71 results about "Neuroplasticity" patented technology

Apparatus and techniques to address the problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and / or a position controller to improve the desired treatment, such as_electrical stimulation and / or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

A neuro-stimulation system employs a includes a stimulator which may include electrode devices and / or vibration elements. A controller may be employed to drive the stimulating elements with an electrical signal. In response to the electrical signal, the stimulating elements deliver electrical and / or mechanical stimulation to the body part. The stimulation may be an aperiodic stimulation and / or may be a subthreshold stimulation. In one embodiment, the stimulator is disposable and the processor determines usage of the stimulator and ensures that the stimulator is limited to a certain amount of use. Neuro-stimulation systems may be applied to sensory cells of body parts during movement of the body parts to induce neuroplastic changes. Such movement may involve a variety of therapeutic applications, e.g. in stroke patient therapy.

According to one aspect, an electrical stimulation system provides reduced neuroplasticity effects in a person's nerve tissue. The system includes an electrical stimulation lead adapted for implantation into the person's body for electrical stimulation of target nerve tissue. The lead includes a number of electrodes adapted to be positioned near the target nerve tissue and to deliver electrical stimulation energy to the target nerve tissue. The system also includes a stimulation source connectable to the lead and operable to generate signals for transmission to the electrodes of the lead to cause the electrodes to deliver electrical stimulation energy to the target nerve tissue to reduce neuroplasticity effects.

A system and method that facilitates stimulating neural pathways, e.g., muscles and / or associated nerves, of a patient's body for the purpose of therapeutic medical treatment by rehabilitating weakened muscles and using neuroplasticity to retrain sequential muscle movements and / or to provide the ability to directly deliver functional motor movements. Use of the present invention is of particular value for treating a patient following a stroke. More particularly, such systems are characterized by a plurality of discrete devices, preferably battery powered but may alternatively include RF-powered devices as well or in combination, configured for implanting within a patient's body via injection, each device being configured to affect a parameter, e.g., via nerve and / or muscle stimulation and / or to sense a body parameter, e.g., temperature, O2 content, physical position, electrical potential, etc., that operate under control of a system controller that coordinates the sequential stimulation via wireless commands to the implanted devices.

Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and / or a position controller to improve the desired treatment, such as electrical stimulation and / or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

A method for changing appearance of EEG or a relationship of brain wave patterns while achieving behavioral changes, the method including individualized assessing of dysregulated patterns of brain function using topographic quantitative electroencephalogram (LORETA [low resolution brain electromagnetic tomography] qEEG) or regular EEG recollection, modifying or priming neuroplasticity with transcranial direct current stimulation (tDCS) or with magnetic or electromagnetic fields to modify cortical excitability of neurons in dysregulated areas, and self-regulating LORETA patterns with neurofeedback to change an appearance of EEG or a relationship of brain wave patterns while achieving behavioral changes.

Systems and methods are provided for treating chronic pain occurring secondarily to subacromial impingement syndrome in a human body. A system is provided to deliver percutaneous electrical stimulation through at least one electrode to neurological motor points of the posterior and middle deltoid muscles to mediate such pain. One-time, continued and / or periodic dosing of treatment methods according to the present invention may result in a change to central nervous system maladaptive neuroplasticity.

A training program is configured to systematically drive neurological changes to treat an addiction, wherein a plurality of addiction-related stimuli stimulate craving for the object of the addiction. The training program comprises at least one computerized reverse conditioning game configured to present a plurality of target and distractor stimuli, wherein a subset of the distractor stimuli are addiction-related stimuli, and prompts a game participant to respond to the target stimuli and ignore the distractor stimuli.

Systems and methods are provided for treating chronic pain occurring secondarily to subacromial impingement syndrome in a human body. A system is provided to deliver percutaneous electrical stimulation through at least one electrode to neurological motor points of the posterior and middle deltoid muscles to mediate such pain. One-time, continued and / or periodic dosing of treatment methods according to the present invention may result in a change to central nervous system maladaptive neuroplasticity.

Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and / or a position controller to improve the desired treatment, such as electrical stimulation and / or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

The invention discloses a walker aid robot system based on a brain-machine-muscle information loop. The system is characterized in that a computer processes electroencephalogram data and electromyography data in real time and acquires a motion intention of a user by analyzing motion-related characters in the electroencephalogram data and the electromyography data; the computer obtains motion intention information and motion state information of the user, then feeds the information into a hybrid walker aid driving model, and outputs two control parameters for respectively controlling a neuromuscular electrical stimulator and robotic exoskeleton; the first control parameter is used for controlling the neuromuscular electrical stimulator to apply electrical stimulation to the striding side with the motion intention to further drive the intention side to produce a striding action; the second control parameter is used for controlling the robotic exoskeleton to adjust a gravity center angleand further maintain the converting balance between standing and walking; the computer optimizes and cooperates a loop model consisting of a brain-machine information interaction module, a machine-muscle information interaction module and a brain-muscle information interaction module by taking neuroplasticity as an index, so as to establish the walker aid robot system with a high-compactness brain-machine-muscle information loop model.

A training program is configured to systematically drive neurological changes to overcome social cognitive deficits. Various games challenge the participant to observe gaze directions in facial images, match faces from different angles, reconstruct face sequence, memorize social details about sequentially presented faces, identify smiling faces, find faces whose expression matches the target, identify emotions implicitly expressed by facial expressions, match pairs of similar facial expressions, match pairs of emotion clips and emotion labels, reconstruct sequences of emotion clips, identify emotional prosodies of progressively shorter sentences, match sentences with tags that identify emotional prosodies with which they are expressed, identify social scenarios that best explain emotions expressed in video clips, answer questions about social interactions in multi-segmented stories, choose expressions and associated prosodies that best describe how a person would sound in given social scenarios, and / or understand and interpret gradually more complex social scenes.

The invention relates to a pure tone-based tinnitus treatment system comprising a control module, an audio playing module, a micro-current generation module, a pure-tone voice frequency and an earphone. The control module controls the audio play module to play pure-tone audios in a random way and eliminates pure-tone frequency in an octave with tinnitus frequency as central frequency; the earphone is provided with conductive electrodes; the micro-current generation module is connected with the conductive electrodes; when the pure-tone audio is played, a micro-current pulse signal is produced, so a nervivagus passing through the surrounding of an auditory meatus can be excited. Compared with the prior art, with pure-tone excitation and nervivagus excitation, a central pivot cortex can be inducted in an orientated way to produce favorable neuroplasticity changes; and tinnitus perception changeover and pathological central pivot plasticity changes can be achieved. Different from a traditional treatment method, a personalized sound treatment method is designed for a tinnitus occurrence mechanism; and great tinnitus treatment effect can be achieved; and the treatment process is simple and convenient.

The invention relates to the field of brain health cognitive rehabilitation training and aims to solve the technical problem of providing a cognitive training method for improving executive functionsand a system. The cognitive training method comprises the following steps: inputting personal information of a user, and registering an account; according to a cognitive function defect grade of the user, selecting corresponding training modes to carry out training; storing data generated in the training process and the personal information of the user into a database, and generating training reports; after one training cycle, evaluating the cognitive capability of the user, and updating training items. The cognitive training method is developed according to dementia disease cognitive damage characteristics, occurrence regularity and neuroplasticity and on the basis of multiple classical cognitive psychology experimental paradigms, meanwhile interestingness and playability are taken into account, elements such as traditional Chinese culture are engaged, and scientific and effective individual and intelligent training on chief action cognitive impairment, mild cognitive impairment and executive functions of people with the risk of dementia can be implemented.

