38results about How to "Medication is stable" patented technology

The present invention discloses a pharmaceutical composition in the form of self nano emulsifying drug delivery formulation comprising curcuminoids. The pharmaceutical composition of the present invention shows an enhanced drug loading ability, better stability and an improved bioavailability. The composition of the present invention comprises of a pharmaceutically effective amount of a curcuminoid, an oil phase, a surfactant and a co surfactant.

The invention discloses an intramedullary nail device, comprising a nail body, locking nail holes which are transversely arranged at the proximal and distal ends of the nail body and a locking nail which is penetrated in the locking nail holes, at least one side channel is arranged along the axial direction of the nail body, and in which a drug sustained release bead or a bead chain is arranged; the intramedullary nail of the invention is arranged and fixed in the medullary cavity strictly in accordance with the requirements of sterile operation, after that, the drug sustained release bead or the bead chain carries out the sustained release of the drug effect by an opening of the side channel, thus maintaining the long-term effective antibacterial concentration of the environment in the cavity and further achieving the purposes of preventing and treating the infections.

The present invention is diarrhea treating plaster and its preparation. The diarrhea treating plaster is prepared with white atractylodes rhizome 5-10 weight portions, white peony root 6-12 weight portions, tangerine peel 3-10 weight portions and ledebouriella root 5-10 weight portions, and through material mixing, grinding to 100-200 micron size, supercritical CO2 extracting, fractioning in a fractioning tower, nanometer dispersing to form nanometer slurry, adding transdermal promoter and contact adhesive, coating in a low temperature rotary coating machine, cutting, inspection and packing. The present invention has extracted medicine filled in matrix skeleton, compatibility of the matrix to skin, slow medicine release, smooth acting, less stimulation and no toxic side effect.

The invention relates to a Chinese medicine patch with anti-inflammation and delactation functions and a method for producing the same. The invention contains the following components in proportion byweight: salt cake 10-20, borneol 3-10, frank incense and myrrh 3-10; the invention includes the steps of: proportionally mixing raw materials, grinding until particle diameter of each component is 100-200 mu m; using CO2 supercritical extraction, fractionating acquired distillates with a fractionating tower, mixing each component in the formula into nano medicinal pulp according to the formula proportionality through the nano dispersing apparatus, adding accelerating agent for percutaneous absorption and contact adhesive into the circular type low temperation drying coater, and after coating,executing shearing, quality test, packaging and then sending the product into warehouse. The invention uses a scientific method for processing and extracting medicinal materials, which are filled inthe framework of the substrate, and the paster substrate has a good compatibility with skin, and is good for medicament molecule to pass; the medicament has the advantages of slow release, smooth andsteady administration, small irritation, easy operation without toxic and side effects, thereby resolving the problem that oral medication and externally applied powder have toxic and side effects forhuman body.

The invention relates to a kendir pressure-reducing sticking agent and a preparation method thereof. The preparation method comprises the following steps: extracting eight kinds of medicinal materials of kendir, self-heal, uncaria stem with hooks, rhizoma alismatis, mother-of-pearl, twotooth achyranthes root, hawthorn and chrysanthemum which are raw material medicines, refining the effective components of the medicinal materials, adding an excipient, polyvinyl alcohol, gelatin, kaolin, glycerol and azone and preparing to obtain the kendir pressure-reducing sticking agent. The kendir pressure-reducing sticking agent obtained by the invention has slow medicine release, stable drug administration, strong pressure-reducing effect, small stimulation and no toxic or side effect.

