47 results about "Clonazepam" patented technology

The present invention includes benzodiazepine compositions formulated for intranasal administration, comprising a binary solvent system comprising a first solvent in which the benzodiazepine is soluble, the first solvent capable of penetrating nasal mucosal tissue, and a second solvent in which the benzodiazepine in less soluble. The compositions of the present invention may be used to treat a variety of disorders including, but not limited to, panic attacks, muscle spasms, anxiety, and seizures. In one aspect, the present invention relates to a fast-acting, clonazepam composition for transnasal administration that can be used for the treatment of seizure clusters.

A treatment is described for diseases with symptoms that can include fatigue, muscle aches and spasms, weakness, demylenation, and nerve pain. Diseases can include fibromyalgia, depression, and auto-immune and immuno-suppressive diseases, such as MS. The treatment comprises about 1-10 mg naltrexone, at least about 20 μg vitamin B12, at least about 5 mg vitamin B6, at least about 2 mg coenzyme Q, and preferably at least one ancillary medication selected from the group consisting of diazepam, cyclcobenzaprine, clonazepam, alprazolam, 9-tetrahydrocannibinol, fumarate, caffeine, and combinations thereof. The treatment can be administered orally, and can decrease mental and physical symptoms such as, for example, fatigue, gait problems, visual dysfunction, and pain while improving cognitive skills.

The pharmaceutical composition of the present invention comprises a carbostyril derivative which is a dopamine-sero-tonin system stabilizer and a mood stabilizer in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof. The mood stabilizer may include but is not limited to lithium, valproic acid, divalproex sodium, carbamaza-pine, oxcarbamazapine, zonisamide, lamotragine, topiramate, gabapentin, levetiracetam or clonazepam. These compositions are used to treat patients with mood disorders, particularly bipolar disorder with or without psychotic features, mania or mixed episodes. Methods are provided for separate administration of a carbostyril derivative and a mood stabilizer to a patient with a mood disorder.

The invention discloses a specific monoclonal antibody capable of recognizing benzodiazepines such as diazepam and nitrazepam and an enzyme for detecting benzodiazepines such as diazepam and nitrazepam Immunization methods and kits. The monoclonal antibody of the present invention is secreted by the hybridoma cell 3D7 whose deposit number is CCTCC NO: C201352. Compared with the prior art, the monoclonal antibody prepared by the invention can simultaneously recognize various benzodiazepines such as diazepam and nitrazepam. The ELISA method and the kit of the invention have the advantages of high detection efficiency and sensitivity, good precision and accuracy, and the like.

The invention discloses a preparation method of a clonazepam molecular imprinting stirring rod coating. The method comprises the following processes of preparation and activation of a magnetic stirring rod; preparation of magnetic nanoparticles modified by diaminobenzene carboxyl in the tail end; preparation of a magnetic field induced self-assemble molecular imprinting stirring rod. The out-field self-assemble molecular imprinting stirring rod prepared through the method provided by the invention has specific recognition capability on benzodiazepines compounds, compared with the traditional stirring rod, polymerization steps are reduced, the adsorption amount is increased, a molecular recognition mode with multiple functions is provided, and the adsorption efficiency in a polar solvent is obviously increased. The accuracy of the method when being applied to a practical sample test can be improved; the coating has no breakage or falling off phenomenon after being used repetitively, and is coupled with chromatography so as to be applied to separation and concentration of the benzodiazepines compounds in complex matrixes such as health food, feed and biological samples.