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Application of pachymic acid A in preparation of drug for treating chronic kidney disease

A chronic kidney disease, pachymic acid technology, applied in the new application field of pachymic acid A, can solve the problems of exacerbation, inability to improve, high recurrence rate, etc.

Active Publication Date: 2017-08-18
NORTHWEST UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Although western medicine has a certain curative effect, it has the disadvantages of large toxic side effects and high recurrence rate. For example, medicinal activated charcoal is effective in the early stage of the disease, but it will aggravate the disease in the later stage. It cannot improve the increase of serum creatinine and urea, and symptoms that are difficult to control appear , which will eventually develop into more serious consequences

Method used

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  • Application of pachymic acid A in preparation of drug for treating chronic kidney disease
  • Application of pachymic acid A in preparation of drug for treating chronic kidney disease
  • Application of pachymic acid A in preparation of drug for treating chronic kidney disease

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Embodiment Construction

[0011] Poria cocos is the dried sclerotia of Poria cocos, a polyporaceae fungus. Poria cocos was first recorded in "Shen Nong's Materia Medica". Poria cocos is flat in nature, sweet and light in taste, and returns to the heart, lung, spleen and kidney channels. Poria is a commonly used traditional Chinese medicine for invigorating the spleen and stomach, diuresis and dampness, and calming the mind; clinical use is divided into Poria, Fushen, Chi Fuling, etc. Poria has been a very important traditional Chinese medicine for both medicine and food since ancient times. There are ten medicines According to the theory of Nine Poria Cocos, Poria Cocos is listed as the top grade. The main active ingredients of Poria cocos are polysaccharides and tetracyclic triterpenoids. Tetracyclic triterpenoids in Poria cocos have anti-cancer, anti-tumor, immune regulation, antagonism of aldosterone in vivo and other activities. The Poria cocos skin is the outer skin of the Poria cocos sclerotium...

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Abstract

The invention relates to an application of a pachymic acid A in preparation of a drug for treating a chronic kidney disease. A research result of an inventor shows that the pachymic acid A has a relatively good treatment effect on a rat model from which 5 / 6 kidneys are cut off. The pachymic acid A is capable of providing a novel candidate drug for treating the chronic kidney disease for clinical use.

Description

technical field [0001] The invention relates to a new application of pachymic acid A, in particular to the application of pachymic acid A as a medicine for treating chronic kidney disease. Background technique [0002] Chronic kidney disease is one of the major diseases affecting human health. The incidence of chronic kidney disease continues to rise along with the increasing prevalence of hypertension and diabetes. [0003] Chronic kidney disease (CKD) refers to chronic kidney structure and dysfunction caused by various reasons (history of kidney damage greater than 3 months), including normal and abnormal pathological damage of renal glomerular filtration rate, blood or urine components Abnormal, abnormal imaging examination, or unexplained decrease in glomerular filtration rate (<60ml / min·1.73m2) for more than 3 months. Statistics from the International Society of Nephrology show that the annual incidence of chronic renal failure in the 4th stage of chronic kidney di...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P13/12
CPCA61K31/575
Inventor 赵英永
Owner NORTHWEST UNIV
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