562 results about "Nitrogenous heterocyclic compound" patented technology

The present invention relates to a compound represented by formula (I): (wherein all the symbols have the same meanings as defined in the above description) and a production method and use thereof. The compounds represented by formula (I), or its salt, N-oxide or solvate, or a prodrug thereof have p38 MAP kinase inhibitory activity, and are useful in the prevention and / or treatment of those diseases that are supposedly caused or deteriorated by abnormal production of cytokines including inflammatory cytokine or chemokine, or by over response thereto, namely cytokine-mediated diseases such as inflammatory diseases, respiratory diseases, cardiovascular disease, central nervous system diseases, and the like.

The invention provides a metal surface treatment agent composed of aqueous solution or aqueous emulsion containing ionic liquid. The metal surface treatment agent comprises the ionic liquid, silicate or silane coupling agent, water-soluble chitin or chitosan, corrosion inhibitor, stabilizer, pH modifier, wetter, coalescing agent, antioxidant, ethanol and water, the ionic liquid is room-temperature ionic liquid consisting of nitrogenous heterocyclic compound cations and inorganic or organic anions, one or more of nanoscale titanium dioxide, zirconium oxide or zirconium fluoride is uniformly mixed into the silicate or silane coupling agent by the weight equivalently accounting for 3%-25% of that of the silicate or silane coupling agent. A chemical conversion coating is formed on a metal surface by the metal surface treatment agent, can inhibit corrosion of the metal surface, and has a fine coating performance. The metal surface treatment agent is used for treating cold-rolled plates, galvanized plates and aluminum plates, and the metal surface treated by the metal surface treatment agent has the coating adhesion force equivalent to that of a metal surface treated by a phosphorus-containing metal surface treatment agent.

As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

The present disclosure provides a nitrogen-containing heterocyclic compound having a general formula (I) and an organic photoelectric apparatus thereof. The general formula (I) is:wherein A1, A2, A3, A4, A5, A6, A7, A8, A9, and A10 are independently selected from a hydrogen atom, a nitrile group and a function group having a general formula (II), and A1, A2, A3, A4, A5, A6, A7, A8, A9, and A10 include at least one nitrile group and at least one function group having the general formula (II),the general formula (II) being:wherein R1, R2, R3, R4, R5, R6, R7, and R8 are independently selected from hydrogen atoms, deuterium atoms, C6-30 aromatic group and C2-30 heterocyclic aromatic group.

The invention discloses a double-functional catalyst of carbon-based non-noble-metal oxygen electrode and a preparation method thereof. The catalyst is a composite material composed of metal, metal oxide grains, N-doped graphene, carbon spheres and nanotubes. The preparation method of the catalyst comprises the following steps of: 1) weighing graphite oxide or graphene oxide, the carbon spheres, a metal compound and a nitrogen-containing heterocyclic compound according to ratios; carrying out ultrasonic treatment on the raw materials in a solvent; uniformly agitating and sufficiently drying to obtain a precursor; and 2) carrying out high-temperature pyrolysis in a precursor inert atmosphere to obtain a composite material catalyst. The catalyst provided by the invention not only has the advantages of high oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalytic performances, good stability and excellent CH3OH / CO tolerance, but also the cost of the raw materials is low, and the preparation method is simple and is easy to operate.

The invention relates to the field of wastewater treatment, and relates to a biological degradation method of nitrogen-containing heterocyclic compound wastewater. An oxidation state compound is added in the nitrogen containing heterocyclic compound wastewater, an anaerobic environment is formed by micro aeration, and mixed electron acceptors of dissolved oxygen and the oxidation state compound simultaneously exist in the system; an upflow biological aerated filter is used as a main reaction device, an optimal degradation effect of nitrogen-containing heterocyclic compounds is achieved according to different components and concentrations of the nitrogen-containing heterocyclic compounds, the pH is controlled to 7.0-7.5, the concentration of the dissolved oxygen is controlled to 0.05-0.3 mg / L (water discharged from the upper part of the filter), and the range of the oxidation-reduction potential is controlled to 150-50 mv; under an anaerobic aeration condition, with the nitrogen-containing heterocyclic compounds as electron donors and oxygen and oxygen-containing compounds as electron acceptors, under the combined effects of micro aerobic bacteria, facultative anaerobic bacteria, aerobic / anoxic denitrifying bacteria and the like, the nitrogen-containing heterocyclic compounds are completely degraded into carbon dioxide and water.

