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Preparation method and application of Poria cocos acidic polysaccharide

The technology of acid polysaccharide and tuckahoe is applied in the field of preparation of tuckahoe acid polysaccharide, which can solve the problems of unfavorable conversion large-scale production, difficulty in continuous production and high viscosity of extracting liquid, and achieve the effects of saving medicinal materials, environmental protection of the process and simple equipment.

Inactive Publication Date: 2019-07-09
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional process is to use concentrated alkali to immerse and extract below 4°C. The extract obtained by this method has high viscosity, difficult filtration, troublesome follow-up treatment, and long production cycle, which is not conducive to large-scale production; it is reported that some people use supercritical extraction to extract Poria cocos acidic polysaccharide, this method not only uses complex co-solvents, but also is not easy to realize industrialized large-scale production due to expensive supercritical equipment, high-pressure operation, high safety requirements, continuous production is difficult, and production cost is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 Poria cocos acidic polysaccharide

[0024] (1) 100kg of Poria cocos medicinal material is placed in an extraction tank, 720L of 95% ethanol is added, reflux extraction is performed 3 times, each time for 3 hours, the dregs of the poria cocos are dried, pulverized, and passed through a 80-mesh sieve to obtain Poria cocos powder;

[0025] (2) Take Poria cocos powder, add 1500L of 0.25mol / L sodium hydroxide solution under rapid stirring, alkalize at 20°C for 4 hours, filter to obtain alkali extract;

[0026] (3) Adjust the pH of the alkaline extract to 5-7 with 2 mol / L hydrochloric acid, centrifuge to separate the precipitate, wash the precipitate with water and ethanol in turn, dry until complete, and pulverize to obtain 70.2Kg of Poria cocos acidic polysaccharide powder.

Embodiment 2

[0027] The preparation of embodiment 2 Poria cocos acidic polysaccharide

[0028] (1) 100kg of Poria cocos medicinal material is placed in an extraction tank, 1000 L of 85% ethanol is added, reflux extraction is performed 4 times, each time for 2 hours, the dregs of the poria cocos are dried, pulverized, and passed through a 100-mesh sieve to obtain Poria cocos powder;

[0029] (2) Take Poria cocos powder, add 4500L of 0.95mol / L potassium hydroxide solution under rapid stirring, alkalize at 50°C for 8 hours, filter to obtain alkali extract;

[0030] (3) Adjust the pH of the alkaline extract to 5-7 with 2 mol / L hydrochloric acid, centrifuge to separate the precipitate, wash the precipitate with water and ethanol in turn, dry until complete, and pulverize to obtain 62.6Kg of Poria cocos acidic polysaccharide powder.

Embodiment 3

[0031] The preparation of embodiment 3 Poria cocos acidic polysaccharide

[0032] (1) Put 100kg of Poria cocos medicinal material in an extraction tank, add 1200L of 80% ethanol, reflux extraction twice, each time for 4 hours, dry the dregs of the poria cocos, pulverize, and pass through a 140-mesh sieve to obtain Poria cocos powder;

[0033] (2) Take Poria cocos powder, add 2000L of 0.65mol / L sodium carbonate solution under rapid stirring, alkalize at 40°C for 12 hours, filter to obtain alkali extract;

[0034] (3) Adjust the pH of the alkaline extract to 5-7 with 2 mol / L hydrochloric acid, centrifuge to separate the precipitate, wash the precipitate with water and ethanol in turn, dry until complete, and pulverize to obtain 55.1Kg of Poria cocos acidic polysaccharide powder.

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PUM

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Abstract

The invention discloses a preparation method and application of Poria cocos acidic polysaccharide. The preparation method is a method of preparing Poria cocos acidic polysaccharide by taking degreasedPoria cocos powder as a raw material and an alkali solution as an extraction solvent, and conducting extracting for 2-12 hours at 20-50 DEG C under a stirring condition. The preparation process provided by the invention is simple to operate, low in cost and environment-friendly, and the obtained Poria cocos acidic polysaccharide is high in content and has an obvious effect of regulating immunity.

Description

technical field [0001] The invention belongs to the field of polymer polysaccharides, in particular to a preparation method and application of poria cocos acidic polysaccharides. Background technique [0002] Poria cocos is the dried sclerotia of Poria cocos (Schw.) Wolf of Polyporaceae. It was first recorded in "Shen Nong's Materia Medica", listed as top grade, and is a commonly used traditional Chinese medicine for both medicine and food. Traditional Chinese medicine believes that Poria is flat in nature, sweet and light in taste, and returns to the heart, lung, spleen, and kidney meridian. Wait. The main components of Poria cocos are polysaccharides and triterpenes. Modern pharmacological studies have shown that it has biological activities such as regulating immune function, anti-tumor, anti-aging, and anti-fatigue, and the effect is remarkable. [0003] The content of chemical components of Poria cocos polysaccharides accounts for about 93% of the dry sclerotia of Por...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P37/02
CPCA61K31/715A23K20/163C08B37/0003
Inventor 史德胜黄松刘爱玲夏雪林李旭东王一凡
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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