33results about How to "Not easy to spit out" patented technology

The present invention relates to propping agent which is widely applied to the oil and gas well hydraulic fracturing technology, and the present invention especially relates to a manufacturing method and a preparation technology of low-consistency propping agent and is characterized in that firstly, plant fibre material is used as the raw material and is crushed and grinded as plant fibre granules; secondly, modifying agent solution dips and solidifies the plant fibre granules; thirdly, macromolecular resin is used to covering the granules which are crushed and filtered again to form the propping agent. The propping agent prepared by the technology and method can conquers that the prior propping agent has large energy consumption and high expense of the whole construction, or the propping agent of the present invention does not easily cause the phenomena of propping agent disgorging or crack emptying.

The invention discloses a method for culturing nucleated pearls, which comprises the following steps of: taking a non-nucleated pearl as a nucleus or grinding shells to form the nucleus; cushioning a cell sheet under the nucleus, and implanting at the position of the viscera or foot of a freshwater mussel or nacre; returning the freshwater mussel or nacre to water for culture; and opening the freshwater mussel or nacre to harvest the pearls formed around the nucleus. Because the foot of the freshwater mussel or nacre is positioned above the visceral sac thereof, has a larger space and secretes more nacrum than the visceral sac or a mantle tissue, the implanted nucleus is difficult to be spit out, the self diameter of the nucleus is increased, and the freshwater mussel or nacre secretes more nacrum after the nucleus is coated. The pearls have the advantages of large particles, good transparency and gloss, short growth period and high economic value.

The invention discloses a pearl cultivating method for nuclear pearl, a tool adopting the method and cultivated pearl. The pearl cultivating method for nuclear pearl comprises the following steps: nuclear-free pearl is used as a pearl nucleus or a shell is grinded to form the pearl nucleus; the pearl nucleus is arranged on a cell sheet and then the pearl nucleus with the cell sheet is implanted on viscera or pelecypodium of a mussel or a pearl shell with a tool; the mussel and the pearl shell is restored in water for culture; the mussel or the pearl shell are opened and a pearl formed around the pearl nucleus is harvested. As the pelecypodium of the mussel or the pearl shell is above a visceral sac and has large space compared with the visceral sac or a mantle, and the pelecypodium secretes more nacre, the pearl nucleus cannot be spit out easily if the pearl nucleus is implanted on the pelecypodium and the diameter of the pearl nucleus is expanded, moreover, the mussel or the pearl shell secretes more nacre after the pearl nucleus is coated. The pearl cultivating method ensures that the pearl nucleus can be inserted into the pelecypodium accurately, the cell sheet can wrap the pearl nucleus better and the pearl nucleus has no need of punching a hole. The pearl has large particle, good translucent luster, short growth cycle and high economic value.

The invention relates to an oxiracetam oral dispersion membrane preparation and a preparation method thereof. The oxiracetam oral dispersion membrane preparation is prepared from a composite membrane forming material, a plasticizing agent, a filling agent and the like. The oxiracetam oral dispersion membrane preparation has the advantages that the preparation can be dissolved by less saliva in an oral cavity, and can be taken without using water, so that the taking is convenient; the easiness in vomiting is avoided after sticking onto a tongue, and the Oxiracetam oral preparation is suitable for patients with difficulty in swallowing; by utilizing mucosae to absorb, the first pass elimination effect is avoided, the bioavailability is improved, the medicine dosage is reduced, and the side effect is decreased. The preparation method has the advantages that the preparation technology is simple, and the preparation method is suitable for industrialized production.

The invention is a cough relieving medicine; it is made up of ingredients with following weight proportion: poppy shell immersed plaster 90-110, aster 26-38, chrysoidine 15-26, stemona root radix stemonae 15-26, magnolia vine fruit 3-7, balloonflower root 26-38, citron or trifoliate orange fruit 3-7, dried tangerine peel 26-38, catnip 10-22, hogfennel root 40-54, dried ginger 3-7, liquorice 85-105, ammonium chloride 65-95, peppermint oil dementholized 0.3-0.7ml. The invention can regulate the lung and relieve phlegm, stops cough. The invention also provides the manufacturing method for the medicine.