A process for preparing cyclic carbonate features that catalytic cycloaddition reaction of CO2 on epoxy compound at 100-140 deg.C and 1.5-4.5 MPa for 4-8 hrs under the existance of the catalyst whichis composed of azacyclic compound (halogenated alkylpyridine or halogenated 1,3-dialkyl imidazole) and non-metal halide, and the cocatalyst which is alkali-metal halide or ammonium tetrebutyl bromide. Its advantages are high catalytic activity, smooth reaction condition, easy separation of resultant from catalyst, and cyclic use of catalyst.

The present invention relates to novel compounds having a xanthine oxidase inhibitory effect and an uricosuric effect and pharmaceutical compositions comprising the same as an active ingredient. That is, the present invention relates nitrogen-containing heterocyclic compounds represented by the following general formula (I):wherein Y1 represents N or C(R4); Y2 represents N or C(R5); R4 and R5 independently represent an alkyl group, a hydrogen atom etc.; one of R1 and R2 represents an optionally substituted aryl group, an alkoxy group or an optionally substituted heterocyclic group; the other of R1 and R2 represents a haloalkyl group, a cyano group, a halogen atom etc.; and R3 represents a 5-tetrazolyl group or a carboxy group, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the same as an active ingredient.

The present invention provides a novel nitrogen-containing heterocyclic compound useful as a phosphodiesterase-4 inhibitor, and a medicament comprising the same. Further, the present invention provides a nitrogen-containing heterocyclic compound represented by the following formula, its salt or hydrates thereof, and a medicament comprising the same.wherein the ring A is an aromatic hydrocarbon ring which may have a heteroatom, the ring B represents (a) a saturated hydrocarbon ring, (b) an unsaturated hydrocarbon ring, (c) a saturated heterocyclic ring or (d) an unsaturated heterocyclic ring, all of which may have a substituent group.

The present invention relates to a compound represented by the formulawherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R2 is an optionally halogenated C1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.

The invention provides a plastic composition and a plastic surface metallizing method. The plastic composition contains plastic matrix resin and metal chelate; the metal chelate is a complex of metal ions and organic chelating agent; and the organic chelating agent is at least one of diketone, aminocarboxylic acid, thiocarboxylic acid, polycarboxylic acid and nitrogen-containing heterocyclic compound with a general formula CnH8N2, wherein n is 10, 12 or 14. The plastic surface metallizing method comprises the following steps of: performing injection molding on the plastic composition provided by the invention to form a plastic piece, then performing laser etching on the plastic piece by adopting laser with wavelength of 1,064 nanometers to 1,000 microns, and chemically plating a laser etching area to form a metal plating layer. The organic chelating agent adopted in the plastic composition has low cost and is sensitive to the laser, so the plastic surface has high activation degree; and when the plastic surface is metallized, the infrared laser with lower cost is adopted so that the metal ions of the metal chelate in the plastic piece are decomposed as an active center of subsequent chemical plating and the precision is very high.