The invention discloses a drug delivery device for oncology department. The device comprises a drug delivery tube and a guide tube, wherein one end of the drug delivery tube is matched with a push rod, and a disc-shaped protrusion, which is integrally connected, is arranged at the other end of the drug delivery tube; the disc-shaped protrusion is matched with a groove formed in one end of the guide tube; the push rod extends into the drug delivery tube end and is fixedly connected with a push block; a sliding groove and a bearing are fixedly formed in one side in the drug delivery tube; a sliding block is matched in the sliding groove; the sliding block is connected with a rotary rod extending out of the sliding groove; a rotary disc is fixedly sleeved to the outer side of the bearing; the other end of the rotary rod is fixedly connected with the rotary disc; the lower part of the middle of the rotary disc is fixedly connected with a soft stirring rod; and a heating sheet is arranged between the outer wall and the inner wall of the horizontal section of the drug delivery tube close to the disc-shaped protrusion. The injection flow can be controlled, so that the drug delivery is more stable, and discomfort to human bodies is avoided; and as the guide tube is provided with a pointed design, the guide tube can be quickly penetrated into the bodies.

The invention relates to a patch for curing heat stroke. The patch is made up of the following ingredients of proportioning by weight: 5-10 shares of agastache leaves, 3-10 shares of common origanum leaves, 3-10 shares of peppermint leaves. The raw materials are mixed equably then are crushed in proportion, and the grain diameter of each ingredient ranges from 100Mum to 200Mum. The CO2 supercritical extraction is adopted, the needed fraction is gained by the fractionation of a fractionating tower, the ingredient in the medicinal formula is made to the nanometre midicine liquid in the proportion of the medicinal formula when the ingredients are gone through the nanometre dispersion equipment, the due transdermal absorption accelerant and the pressure-sensitive adhesive are added, and the midicine liquid is coated when the midicine liquid enters the screw cryodrying coating machine, the cutting and the quality testing of midicine liquid is carried out, and the midicine liquid is packed and stored. The medicinal materials are extracted and processed with a scientific method, the medicinal materials are filled in the framework of a stroma. The good intermiscibility of the patch stroma and the skin is favorable for the passing of the drug molecules, the invention has the advantages that the releasing of the drug is slow, the drug supply is steady, the acrimony is little, and the invention has no toxicity. The toxicity to the body brought by the oral medication and the injection is solved, and the toxicity of the drug which is taken by mouth is avioded.

A process for preparing the coarse dust of root and rhizome type Chinese-medicinal materials includes preparing coarse dust and loading it in bags of different dosages for using them as the raw materials of Chinese-medicinal decoction. Its advantages are high extracting rate and low cost.

A process for preparing the coarse dust of bark-type Chinese-medicinal materials including preparing coarse dust and loading in bags of different dosages for using them as the raw material of Chinese-medicinal decoction. Its advantages are high extracting rate and low cost.

The present invention is sunstroke treating plaster and its preparation. The sunstroke treating plaster is prepared with agastache leaf 5-10 weight portions, common origanum leaf 3-10 weight portions and peppermint leaf 3-10 weight portions, and through material mixing, grinding to 100-200 micron size, supercritical CO2 extracting, fractioning in a fractioning tower, nanometer dispersing to form nanometer slurry, adding transdermal promoter and contact adhesive, coating in a low temperature rotary coating machine, cutting, inspection and packing. The present invention has extracted medicine filled in matrix skeleton, compatibility of the matrix to skin, slow medicine release, smooth acting, less stimulation and no toxic side effect.

The invention discloses an applicator for a gynecologic drug for external use. The applicator comprises a pipe body and a booster, a containing cavity for containing the booster and a cleaning cavityfor disinfecting and cleaning an infected part are formed in the pipe body along the axis, the booster comprises a first tube, a drug tube and a push rod, a baffle is arranged at the front end of thecontaining cavity, a detachable gel sprayer is arranged at the front end of the drug tube, and a constant-temperature heating layer is arranged in the internal side wall of the pipe body. The drug tube is arranged in the first tube, before use, the drug tube cannot make contact with the outside, and the drug is prevented from being contaminated by the outside; through the cooperation of the firsttube and the containing cavity, it is achieved that the containing cavity is controlled by a first baffle body and a second baffle body to be opened and closed, and it is ensured that the drug is smoothly and precisely applied. Due to a lighting device, it is ensured that the drug tube is bright, and the push rod is confidently controlled to be pushed in; due to the formation of the cleaning cavity, disinfection of the infected part is ensured; by arranging the heating layer, the comfort in the drug pushing process is ensured, and it can be ensured that the effective components of the drug areeffectively volatilized and absorbed.

