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Enrofloxacin cataplasm and preparation method thereof

A paste and weight proportioning technology, applied in the field of enrofloxacin paste and its preparation, can solve the problems of complex preparation process, high requirements on auxiliary materials, unfavorable large-scale production, etc. Ease of administration

Inactive Publication Date: 2013-08-21
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the development of preparation technology, new dosage forms have been developed, including nanoparticles, microspheres, liposomes, β-cyclodextrin inclusion complexes, sustained-release granules, microcapsules, microcapsules, etc. These preparations Designed to cover the bitter taste of enrofloxacin, improve its palatability, increase its stability, delay drug release, improve bioavailability, thereby improving its curative effect. (Yang Xuefeng, et al., preparation and quality of enrofloxacin nanoemulsion Evaluation, Journal of Zhejiang University (Agriculture and Life Science Edition) 38(6):693~699, 2012), but due to the complex preparation process of the above preparations, high requirements for excipients and high cost, it is not conducive to large-scale production

Method used

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  • Enrofloxacin cataplasm and preparation method thereof
  • Enrofloxacin cataplasm and preparation method thereof
  • Enrofloxacin cataplasm and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 paste of the present invention

[0019] Prescription composition:

[0020]

[0021] Preparation:

[0022] (1) Take the prescribed amount of glycerol and add ethylparaben, heat it on a water bath to 50-60°C to melt it, then add an appropriate amount of water, add enrofloxacin, sodium hydroxide, and powdered sugar and stir to dissolve . (2) Heat liquid paraffin, lanolin, and vaseline on a water bath to about 50°C. Then pour (1) into (2), stir and add water to the full amount, stir evenly until cooled, divide into packages, 5g per package.

Embodiment 2

[0023] Embodiment 2 The paste formulation optimization test of enrofloxacin paste of the present invention made by different matrix types

[0024] Table 1 Prescription Matrix Screening

[0025]

[0026] The prescription group was stored airtightly at 37°C, room temperature (25°C) and 4°C for one month and then observed in the table

[0027] Table 2 The comparison of the properties of the paste placed in January under the condition of 37°C

[0028]

[0029]

[0030] Table 3 The comparison of the properties of the paste placed in January under the condition of 25°C

[0031]

[0032] Table 4 The comparison of the properties of the paste placed in January under the condition of 25°C

[0033]

[0034] In summary, after the enrofloxacin pastes were placed under the three conditions, it can be seen that the contents of the 7 groups of pastes were relatively stable under each condition, indicating that the contents of the pastes reached the standard. Based on various...

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Abstract

The invention provides an enrofloxacin cataplasm which is prepared from raw material medicines and auxiliary materials in parts by weight: 2.5-7.5 parts of enrofloxacin, 1-3 parts of ethylparaben, 15-20 parts of glycerol, 60-100 parts of powdered sugar, 30-70 parts of liquid paraffin, 100-130 parts of wool fat, 180-200 parts of vaseline and 0-40 parts of octadecanol. The invention further provides a preparation method and use of the enrofloxacin cataplasm. The cataplasm is adopted to be attached to the palate of a piglet, the piglet can swallow automatically and the cataplasm is not easy to spit out, so that the piglet is prevented from being irritated, the growth of the piglet is not affected, and the cataplasm is convenient to feed. The cataplasm is stable in quality, and the maintaining time of blood concentration in vivo is longer. The cataplasm is slowly eliminated and the effect is prolonged, and the plasma medicine peak concentration is relatively slow to the benefit of reducing the toxic and side effects, so that the cataplasm is safer and more reliable to use.

Description

technical field [0001] The invention relates to a paste for treating diarrhea of ​​piglets, a preparation method and application thereof. Background technique [0002] Enrofloxacin is also known as ethyl ciprofloxacin and enrofloxacin. Systematic name: 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. This product is currently designated as an animal-specific drug by the state. It has a long half-life in animals and good tissue distribution. It is a broad-spectrum bactericidal drug and has special effects on mycoplasma. It has bactericidal effect on Escherichia coli, Klebsiella, Salmonella, Proteus, Pseudomonas aeruginosa, Haemophilus, Pasteurella multocida, Pasteurella hemolyticus, Staphylococcus aureus, Streptococcus, etc. After ingestion by animals, not only will it remain in livestock and poultry products, but the drug will enter the ecological environment from feces, urine and other excreta in the form of prototype compoun...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/496A61P1/12A61P31/04
Inventor 徐莎杨海涵房春林李超丁晓刚
Owner CHENGDU QIANKUN VETERINARY PHARMA
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