative effect, reduce side effects, and obvious synergistic effects

Inactive Publication Date: 2006-08-09
YAKEXI PHARMA INST BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a compound naftifine hydrochloride composition for the treatment of skin diseases, especially to provide a compound naftifine hydrochloride containing naftifine hydrochloride and a The pharmaceutical composition of one component of tamethasone, betamethasone valerate or clobetasol propionate overcomes the fact that the above-mentioned single components cannot more effectively treat skin fungal infections, skin allergies, dermatitis or eczema, etc. or fungal infections and skin infections. Allergies, dermatitis, and eczema, etc., have the disadvantages of being sick at the same time, and alleviate the side effects of dermatitis, eczema, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0138] Medicinal cream of the present invention

[0139] Take by weighing 1.0 grams of naftifine hydrochloride and 0.025 grams of clorfluxone hydrochloride according to the formula ratio of 1.0:0.025, dissolve them with a small amount of ethanol, and use 0 / W dosage form. The excipients are 10 grams of liquid paraffin, glyceryl monostearate 10 grams, 10 grams of white petrolatum, 10 ml of glycerin, 801.5 grams of Span, 3.5 ml of Tween-80, 0.3 grams of preservative chlorhexidine acetate, and 100 grams of ointment prepared with purified water.

Embodiment 2

[0141] Pharmaceutical gel of the present invention

[0142] Take by weighing 1.0 grams of naftifine hydrochloride and 0.05 grams of clonazepam according to the formula ratio of 1.0:0.05, add a small amount of ethanol to dissolve, add carbomer 2%, propylene glycol 20ml, polyethylene glycol-400 5 grams, EDTA-2Na0 .1 gram, Tween-80 3ml, triethanolamine 0.6ml, and the remainder is prepared into 100g of gel.

Embodiment 3

[0144] Medicinal solution of the present invention

[0145] Take by weighing 0.5 gram of naftifine hydrochloride, 0.01 gram of clobetasol propionate by weighing 0.5: 0.01 formula ratio, add ethanol 20ml, glycerol 20ml and surplus purified water and prepare spray 100ml.

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PUM

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Abstract

The present invention discloses a medicine composition for curing dermopathy and its preparation method. Said medicine composition contains the following components: (by weight portion) 0.3-3.0 portions of naftifine and 0.005-0.50 portion of one component selected from halcinonide, triamcinolone acetonide acetate, betamethasone (containing betamethasone propionate and betamethasone valerate) or clobetasol propionate. Said medicine composition can be made into various medicine preparations for external application.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating skin diseases, in particular to a pharmaceutical composition containing naftifine hydrochloride and selected from clorfluxasone, triamcinolone acetonide, betamethasone, betamethasone propionate, and betamethasone valerate A pharmaceutical composition with one component of clobetasol propionate and a preparation method thereof. Background technique [0002] Naftifine hydrochloride (abbreviated as naftifine, Naiffifine) is an allylamine antifungal drug, which is characterized in that it has a higher fungicidal cure rate and a lower recurrence rate in a short period of time, but some dermatophytosis is often associated with Dermatitis and eczema are indistinguishable, causing misdiagnosis and affecting treatment. [0003] Clofluxasone, triamcinolone acetonide acetate, betamethasone, and clobetasol propionate are all adrenocortical hormone drugs, which have anti-inflammatory effects, but h...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K31/573A61K31/131A61K9/00A61P17/00A61P31/10
Inventor 黄家章黄声德
Owner YAKEXI PHARMA INST BEIJING
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