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Ginkgolide sublingual tablet and preparation method thereof

A technology of ginkgolides and sublingual tablets, which is applied in the direction of antidote, sugar-coated pills, pill delivery, etc., can solve the problems of no sublingual tablet preparations, achieve good taste, improve compliance, and ensure the effect of treatment

Inactive Publication Date: 2014-08-13
HUNAN UNIV OF SCI & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many ginkgolide preparations disclosed at present, but there are no sublingual tablet preparations. The drug avoids the damage to the drug by the digestive enzymes in the gastrointestinal tract and the first-pass metabolism of the liver, improves the bioavailability, enables the drug to be absorbed quickly, and rapidly exerts its efficacy

Method used

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  • Ginkgolide sublingual tablet and preparation method thereof
  • Ginkgolide sublingual tablet and preparation method thereof
  • Ginkgolide sublingual tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A ginkgolide sublingual tablet, which is made of ginkgolide 50g, pregelatinized starch 100g, dextrin 30g, sodium carboxymethyl starch 2g, magnesium stearate 1g; the ginkgolide contains the following mass fraction Components: Ginkgolide A35%, Ginkgolide B15%, Ginkgolide C25%, Bilobalide 25%.

[0026] The specific preparation method is as follows: the above-mentioned main drug ginkgolide, filler pregelatinized starch, dextrin, disintegrant sodium carboxymethyl starch and lubricant magnesium stearate are dried, pulverized, and sieved for pretreatment; After pretreatment of the main drug, filler and disintegrant, use pure water and ethanol as binder to make the mixed material into soft material, granulate with 40 mesh sieve; and dry at 60°C until it meets the requirements of Moisture ≤ 3%; then add lubricant to the dry granules obtained above, carry out total mixing, and finally compress into tablets to obtain ginkgolide sublingual tablets.

Embodiment 2

[0028] A ginkgolide sublingual tablet, which is made of ginkgolide 50g, lactose 60g, microcrystalline cellulose 60g, sucralose 2g, crosslinked polyvinylpyrrolidone 3g, magnesium stearate 1g, micropowder silica gel 1g; The ginkgolide contains the following components in mass fraction: ginkgolide A 45%, ginkgolide B 15%, ginkgolide C 20%, bilobalide 20%. .

[0029] The specific preparation method is as follows: the above-mentioned components are pretreated by drying, pulverizing and sieving; after being mixed evenly, the ginkgolide sublingual tablets are directly compressed into tablets.

Embodiment 3

[0031] A ginkgolide sublingual tablet, which is made of ginkgolide 80g, xylitol 40g, microcrystalline cellulose 50g, stevioside 3g, lactose 10g, low-substituted hydroxypropyl cellulose 3g, polyethylene glycol 60001g , the ginkgolide contains the following components in mass fraction: ginkgolide A40%, ginkgolide B10%, ginkgolide C21%, bilobalide 29%.

[0032] The specific preparation method is as follows: dry, pulverize, and sieve the above-mentioned components; then mix the components except polyethylene glycol 6000 evenly, and use a dry granulator to make granules over 40 mesh, and then add polyethylene glycol Glycol 6000, compressed into tablets to obtain ginkgolide sublingual tablets.

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Abstract

The invention discloses a ginkgolide sublingual tablet, belonging to the technical field of a pharmaceutical composition, and a preparation method thereof. The sublingual tablet comprises the following materials in parts by weight: 1-200 parts of ginkgolide, 2-20 parts of a disintegrating agent and 40-200 parts of a filler, wherein the ginkgolide includes the following components in percentage by weight: 35-50% of ginkgolide A, 6-16% of ginkgolide B, 15-25% of ginkgolide C and 30-45% of bilobalide. The ginkgolide sublingual tablet disclosed by the invention is prepared by organically combining the disintegrating agent, the filler and the like; the sublingual tablet, which is located under the tongue when being taken, can disintegrate rapidly under the tongue; the sublingual tablet is absorbed through sublingual mucosa and directly participates in blood circulation through jugular vein and superior vena cava to become effective rapidly, so as to relieve migraine rapidly.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical compositions, and in particular relates to a ginkgolide sublingual tablet and a preparation method thereof. Background technique [0002] Ginkgo biloba preparations are currently one of the most important drugs used for the treatment and prevention of cardiovascular and cerebrovascular diseases in the world and at home, and are also the herbal medicines with the largest sales volume and widest acceptance. my country's ginkgo resources account for more than 70% of the world's total resources. The annual output of ginkgo leaves is as high as 20,000 tons, and the annual output of ginkgo leaf standard extract (EGb761) is more than 100 tons. The raw materials are sufficient. The raw materials of foreign ginkgo products are also mainly from my country. The export value of Ginkgo biloba and Ginkgo biloba standard extracts ranks first in Chinese herbal medicines in my country. But the research and ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/28A61K31/365A61P7/02A61P9/10A61P25/00A61P39/06
Inventor 何福林李治章陈小明刘小文姜红宇刘婷顾群王峥陈修文王宗成邵金华
Owner HUNAN UNIV OF SCI & ENG
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