390 results about "Curcuminoid" patented technology

The invention provides a curcumin oral emulsion and injection, wherein the emulsion comprises curcumin, oil, emulsifying agent and water, the injection also contains isotonic agent. The invention also discloses the process for preparing the emulsion and its use in preparing medicaments for treating or preventing tumor, resisting tumor transfer, enhancing curative effects of chemotherapy drugs, reducing side effects of chemotherapy and improving immunity functions for tumor patients.

A composition for treating inflammation and pain in mammals, particularly humans. Effective amounts of a boswellic acid, a curcuminoid, a gingerol, a capsaicinoid, a bioflavonoid, and a vitamin C source, in various combinations, all preferably from a botanical source, are blended to form a dose for oral administration. Administration of the dose provides relief from pain and inflammation of connective tissue. The dose may be administered as a tablet, a liquid, or a powder.

The invention provides compositions containing a fraction isolated or derived from hops and a methylxanthine. The invention additionally provides compositions containing a fraction derived from hops and a curcuminoid. The invention also provides methods of using such compositions to reduce inflammation.

Curcuminoid formulations having enhanced bioavailability are provided and comprise a curcuminoid, antioxidant, glucuronidation inhibitor, and water-soluble, pharmaceutically acceptable inhibitor. A method of treating Alzheimer's and other age-related diseases by administering such a composition is also provided.

A process for obtaining the apolar extract comprises: (a) extracting the rhizomes with an organic solvent; (b) filtration and evaporation to dryness of the extract; (c) dissolution of the oleoresin obtained in hot conditions, precipitation while allowing to cool down and filtration of the solid; (d) drying and recrystallizing the solid in order to obtain a product having a purity in curcuminoids higher than 90%. Obtaining the polar extract comprises: (a') extraction of the rhizomes with water at 50-70° C. and (b') filtration and evaporation of the water. Application of the compositions and preparations as catchers of free radicals and antiageing agents, as well as reducing agents to reduce the plasma levels of lipid peroxides in human beings are disclosed.

This invention concerns to a topical pharmaceutical composition comprising an water soluble Curcuma extract, and suitable excipients for said topical administration; the process for obtaining said pharmaceutical compositions; the use of different Curcuma extracts as photosensitizing agents for the treatment of proliferative diseases; and the use of Curcuma extract or curcuminoids in combination with a radiation for the treatment of proliferative diseases on eukaryote cells.

The invention discloses a type of amino acid modified curcumin, a synthesis method thereof, and an application thereof. According to the invention, structural modification is carried out upon curcumin by using natural amino acid, such that 1-(4-hydroxy-3-methoxyphenyl)-7-(4-oxyacetyl amino carbobenzoxy-3-methoxyphenyl)-1,6-heptadiene-3,5-diketone which is represented by a general formula (I) is obtained. With an MTT method, evaluation is carried out upon the compound represented by the general formula (I) in the inhabitance of proliferation activities of four cells which are K562, H22, HL60 and S180. IC50 values of the compound represented by the general formula (I) in inhibiting the proliferations of the four tumor cells are calculated. As a result of experiments, with the compound represented by the general formula (I), proliferations of tumor cells can be substantially inhibited. The compound has excellent anti-tumor activity, and can be prepared into anti-tumor medicines.

Disclosed are compositions useful for treating Alzheimer's disease, atherosclerosis, arteriosclerosis, osteoarthritis and other degenerative joint diseases, Huntington's chorea, Parkinson's disease, optic atrophy, retinitis pigmentosa, macular degeneration, muscular dystrophy, aging-associated degenerative processes, asthma, dermatitis, laminitis, pemphigoid, pemphigus, reactive airway disease (e.g., COPD, IAD), inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis), multiple sclerosis, rheumatoid arthritis, periodontal disease, systemic lupus erythematosus, sarcoidosis, psoriasis, type I diabetes, ischemia-reperfusion injury, chronic inflammatory diseases, geriatric wasting, cancer cachexia, cachexia associated with chronic inflammation, sick feeling syndrome, and other inflammatory and / or degenerative diseases, disorders, conditions, and processes in humans and other animals. In one embodiment, the compositions include at least 4 of the following: a MMP1 inhibitor, a MMP2 inhibitor, a MMP3 inhibitor, a MMP7 inhibitor, a MMP9 inhibitor, an ADAMTS-4 inhibitor, a MMP13 inhibitor, and a MMP14 inhibitor. In another embodiment, the compositions include a curcuminoid, a polymethoxylated flavone, a catechin, and a boswellic acid.