The invention relates to a method for preparing reducing sugar by catalyzing hydrocellulose, which comprises the following steps: A) adding 40 to 50 portions of ionic liquid by weight, dissolving the ionic liquid at a temperature of between 80 and 100 DEG C, and adding 2 to 3.2 portions of cellulose by weight into the ionic liquid to obtain transparent cellulose solution; B) adding 0.6 to 1 portion of water and 2 to 3.2 portions of acid functional ionic liquid by weight as a catalyst into the cellulose solution prepared in step A, and reacting the mixture for 10 minutes to 8 hours at a temperature of between 100 and 120 DEG C; and C) filtering the reaction solution obtained in step B and removing the precipitated cellulose, and separating the reducing sugar and the ionic liquid from the filtrate through an ion exchange resin column, wherein the ionic liquid is 1-butyl-3-methylimidazole chlorine salt; and the acid functional ionic liquid consists of cations containing nitrogen heterocyclic compounds and anions. The method overcomes the defects that an acid catalyst cannot be recycled after the reaction is finished and erodes equipment.

The present invention relates to the use of at least one heterocyclic compound of the formula (I)in which P is H or C1-C3-alkylas a frictional wear-reducing additive in fuel compositions; to corresponding additized fuel compositions and their preparation; and to additive concentrates which comprise such compounds.

The invention relates to a molecular sieve with TON structure and preparation method thereof, wherein the molecular sieve synthesizing process employs diamine compound and nitrogen-containing heterocyclic compound as double mould agent, said TON type molecular sieve is prepared through full crystallization reaction.

This invention relates to a method to prepare a flame retardant and its product, and especially relates to a method to prepare graft nitrogenous heterocyclic compounds with P-O backbones from phosphorus pentoxide and ammonium dihydrophosphate, a method to prepare nonhalogen intumescent flame retardant for polyolefin and its product. The nonhalogen intumescent flame retardant produced in this invention has following advantages compared to nonhalogen intumescent flame retardants produced by current techniques: a) two-step method is adopted so that production time is shortened, temperature is lowered, operation is simple and energy cost is low; b) phase transmission catalyst is solid-liquid system so that grafting efficiency of oxygen-containing amine is ensured; c) crystallization is accelerated by the introduction of ammonia and tightly and perfectly crystallized nonhalogen intumescent flame retardant backbone intermediate can be obtained.

A novel nitrogen-containing heterocyclic compound having a specific structure and an organic electroluminescence device comprising an anode, a cathode and an organic thin film layer which comprises a single layer or a plurality of layers comprising at least a light emitting layer and is disposed between the anode and the cathode, wherein at least one layer in the organic thin film layer comprises the above nitrogen-containing heterocyclic derivative singly or as a component of a mixture. The organic electroluminescence device exhibits a great luminance of emitted light and a great efficiency of light emission even under application of a low voltage.

An electrolytic membrane comprising a porous membrane substrate containing a cross-linked polymer electrolyte having at least a structural component shown by following chemical formula 1: wherein A represents a repeating unit having an aromatic hydrocarbon group substituted by at least a sulfonic acid group, B represents a repeating unit having one of a nitrogen-containing hetero ring compound residue, and the sulfate, hydrochloride or organic sulfonate thereof, C represents a repeating unit having a cross-linked group, and X, Y and Z represent mol fractions of respective repeating units in the chemical formula 1, with 0.34≦X≦0.985, 0.005≦Y≦0.49, 0.01≦Z≦0.495 and Y≦X and Z≦X, provided that, in the repeating unit A, a ratio of the aromatic hydrocarbon group substituted by at least a sulfonic acid group is 0.3 to 1.0, and the number of the sulfonic acid group in the aromatic hydrocarbon group is 1 to 3.

The present invention relates to a nitrogen-containing heterocyclic compound or salt thereof, represented by the following formula (I), and a pest control agent containing the compound or salt thereof, as an active ingredient of the pest control agent:(wherein, R0 represents a halogen atom, or the like; Z represents an unsubstituted or substituted aryl group, or the like; Y represents a nitro group, or the like; n represents an integer of 0 to 3; D represents a 5-membered to 8-membered hydrocarbon ring group or heterocyclic group; X represents a functional group represented by the following formula (II)-1 or formula (II)-2:(wherein, in the formula (II)-1, the dotted line represents a single bond or double bond, and R1 and R2 respectively and independently represent a hydrogen atom, nitro group, hydroxyl group, mercapto group, unsubstituted or substituted amino group, or organic group; and, in the formula (II-2), W represents an oxygen atom or sulfur atom; and, R11 represents a hydrogen atom, hydroxyl group, mercapto group, unsubstituted or substituted amino group, or the like); n1 represents an integer of 0 to 2; and, A represents a carbon atom or nitrogen atom).

