380 results about "Curcuminoid" patented technology

The invention provides a curcumin oral emulsion and injection, wherein the emulsion comprises curcumin, oil, emulsifying agent and water, the injection also contains isotonic agent. The invention also discloses the process for preparing the emulsion and its use in preparing medicaments for treating or preventing tumor, resisting tumor transfer, enhancing curative effects of chemotherapy drugs, reducing side effects of chemotherapy and improving immunity functions for tumor patients.

Curcuminoid formulations having enhanced bioavailability are provided and comprise a curcuminoid, antioxidant, glucuronidation inhibitor, and water-soluble, pharmaceutically acceptable inhibitor. A method of treating Alzheimer's and other age-related diseases by administering such a composition is also provided.

A process for obtaining the apolar extract comprises: (a) extracting the rhizomes with an organic solvent; (b) filtration and evaporation to dryness of the extract; (c) dissolution of the oleoresin obtained in hot conditions, precipitation while allowing to cool down and filtration of the solid; (d) drying and recrystallizing the solid in order to obtain a product having a purity in curcuminoids higher than 90%. Obtaining the polar extract comprises: (a') extraction of the rhizomes with water at 50-70° C. and (b') filtration and evaporation of the water. Application of the compositions and preparations as catchers of free radicals and antiageing agents, as well as reducing agents to reduce the plasma levels of lipid peroxides in human beings are disclosed.

The invention discloses a type of amino acid modified curcumin, a synthesis method thereof, and an application thereof. According to the invention, structural modification is carried out upon curcumin by using natural amino acid, such that 1-(4-hydroxy-3-methoxyphenyl)-7-(4-oxyacetyl amino carbobenzoxy-3-methoxyphenyl)-1,6-heptadiene-3,5-diketone which is represented by a general formula (I) is obtained. With an MTT method, evaluation is carried out upon the compound represented by the general formula (I) in the inhabitance of proliferation activities of four cells which are K562, H22, HL60 and S180. IC50 values of the compound represented by the general formula (I) in inhibiting the proliferations of the four tumor cells are calculated. As a result of experiments, with the compound represented by the general formula (I), proliferations of tumor cells can be substantially inhibited. The compound has excellent anti-tumor activity, and can be prepared into anti-tumor medicines.

Curcumin and curcuminoid compounds as photosensitizers for onium salt photoinitiators in cationic photopolymerization reactions are presented.

The invention discloses a high quality and yield culture technology of curcuma, which comprises the following steps: land selection and preparation, seed curcuma preparation, sowing, field management, harvesting and prevention and cure of plant diseases and insect pests. The technology of the invention is characterized in that: the loosening, fertile and sandy loamy soil with deep soil layers in which curcuma is not planted within one year is chosen for planting; prior to sowing, fossas are dug as per the depth of 0.08-0.12m, the suitable time for sowing is from June 20 to June 30, the planting density is 0.33-0.38m of row spacing, and the number of plants is 4600-6100 per mu; prior to sowing, the parent curcumas without plant diseases and insect pests are selected, curcuma is cut into small sections with 2-3 tubers, 4-6 sections are planted in each fossa, and the hurt and funked curcuma can not be taken as parent curcuma; during sowing, fossias are dug in field, and sowing is carried out according to the planting spacing of 0.33-0.38m. The bottom fertilizer is applied in the space between the parent curcumas, and covering soil is carried out. The technology can improve the yield of the medicinal materials of the produced curcumas and radix curcume longae by 15%-20%, increase the content of curcuminoids, the content of curcuma dione and the content of naphtha by 15%-20%, 17%-22% and 15%-18% respectively, and increase the economic benefit by 15%-20%.

The invention relates to the construction and application of a gold-magnetic nanoparticle-based medicament carrying platform, which belong to the technical field of magnetic nanophase materials. The construction comprises the synthesis of magnetic nanoparticles, the synthesis of an Fe3O4-SiO2 nuclear shell structure, the amine surface modification of the Fe3O4-SiO2 nuclear shell structure, protonation and the electrostatic adherence of gold nanoparticles after the surface modification, the coupling of curcumin and the coupling of mercapto polyethylene glycol PEG-SH so as to prepare a multifunctional gold-magnetic nano-platform. The construction and the application have the following advantages that: the gold-magnetic nanoparticle-based medicament carrying platform is a magnetic carrier with a modified surface and has the characteristics of relatively stronger magnetism, good chemical inertness, biocompatibility, easy functionalization and the like, and can be prepared by a simple method; and the magnetic nanophase materials can be quickly separated with a magnetic field in a suspension system, are highly concentrated and act on tumor cells under the guidance of an external magnetic field, and can be applied in biological fields, such as bioseparation, medicament transportation, biological tags, cell imaging and developing and study on the separation of cells or other biomolecules.