The present invention provides a method of treating a cancerous or pre-cancerous state in an individual in need of such treatment, comprising the step of administering a pharmacologically effective dose of a curcuminoid to the individual.

Curcumin and curcuminoid compounds as photosensitizers for onium salt photoinitiators in cationic photopolymerization reactions are presented.

Polymeric and co-polymeric compositions useful for preparing ophthalmic and ocular devices, such as implantable intraocular lenses (IOL) and contact lenses, and processes of forming the compositions and devices are provided. The disclosed polymeric or co-polymeric composition may include a curcuminoid compound as a UV-blocker, and is derived from a pre-polymerization mixture of monomers which comprises at least 50 weight percents acrylate monomers and exhibiting visible light transparency and ultraviolet light opacity. The disclosed co-polymeric composition may alternatively, or in addition, be derived from a pre-polymerization mixture of defined monomers.

The invention discloses a high quality and yield culture technology of curcuma, which comprises the following steps: land selection and preparation, seed curcuma preparation, sowing, field management, harvesting and prevention and cure of plant diseases and insect pests. The technology of the invention is characterized in that: the loosening, fertile and sandy loamy soil with deep soil layers in which curcuma is not planted within one year is chosen for planting; prior to sowing, fossas are dug as per the depth of 0.08-0.12m, the suitable time for sowing is from June 20 to June 30, the planting density is 0.33-0.38m of row spacing, and the number of plants is 4600-6100 per mu; prior to sowing, the parent curcumas without plant diseases and insect pests are selected, curcuma is cut into small sections with 2-3 tubers, 4-6 sections are planted in each fossa, and the hurt and funked curcuma can not be taken as parent curcuma; during sowing, fossias are dug in field, and sowing is carried out according to the planting spacing of 0.33-0.38m. The bottom fertilizer is applied in the space between the parent curcumas, and covering soil is carried out. The technology can improve the yield of the medicinal materials of the produced curcumas and radix curcume longae by 15%-20%, increase the content of curcuminoids, the content of curcuma dione and the content of naphtha by 15%-20%, 17%-22% and 15%-18% respectively, and increase the economic benefit by 15%-20%.

Disclosed are sustained-release medicaments / drug compositions / formulations / therapeutics for the management of pain and inflammation associated disorders in general, more particularly arthritic inflammation. The sustained-release compositions comprise effective amounts of glucosamine, curcuminoids, boswellic acids and piperine.

The invention relates to the construction and application of a gold-magnetic nanoparticle-based medicament carrying platform, which belong to the technical field of magnetic nanophase materials. The construction comprises the synthesis of magnetic nanoparticles, the synthesis of an Fe3O4-SiO2 nuclear shell structure, the amine surface modification of the Fe3O4-SiO2 nuclear shell structure, protonation and the electrostatic adherence of gold nanoparticles after the surface modification, the coupling of curcumin and the coupling of mercapto polyethylene glycol PEG-SH so as to prepare a multifunctional gold-magnetic nano-platform. The construction and the application have the following advantages that: the gold-magnetic nanoparticle-based medicament carrying platform is a magnetic carrier with a modified surface and has the characteristics of relatively stronger magnetism, good chemical inertness, biocompatibility, easy functionalization and the like, and can be prepared by a simple method; and the magnetic nanophase materials can be quickly separated with a magnetic field in a suspension system, are highly concentrated and act on tumor cells under the guidance of an external magnetic field, and can be applied in biological fields, such as bioseparation, medicament transportation, biological tags, cell imaging and developing and study on the separation of cells or other biomolecules.