The present invention discloses a levo-salbutamol slowly-released tablet and its preparation method. Said preparation method includes the following steps: mixing levo-salbutamol and filling agent, then adding adhesive to obtain soft material, granulating, drying, tableting and coating with a layer of film coating layer so as to obtain the invented levo-salbutamol slowly-released tablet.

The invention provides an enrofloxacin cataplasm which is prepared from raw material medicines and auxiliary materials in parts by weight: 2.5-7.5 parts of enrofloxacin, 1-3 parts of ethylparaben, 15-20 parts of glycerol, 60-100 parts of powdered sugar, 30-70 parts of liquid paraffin, 100-130 parts of wool fat, 180-200 parts of vaseline and 0-40 parts of octadecanol. The invention further provides a preparation method and use of the enrofloxacin cataplasm. The cataplasm is adopted to be attached to the palate of a piglet, the piglet can swallow automatically and the cataplasm is not easy to spit out, so that the piglet is prevented from being irritated, the growth of the piglet is not affected, and the cataplasm is convenient to feed. The cataplasm is stable in quality, and the maintaining time of blood concentration in vivo is longer. The cataplasm is slowly eliminated and the effect is prolonged, and the plasma medicine peak concentration is relatively slow to the benefit of reducing the toxic and side effects, so that the cataplasm is safer and more reliable to use.

The invention specifically discloses a liposome adjuvant, a temperature-sensitive gel and a temperature-sensitive gel preparation. The liposome adjuvant is prepared from the following components in parts by weight: 1 to 4 parts of DOTAP, 280 to 320 parts of soybean lecithin and 40 to 60 parts of cholesterol. The preparation method comprises the following steps: S1, dissolving DOTAP, soybean lecithin and cholesterol in a solvent; rotating and evaporating the solvent to dryness to obtain a film; s2, adding PBS (Phosphate Buffer Solution) into the film obtained in S1, stirring at 45-55 DEG C for 0.5-1.5 hours, and dissolving the film to obtain a liposome stock solution; s3, enabling the liposome stock solution to pass through a polycarbonate film, and extruding for 20-80 times to obtain the liposome adjuvant. The temperature-sensitive gel is prepared from poloxamer gel and a liposome adjuvant; the temperature-sensitive gel can be used for preparing a temperature-sensitive gel adjuvant. The liposome adjuvant has the advantages that the phase change temperature and viscosity of the temperature-sensitive gel can be adjusted, and the administration efficiency of the temperature-sensitive gel preparation can be improved.

A process for preparing the coarse dust of stem or wood type Chinese-medicinal materials is characterized by that said materials are made into coarse dust and then loaded in the bags of different dosages, which can be directly used for high extracting rate and high utilization rate.

The present invention is constipation treating plaster and its preparation. The constipation treating plaster is prepared with edestan 9-15 weight portions, almond 3-10 weight portions and Mongolian snake gourd 12-30 weight portions, and through material mixing, grinding to 100-200 micron size, supercritical CO2 extracting, fractioning in a fractioning tower, nanometer dispersing to form nanometer slurry, adding transdermal promoter and contact adhesive, coating in a low temperature rotary coating machine, cutting, inspection and packing. The present invention has extracted medicine filled in matrix skeleton, compatibility of the matrix to skin, slow medicine release, smooth acting, less stimulation and no toxic side effect.