The invention provides an enrofloxacin cataplasm which is prepared from raw material medicines and auxiliary materials in parts by weight: 2.5-7.5 parts of enrofloxacin, 1-3 parts of ethylparaben, 15-20 parts of glycerol, 60-100 parts of powdered sugar, 30-70 parts of liquid paraffin, 100-130 parts of wool fat, 180-200 parts of vaseline and 0-40 parts of octadecanol. The invention further provides a preparation method and use of the enrofloxacin cataplasm. The cataplasm is adopted to be attached to the palate of a piglet, the piglet can swallow automatically and the cataplasm is not easy to spit out, so that the piglet is prevented from being irritated, the growth of the piglet is not affected, and the cataplasm is convenient to feed. The cataplasm is stable in quality, and the maintaining time of blood concentration in vivo is longer. The cataplasm is slowly eliminated and the effect is prolonged, and the plasma medicine peak concentration is relatively slow to the benefit of reducing the toxic and side effects, so that the cataplasm is safer and more reliable to use.

The invention provides a method for preparing dextrorotatory oxiracetam oral fast dissolving films by hot-melt extrusion. Dextrorotatory oxiracetam, a film-forming material, a plasticizer and a filling agent are evenly mixed to obtain a mixture, the mixture is added into a hot-melt film laminator, conveyed from a feeding area of the hot-melt film laminator to a hot melting area and then melted gradually and evenly, the melted mixture is discharged through a dosing area continuously and poured into dies, and the films are obtained after the melted mixture in the dies are cooled. The dextrorotatory oxiracetam oral fast dissolving films prepared by the method is moderate in thickness, good in mechanical property and short in disintegration time. The method for preparing the dextrorotatory oxiracetam oral fast dissolving films by hot-melt extrusion is simple and applicable to industrial production.

The invention discloses a method used for preparing an oxiracetam oral cavity rapidly dissolved film preparation. According to the method, oxiracetam, a film forming material, a filling material, a plasticizer, a saliva irritant, and a corrigent are taken as raw materials, a drug film coating machine is adopted to prepare the oxiracetam oral cavity rapidly dissolved film preparation. The thickness of the oxiracetam oral cavity rapidly dissolved film preparation, coating speed, and drying temperature are controlled strictly, so that technology is stabilized, product quality is ensured, and the brittleness, the disintegration time, and dissolving time of the oxiracetam oral cavity rapidly dissolved film preparation are modified to be beneficial for clinical applications.

The invention relates to an L-oxiracetam oral dispersible membrane and a preparation method thereof. The L-oxiracetam oral dispersible membrane is prepared by adopting materials, such as a composite membrane-forming material, a plasticizer and a filler. After being stuck to the tongue, the L-oxiracetam oral dispersible membrane cannot be easily spit out, and therefore is suitable for old people with dysphagia. Moreover, because the L-oxiracetam oral dispersible membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced. The preparation process of the invention is simple, and therefore is suitable for industrialized production.

The invention provides a dextrorotatory oxiracetam soluble oral membrane which is prepared from dextrorotatory oxiracetam, membrane forming materials, a plasticizer and a cosolvent. As the preparationprocess is performed without presence of water or organic solvents, the problems about air bubbles caused by presence of solvents and high moisture content of the membrane are avoided, and homogeneity of the dextrorotatory oxiracetam soluble oral membrane is guaranteed effectively. Besides, the technical problems that conventional membranes are easy to break, poor in strength and toughness, slowin disintegration, long in dissolving, poor in drug absorption effect and the like are solved effectively; the dextrorotatory oxiracetam soluble oral membrane prepared by the method has good strippingperformance, is soft, not easy to break and quick to dissolve. The preparation method is simple and suitable for industrial production.

The invention relates to an L-oxiracetam oral instant membrane, which is prepared by adopting materials, such as a composite membrane-forming material, a plasticizer and a filter. By means of the combination of the specific composite membrane-forming material, the plasticizer and the filler, the invention uses a membrane coating machine to prepare the L-oxiracetam oral instant membrane, and strictly controls the thickness of the oral instant membrane, coating speed and drying temperature, thus stabilizing the process and ensuring the quality of the product, and thereby the brittleness, disintegration time, solution time and other aspects of the L-oxiracetam oral instant membrane are more favorable for clinical application. A preparation method of the invention is simple, and therefore is suitable for industrialized production.