The invention relates to a process for the preparation of a plant extract from Curcuma plants, characterized by the process steps process step A) liquid extraction of Curcuma rhizomes, process step B) optionally, separation of a curcuminoid-containing solid obtained by precipitation from the extraction mixture obtained in process step A), process step C) removal of solvents present from the extraction mixture obtained in process step A) or B) to obtain a concentrate and process step D) distillation of the concentrate at a pressure of less than 1 bar to give the extract as distillate.

The invention provides novel curcuminoid formulations which have improved aqueous solubility and bioavailability when compared to known curcuminoid dosage forms. Formulations of the invention exhibit an enhanced intestinal absorption of curcuminoids, a slower curcuminoid metabolism and a reduced rate of systemic curcuminoid elimination. Additionally, upon administration in vivo, the formulations described and claimed herein produce a high, sustained level of the curcuminoid metabolite tetrahydrocurcumin. For example, at about eight to about ten hours after oral administration to a human, tetrahydrocurcumin plasma levels of between about 50 ng/mL to about 175 ng/mL are detectable, even when that metabolite is absent from the administered formulation. Novel processes for making curcuminoid formulations which have improved aqueous solubility and oral bioavailability, and methods of treating a wide variety of inflammatory, immune and neurogenerative disorders and cancers, are also provided.

The present invention provides a natural pigment composition, which comprises an emulsifier and two or more than two pigments selected from gardenia yellow pigment, curcuminoid, saffower yellower, orange yellow pigment, lutein, riboflavin, capsanthin, monascus red pigment, annatto and gardenia blue pigment. According to the present invention, various natural pigkments are blended according to any ratios so as to obtain the natural pigment compositions having different color systems and different tones such as yellow, orange, red, green and purple, and the natural pigment composition contains the emulsifier so as to make the composition uniform and stable, such that in the natural pigment composition, the combination of different natural pigments can make up the defects of the single pigment, wherein the light resistance of the natural yellow pigment obtained by combining the poor light resistance riboflavin, the poor light resistance curcuminoid and the like and the stable gardenia yellow pigment is superior to the light resistance of the riboflavin or curcuminoid so as to reduce the use amount and reduce the cost.

The invention belongs to the field of medicinal chemistry, and more particularly relates to conjugate conjugated from polyethylene glycol and curcumin derivative as shown in formula 1 and pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently selected from nitro, amidogen, bi-low alkyl amidogen and low alkoxy; R3 and R4 are independently selected from halogen, nitro and hydrogen; R5 is low alkyl or hydrogen; R6 is hydrogen or low alkyl that can be substituted by low alkyl, nitro, hydroxide radical or sulfhydryl which are randomly selected; and n is 1 or 2. The conjugate has good water solubility, overcomes the disadvantages of poor water solubility, low bioavailability, and the like, existing in curcumin, and has low preparation cost and better antitumor activity. In addition, the invention also relates to the pharmaceutical composition, the preparation method and the application as medicament of the conjugate.

The invention discloses a high quality and yield culture technology of curcuma zedoaria, which comprises the following steps: land selection and preparation, seed curcuma preparation, sowing, field management, harvesting and prevention and cure of plant diseases and insect pests. The technology of the invention is characterized in that: the rotation land or clay with neutral PH or micro acid in which curcuma zedoaria is not planted in the previous year is selected; prior to sowing, the rootstalk with two or three heads which has a diameter of more than 20mm and a length of more than 50mm, or a big curcuma which has the diameter of more than 15mm and the length of more than 70mm is selected as the seed curcuma, and the seed curcuma is sowed from May 20 to May 30 in a normal year; the planting density is 2700-3300 plants per mu with the row spacing of 0.45-0.50m; during sowing, fossias are dug in field, sowing is carried out according to the planting spacing of 0.45-0.50m. The bottom fertilizer is applied in the space between seed curcumas, and covering soil is carried out. The technology can improve the yield of the medicinal materials of zedoary root and radix curcume longae produced by curcuma zedoaria by 15%-20%, increase the content of curcuminoids, the content of germacrone, the content of naphtha by 15%-20%, 16%-20% and 10%-15% respectively, and increase the economic benefit by 15%-20%.