Compositions comprising an effective amount of a curcuminoid species and an effective amount of a diterpene lactone species, a triterpene species or derivatives thereof that have a synergistic effect on specific inhibition of inducible COX-2 activity and have minimal effect on COX-1 activity are disclosed. Methods of using the compositions for providing synergistic anti-inflammatory effects are also disclosed.

The present invention pertains to a process of improving the total yield of curcuminoids from curcuminoid-containing material. More specifically, there is provided a process wherein a second residue, previously considered a waste resulting from a crystallization step of a curcuminoid-containing phase, is made useful by improving the coloring properties of this second residue by extraction with hexane and / or methanol at ambient temperature. The process improves the total yield of curcuminoids by 30-40%.

The invention relates to a process for the preparation of a plant extract from Curcuma plants, characterized by the process steps process step A) liquid extraction of Curcuma rhizomes, process step B) optionally, separation of a curcuminoid-containing solid obtained by precipitation from the extraction mixture obtained in process step A), process step C) removal of solvents present from the extraction mixture obtained in process step A) or B) to obtain a concentrate and process step D) distillation of the concentrate at a pressure of less than 1 bar to give the extract as distillate.

A composition comprising a water-soluble and stable complex formed by an alkyl ether derivative of gamma-cyclodextrin and curcumin and optionally comprising non-complexed cyclodextrin, the molar ratio of curcumin to cyclodextrin being between 1:1 and 1:6, and a method of manufacturing such a composition. The water-soluble and stable complex of curcumin is useful in therapy, e.g. for treatment of cancer, leukemia, myocardial infarction, stroke, sepsis, acute lung injury, acute liver failure, acute tubular necrosis, acute pancreatitis, radiation injury and other life-threatening conditions in a human or animal subject, as well as for preserving human or animal organs, tissues or cells at a hypothermic temperature.

This invention concerns to a topical pharmaceutical composition comprising an water soluble Curcuma extract, and suitable excipients for said topical administration; the process for obtaining said pharmaceutical compositions; the use of different Curcuma extracts as photosensitizing agents for the treatment of proliferative diseases; and the use of Curcuma extract or curcuminoids in combination with a radiation for the treatment of proliferative diseases on eukaryote cells.

The present invention includes compositions and methods of making a nanoparticle composition comprising a polymeric core comprising one or more polymers and one or more active agents, and at least one layer of one or more lipids on the surface of the polymeric core; more specifically, the invention relates to the use of curcumin within such a lipid-polymer nanoparticle formulation for minimizing QT prolongation associated with curcumin in treatment of cancer.

The present invention provides a natural pigment composition, which comprises an emulsifier and two or more than two pigments selected from gardenia yellow pigment, curcuminoid, saffower yellower, orange yellow pigment, lutein, riboflavin, capsanthin, monascus red pigment, annatto and gardenia blue pigment. According to the present invention, various natural pigkments are blended according to any ratios so as to obtain the natural pigment compositions having different color systems and different tones such as yellow, orange, red, green and purple, and the natural pigment composition contains the emulsifier so as to make the composition uniform and stable, such that in the natural pigment composition, the combination of different natural pigments can make up the defects of the single pigment, wherein the light resistance of the natural yellow pigment obtained by combining the poor light resistance riboflavin, the poor light resistance curcuminoid and the like and the stable gardenia yellow pigment is superior to the light resistance of the riboflavin or curcuminoid so as to reduce the use amount and reduce the cost.

This invention provides a compound having the structurewherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and / or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFκ-B activation in a population of cells.