The invention relates to the field of cognition rehabilitation training of brain health and provides a cognition training method and system for improving sensory perception. The training method comprises the following steps that personal information of a user is input for account number register; according to a cognition function defect grade of the user, a corresponding training mode is selectedfor training; data generated in the training process and the personal information of the user are stored into a database, and a training report is generated; after a training period is completed, thecognition ability of the user is evaluated, and a training item is updated. According to cognition injury characteristics and occurrence rules of the dementia disease and neuroplasticity, based on various classical cognition psychological experiment paradigms, research and development are conducted, the interestingness and playability are considered at the same time, the method is infused with elements such as Chinese traditional culture, and scientific, effective, individual and intelligent training is conducted on the sensory perception of chief complaint cognitive impairment, mild cognitiveimpairment and dementia risk people.

The present invention provides a method of using non-hallucinogenic analogs of psychedelic compounds for increasing neural plasticity of the neuronal cell, and a method of using thereof for treating a brain disorder.

The present invention provides compositions and methods of treating a patient having a condition selected from the group of cerebral stroke, heart stroke, neurodegenerative diseases, brain or nervous system trauma, or neuroplasticity wherein the composition comprises: (i) at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 of: Radix Astragali (milkvetch root or Huang Qi); Rhizoma Salviae Miltiorrhizae root (red sage or Dan Shen); Radix Paeoniae Rubra (red peony or chi shao); Ligusticum Chuanxiong (Chuan Xiong); Rhizoma Notoginseng (Sanqi); Odoriferous Rosewood (Jiang Xiang); Scorpion (Quan Xie); Radix Polygalae (Yuan Zhi); Grassleaf sweetflag (Shi Changpu); Leech (Hirudo or Shuizhi); Ground beetle (Tu Bie Chong); Cow bezoar (calculus Bovis artifactus or Rengong Niuhuang); Gambirplant (ramulus uncariae cum uncis or Gou teng); and (ii) an agent used in Western medicine.

The invention discloses a lactic acid bacteria complex microbial agent for treating depression. The lactic acid bacteria complex microbial agent is a JF complex lactic acid bacteria preparation, and mainly comprises lactobacillus helveticus and lactobacillus fermentum, wherein the lactobacillus helveticus and lactobacillus fermentum are combined according the weight ratio of 1:3. The lactic acid bacteria complex microbial agent provided by the invention has the advantages that an anti-depression effect is realized by restoring healthy flora and regulating bacteria, intestinal and brain axis functions, and the lactic acid bacteria complex microbial agent has a good therapeutic effect for depression, and the effective rate is 90% or higher, not only is peripheral inflammation reduced, but also neuroinflammation is improved, the neurogenesis in brain is increased, and the brain neuroplasticity is enhanced.

The present invention is directed towards a medicament comprising a capsaicinoid possessing antiviral activity and useful in the treatment of viral infections and in the treatment of HIV / AIDS. The medicament also possesses neuroplasticity-enhancing activity and is useful in the treatment of stress and other psychological conditions. Further, the medicament possesses anti-inflammatory activity and is useful in the treatment of arthritis. The medicament has also been shown to possess antibacterial activity.

The invention relates to a collaborative rehabilitation training device for upper limb sensory dyskinesia. The collaborative rehabilitation training device comprises a box body, temperature control equipment, a control device, monitoring equipment and a motor imagery visualization module, wherein the box body is provided with an arm insertion opening with a bag; the temperature control equipment is used for providing cold and hot airflow; a filler is laid at the bottom of the box body; the monitoring equipment comprises a camera, an illumination device and a pressure and temperature sensor; the control device comprises a display module and a control button and is used for adjusting the training state; the motor imagery visualization module comprises an imaging terminal and a monitoring terminal, the monitoring terminal transmits data to the imaging terminal, visual processing of brain waves is achieved, and the motor imagery ability of the cortex of the patient is monitored; accordingto the collaborative rehabilitation training device, the sensory nerve conduction path is enhanced through multi-sensory stimulation cooperative training, the motor imagination ability is improved, the somatosensory region, the motor auxiliary front region, the main motion region, the primary and secondary motor sensory cortex and the prefrontal mirror image neuron system are activated, and the central nervous plasticity is improved.

