41 results about "Curdione" patented technology

The invention discloses a high quality and yield culture technology of curcuma, which comprises the following steps: land selection and preparation, seed curcuma preparation, sowing, field management, harvesting and prevention and cure of plant diseases and insect pests. The technology of the invention is characterized in that: the loosening, fertile and sandy loamy soil with deep soil layers in which curcuma is not planted within one year is chosen for planting; prior to sowing, fossas are dug as per the depth of 0.08-0.12m, the suitable time for sowing is from June 20 to June 30, the planting density is 0.33-0.38m of row spacing, and the number of plants is 4600-6100 per mu; prior to sowing, the parent curcumas without plant diseases and insect pests are selected, curcuma is cut into small sections with 2-3 tubers, 4-6 sections are planted in each fossa, and the hurt and funked curcuma can not be taken as parent curcuma; during sowing, fossias are dug in field, and sowing is carried out according to the planting spacing of 0.33-0.38m. The bottom fertilizer is applied in the space between the parent curcumas, and covering soil is carried out. The technology can improve the yield of the medicinal materials of the produced curcumas and radix curcume longae by 15%-20%, increase the content of curcuminoids, the content of curcuma dione and the content of naphtha by 15%-20%, 17%-22% and 15%-18% respectively, and increase the economic benefit by 15%-20%.

The invention discloses a near infrared spectroscopy detection method of a radix curcumae medicinal material. The method comprises near infrared detection of a water content, and / or, curdione, germacrone, and cincumol in radix curcumae. The method comprises the following steps: (1) preparation of a medicinal material sample, in which, a medicinal material is pulverized and sieved for later use; (2) target component detection, which comprises water content detection (through a methylbenzene method) or detection of curdione, germacrone, and cincumol (through a liquid phase method); (3) collection of near infrared spectroscopic data; (4) establishment of a quantitative model, in which, the near infrared spectroscopic data is associated with a known component content and the water content to establish the calibration quantitative model; and (5) near infrared detection of an unknown to-be-detected sample. The radix curcumae medicinal material can be quickly detected through the method; the method has advantages of simple operation and high accuracy; and the material is not wasted. Safe, efficient, controllable, and stable quality of the radix curcumae medicinal material is ensured.

The invention discloses an establishment method of a curcuma aromatica medicine fingerprint map and the fingerprint map thereof, and particularly, provides establishment of a HPLC fingerprint map for controlling the quality of curcuma aromatica medicine. The method includes the steps of: 1) preparation of a reference substance solution: preparing the reference substance solutions of curdione, curcumadiol, procurcumenol; 2) preparation of a sample solution: extracting the curcuma aromatica medicine and filtering an extract liquid; 3) HPLC detection to obtain the fingerprint map: performing HPLC detection with octadecylsilane chemically bonded silica as a filler and an acetonitrile-tetrahydrofuran-0.1% phosphoric acid water system as a mobile phase in a chromatographic column in a gradient elution manner, wherein column temperature is 30 DEG C, ultraviolet detection wavelength is 230-250 nm and time is 60-65 min; and 4) similarity evaluation: introducing the obtained fingerprint map into "fingerprint similarity evaluation system of traditional Chinese medicine chromatography" (2004A version) similarity software for performing similarity evaluation. The method is simple, quick and accurate, has good repeatability, and provides powerful guarantee for comprehensive and effective control on quality of the curcuma aromatica medicine.

The invention relates to a method for extracting and purifying curdione from the oil of zedoary turmeric, a natural medicinal plant volatile oil. The purity of the curdione obtained by the method reaches 99.9%, and the curdione conforms to the requirement of the purity of a contrast product in the field of traditional Chinese medicine and provides a superior raw material for developing a subsequent product. The method comprises the following steps: mixing the oil of the zedoary turmeric and silica gel used for chromatography evenly, coating a silica gel column, taking petroleum ether and ethyl acetate which have different proportions as an eluent for gradient elution, collecting and merging eluant containing the component of the curdione, concentrating, refrigerating, standing, precipitating crystals and separating and purifying the crystals again by the same method to obtain recrystallized crystals so as to obtain the curdione. The method features simple operation and good repeatability.

