71 results about "Neuroplasticity" patented technology

A neuro-stimulation system employs a includes a stimulator which may include electrode devices and/or vibration elements. A controller may be employed to drive the stimulating elements with an electrical signal. In response to the electrical signal, the stimulating elements deliver electrical and/or mechanical stimulation to the body part. The stimulation may be an aperiodic stimulation and/or may be a subthreshold stimulation. In one embodiment, the stimulator is disposable and the processor determines usage of the stimulator and ensures that the stimulator is limited to a certain amount of use. Neuro-stimulation systems may be applied to sensory cells of body parts during movement of the body parts to induce neuroplastic changes. Such movement may involve a variety of therapeutic applications, e.g. in stroke patient therapy.

According to one aspect, an electrical stimulation system provides reduced neuroplasticity effects in a person's nerve tissue. The system includes an electrical stimulation lead adapted for implantation into the person's body for electrical stimulation of target nerve tissue. The lead includes a number of electrodes adapted to be positioned near the target nerve tissue and to deliver electrical stimulation energy to the target nerve tissue. The system also includes a stimulation source connectable to the lead and operable to generate signals for transmission to the electrodes of the lead to cause the electrodes to deliver electrical stimulation energy to the target nerve tissue to reduce neuroplasticity effects.

A method for changing appearance of EEG or a relationship of brain wave patterns while achieving behavioral changes, the method including individualized assessing of dysregulated patterns of brain function using topographic quantitative electroencephalogram (LORETA [low resolution brain electromagnetic tomography] qEEG) or regular EEG recollection, modifying or priming neuroplasticity with transcranial direct current stimulation (tDCS) or with magnetic or electromagnetic fields to modify cortical excitability of neurons in dysregulated areas, and self-regulating LORETA patterns with neurofeedback to change an appearance of EEG or a relationship of brain wave patterns while achieving behavioral changes.

Systems and methods are provided for treating chronic pain occurring secondarily to subacromial impingement syndrome in a human body. A system is provided to deliver percutaneous electrical stimulation through at least one electrode to neurological motor points of the posterior and middle deltoid muscles to mediate such pain. One-time, continued and/or periodic dosing of treatment methods according to the present invention may result in a change to central nervous system maladaptive neuroplasticity.

The invention discloses a walker aid robot system based on a brain-machine-muscle information loop. The system is characterized in that a computer processes electroencephalogram data and electromyography data in real time and acquires a motion intention of a user by analyzing motion-related characters in the electroencephalogram data and the electromyography data; the computer obtains motion intention information and motion state information of the user, then feeds the information into a hybrid walker aid driving model, and outputs two control parameters for respectively controlling a neuromuscular electrical stimulator and robotic exoskeleton; the first control parameter is used for controlling the neuromuscular electrical stimulator to apply electrical stimulation to the striding side with the motion intention to further drive the intention side to produce a striding action; the second control parameter is used for controlling the robotic exoskeleton to adjust a gravity center angleand further maintain the converting balance between standing and walking; the computer optimizes and cooperates a loop model consisting of a brain-machine information interaction module, a machine-muscle information interaction module and a brain-muscle information interaction module by taking neuroplasticity as an index, so as to establish the walker aid robot system with a high-compactness brain-machine-muscle information loop model.

The present invention provides compositions and methods of treating a patient having a condition selected from the group of cerebral stroke, heart stroke, neurodegenerative diseases, brain or nervous system trauma, or neuroplasticity wherein the composition comprises: (i) at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 of: Radix Astragali (milkvetch root or Huang Qi); Rhizoma Salviae Miltiorrhizae root (red sage or Dan Shen); Radix Paeoniae Rubra (red peony or chi shao); Ligusticum Chuanxiong (Chuan Xiong); Rhizoma Notoginseng (Sanqi); Odoriferous Rosewood (Jiang Xiang); Scorpion (Quan Xie); Radix Polygalae (Yuan Zhi); Grassleaf sweetflag (Shi Changpu); Leech (Hirudo or Shuizhi); Ground beetle (Tu Bie Chong); Cow bezoar (calculus Bovis artifactus or Rengong Niuhuang); Gambirplant (ramulus uncariae cum uncis or Gou teng); and (ii) an agent used in Western medicine.

The invention relates to a collaborative rehabilitation training device for upper limb sensory dyskinesia. The collaborative rehabilitation training device comprises a box body, temperature control equipment, a control device, monitoring equipment and a motor imagery visualization module, wherein the box body is provided with an arm insertion opening with a bag; the temperature control equipment is used for providing cold and hot airflow; a filler is laid at the bottom of the box body; the monitoring equipment comprises a camera, an illumination device and a pressure and temperature sensor; the control device comprises a display module and a control button and is used for adjusting the training state; the motor imagery visualization module comprises an imaging terminal and a monitoring terminal, the monitoring terminal transmits data to the imaging terminal, visual processing of brain waves is achieved, and the motor imagery ability of the cortex of the patient is monitored; accordingto the collaborative rehabilitation training device, the sensory nerve conduction path is enhanced through multi-sensory stimulation cooperative training, the motor imagination ability is improved, the somatosensory region, the motor auxiliary front region, the main motion region, the primary and secondary motor sensory cortex and the prefrontal mirror image neuron system are activated, and the central nervous plasticity is improved.

The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.

The present disclosure provides methods for treating a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in central gain, and/or changes in neural sensitivity in a subject by inhibiting the function and/or production of tumor necrosis factor alpha (TNF-α) in the subject. The present disclosure provides methods of administering to the subject a TNF-α inhibitory agent in an amount effective to treat the subject for a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in central gain, and/or changes in neural sensitivity. TNF-α inhibitory agents of the subject disclosure include agents that inhibit the function TNF-α, inhibit the production of TNF-α, inhibit TNF-α signaling, inhibit TNF-α expression, or inhibit TNF-α signaling pathway genes in the subject. The present disclosure also provides methods for treating a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in central gain, and/or changes in neural sensitivity in a subject by disrupting one or more alleles of a TNF-α signaling pathway gene in a cell of the subject.

The invention relates to a procedure for screening of neuroactive substance and the associated neural plasticity by treating fruitfly Drosophila melanogaster adult males with fly medium containing either of the neuroactive compounds strychnine, pentylenetetrazol, pilocarpine hydrochloride, tetraethylammonium chloride, lithium carbonate and ethosuximide, subjecting flies to negative geotaxis and horizontal locomotor assays, observing the height climbed and distance walked by and the climbing speed of the flies wherein an altered height climbed by flies under drug treatment and a long-lasting alteration in climbing speed of flies after drug withdrawal is most characteristic of the neuractive compounds.