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Medicinal composition for treating senile dementia disease

A technology for senile dementia and its composition, which is applied in the field of preparation of drugs for treating senile dementia, and can solve the problems of restricting the in-depth development and evaluation of traditional Chinese medicine, late senile dementia, and less research

Inactive Publication Date: 2018-05-29
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the active ingredients of traditional Chinese medicine for the treatment of senile dementia started relatively late, and there are relatively few studies, which seriously restrict the in-depth development and evaluation of traditional Chinese medicine.

Method used

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  • Medicinal composition for treating senile dementia disease
  • Medicinal composition for treating senile dementia disease
  • Medicinal composition for treating senile dementia disease

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0078] Weigh 200 grams each of Fushen, Shichangpu, and Polygala, add 6.0L of water, soak for 30 minutes, decoct and extract twice, each decoction time is 1.5 hours, combine the two extracts, filter, and decompress Concentrate to a relative density of 1.29 (60°C), dry and pulverize the thick paste to obtain the extract. As determined by high-performance liquid chromatography, the content of pachymic acid in the extract is 0.08%, the content of α-asarone is 0.03%, the content of β-asarone is 0.18%, the content of polygala saponin is 0.48%, and polygala saponin B The content is 0.73%, polygala The ketone III content was 0.06%. The total polysaccharide content measured by ultraviolet spectrophotometry is 7.95%.

preparation Embodiment 2

[0079] Preparation Example 2——Preparation of Poria Cocos, Shichangpu and Polygala Mixed Extract

[0080] Weigh 500g of Acorus acorus and 250g of Polygala, add 10 times the amount of 60% ethanol, reflux extraction twice, 2 hours each time, combine the extracts, filter, recover ethanol under reduced pressure, continue to concentrate under reduced pressure to a relative density of 1.28 (60°C ), the thick paste is dried and pulverized to obtain the mixed extract of Acorus calamus and Polygala. Take 250 g of Poria cocos medicinal material, add 8 times the amount of water to decoct twice, each time for 1.5 hours, combine the decoction, filter, concentrate the filtrate under reduced pressure, dry and pulverize the thick paste, and obtain the Poria cocos extract. The above-mentioned mixed extracts of Acorus iris and Polygala and the extract of Poria cocos are combined at a ratio of 3:1 to obtain the mixed extract of Acorus iris, Polygala and Poria cocos.

preparation Embodiment 3

[0081] Preparation Example 3——Preparation of Pachymic Acid

[0082] Poria cocos 500g, add 8 times the amount of 90% ethanol, reflux extraction twice, 2 hours each time, combine the extracts and filter, concentrate under reduced pressure to recover ethanol, continue to concentrate under reduced pressure to a relative density of 1.28 (60°C); Add 3L of water to the ointment, extract 3 times with petroleum ether, remove the petroleum ether extract, extract the remaining water phase 3 times with ethyl acetate, combine the ethyl acetate extract, recover to dryness, and obtain the crude product of dark gray pachymic acid; The above crude product is subjected to silica gel column chromatography (1:20, g / g), eluted with petroleum ether: acetone=8:1, and subjected to thin-layer chromatography detection, according to the situation of thin-layer chromatography, the fractions containing pachymic acid are combined , and then recrystallized from acetone to obtain pachynic acid.

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Abstract

The present invention relates to a medicinal composition for treating senile dementia disease. Specifically, the medicinal composition for treating senile dementia disease comprises the following active ingredients and a pharmaceutically acceptable carrier; wherein the active ingredients are selected from the group consisting of pachymic acid, alpha-asarone, beta-asarone, tenuifolin, Onjisaponin B, Polygalaxanthone III, pachymaran, polysaccharide of rhizoma acori graminei, polysaccharide of Polygala tenuifolia and a combination thereof. Pharmacological experiments find that the medicinal composition has a good therapeutic effect on various animal models of senile dementia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating senile dementia and its preparation method and application. More specifically, the present invention relates to a compound pharmaceutical composition of active ingredients in Fushen or Poria cocos, Shichangpu and Polygala medicinal materials, and its use in the preparation of medicines for treating senile dementia. Background technique [0002] Alzheimer's disease is a disease of chronic progressive or stage-progressive mental decline that occurs in old age, and is mainly divided into senile dementia (Alzheimer's disease, AD) including primary brain degeneration and cerebrovascular disorders Vascular dementia (VD), mixed dementia and other dementias are caused by it, but AD and VD are the most common types, accounting for more than 90% of all dementias. AD is a degenerative disease of the central nervous system, characterized by advanced cognitive dysfunction, and a syndrome of senile ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/575A61K31/09A61K31/7048A61K31/194A61K31/704A61K31/7024A61P25/28A61P25/16A61P21/00A61P25/14A61P25/00
CPCA61K31/09A61K31/194A61K31/575A61K31/7024A61K31/704A61K31/7048A61K31/715A61K36/076A61K36/69A61K36/888A61K2300/00
Inventor 裴钢黄成钢赵简李志雄侯羽君高羽李晓行
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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