The invention discloses a detection method for a sesquiterpene component in radix curcumae. The method comprises the following steps: volatilizing and drying a solvent of a radix curcumae extracting solution and carrying out buffering solution re-dissolution by utilizing electrophoresis; filtering the solution with a 0.22mu m filter membrane and taking filtrate as a sample to be detected; detecting peak area of each effective component in the sample to be detected by adopting a micro-emulsion electrokinetic capillary chromatography; obtaining the content of curdione, curcumol, germacrone, furanodiene and beta-elemene in the sample to be detected of the radix curcumae respectively according to each reference substance standard curve of the curdione, the curcumol, the germacrone, the furanodiene and the beta-elemene. The invention innovatively provides a micro-extraction detection method of volatile oil type components in traditional Chinese medicines. According to the method disclosed by the invention, a matrix solid-phase dispersion and extraction technology taking a molecular sieve as an adsorbent is combined with a micro-emulsion electrokinetic capillary chromatography technology, so that the content of the volatile oil type effective components in the medicinal material radix curcumae can be efficiently and environmentally friendly extracted and detected.

The invention discloses a measuring method of the contents of multiple index components in a Xingnaojing injection or an intermediate thereof. The method adopts a liquid chromatography analytic technique, and by the aid of a method of quantitative analysis of multi-components by a single marker, the contents of 9 index components in the Xingnaojing injection or the intermediate thereof can be simultaneously measured by using a curdione single reference substance. The method has high detection sensitivity and good accuracy, can evaluate the quality of the Xingnaojing injection or the intermediate thereof at lower cost, can solve the problem that the contents cannot be measured due to lack of the reference substances of the components to be measured, and is helpful to carry out quality control on the Xingnaojing injection more comprehensively.

The zedoary extractive is prepared with zedoary oil as material and through chromatography with silica gel column, and contains curdione 30-60 wt%, elemenone 15-40 wt%, neo-curdione 1-15 wt%, curcumenol1-20 wt% and no instable benzofuran derivative. The zedoary extractive has high effect, less side effect and high stability, and may be mixed with different medicine carrier to prepare various medicine preparations, such as capsule and injection, for treating viral diseases, cardiac and cerebral vascular diseases and tumor.

The invention discloses a method for rapidly testing multiple component contents in a radix curcumae-jasmine steam distillation and extracting process based on an ultraviolet spectrum. Based on the ultraviolet spectrum and a multielement quantified correcting model, the rapidly, exactly and low-cost test the contents of isophorone, 4- methylene- isophorone, curcuma zedoary bicyclo- ketene, curcumazedoary enol, curcuma zedoary diketone, curcuma zedoary ketone, curcuma zedoary furanodienone, curcuma zedoary alcohol and germacrone in the radix curcumae-jasmine steam distillation and extracting process. The method is simple in operation, rapid in analysis, low in analysis cost, and free from damaging samples and consuming chemical reagents, and others. The method can be applied to the production process monitoring and quality control of Chinese material medical preparation (such as consciousness restoring injection) during the radix curcumae-jasmine steam distillation and extracting process.

The invention belongs to the technical field of medicines and provides a pharmaceutical composition. The pharmaceutical composition comprises germacrone, furanodiene, curdione, beta-elemene, curcumol, curzerene and borneol. The components of the pharmaceutical composition are definite, and the quality can be controlled. The pharmaceutical composition can be used for preparing vaginal or rectal preparations and has a good effect of treating HR-HPV (high risk human papillomavirus) and / or LR-HPV (low risk human papillomavirus) infection and cervical diseases and can be used widely clinically.

The invention provides a curcuma total sesquiterpene and tri-sesquiterpene monomer as well as a preparation method and application on an aspect of resisting diabetes. A curcuma plant is taken as a raw material and is subjected to supercritical CO2 extraction or organic solvent extraction, then, low-polarity organic solvent is used for extraction to obtain a low-polarity total sesquiterpene extractive, and the low-polarity total sesquiterpene extractive is subjected to further chromatographic separation to obtain three types of sesquiterpene pure products of curcumenol, curdione and zedoary epoxy ketone. Activity research indicates that the total sesquiterpene, the curcumenol, the curdione and the zedoary epoxy ketone can be used for effectively increasing the consumption of glucose of HepG2 cells so as to obtain antidiabetic activity, and the total sesquiterpene, the curcumenol, the curdione and the zedoary epoxy ketone can be used for preparing antidiabetic medicines, antidiabetic health care food, functional foods and the like. The invention researches and develops new application of the diabetes resistance of the sesquiterpene in curcuma plants, the medicine function range of the curcuma plant is expanded, a basis is provided for carrying out popularization, utilization and deep processing on traditional Chinese medicinal materials, and a new application direction is provided.

