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Clonazepam medicinal composition and medicinal application thereof

A technology of clonazepam and composition, applied in the directions of drug combination, preparation of organic compounds, antipyretics, etc., can solve problems such as no related reports of clonazepam, and achieve good and significant anti-inflammatory and cough-relieving effect. Progress and the effect of highlighting substantive features

Inactive Publication Date: 2016-06-15
贺玉皓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there is no report on the correlation between clonazepam and its pharmaceutical composition and anti-inflammatory and cough-relieving

Method used

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  • Clonazepam medicinal composition and medicinal application thereof
  • Clonazepam medicinal composition and medicinal application thereof
  • Clonazepam medicinal composition and medicinal application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0022] Separation method: (a) Grind Centella asiatica (2kg), extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and successively use petroleum ether (4L×3 times), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) Use D101 macroporous resin to remove impurities from the n-butanol extract, first elute with 15% ethanol for 6 column volumes, then use 70% ethanol for 10 column volumes, collect 70% eluate, and co...

Embodiment 2

[0025] Embodiment 2: pharmacological action

[0026] 1. Materials and methods

[0027] 1.1 Drugs and reagents

[0028] Clonazepam was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Glacial acetic acid is produced by Guangxi Nanning Chemical Reagent Factory; xylene is produced by China National Pharmaceutical Group Shanghai Chemical Reagent Company; Aspirin tablets (100mg / tablet) were produced by Bayer Pharmaceutical Company; Guilong Kechuanning Capsules were produced by Shanxi Guilong Pharmaceutical Co., Ltd.; Juhong Granules were produced by Nanchang Kangzhengde Pharmaceutical Co., Ltd.

[0029] 1.2 Experimental animals

[0030] 90 Kunming mice, weighing (20±2) g, male and female, 60 Wistar rats, weighing (200±20) g, male and female, were provided by Hubei Experimental Animal Center.

[0031] 1.3 Equipment

[0032] 1. 80-2 type centrifuge, produ...

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PUM

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Abstract

The invention discloses a pharmaceutical composition of clonazepam and its medical use. The pharmaceutical composition of clonazepam provided by the invention contains clonazepam and a natural product compound (I) with a novel structure. The composition of clonazepam and compound (I) has obvious anti-inflammatory and antitussive effects, and is better than the independent anti-inflammatory and antitussive effects of clonazepam or compound (I), and can be developed into an anti-inflammatory and antitussive drug, which is different from existing Compared with the technology, it has outstanding substantive characteristics and significant progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of clonazepam, in particular to a pharmaceutical composition of clonazepam and its application in anti-inflammatory and cough-relieving. Background technique [0002] Clonazepam acts like diazepam and nitrazepam. But the anticonvulsant effect is 5 times stronger than the former two, and the effect is rapid. Similar to the central inhibitory effect of other BDZ drugs, it accelerates the influx of chloride ions in nerve cells, hyperpolarizes the cells, and reduces the excitability of nerve cells. At the same time, it also has a certain effect on glutamic acid decarboxylase, so it has a broad-spectrum antiepileptic effect. This product still has anti-anxiety, hypnotic and central muscle relaxation effects. [0003] So far, there is no report on the correlation between clonazepam and its pharmaceutical composition and anti-inflammatory and cough-relieving. Contents of t...

Claims

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Application Information

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IPC IPC(8): A61K31/5513A61K31/22C07C69/73C07C67/48C07C67/56A61P29/00A61P11/14
CPCA61K31/5513A61K31/22C07C67/48C07C67/56C07C69/73
Inventor 贺玉皓
Owner 贺玉皓
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