The invention provides a dextrorotatory oxiracetam oral dispersing membrane which is prepared from a PVA-containing membrane forming material together with specific adjuvant materials such as a plasticizer, a filler and a corrigent by a coating method. The dextrorotatory oxiracetam oral dispersing membrane can be dissolved in the mouth with a small amount of saliva and can be taken without water,which brings convenience in use. As the dextrorotatory oxiracetam oral dispersing membrane is not easy to spit when being adhered to the tongue, it is suitable for patients having dysphagia. As the membrane is absorbed through oral mucosa, the first pass elimination effect is eliminated, bioavailability is improved, applying dosage is reduced, and further the side effect of drug is reduced. The preparation method is simple, can be implemented without large-size industrial equipment, and is suitable for industrial production.

The invention discloses a traditional Chinese medicine for treating chronic bronchitis.The traditional Chinese medicine is prepared from three Chinese herbs and is characterized by being powder prepared from borax, processed rhizoma arisaematis and white mustard seeds with the equal parts, and all the Chinese herbs are milled into fine powder together.

The invention discloses an oxiracetam film preparation prepared from a composite film forming material, a plasticizer, and a filling material using a drug film coating machine. The specific composite film forming material, the plasticizer, and the filling material are combined, and the thickness, the coating speed, and the drying temperature of the oxiracetam film preparation are controlled strictly, so that stabilization of the technology is realized, product quality is ensured, and the brittleness, disintegration time, and dissolving time are more beneficial for clinical applications; and the preparation method is simple, and is suitable for industrialized production.

An oxiracetam oral film prepared by oxiracetam, a film-forming material, a filler, a plasticizer, a saliva stimulating agent and a flavoring agent, the prepared oxiracetam oral instant film, which is in It can be dissolved in a small amount of saliva in the mouth, and can be used without water, which is convenient for medication; and it is not easy to spit out after sticking to the tongue, which is suitable for patients with dysphagia, and it is absorbed through the mucosa, avoiding the first-pass elimination effect and improving The bioavailability is improved, the medicinal dosage is reduced, thereby reducing the side effects of the drug. The preparation method of the invention is simple to operate, does not need large-scale industrial equipment, and is suitable for industrial production.

The invention relates to an L-oxiracetam oral instant membrane, which is prepared from 3 to 20 parts of L-oxiracetam, 40 to 70 parts of membrane-forming material, 10 to 30 parts of filter, 5 to 20 parts of plasticizer and 2 to 4 parts of corrigent, wherein the membrane-forming material is maltodextrin. The L-oxiracetam oral instant membrane can be dissolved by a small amount of saliva in the oral cavity, and can be taken without water for delivery, so administration is convenient. After being stuck to the tongue, the L-oxiracetam oral instant membrane cannot be easily spit out, and therefore is suitable for children with dysphagia. Moreover, because the L-oxiracetam oral instant membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced. A preparation method of the invention is simple, the process cost is low, and therefore the preparation method is suitable for mass production.

The invention relates to a preparation method for an L-oxiracetam oral membrane. The L-oxiracetam oral membrane is prepared from L-oxiracetam, a membrane-forming material, a filler, a plasticizer and a corrigent. The prepared oral dispersible membrane can be dissolved by a small amount of saliva in the oral cavity, and can be taken without water for delivery, so administration is convenient. After being stuck to the tongue, the L-oxiracetam oral membrane cannot be easily spit out, and therefore is suitable for old people with dysphagia. The preparation method of the invention is simple, the process cost is low, and therefore the preparation method is suitable for mass production.

The invention relates to a preparation method for an L-oxiracetam oral preparation. The L-oxiracetam oral preparation is prepared by adopting materials, such as a composite membrane-forming material, a plasticizer and a filler. By means of the combination of the specific composite membrane-forming material, the plasticizer and the filler, the preparation method uses a membrane coating machine to prepare the L-oxiracetam oral membrane, and strictly controls the thickness of the membrane, coating speed and drying temperature, thus stabilizing the process and ensuring the quality of the product, and thereby the brittleness, disintegration time, solution time and other aspects of the L-oxiracetam oral preparation are more favorable for clinical application.