The invention discloses a medical 'zedoary oil' and a manufacturing method for its micro capsule, the zedoary oil is acquired by confecting the beta-elemene, zedoary alcohol, curdione according to a fixed proportion, compared with natural zedoay oil, its effective ingredients content are high, and in virtue of the cooperation among the three, thus it has higher functions for resisting tumor, bacteria, and virusl; the producing method for mciro capsule is: because of increasing the even process, and through controlling the inner circulation in the even process, the particle size of the capsule is controllable between 50nm and 500nm, it can acquire the micro capsule with the uniform particle size, its irregularity is not more than plus and minus 5 nm.

The invention belongs to the technical field of medicine, and relates to a preparation method for a zedoary turmeric lactone enantiomer having anti-tumor activity. The structure of the zedoary turmeric lactone enantiomer is represented by a structure (I). The preparation method comprises: adopting new curdione separated from zedoary turmeric oil as a substrate, carrying out a three-step chemical reaction to carry out isomerization on chiral carbon on site 4 to obtain a curdione enantiomer, and carrying out acid catalysis. The test results show that the prepared enantiomer has good anti-tumor activity.

The invention belongs to the technical field of medicines, and provides a medical compound containing borneol. The medical compound contains germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The medical compound containing borneol is definite in ingredients and controllable in quality; the content of camphol in the borneol is controlled, so that the blood concentration and the mucosa absorbing rate of the medical compound are improved; the medical compound provided by the invention can be used for preparing suppository, ointment, capsules, effervescent tablets, gels, lotions, film agents or foaming agents; and the medical compound provided by the invention can well treat HR-HPV (high-risk human papilloma virus) and / or LR-HPV (low-risk human papilloma virus), cervical disease and the like, and is suitable for wide clinical application.

The invention belongs to the technical field of medicine, and provides a drug composition, which comprises germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The drug composition has characteristics of definite components and controllable quality. With the drug composition, weights of curcumenol and curzerene are controlled so as to reduce drug irritation. The drug composition can be adopted for preparing suppositories, ointments, capsules, effervescent tablets, gelatas, lotions, pellicles or foam agents, provides good treatment effects for HR-HPV and / or LR-HPV and cervical diseases, and is suitable for wide clinical applications.

The invention provides a retroperitoneal fibrosis and infection resistant peritoneal dialysis solution. The peritoneal dialysis solution is prepared from an electrolyte, a permeating agent and curdione, wherein the electrolyte is prepared from one or more of sodium chloride, calcium chloride and magnesium chloride; the permeating agent is prepared from one or more of glucose, dextran and fructose; the peritoneal dialysis solution also can be prepared from buffer base, wherein the buffer base is lactate and / or bicarbonate, the content of the curdione is 0.03 to 2 percent by weight / volume, and the curdione has a key effect on resisting retroperitoneal fibrosis. By adopting a reasonable formula, the peritoneal dialysis solution disclosed by the invention can have better retroperitoneal fibrosis and infection resistant effects, thus improving the ultra-filtration efficiency.

The invention belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a processing method of rhizoma curcumae. The processing method comprises the following steps: S1, cleaning a rhizoma curcumae raw medicinal material, soaking the raw medicinal material in saline water for 16-35 hours, and taking out, cleaning and airing the raw medicinal material; S2, putting the rhizoma curcumae aired in S1 into a NaOH solution for soaking for 20-50 minutes, and performing washing with water until a washing liquid is neutral; S3, placing the rhizoma curcumae obtained in the S2 in an oven at 30-40 DEG C for 18-26 hours; S4, putting the rhizoma curcumae obtained in S3 into 95% ethanol, adding fresh ginger in a weight ratio of the rhizoma curcumae to the freshginger being 5: 1, performing soaking for 12-30 hours, and performing airing; S5, boiling the rhizoma curcumae obtained in S4 for 10-30 minutes, and performing cooling; S6, soaking the rhizoma curcumae obtained in S5 in vinegar for 8-36 hours, and performing airing; S7, placing the rhizoma curcumae obtained in S6 in an oven at 20-35 DEG C for 10-24 hours. The content of curcumol and curdione in the rhizoma curcumae is increased.

