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Drug composition containing curdione

A technology of curcuma dione and a composition is applied in the field of medicine, which can solve the problems of easy sublimation of curcumitol, unstable preparation quality, influence on curative effect, etc., and achieve the effects of good therapeutic effect, controllable quality and clear composition.

Active Publication Date: 2013-01-02
HAINAN HUIYUANTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006]The LD50 of curcumedione is significantly lower than that of curcumol, and curcumol is easy to sublimate, so the quality of preparations containing curcumol is unstable, which affects its curative effect

Method used

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  • Drug composition containing curdione
  • Drug composition containing curdione
  • Drug composition containing curdione

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] Prescription: Gemacerone 19g, Furandiene 38.4g, Curdione 9g, β-Elemene 9g, Curcumol 1.5g, Curcumene 0.09g, Borneol 75g.

[0162] Dosage form: suppository.

[0163] Preparation method: mix the prescribed amount of gemmacone, furandadiene, curdione, β-elemene, curcumol, curcumene with 67g of polysorbate 80, dissolve 75g of borneol with an appropriate amount of ethanol, and mix with the above solution Mix well.

[0164] The polyoxyethylene stearate 1523g of recipe quantity is put on the water bath and is heated and melted, adds above-mentioned medicinal liquid, stirs, filling, makes 1000 suppositories, each 1.74g.

Embodiment 2～8

[0166] Prepare the suppository according to the following prescription, and the preparation method is the same as in Example 1.

[0167] Example

Embodiment 9

[0169] Prescription: Gemacerone 16.5g, Furandiene 32g, Curdione 21g, β-Elemene 8.5g, Curcumol 2.9g, Borneol 35g.

[0170] Dosage form: effervescent tablet.

[0171] Preparation:

[0172] 1) Take β-cyclodextrin, add appropriate amount of water according to 25ml / g, stir to make it fully dissolved, and heat if necessary to obtain β-cyclodextrin solution; ene, curcumol, borneol 35g, diluted with absolute ethanol, slowly added to the β-cyclodextrin solution, continued to stir until a homogeneous phase was formed, placed in the refrigerator overnight, filtered with suction, washed 3 times with a small amount of petroleum ether, frozen, A white powder was obtained.

[0173]2) Mix the above-mentioned white powder with 35g of borneol, 150g of citric acid and 160g of lactose; take another 120g of sodium bicarbonate and 160g of lactose, mix them evenly, and use 5% PVP absolute ethanol solution as a binder to granulate, at 50°C Dry, granulate, add appropriate amount of PEG6000, mix wel...

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PUM

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Abstract

The invention belongs to the technical field of drugs, and provides a drug composition containing curdione. The drug composition contains germacrone, furanodiene, the curdione, beta-elemene, curcumenol, curzerene and borneol. The drug composition has clear ingredients and is controllable in quality; and the weight parts of the curzerene and the curcumenol are controlled, and irritation of drugs is reduced. The drug composition can be used for preparing suppository, ointment, capsules, effervescent tablets, gel, wash lotion, film agents or foaming agents, has excellent treatment effects to diseases such as HR-HPV (high risk human papillomavirus) and / or LR-HPV (low risk human papillomavirus) and cervical cancers, and is suitable to be clinically applied widely.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing gemmacone, furadienes, curdione, β-elemene, curcumol, curcumene and borneol. Background technique [0002] The zedoary oil extracted from the traditional Chinese medicine zedoary is the first clinically used drug for the treatment of cervical cancer in China, and it has been recorded in the Chinese Pharmacopoeia. The main chemical component of zedoary oil is sesquiterpenes; clinical practice has proved that the total effective rate of treating cervical cancer is 64.4%; it has a destructive effect on cancer tissue and has no obvious effect on normal tissue. Zedoary oil not only has a direct inhibitory effect on mouse Ehrlich's ascites cancer cells in vitro; moreover, the Ehrlich's ascites cancer cells that have been exerted by Curcuma can successfully make mice obtain obvious active immunity. Preliminary observations of pathom...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P15/02A61P15/00A61P35/00A61K31/20A61K31/35A61K31/343A61K31/122A61K31/045
Inventor 陈容徐扬冯仲异史朝辉
Owner HAINAN HUIYUANTANG PHARMA
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