The invention belongs to the field of medicinal chemistry, and more particularly relates to conjugate conjugated from polyethylene glycol and curcumin derivative as shown in formula 1 and pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently selected from nitro, amidogen, bi-low alkyl amidogen and low alkoxy; R3 and R4 are independently selected from halogen, nitro and hydrogen; R5 is low alkyl or hydrogen; R6 is hydrogen or low alkyl that can be substituted by low alkyl, nitro, hydroxide radical or sulfhydryl which are randomly selected; and n is 1 or 2. The conjugate has good water solubility, overcomes the disadvantages of poor water solubility, low bioavailability, and the like, existing in curcumin, and has low preparation cost and better antitumor activity. In addition, the invention also relates to the pharmaceutical composition, the preparation method and the application as medicament of the conjugate.

Compounds, compositions and methods are contemplated in which senile plaques and / or neurofibrillary tangles are labeled using compounds with improved permeability across the blood brain barrier and improved selective binding to senile plaques and / or neurofibrillary tangles. Contemplated compounds are derivatives of FDDNP or curcumin, which most preferably have improved solubility in aqueous solvents. Labeling is typically performed using a PET detectable label, and especially 11C and 18F.

The invention relates to a target drug feeding system with combination of nano-silver and curcumin or a curcumin derivative and belongs to the technical field of biological medicines. The nano-silver target drug feeding system particularly takes an aptamer as a target point; the curcumin or the curcumin derivative or the nano silver is used as a combined anti-tumor drug and is polymerized to the outer surface of a biodegradable high-molecular polymer nano-system (PNS) by the aptamer to synthesize an aptamer-PNS polymer which is used as a shell; the PNS simultaneously encapsulates the curcumin or the curcumin derivative and the nano silver, so as to prepare the nano-silver target drug feeding system which is loaded with active components including the curcumin or the curcumin derivative and improve the solubility and bioavailability of the curcumin and the curcumin derivative; meanwhile, drugs can be targeted into non-small-cell lung cancer cells or prostate cancer cells; the anti-tumor effects of the curcumin or the curcumin derivative and the nano silver are expressed so that the target drug feeding and drug slow releasing effects are realized; the nano-silver target drug feeding system is used for preventing and treating lung cancers and prostatic cancers, the treatment effect is improved and the toxic side effect is reduced.

Methods and compositions for preventing memory loss and reducing the onset of Alzheimer's disease and the pathological symptoms associated therewith including memory loss, reduced cognitive function and dementia are provided. These methods and compositions comprise dosage regimens that provide for the daily administration of effective amounts of Vitamin C, Vitamin E, DHA, and Curcumin.

The invention discloses a high quality and yield culture technology of curcuma zedoaria, which comprises the following steps: land selection and preparation, seed curcuma preparation, sowing, field management, harvesting and prevention and cure of plant diseases and insect pests. The technology of the invention is characterized in that: the rotation land or clay with neutral PH or micro acid in which curcuma zedoaria is not planted in the previous year is selected; prior to sowing, the rootstalk with two or three heads which has a diameter of more than 20mm and a length of more than 50mm, or a big curcuma which has the diameter of more than 15mm and the length of more than 70mm is selected as the seed curcuma, and the seed curcuma is sowed from May 20 to May 30 in a normal year; the planting density is 2700-3300 plants per mu with the row spacing of 0.45-0.50m; during sowing, fossias are dug in field, sowing is carried out according to the planting spacing of 0.45-0.50m. The bottom fertilizer is applied in the space between seed curcumas, and covering soil is carried out. The technology can improve the yield of the medicinal materials of zedoary root and radix curcume longae produced by curcuma zedoaria by 15%-20%, increase the content of curcuminoids, the content of germacrone, the content of naphtha by 15%-20%, 16%-20% and 10%-15% respectively, and increase the economic benefit by 15%-20%.

The present invention discloses a pharmaceutical composition in the form of self nano emulsifying drug delivery formulation comprising curcuminoids. The pharmaceutical composition of the present invention shows an enhanced drug loading ability, better stability and an improved bioavailability. The composition of the present invention comprises of a pharmaceutically effective amount of a curcuminoid, an oil phase, a surfactant and a co surfactant.