The invention belongs to the technical field of medicines, and provides a drug combination containing borneol. The drug combination comprises germacrone, furanodiene, curdione, Beta-elemene, curcumenol, curzerene and borneol. The drug combination contains definite components which is controllable in quality; the drug combination can control the content of camphol in borneol so as to improve the plasma concentration and the mucous membrane absorption rate of the drug combination; the drug combination can be used for preparing suppository, ointments, capsules, effervescent tablets, gelata, lotion, film agents or foaming agents; and the drug combination can achieve an excellent therapeutic effect on diseases such as HR-HPV (High Risk-Human PapillomaVirus) and / or LR-HPV (Low Risk-Human PapillomaVirus) and cervical diseases, and is suitable for clinical wide application.

The invention discloses a method for measuring volatile components of medicinal material radix curcumae by QAMS (Quantitative Analysis of Multi-components by Single-marker). The method comprises the following steps: (1) preparation of a test liquor: taking the medicinal material radix curcumae, extracting a volatile oil by a steam distillation method, passing through a C8 or C18 stationary phase column, abandoning effluent, eluting with methanol, and collecting a methanol eluent for fixing a volume and being used as the test solution; (2) preparation of a reference liquor: taking curdione, dissolving with methanol, fixing the volume and using as the reference solution; (3) taking the test solution and the reference solution, respectively injecting into a high performance liquid chromatograph to obtain a chromatogram; and (4) first, using the reference product curdione as a reference, using a one-point external standard method or a working curve method to calculate the content of curdione in the test solution, then using a correction factor to calculate contents of curcumene ketone, curcumenol, curzerenone and germacrone. The method realizes simultaneous measurement of five sesquiterpenoids, reduces production cost, improves production efficiency and economic benefits, is fast and accurate, and can more comprehensively cover the quality of the medicinal materials.

The invention belongs to the technical field of medicine, and provides a medicine compound for curing cervical diseases. The medicine compound contains germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The medicine compound has the advantages of clear composition and mass controllability; in the medicine compound, the weight parts of the curzerene and curcumenol are controlled, so the irritation of the medicine is reduced; and the medicine compound provided by the invention can be used for preparing suppositories, ointment, capsules, effervescent tablets, gels, lotions, membranes or foaming agents, achieves a good curative effect on HR-HPV (high-risk human papillomavirus) and / or LR-HPV (low-risk human papillomavirus) and the cervical diseases, and is suitable for clinical extensive use.

The invention belongs to the technical field of drugs, and provides a drug composition containing curdione. The drug composition contains germacrone, furanodiene, the curdione, beta-elemene, curcumenol, curzerene and borneol. The drug composition has clear ingredients and is controllable in quality; and the weight parts of the curzerene and the curcumenol are controlled, and irritation of drugs is reduced. The drug composition can be used for preparing suppository, ointment, capsules, effervescent tablets, gel, wash lotion, film agents or foaming agents, has excellent treatment effects to diseases such as HR-HPV (high risk human papillomavirus) and / or LR-HPV (low risk human papillomavirus) and cervical cancers, and is suitable to be clinically applied widely.

The present invention belongs to the technical field of medicine, and the present invention provides a pharmaceutical composition, which contains gemmacone, furandiene, curdione, β-elemene, curcumol, curcumene, and borneol. things. The pharmaceutical composition has clear ingredients and controllable quality; the pharmaceutical composition controls the weight of curcumene and curcumol to reduce the irritation of the drug; the pharmaceutical composition of the present invention can be used to prepare suppositories, ointments, capsules, Effervescent tablet, gel, lotion, film or foam; the pharmaceutical composition of the present invention has a good therapeutic effect on HR-HPV and / or LR-HPV and cervical diseases, and is suitable for a wide range of clinical application.