The invention relates to a traditional Chinese medicine for treating the sicca syndrome, which can be used for effectively solving the medication problem of the sicca syndrome. According to the technical scheme solving the problem, the traditional Chinese medicine is prepared from the raw medicinal materials by weight: 25-35g of adenophora tetraphylla, 12-18g of Radix Ophiopogonis, 8-12g of radix asteris, 8-12g of smoked plum, 8-12g of rhizoma anemarrhenae, 25-35g of raw oyster shell, 8-12g of concha meretricis seu cyclinae, 8-12g of Platycodon grandiflorum, 8-12g of peach kernels, 8-12g of dried rehmannia root, 12-18g of white lablab bean, 8-12g of radix paeoniae rubra, 2-4g of Radix Aconiti Carmichaeli Preparata, 4-8g of honey-fried licorice root, 8-12g of Lycium barbarum and 8-12g of dendrobe. The raw materials of the traditional Chinese medicine are abundant, scientific in components and reasonable in compatibility and support to one another and belong to effective medicinal materials for treating the sicca syndrome. The traditional Chinese medicine has the efficacies of dispersing lung, clearing stomach, tonifying spleen, warning kidney and activating blood, is used for effectively treating the sicca syndrome and is good in curative effect, safe to administrate, free of toxic and side effect, stable in curative effect as well as safe and reliable and is an innovation of medicaments for treating the sicca syndrome.

The invention belongs to the technical field of pesticides and discloses an insecticidal composition containing butyl chlorantraniliprole and a molting hormone. The insecticidal composition comprisesan active ingredient A and an active ingredient B at a weight ratio of (50-1):(1-50), wherein the active ingredient A is butyl chlorantraniliprole; the active ingredient B is one of tebufenozide and dibenzoyl-1-tert-butylhydrazine. The composition can be prepared into various agriculturally allowable dosage forms, has a better effect on prevention and control of homona coffearia, rice leaf rollers, diamondback moths and the like, and can effectively retard resistance generation of pests; compared with a single preparation, the composition has a good prevention and control effect, is good in fast-acting property and persistence, and has an obvious synergetic effect; an insecticidal spectrum is enlarged.

A process for preparing the coarse dust of fruit and seed type Chinese-medicinal materials include preparing coarse dust and loading it in bags of different dosages for using them as raw material of Chinese-medicinal decoction. Its advantages are high extracting rate and low cost.

The invention discloses a skin external use preparation containing a calcium receptor activity compound. The preparation avoids hepatic first pass effect and gastrointestinal adverse reactions of an oral preparation. The preparation comprises a medicine active component, a high-molecular gel skeleton, a tackifier, a moisturizer, and other pharmaceutically acceptable excipients. The preparation has high drug load and is free of problems of irritation and allergy, has no crystallization phenomenon, has better stability and is more safe and convenient to use.

The invention provides a drug sustained-release gel for subconjunctival implantation and a preparation method of the drug sustained-release gel, and belongs to the field of drugs and drug preparation. According to the preparation method, levofloxacin and prednisolone are taken as main drug components, drug molecules are protected and stabilized through nano particles and polymer nano-micelles, and solution injection under conjunctiva, liquid and semi-solid conversion and lasting and slow release of drugs are realized by utilizing the temperature sensitivity of a composite drug sustained-release system; and the composite drug sustained-release system is liquid at low temperature in vitro, and is gradually converted into a semi-solid state due to contact with the body temperature when being injected into the subconjunctiva, so that the sustained-release capability of the drug property is effectively prolonged, and stable and long-acting drug administration can be realized. When the drug sustained-release gel is used for administration, not only can the drug be quickly and conveniently administered, but also the flat gel can be quickly, timely, hygienically, reliably and effectively formed under the conjunctiva, so that the antibacterial and anti-inflammatory effects of the antibacterial drug and the anti-inflammatory drug can be well and stably exerted.