The invention relates to an L-oxiracetam oral instant membrane, which is prepared from 3 to 20 parts of L-oxiracetam, 40 to 70 parts of membrane-forming material, 10 to 30 parts of filter, 5 to 20 parts of plasticizer and 2 to 4 parts of corrigent, wherein the membrane-forming material is maltodextrin. The L-oxiracetam oral instant membrane can be dissolved by a small amount of saliva in the oral cavity, and can be taken without water for delivery, so administration is convenient. After being stuck to the tongue, the L-oxiracetam oral instant membrane cannot be easily spit out, and therefore is suitable for children with dysphagia. Moreover, because the L-oxiracetam oral instant membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced. A preparation method of the invention is simple, the process cost is low, and therefore the preparation method is suitable for mass production.

The invention relates to an L-oxiracetam oral dispersible membrane and a preparation method thereof. The L-oxiracetam oral dispersible membrane is prepared from L-oxiracetam, a membrane-forming material, a filler, a plasticizer, a saliva stimulant and a corrigent. The prepared L-oxiracetam oral dispersible membrane can be dissolved by a small amount of saliva in the oral cavity, and can be taken without water for delivery, so administration is convenient; moreover, after being stuck to the tongue, the L-oxiracetam oral dispersible membrane cannot be easily spit out, and therefore is suitable for patients with dysphagia. Furthermore, because the L-oxiracetam oral dispersible membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced.

The invention discloses a method for preparing an oxiracetam oral membrane. The method comprises the following steps of fully grinding and uniformly mixing oxiracetam, a membrane forming material, a plasticizing agent, a saliva stimulating agent and a flavoring agent, and forming a membrane by hot melting and extruding. The method solves the technical problems of easiness in breaking of the membrane, poor strength and toughness, delaying of disintegration, longer dissolving time, difficulty in medicine absorbing and the like. The oxiracetam oral membrane preparation has the beneficial effects that the stripping property is good, the medicine membrane is flexible, the easiness in breaking is avoided, and the dissolving time is short.

The invention relates to an L-oxiracetam oral membrane, which is prepared from L-oxiracetam, a membrane-forming material, a filler, a plasticizer, a sweetener and a saliva stimulant, wherein the membrane-forming material is prepared from maltodextrin and at least another type of high-polymer membrane-forming material; and the high-polymer membrane-forming material is one or the combination of more of hydroxypropyl cellulose, amylopectin, sodium alginate, pulullan, povidone-vinyl acetate and sodium carboxymethylcellulose. The invention solves the technical problems of oral membrane, such as easiness in softening, badness in membrane-forming property and difficulty in demoulding, thus improving product quality. The preparation method of the invention is simple, and therefore is suitable for industrialized production.

The invention relates to an oxiracetam oral membrane preparation and a preparation method thereof. The oxiracetam oral dispersion membrane preparation is prepared from Oxiracetam, a membrane forming material, a plasticizing agent and a filling agent. The oxiracetam oral membrane preparation has the advantages that the preparation can be dissolved by less saliva in an oral cavity, and can be taken without using water, so that the taking is convenient; the easiness in vomiting is avoided after sticking onto a tongue, and the oxiracetam oral preparation is suitable for old people with difficulty in swallowing; by utilizing mucosae to absorb, the first pass elimination effect is avoided, the bioavailability is improved, the medicine dosage is reduced, and the side effect is decreased. The preparation method has the advantages that the preparation is simple, the technology cost is low, and the preparation method is suitable for industrialized production.

The invention relates to an oxiracetam oral preparation and a preparation method thereof. The oxiracetam oral preparation is prepared from a composite membrane forming material, a plasticizing agent, a filling agent and the like. The oxiracetam oral preparation has the advantages that the easiness in vomiting is avoided after sticking onto a tongue, and the oxiracetam oral preparation is suitable for old people with difficulty in swallowing; by utilizing mucosae to absorb, the first pass elimination effect is avoided, the bioavailability is improved, the medicine dosage is reduced, and the side effect is decreased. The preparation method has the advantages that the preparation technology is simple, and the preparation method is suitable for industrialized production.

The invention relates to an L-oxiracetam oral dispersible membrane and a preparation method thereof. The L-oxiracetam oral dispersible membrane is prepared by adopting materials, such as a composite membrane-forming material, a plasticizer and a filler. After being stuck to the tongue, the L-oxiracetam oral dispersible membrane cannot be easily spit out, and therefore is suitable for old people with dysphagia. Moreover, because the L-oxiracetam oral dispersible membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced. The preparation process of the invention is simple, and therefore is suitable for industrialized production.