The invention discloses a rapid analysis method of Xingnaojing injection based on an ultraviolet spectrum. The method is characterized in that acetonitrile is used as a mobile phase A, 0.1 wt% phosphoric acid-aqueous solution is used as a mobile phase B for linear gradient elution, and an elution procedure is 0 min, 30% A; 10min, 55%A; 24min, 55%A; 24.1min, 70%A; 35min, 70%A; 40min, 100%A; a flowrate is 0.6 mL / min, a column temperature is 40 DEG C, a sample size is 50 [mu]L, and a PDA detection wavelength range is 200-400 nm; and the detection wavelength of each component is as follows: isophorone with the wavelength of 238 nm; 4-methylene-isophorone with the wavelength of 275nm; curcuma zedoary bicyclo-enone with the wavelength of 256 nm; curcumenol with the wavelength of 261 nm; curcumazedoary diketone with the wavelength of 220 nm; curcumenone with the wavelength of 274 nm; curcuma zedoary furandienone with the wavelength of 274 nm; curcumenol with the wavelength of 210 nm; and germacrone with the wavelength of 210 nm. The analysis method established by the invention has advantages of rapidness, simplicity, convenience and low cost, and can be used for monitoring an extractionprocess and judging an extraction end point so that production efficiency is improved, and product quality defects and quality differences are reduced.

The invention discloses a measuring method of the contents of multiple index components in a Xingnaojing injection or an intermediate thereof. The method adopts a liquid chromatography analytic technique, and by the aid of a method of quantitative analysis of multi-components by a single marker, the contents of 9 index components in the Xingnaojing injection or the intermediate thereof can be simultaneously measured by using a curdione single reference substance. The method has high detection sensitivity and good accuracy, can evaluate the quality of the Xingnaojing injection or the intermediate thereof at lower cost, can solve the problem that the contents cannot be measured due to lack of the reference substances of the components to be measured, and is helpful to carry out quality control on the Xingnaojing injection more comprehensively.

The application discloses a pharmaceutical composition for treating chronic liver injury and application of the pharmaceutical composition. Schisandrin C and curdione are used as active ingredients in the pharmaceutical composition, and the pharmaceutical composition optionally comprises pharmaceutically acceptable auxiliary materials. Meanwhile, the application further discloses application of the schisandrin C and curdione combined medicine in treating chronic liver injury such as hepatic fibrosis diseases.

The invention belongs to the technical field of medicine, and provides a medicine compound for curing cervical diseases. The medicine compound contains germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The medicine compound has the advantages of clear composition and mass controllability; in the medicine compound, the weight parts of the curzerene and curcumenol are controlled, so the irritation of the medicine is reduced; and the medicine compound provided by the invention can be used for preparing suppositories, ointment, capsules, effervescent tablets, gels, lotions, membranes or foaming agents, achieves a good curative effect on HR-HPV (high-risk human papillomavirus) and / or LR-HPV (low-risk human papillomavirus) and the cervical diseases, and is suitable for clinical extensive use.

The invention provides a curcuma total sesquiterpene and tri-sesquiterpene monomer as well as a preparation method and application on an aspect of resisting diabetes. A curcuma plant is taken as a raw material and is subjected to supercritical CO2 extraction or organic solvent extraction, then, low-polarity organic solvent is used for extraction to obtain a low-polarity total sesquiterpene extractive, and the low-polarity total sesquiterpene extractive is subjected to further chromatographic separation to obtain three types of sesquiterpene pure products of curcumenol, curdione and zedoary epoxy ketone. Activity research indicates that the total sesquiterpene, the curcumenol, the curdione and the zedoary epoxy ketone can be used for effectively increasing the consumption of glucose of HepG2 cells so as to obtain antidiabetic activity, and the total sesquiterpene, the curcumenol, the curdione and the zedoary epoxy ketone can be used for preparing antidiabetic medicines, antidiabetic health care food, functional foods and the like. The invention researches and develops new application of the diabetes resistance of the sesquiterpene in curcuma plants, the medicine function range of the curcuma plant is expanded, a basis is provided for carrying out popularization, utilization and deep processing on traditional Chinese medicinal materials, and a new application direction is provided.

The invention relates to a method for extracting and purifying curdione from the oil of zedoary turmeric, a natural medicinal plant volatile oil. The purity of the curdione obtained by the method reaches 99.9%, and the curdione conforms to the requirement of the purity of a contrast product in the field of traditional Chinese medicine and provides a superior raw material for developing a subsequent product. The method comprises the following steps: mixing the oil of the zedoary turmeric and silica gel used for chromatography evenly, coating a silica gel column, taking petroleum ether and ethyl acetate which have different proportions as an eluent for gradient elution, collecting and merging eluant containing the component of the curdione, concentrating, refrigerating, standing, precipitating crystals and separating and purifying the crystals again by the same method to obtain recrystallized crystals so as to obtain the curdione. The method features simple operation and good repeatability.