The invention provides a pharmaceutical composition for increasing satiety and a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is a preparation prepared from the following raw materials in parts by weight: 3-40 parts of semen lablab album, 3-40 of red beans 3 parts, 40 parts, 1 to 20 parts of lotus leaf, 4 to 50 parts of Laiwuzi, 4 to 50 partsof Hemp seed, 4.5 to 55 parts of medlar, 4.5 to 55 parts of yam, 5 to 60 parts of coix seed, melon 4 to 50 parts of kernels, 1 to 20 parts of dried ginger, 1 to 20 parts of nutmeg, 1 to 20 parts of cinnamon, 1 to 20 parts of ginseng, 10 to 130 parts of sesame seeds, 8 to 110 parts of hair fungus, and 8 to 110 parts of red dates. The pharmaceutical composition of the invention has the effect of increasing satiety and has broad market application prospects.

The invention discloses a patch for treating miocardial infarction, which comprises the following components according to the parts by weight: 5-10 parts of safflower, 3-10 parts of peach kernel and 3-10 parts of trogopterus dung. A method for preparing the patch comprises the following steps: the raw materials are uniformly mixed and ground according to a proportion, and the grain diameter of each component is between 100 microns and 200 microns; CO2 supercritical fluid extraction is adopted, and a fractionating tower is used for fractionating and obtaining required fractions; after all components in the formula are processed through nanometer disperse equipment, the components are prepared into a nanometer medicinal slurry according to the proportion of the formula; required skin penetration enhancers and pressure-sensitive adhesive are added; the obtained mixture enters a spiral low-temperature drying and coating machine; and after coating, processes of cutting, quality inspection, packaging and storage are carried out. A scientific method is used for processing and extracting medicinal materials and filling the medicinal materials in a skeleton of a matrix, and the compatibility of the matrix of the patch with skin is good and beneficial to drug molecules to pass through, thus the patch has stable medicinal property and the characteristics of quick percutaneous absorption, good air permeability, gradual medicine release, and the like. Compared with an oral formulation, the patch has no intestinal tract first pass effect, is not influenced by the degradation of gastrointestinal tracts and has high bioavailability, convenient use, accurate dosage and fixed absorption area and the advantages of long-term action, skin absorption and convenient carrying and use.

The invention relates to an HPLC quality control construction method and application of a lung-clearing decoction preparation.The method comprises the steps that at least one of chlorogenic acid, amygdalin, geniposide, hesperidin, baicalin, wogonoside, ammonium glycyrrhizinate and schizandrin serves as an effective component, and at least one process of HPLC content determination and HPLC fingerprint spectrum construction is conducted through the effective component. According to the invention, the HPLC quality control construction method is used for detecting and evaluating lung-heat clearingdecoction products which are sold in the market at home and abroad, so as to control the quality of the commercially available preparation of lung-heat clearing decoction, distinguish the source of the commercially available preparation of lung-heat clearing decoction and ensure the clinical curative effect of the commercially available preparation of lung-heat clearing decoction. According to the HPLC quality control construction method, the quality of the lung-heat clearing decoction preparation can be monitored, a reference basis is provided for ensuring the medication safety, stability and quality controllability of lung-heat clearing decoction, and the inheritance and development of traditional Chinese medicines are promoted.

The invention provides a medicine composition for diuresis. The medicine composition is prepared from, by weight, 3-40 parts of semen lablab album, 4-50 parts of semen phaseoli, 4-50 parts of poria cocos, 1.5-25 parts of folium nelumbinis, 1-20 parts of semen cassiae, 4-50 parts of semen raphani, 3-40 parts of semen cannabis, 3-40 parts of semen euryales, 3-40 parts of rhizoma dioscoreae, 4-50 parts of semen coicis, 5-60 parts of fructus benincasae, 2-30 parts of fructus mulberry, 1.5-25 parts of radix ginseng, 1-20 parts of semen ziziphi spinosea, 10-110 parts of semen sesami nigrum, 6-70 parts of auricularia polytricha and 8-90 parts of fructus ziziphi jugubae. The medicine composition tonifies qi and blood, clears damp to promote diuresis, has diuresis effect due to matching of medicinal and edible traditional Chinese medicine and is free of causing electrolyte disorder, little in side effect, short in treatment course, lasting in efficacy, high in safety and wide in market application prospect.