The invention relates to a preparation method of an oxiracetam oral membrane preparation. The Oxiracetam oral dispersion membrane preparation is prepared from oxiracetam, a membrane forming material, a filling agent, a plasticizing agent, a flavoring agent and a saliva stimulating agent, wherein the membrane forming material comprises maltodextrin and at least the other macromolecular membrane forming material; the other macromolecular membrane forming material is selected from one or several of hydroxy propyl cellulose, branched starch, sodium alginate, Pulullan, povidone-vinyl acetate or sodium carboxymethylcellulose. The preparation method has the advantages that the technical problems of poor mechanic property, long disintegrating time, crispness, easiness in breaking and the like of the membrane preparation are solved, and the product quality is guaranteed; the preparation is simple, and is suitable for industrialized production.

The invention relates to an L-oxiracetam membrane, which is prepared by adopting a composite membrane-forming material, a plasticizer, a filler and a corrigent. The L-oxiracetam membrane disclosed by the invention can be dissolved by a small amount of saliva in the oral cavity, and can be taken without water, so administration is convenient. After being stuck to the tongue, the L-oxiracetam membrane cannot be easily spit out, and therefore is suitable for patients with dysphagia. Furthermore, because the L-oxiracetam membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced. A preparation process of the invention is simple, and therefore is suitable for industrialized production.

The invention discloses a medicine for treating respiratory system diseases, and a preparation method thereof. The medicine for treating respiratory system diseases is prepared through combining, by weight, 36-43 parts of herba ephedrae, 27-34 parts of cassia twig, 7-12 parts of Herba Asari, 28-34 parts of Radix paeoniae alba, 29-31 parts of Cortex Phellodendri, 13-16 parts of Rhizoma AtractylodisMacrocephalae, 18-22 parts of coix seeds, 18-23 parts of Sargentodoxa cuneata, 27-34 parts of Chinese magnoliavine, 13-17 parts of fresh ginger, 14-16 parts of Blackberrylily Rhizome, 19-22 parts ofPericarpium Arecae, 7-12 parts of dahurian angelica root, 27-34 parts of radix bupleuri, 37-44 parts of Radix Puerariae, 28-33 parts of perilla seed, 27-32 parts of semen brassicae, 29-31 parts of radish seeds, 27-32 parts of Incised Notopterygium and Radix Angelicae Pubescentis, 17-22 parts of pinellia ternate, 28-32 parts of Bulbus Fritillaria, 37-43 parts of Radix Sophorae Flavescentis, 14-18 parts of Radix Asparagi and Radix Ophiopogonis, and 18-22 parts of Stellaria aquatica. The medicine has a good curative effect on respiratory system diseases, is simple in preparation procedure, is safe and efficient to use, and is of great significance to clinically treating respiratory system diseases.

The invention discloses a pearl cultivating method for nuclear pearl, a tool adopting the method and cultivated pearl. The pearl cultivating method for nuclear pearl comprises the following steps: nuclear-free pearl is used as a pearl nucleus or a shell is grinded to form the pearl nucleus; the pearl nucleus is arranged on a cell sheet and then the pearl nucleus with the cell sheet is implanted on pelecypodium of a mussel or a pearl shell with a tool; the mussel and the pearl shell is restored in water for culture; the mussel or the pearl shell are opened and a pearl formed around the pearl nucleus is harvested. As the pelecypodium of the mussel or the pearl shell is above a visceral sac and has large space compared with the visceral sac or a mantle, and the pelecypodium secretes more nacre, the pearl nucleus cannot be spit out easily if the pearl nucleus is implanted on the pelecypodium and the diameter of the pearl nucleus is expanded, moreover, the mussel or the pearl shell secretes more nacre after the pearl nucleus is coated. The pearl cultivating method ensures that the pearl nucleus can be inserted into the pelecypodium accurately, the cell sheet can wrap the pearl nucleus better and the pearl nucleus has no need of punching a hole. The pearl has large particle, good translucent luster, short growth cycle and high economic value.

The invention provides an oral film for treating infantile hemangioma and a preparation method thereof. The oral film for treating infantile hemangioma includes a β-receptor blocker and pharmaceutically acceptable auxiliary materials. The drug content of each tablet of the oral film is accurate, and convenient and accurate quantitative administration can be realized, which is convenient for children to take medicine to ensure curative effect, and is completely suitable for industrialized mass production.