Nano-silver target drug feeding system loaded with curcumin or curcumin derivative

Abstract

The invention relates to a target drug feeding system with combination of nano-silver and curcumin or a curcumin derivative and belongs to the technical field of biological medicines. The nano-silver target drug feeding system particularly takes an aptamer as a target point; the curcumin or the curcumin derivative or the nano silver is used as a combined anti-tumor drug and is polymerized to the outer surface of a biodegradable high-molecular polymer nano-system (PNS) by the aptamer to synthesize an aptamer-PNS polymer which is used as a shell; the PNS simultaneously encapsulates the curcumin or the curcumin derivative and the nano silver, so as to prepare the nano-silver target drug feeding system which is loaded with active components including the curcumin or the curcumin derivative and improve the solubility and bioavailability of the curcumin and the curcumin derivative; meanwhile, drugs can be targeted into non-small-cell lung cancer cells or prostate cancer cells; the anti-tumor effects of the curcumin or the curcumin derivative and the nano silver are expressed so that the target drug feeding and drug slow releasing effects are realized; the nano-silver target drug feeding system is used for preventing and treating lung cancers and prostatic cancers, the treatment effect is improved and the toxic side effect is reduced.

Description

technical field [0001] The invention relates to a targeted drug delivery system, in particular to a targeted drug delivery system composed of curcumin or curcumin derivatives and nano-silver, which is used for the prevention and treatment of lung cancer and prostate cancer, and belongs to the technical field of biomedicine. Background technique [0002] In China, the number of deaths due to lung cancer is more than the sum of deaths from breast cancer, prostate cancer and intestinal cancer, among which the prevalence of non-small cell lung cancer is the highest. Current lung cancer treatment methods can achieve a certain degree of control, but the overall curative effect is not great. In addition to the high toxicity and side effects, there is also a certain degree of recurrence risk. More than 80% of lung cancer patients are diagnosed or treated too late, missing surgery and radical cure. best time. Therefore, the development of lung cancer treatment means is crucial. Pro...

AI Technical Summary

Problems solved by technology

Although many compounds have good anti-tumor activity in vitro, they cannot efficiently reach the lesion site in vivo, or non-selectively damage normal cells while reaching the lesion site, resulting in damage to important organs such as liver and kidney, decreased immunity, and serious complications. Toxic side effects, which lead to in vivo treatment failure