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Medicinal oleum curcumae Aromaticae oils and preparation for its capsule thereof

A technology of curcuma oil and micro-nanocapsules, applied in the field of micro-nanocapsules of medicinal curcuma oil and its preparation, can solve problems such as ratio differences, achieve the effects of improved efficacy, convenient clinical administration and low toxicity

Inactive Publication Date: 2005-02-16
EAST CHINA UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the different origins of Zedoary, even in the same origin, due to the different growth years of Zedoary, the proportions of active components in the obtained Zedoary oil are very different, which brings many uncertain factors to the evaluation of the clinical promotion and use of Zedoary. , this is a common problem of all Chinese medicinal materials, and it is also a problem that plagues Chinese medicinal materials to go to the world

Method used

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  • Medicinal oleum curcumae Aromaticae oils and preparation for its capsule thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Preparation of "Curcuma oil-like" micronanocapsules by polymer emulsification and dispersion

[0022] A "cure-like oil" composed of β-elemene, curcumol and curdione in a weight ratio of 2:1:1 as the core material of the capsule, and polylactic acid or polylactic acid copolyglycolic acid as the shell of the capsule The preparation method of the micro-nanocapsule of the material is specifically described as follows:

[0023] ① Dissolve 100mg of polylactic acid and 125mg of lecithin with 15ml of acetone to form a uniform solution, then take 80mg of the above-mentioned "curecum-like oil" and dissolve it in 15ml of benzyl benzoate, then add it to the previous solution, and mix to form a uniform oil phase A1;

[0024] ② Dissolve 100mg of Dextran 70 in 1000ml of distilled water to form water phase B 1 ;

[0025] ③Under stirring, mix oil phase A 1 Slowly add dropwise to aqueous phase B 1 In, make it dispersed into a uniform emulsion W 1 ;

[0026] ④The above emulsion W ...

Embodiment 2

[0035] Preparation of "Curcuma oil-like" micronanocapsules by monomer emulsion polymerization

[0036] A "cure-like oil" composed of β-elemene, curcumol and curcumadione in a weight ratio of 1:2:1 is used as the core material of the capsule, and polybutylcyanoacrylate is used as the shell material of the capsule. The preparation method of micronanocapsule,

[0037] The details are as follows:

[0038] ①Take 100mg of the above-mentioned "curecum-like oil", dissolve it in 0.5ml of glycerol trioleate, and then dissolve it in 30ml of absolute ethanol together with 0.2-0.8ml of monomeric butyl cyanoacrylate (BCA) , forming a homogeneous organic phase, the oil phase A 2 ;

[0039] ② Take nonionic surfactant (as dispersant) Poloxamer (Pluronic) F 68 Form a 0.5% (w / v) solution with 60ml of distilled water, that is, aqueous phase B 2 ;

[0040] ③Under stirring, mix oil phase A 2 Slowly add dropwise to aqueous phase B 2 In the process, a milky white emulsion W was obtained 2 ; ...

Embodiment 3

[0049] "Curcuma oil-like" micronanocapsules prepared by natural polymer cross-linking method

[0050] A kind of "curcuma-like oil" composed of β-elemene, curcumol and curcumadione in a weight ratio of 1:1:2 is used as the core material of the capsule, and gelatin or canarin is used as the shell material of the capsule. The preparation method of nanocapsule is specifically described as follows:

[0051] ①Get 10ml concentration of 1% (w / v) gelatin or canna gum aqueous solution, get 50ml containing dispersant Tween 20 or Tween 80 concentration of 1% (w / v) aqueous solution, and the aforementioned "curcuma-like "Oil" 20mg, placed in a beaker, continuously stirred and dispersed at 37°C by means of an electromagnetic stirrer with a stirring speed of 200 rpm, then added 7ml of 20% (w / v) sodium sulfate aqueous solution and 1.2ml of isopropyl Alcohol solubilizer, stir until the flocculation-like turbidity disappears completely (but the above-mentioned system is not stable, and the cond...

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Abstract

The invention discloses a medical 'zedoary oil' and a manufacturing method for its micro capsule, the zedoary oil is acquired by confecting the beta-elemene, zedoary alcohol, curdione according to a fixed proportion, compared with natural zedoay oil, its effective ingredients content are high, and in virtue of the cooperation among the three, thus it has higher functions for resisting tumor, bacteria, and virusl; the producing method for mciro capsule is: because of increasing the even process, and through controlling the inner circulation in the even process, the particle size of the capsule is controllable between 50nm and 500nm, it can acquire the micro capsule with the uniform particle size, its irregularity is not more than plus and minus 5 nm.

Description

technical field [0001] The invention relates to a micronanocapsule of medicinal curcuma oil and a preparation method thereof. In particular, a medicinal "cure-like oil" composed of active components extracted from zedoary oil and having a stable component ratio is a nanocapsule with a core as the core and a preparation method thereof. Background technique [0002] Zedoary oil extracted from the rhizome of the Chinese herbal medicine Zedoary oil has a good anti-tumor effect, which has been confirmed by clinical trials and listed in the Chinese Pharmacopoeia. According to the Chinese Pharmacopoeia, the active components in turmeric oil with antitumor, antibacterial and antiviral functions are β-elemene, curcumol and curcumedione. However, due to the different origins of Zedoary, even in the same origin, due to the different growth years of Zedoary, the proportions of active components in the obtained Zedoary oil are very different, which brings ma...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61P31/04A61P31/12A61P35/00
Inventor 蓝闽波王进玲袁慧慧沈平孃张玉兰林志宏刘志远虞伟
Owner EAST CHINA UNIV OF SCI & TECH
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