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High-purity ginkgolide composition

A ginkgolide and high-purity technology, applied in the field of high-purity ginkgolide and compositions, can solve the problems of high-purity lactone lacking bilobalide and the like, and achieve stable and controllable product quality, simple preparation process and low cost. Effect

Inactive Publication Date: 2011-12-28
TIANJIN TAIYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nankai University invented a method of separating ginkgolides by using macroporous resins. High-purity ginkgolides were prepared by macroporous resin chromatography and crystallization, but the obtained high-purity lactones lack bilobalide. Bilobalide is an important component of ginkgolide that exerts pharmacological effects on the nervous system
Pan Jianzeng invented a method for separating bilobalide by coordination method. The resin used in this method needs to introduce metal ions, so-called ligands. At the same time, the adsorption must be carried out in a non-aqueous system. There are many problems in practical application of this method.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 100kg of ginkgo leaves and add them to the extraction kettle, add 600L of 80% ethanol, stir and extract at 70°C for 3 hours, release the extract, then add 400L of 80% ethanol to the extraction kettle, stir and extract for 2 hours at 70°C, and release the extract. Combine the two extracts, recover ethanol under reduced pressure, add water to dilute to 400L, let stand for 5h, and filter to obtain clear liquid. 100L ME-1 macroporous adsorption resin (Tianjin Orui Biological Co., Ltd.) on the supernatant, control flow rate 100L / h, rinse with 200L pure water after adsorption, flow rate 100L / h, desorb with 300L 70% ethanol after rinsing , collect the desorption solution, recover ethanol under reduced pressure to obtain liquid extract, add pure water to dilute to 800L. 100L MG-2 gel-type hydrogen bond adsorption resin (Tianjin Ou Rui Biological Co., Ltd.) on the diluent, control the flow rate 200L / h, then desorb with 200L 5% ethanol, collect the effluent and the desorbent...

Embodiment 2

[0022] Take 200kg of ginkgo leaves and put them into the extraction kettle, add 1200L of 80% ethanol, stir and extract at 70°C for 3 hours, release the extract, then add 400L of 80% ethanol to the extraction kettle, stir and extract for 2 hours at 70°C, and release the extract. Combine the two extracts, recover ethanol under reduced pressure, add water to dilute to 800L, let stand for 5 hours, and filter to obtain clear liquid. 200L D101 macroporous adsorption resin (provided by Tianjin Ou Rui Biotechnology Co., Ltd.) on the supernatant, control the flow rate of 200L / h, rinse 400L with pure water after the adsorption is completed, the flow rate is 200L / h, desorb with 600L 70% ethanol after washing , collect the desorption solution, recover ethanol under reduced pressure to obtain liquid extract, add pure water to dilute to 1600L. 200L MG-2 gel-type hydrogen bond adsorption resin (Tianjin Ou Rui Biological Co., Ltd.) on the diluent, control the flow rate 400L / h, desorb with 400...

Embodiment 3

[0024] Get 1000g ginkgo leaf extract (produced by our company, total flavonoid content 25%, total lactone content 7%, add 120L pure water and stir to dissolve, 30L MG-2 gel type hydrogen bond adsorption resin on the solution (Tianjin Ou Rui Biological Co., Ltd. Company), control flow rate 30L / h, then desorb with 60L 5% ethanol, collect effluent and desorption liquid, concentrate and dry to get 140g ginkgolide crude product, resin rinses 300L regeneration backup next time with 70% ethanol and reuses. 140g Heat the crude ginkgolide with 14L of absolute ethanol (60°C) and stir to dissolve, add 210g of activated carbon, keep stirring for 30min, filter, add 210g of activated carbon to the filtrate, keep stirring for 30min, filter, concentrate and dry the filtrate, and obtain nearly white total ginkgo Esters 120g. After testing, the ginkgolide A content is 14.5%, the ginkgolide B content is 16.3%, the ginkgolide C content is 11.2%, the bilobalide content is 41.6%, and the total lacto...

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PUM

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Abstract

The invention relates to a high-purity ginkgolide and its composition. It is a white powder with slightly bitter taste. The content of ginkgolide A is 10-20%, the content of ginkgolide B is 10-20%, and the content of ginkgolide C is 10-20%. 5-15%, the bilobalide content is 30-50%, and the total lactone content is 80-95%. Ginkgo biloba is used as raw material, heated and refluxed with ethanol solution with a mass fraction of 20-80% to extract, the extract is concentrated to recover ethanol, separated by a macroporous resin column, desorbed by ethanol, diluted with water, and then passed through a gel-type hydrogen bond Adsorption and desorption of the adsorption resin, collection of effluent and desorption liquid, concentration, drying, ethanol dissolution, activated carbon decolorization, concentration and drying. The preparation process is simple, reliable, low in cost and high in yield, and no toxic organic solvent is used in the process, which is an environment-friendly process. The high-purity ginkgolide is used as an active ingredient to prepare a composition that can be used as various preparations (capsules, tablets, oral liquids, granules, powders, injections, etc.) of ginkgolide medicines or health care products.

Description

technical field [0001] The invention relates to a high-purity ginkgolide and its composition, in particular to a production process for extracting high-purity ginkgolide from ginkgo leaves. Background technique [0002] Ginkgo biloba (Ginkgo biloba L.) is an important medicinal plant. Ginkgo biloba is the leaf of Ginkgo biloba. . In the 1970s, Germany took the lead in formulating quality standards for ginkgo extract (abbreviated as GBE), that is, standard ginkgo extract (ginkgo total flavonoids ≥ 24%, terpene lactones ≥ 6%, ginkgolic acid ≤ 10ppm), and this standard then also It has become the international international standard for ginkgo extract. Further studies have shown that ginkgolides (ginkgolides, GK) are the main medicinal ingredients in Ginkgo biloba extract, which are diterpenoid ester compounds, including ginkgolides A, B, C, J and M (GKA, GKB , GKC, GKJ, GKM) etc. Ginkgolides are recognized as platelet activating factor (PAF) receptor antagonists, and their...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A23L1/29A61P25/28A61P9/00A61P25/00A61K127/00A23L33/00
Inventor 王为超欧来良
Owner TIANJIN TAIYANG PHARMA
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