Drug composition

A composition and medicine technology, applied in the field of medicine, can solve the problems of easy sublimation of curcumin, unstable preparation quality, influence on curative effect, etc., and achieve the effects of good therapeutic effect, controllable quality and clear ingredients.

Active Publication Date: 2013-03-20
HAINAN BIKAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006]The LD50 of curcumedione is significantly lower than that of curcumol, and curcumol is easy to sublimate, so the quality of preparations containing curcumol is unstable, which affects its curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0156] Prescription: Gemacerone 8g, furadienes 38.4g, curdione 18g, β-elemene 4g, curcumol 0.1g, curcumene 0.1g, borneol 75g.

[0157] Dosage form: suppository.

[0158] Preparation method: mix the prescribed amount of gemmacone, furadienes, curdione, β-elemene, curcumol, curcumene with 70g of polysorbate 80, dissolve 75g of borneol with an appropriate amount of ethanol, and mix with the above solution Mix well.

[0159] The polyoxyethylene stearate 1510g of prescription quantity is put on the water bath and is heated and melted, adds above-mentioned medicinal liquid, stirs, filling, makes 1000 suppositories, each 1.74g.

Embodiment 2～8

[0161] Prepare the suppository according to the following prescription, and the preparation method is the same as in Example 1.

[0162] Example 2 3 4 5 6 7 8 gemmaton 5.5 6 9 10 11 13 14 furadienes 37 33 30 28 25 15 11 Curcumadione 6 8 9 15 18 20 23 β-Elemene 10.5 10 9.5 8 6.5 5 4.5 Curcumol 0 0.05 0.15 0.1 0.4 0.35 0.5 Curcumene 0.05 0 0.02 0.03 0.04 0.05 0.045 ice flakes 30 40 50 60 70 80 90 Polysorbate 80 52 57 64 68 73 80 84 Polyoxyethylene stearate 1561 1572 1465 1571 1582 1541 1547

Embodiment 9

[0164] Prescription: Gemacerone 6.5g, Furandiene 32g, Curdione 21g, β-Elemene 8.5g, Curcumol 0.45g, Borneol 35g.

[0165] Dosage form: effervescent tablet.

[0166] Preparation:

[0167] 1) Take β-cyclodextrin, add appropriate amount of water according to 25ml / g, stir to make it fully dissolved, and heat if necessary to obtain β-cyclodextrin solution; ene, curcumol, borneol 35g, diluted with absolute ethanol, slowly added to the β-cyclodextrin solution, continued to stir until a homogeneous phase was formed, placed in the refrigerator overnight, filtered with suction, washed 3 times with a small amount of petroleum ether, frozen, A white powder was obtained.

[0168]2) Mix the above-mentioned white powder with 35g of borneol, 150g of citric acid and 160g of lactose; take another 120g of sodium bicarbonate and 160g of lactose, mix them evenly, and use 5% PVP absolute ethanol solution as a binder to granulate, at 50°C Dry, granulate, add appropriate amount of PEG6000, mix we...

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Abstract

The invention belongs to the technical field of medicine, and provides a drug composition, which comprises germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The drug composition has characteristics of definite components and controllable quality. With the drug composition, weights of curcumenol and curzerene are controlled so as to reduce drug irritation. The drug composition can be adopted for preparing suppositories, ointments, capsules, effervescent tablets, gelatas, lotions, pellicles or foam agents, provides good treatment effects for HR-HPV and/or LR-HPV and cervical diseases, and is suitable for wide clinical applications.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing gemmacone, furadienes, curdione, β-elemene, curcumol, curcumene and borneol. Background technique [0002] The zedoary oil extracted from the traditional Chinese medicine zedoary is the first clinically used drug for the treatment of cervical cancer in China, and it has been recorded in the Chinese Pharmacopoeia. The main chemical component of zedoary oil is sesquiterpenes; clinical practice has proved that the total effective rate of treating cervical cancer is 64.4%; it has a destructive effect on cancer tissue and has no obvious effect on normal tissue. Zedoary oil not only has a direct inhibitory effect on mouse Ehrlich's ascites cancer cells in vitro; moreover, the Ehrlich's ascites cancer cells that have been exerted by Curcuma can successfully make mice obtain obvious active immunity. Preliminary observations of pathom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/35A61K31/343A61K31/122A61K31/045A61K31/015A61P31/20A61P15/02A61P15/00A61P35/00
Inventor 陈容徐扬冯仲异史朝辉
Owner HAINAN BIKAI PHARM CO LTD
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