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Medicine composition of azithromycin and medicinal application of medicine composition in cough relieving

A technology of azithromycin and composition, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve tract infection; skin and soft tissue infection; acute otitis media; sinusitis, pharyngitis, tonsillitis, no azithromycin Treatment and prevention of rheumatic fever and other issues, to achieve the effect of improving anti-inflammatory and cough-relieving effects, highlighting substantive characteristics, and significantly improving the effect

Inactive Publication Date: 2016-11-23
赵吉永
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Azithromycin is suitable for the following infections caused by sensitive bacteria: bronchitis, pneumonia and other lower respiratory tract infections; skin and soft tissue infections; acute otitis media; sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections It is also a commonly used drug to prevent rheumatic fever; azithromycin can effectively clear oropharyngeal streptococci, but there is no data on the efficacy of azithromycin in the treatment and prevention of rheumatic fever)

Method used

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  • Medicine composition of azithromycin and medicinal application of medicine composition in cough relieving
  • Medicine composition of azithromycin and medicinal application of medicine composition in cough relieving
  • Medicine composition of azithromycin and medicinal application of medicine composition in cough relieving

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0018] Separation method: (a) Grind the dried tuber (2kg) of Araceae, extract with 70% ethanol under hot reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times) 3 times), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) The ethyl acetate extract in (a) was removed with D101 type macroporous resin, first eluted with 20% ethanol for 9 column volumes, then eluted with 65% ethanol for 10 column volumes, collected 65% eluate, and subtracted Concentrate under pressure to obtain the 65% ethanol elution concentrate; (c) 65% ethanol elution concentrate in step (b) is separated with normal phase silica gel, with a volume ratio of 65:1 (9 column volumes), 35:1 successively (10 column volumes)...

Embodiment 2

[0022] Embodiment 2: pharmacological action

[0023] 1. Materials and methods

[0024] 1.1 Drugs and reagents

[0025] Azithromycin was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Glacial acetic acid is produced by Guangxi Nanning Chemical Reagent Factory; xylene is produced by China National Pharmaceutical Group Shanghai Chemical Reagent Company; Aspirin tablets (100mg / tablet) were produced by Bayer Pharmaceutical Company; Guilong Kechuanning Capsules were produced by Shanxi Guilong Pharmaceutical Co., Ltd.; Juhong Granules were produced by Nanchang Kangzhengde Pharmaceutical Co., Ltd.

[0026] 1.2 Experimental animals

[0027] 90 Kunming mice, weighing (20±2) g, male and female, 60 Wistar rats, weighing (200±20) g, male and female, were provided by Hubei Experimental Animal Center.

[0028] 1.3 Equipment

[0029] 1. 80-2 type centrifuge, p...

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Abstract

The invention discloses a medicine composition of azithromycin and medicinal application of the medicine composition in cough relieving. The medicine composition contains azithromycin and a natural product compound (I) which is novel in structure and obtained by separating dry tuber of rhizoma arisaematis. When acting solely, azithromycin and the natural product compound (I) have anti-inflammation and cough-relieving effect; when acting jointly, anti-inflammation and cough-relieving effect is further improved, and the medicine composition can be developed into anti-inflammation and cough-relieving drugs; compared with the prior art, the medicine composition has outstanding substantive features and remarkable progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of azithromycin, in particular to a pharmaceutical composition of azithromycin and its medical application for relieving cough. Background technique [0002] Azithromycin is a second-generation macrolide drug, mainly used for the treatment of respiratory and reproductive tract infections. It can treat respiratory tract infections in children and adults caused by a variety of pathogens, genital chlamydia trachomatis infection, etc., and is recommended by the medical guidelines of many countries and regions as the first-line treatment for the above infections (such as the United States, Japan, China, the United States and other countries) China CDC). [0003] Azithromycin is suitable for the following infections caused by sensitive bacteria: bronchitis, pneumonia and other lower respiratory tract infections; skin and soft tissue infections; acute otitis media; sinusitis, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61K31/7052A61K31/56A61P29/00A61P11/14
CPCA61K31/56A61K31/7052A61K36/8884C07J63/008A61K2300/00A61P11/14A61P29/00C07J63/00
Inventor 不公告发明人
Owner 赵吉永
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