The invention belongs to the technical field of pesticides and particularly relates to an insecticide composition comprising butyl chlorantraniliprole and nicotine. The insecticide composition comprises an effective ingredient A and an effective ingredient B, wherein the effective ingredient A is butyl chlorantraniliprole, and the effective ingredient B is one of imidacloprid, acetamiprid and nitenpyram. The weight ratio of the effective ingredient A to the effective ingredient B is (10-1):(1-10). The provided composition can be prepared into various agriculturally allowable preparations, hasbetter effects on preventing and controlling rice leaf folders, plutella xylostella, european corn borer, dichocrocis punctiferalis, prodenia litura, cotton bollworms, aphids, thrips and leafhoppers of various commercial crops like rice, vegetables, corns and citrus, and can effectively delay the production of pest resistance; compared with the single preparation, the prevention and control effects are good, the lasting period is long, the insecticidal spectrum is expanded, and the synergistic effect is obvious.

The invention relates to a traditional Chinese medicine for treating Sjogren's syndrome, which can effectively solve the medication problem of Sjögren's syndrome. The technical solution is that it is made of the following raw materials by weight: 25-35g of Nansha ginseng, 12-18g of Ophiopogon japonicus, and aster 8‑12g, ebony plum 8‑12g, Anemarrhena 8‑12g, raw oyster 25‑35g, sea clam shell 8‑12g, bellflower 8‑12g, peach kernel 8‑12g, raw rehmannia 8‑12g, white lentils 12‑18g, Radix Paeoniae Rubra 8‑12g, Danfu Tablets 2‑4g, Radix Glycyrrhizae 4‑8g, Lycium Barbarum 8‑12g and Dendrobium 8‑12g, the present invention has rich raw materials, scientific components, reasonable compatibility and mutual support, and is used for treating dryness syndrome. It is an effective drug for treating Sjogren's syndrome. It has the functions of clearing the lung, clearing the stomach, invigorating the spleen, warming the kidney, and promoting blood circulation. It is effective in treating Sjögren's syndrome. innovation in medicine.

The invention relates to a kendir pressure-reducing sticking agent and a preparation method thereof. The preparation method comprises the following steps: extracting eight kinds of medicinal materials of kendir, self-heal, uncaria stem with hooks, rhizoma alismatis, mother-of-pearl, twotooth achyranthes root, hawthorn and chrysanthemum which are raw material medicines, refining the effective components of the medicinal materials, adding an excipient, polyvinyl alcohol, gelatin, kaolin, glycerol and azone and preparing to obtain the kendir pressure-reducing sticking agent. The kendir pressure-reducing sticking agent obtained by the invention has slow medicine release, stable drug administration, strong pressure-reducing effect, small stimulation and no toxic or side effect.

The invention discloses a flushing drug deliverer for clinical application in gynaecology. The flushing drug deliverer comprises a cylinder, wherein a rubber stopper is placed on the left side in thecylinder, a pushing rod is in inserting connection to the left side of the rubber stopper, a disk is welded to the left side of the pushing rod, a connecting plate is welded to the outer side of the disk, a sliding block is welded to the outer side of the connecting plate, a sliding groove is formed in a rectangular plate, electric telescopic rods are mounted on the left side of the rectangular plate, output ends of the electric telescopic rods are connected with the connecting plate, a liquid inlet pipe is welded to the right side of the top end of the cylinder, a display screen is mounted onthe right side of the front surface of the cylinder, and control switches are respectively mounted at the upper end and the lower end of the right side of the display screen. Patients can be smoothlymedicated, the phenomenon that the comfort degree of the inner part of a vagina is poor when the patient is treated because the medication speed is too high, can be avoided, the comfort degree of thepatient during treatment can be increased, and the rehabilitation of the patient can be accelerated.