The present invention discloses a method to recover and restore dendritic and synaptic neuron connections that have been degraded or destroyed by neurodegenerative diseases. In the present invention tryptamines are used to induce neuro plasticity and restore both dendritic density and synaptic connections of neurons in the brain. In the preferred embodiment LSD given in micro doses can induce dendritic and synaptic genesis in neuronal networks and improve the quality of life of people with neurodegenerative diseases such as Alzheimer's, Huntington's, Multiple Sclerosis, Parkinson's and Frontotemporal dementia.

The present disclosure provides methods for treating a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in central gain, and / or changes in neural sensitivity in a subject by inhibiting the function and / or production of tumor necrosis factor alpha (TNF-α) in the subject. The present disclosure provides methods of administering to the subject a TNF-α inhibitory agent in an amount effective to treat the subject for a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in central gain, and / or changes in neural sensitivity. TNF-α inhibitory agents of the subject disclosure include agents that inhibit the function TNF-α, inhibit the production of TNF-α, inhibit TNF-α signaling, inhibit TNF-α expression, or inhibit TNF-α signaling pathway genes in the subject. The present disclosure also provides methods for treating a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in central gain, and / or changes in neural sensitivity in a subject by disrupting one or more alleles of a TNF-α signaling pathway gene in a cell of the subject.

The invention discloses application of a small dose of propofol in preparing products for preventing and curing post-traumatic stress disorder (PTSD). Stress disorder and its related diseases include acute stress disorder (ASD) and PTSD. According to the test of injecting a small dose of propofol in the abdominal cavity of a PTSD pattern animal, the small dose of propofol has function of relieving fear, anxiety and learning and memory impairment of the PTSD pattern animal, and can decrease expressions of inducible nitric oxide synthase (iNOS) and neurons nitric oxide synthase (nNOS) which are caused by strong stress, increase expression of brain derived neurotrophic factor (BDNF) which plays an important role in neuroplasticity regulation and reduce release of nitric oxide (NO) of glioma cell of the pattern animal greatly. Accordingly, propofol with the advantages of quick action, quick metabolic clearance and no residues has good application prospect.

The invention discloses a hederagenin amide derivative which is N-(3-dimethylaminopropyl)-hederagenin-17-formamide (HGA). According to the hederagenin amide derivative, 3-dimethylamino propylamine is introduced at the 28th position of the hederagenin, the hederagenin and a drone form a hydrogen bond due to the existence of amino, so that the biological activity of the hederagenin is improved, and an anti-depression effect of the hederagenin is better, and furthermore, a lot of experiments prove that the N-(3-dimethylaminopropyl)-hederagenin-17-formamide also has a good effect in neuroprotection and anti-tumor. The hederagenin amide derivative shows that neuroplasticity and depression are closely related, and a BDNF (brain derived neurotrophic factor) has a certain relationship with depression and is beneficial for the nerve plasticity to recover. The invention also discloses a mechanism studying an HGA neuroprotective effect from the point of view of BDNF and neuroplasticity.

The invention relates to a procedure for screening of neuroactive substance and the associated neural plasticity by treating fruitfly Drosophila melanogaster adult males with fly medium containing either of the neuroactive compounds strychnine, pentylenetetrazol, pilocarpine hydrochloride, tetraethylammonium chloride, lithium carbonate and ethosuximide, subjecting flies to negative geotaxis and horizontal locomotor assays, observing the height climbed and distance walked by and the climbing speed of the flies wherein an altered height climbed by flies under drug treatment and a long-lasting alteration in climbing speed of flies after drug withdrawal is most characteristic of the neuractive compounds.