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Method for measuring tepene lactone content in compositions extracted from Ginkgo biloba leaves

A ginkgolide and composition technology, applied in the field of ginkgo biloba composition and its preparation, can solve problems such as endangering the health of operators, harmful drugs, and environmental threats, and achieve the goals of increasing safety, reducing volume, and inhibiting allogeneic rejection Effect

Inactive Publication Date: 2006-03-01
SPH XING LING SCI & TECH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problems with these processes are possible hazards to the health of operators, potential threats to the environment, and harmful residues in pharmaceutical products

Method used

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  • Method for measuring tepene lactone content in compositions extracted from Ginkgo biloba leaves

Examples

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Effect test

example 1

[0104] The invention provides a kind of method for preparing ginkgo composition, and the steps are as follows:

[0105] (a) Extraction: Ginkgo biloba green leaves are collected from late summer to early autumn. At this time, the content of effective therapeutic ingredients is high and the water content is lower than 8%. The 60% aqueous ethanol was refluxed twice under normal pressure, each time for 3 hours, the solid residue was removed by filtration and then refluxed for the third time with 10 times the volume of water for 0.5 hour, and the three filtrates were combined.

[0106] (b) Concentration: Concentrate the filtrate obtained in step a under reduced pressure to an alcohol-free viscous extract (density d=1.2-1.25, temperature t=60° C.).

[0107] (c) Precipitation: dissolve the viscous extract of step (b) with 2 times the amount of hot water, form a precipitate after cooling, and filter to remove the precipitate.

[0108] (d) column chromatography: the macroporous resin ...

example 2

[0115] The invention provides a method for preparing ginkgo composition, the steps are as follows:

[0116] (a) Extraction: Gather ginkgo green leaves in late summer and early autumn, when the content of effective therapeutic ingredients is high and the water content is lower than 8%, after drying, it is pulverized into leaves less than 4mm in a pulverizer. Then use 12 times the amount of solvent system to reflux twice, each time for 1 to 3 hours. The solvent system can be water, water-ethanol and acetone-water, filter to remove solids or residue, and combine the above two filtrates.

[0117] (b) concentrated: the filtrate that step (a) obtains is concentrated into the medicinal extract that does not contain organic solvent through vacuum concentration,

[0118] (d=1.2~1.25, t=60℃)

[0119] (c) Precipitation: Dissolve the extract obtained in step (b) in 2 times the amount of boiling water, cool to about 12°C, a precipitate forms, and separate by filtration.

[0120] (d) Colu...

example 3

[0124] The invention provides a method for preparing ginkgo composition, the steps are as follows: reflux 100kg of dry ginkgo leaf powder and 1000kg, 50% ethanol solution for 2 hours, filter, and then use 1000kg of filter residue, reflux with 50% ethanol for 2 hours, filter , combined two filtrates, concentrated in vacuum at 60° C. to no alcohol (d=1.2), dissolved the concentrate in 300 kg of water and left it for 48 hours, and filtered. The mixed column of macroporous resin and polyamide on the filtrate is respectively eluted with 100kg of water, 100kg of 30% ethanol solution, 100kg of 60% ethanol solution, and 100kg of 90% ethanol solution. The liquid was removed, the combined liquid was concentrated in vacuo to about 70 kg of extract, the extract was extracted three times with n-hexane, and the aqueous phase was concentrated in vacuo and dried. 1.5kg of the final product contains less than 5% water and 47.2% flavonoids, including about 24.8% flavonoid glycosides, 6.3% lacto...

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Abstract

This invention provides different compositions extracted from Ginkgo biloba leaves. Said compositions comprise new active components. This invention also provides a method of preparation of the compositions and individual components of said compositions. Finally, this invention provides various uses of this composition.

Description

[0001] The present invention is submitted on December 12, 2003 with the application number 200310118517.2 (the application date is March 19, 1999, and its original application number is 99803683.8), and the invention name is "Ginkgo biloba composition and its preparation method and application". A divisional application of a patent application. technical field [0002] The invention relates to herbal preparations, in particular to a ginkgo biloba composition and its preparation method and application. [0003] Ginkgo Biloba is the oldest living seed plant and the only survivor of the Ginkgo family dating back to the Permian period more than 200 million years ago. Ginkgo biloba preparations have been used for healing in China for more than 5,000 years, that is, since the earliest origins of Chinese herbal medicine. Since the 1960s, herbal extracts of Ginkgo biloba have been used in the treatment of cerebrovascular and peripheral vascular diseases in many countries, such as Ger...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N1/28A01N43/04A61K31/70A61K36/16A61P3/06A61P9/10C12Q1/00
CPCY10S435/967A61K36/16A61P3/06A61P9/10
Inventor 谢德隆王宁高崎张国安邵宝平金小吾黄新生
Owner SPH XING LING SCI & TECH PHARM CO LTD
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