A specific nitrogen-containing heterocyclic compound having a urea structure, an electron transporting material containing the nitrogen-containing heterocyclic compound, and an organic electroluminescence device including a light emitting layer and an electron transporting layer between a cathode and an anode in which the electron transporting layer includes the electron transporting material or the nitrogen-containing heterocyclic derivative. An organic EL device exhibiting high emission efficiency even at low voltage and a material for organic EL devices are described.

The invention relates to a seawater corrosion inhibitor of copper, in particular to a Schiff base containing nitrogenous heterocyclic compound and a preparation method and application thereof. The Schiff base containing nitrogenous heterocyclic compound is 4-[(4-hydroxybenzyl)amino]-5-p-methylbenzene-4H-[1,2,4]triazole-3-sulfydryl with structural formula shown in the specification. 4-[(4-hydroxybenzyl)amino]-5-p-methylbenzene-4H-[1,2,4]triazole-3-sulfydryl can serve as a seawater corrosion inhibitor to inhibit corrosion of copper products in seawater or a sodium chloride medium. The corrosion inhibitor can prevent general corrosion and local corrosion of metallic copper in the process of contact with seawater or sodium chloride solution. The compound has not been used as a metal corrosion inhibitor yet at present. The corrosion inhibitor has low dosage and toxicity, high efficiency and strong continuing capacity, can effectively inhibit corrosion damage of metallic copper and has broad application prospect.

The invention discloses a nitrogen-containing heterogeneous ring compound, a preparation method thereof and an application of the nitrogen-containing heterogeneous ring compound in inhibition of kinase activity. The general formula of the nitrogen-containing heterogeneous ring compound is represented as a formula I or a formula I', wherein R1, R2, R3 and R4 in the formula I or the formula I' are selected from any one of hydrogen, halogen, cyanogroup, hydroxyl, amidogen and substituted or unsubstituted C1-C6 alkyl groups independently, and a 3-10-membered ring system can be formed by any two groups in R1, R2, R3 and R4; M1, M2 and M3 are selected from CRa or N independently, and at least one of M1, M2 and M3 is N; W is selected from substituted or unsubstituted C1-C6 alkyl groups, substituted or unsubstituted C2-C6 alkenyl, unsubstituted or halogenated 4-8-membered alkine groups, substituted or unsubstituted C3-C8 naphthenic base, substituted or unsubstituted 4-8-membered heterocyclic groups, 5-10-membered aromatic or heteroaryl groups, substituted carbonyl, substituted sulfonyl and substituted or unsubstituted amidogen. The nitrogen-containing heterogeneous ring compound can inhibit EGFR (epidermal growth factor receptor) mutant kinase activity or ALK (anaplastic lymphoma kinase) activity and is a multi-target tumor therapeutic drug with a brand-new action mechanism.

The invention relate to a leveling agent solution and a preparation method and application thereof. The leveling agent solution is obtained in the mode that a nitrogenous heterocyclic compound and a diepoxide compound are polymerized and then 1,3-propane sultone is used for an alkylation reaction. The leveling agent solution, a brightener and an inhibitor are used together, and a good electroplating effect can be obtained in electroplating of circuit board through holes.

The present invention relates to a compound represented by the formulawherein ring A is a nitrogen-containing heterocycle;ring B is an aromatic ring optionally having substituent(s);ring D is an aromatic ring optionally having substituent(s);L is a group represented by the formulaR2, R3, R4a and R4b are each independently a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 are optionally bonded via an alkylene chain or an alkenylene chain, or R4a and R4b are optionally bonded via an alkylene chain or an alkenylene chain;R1 is a hydrogen atom or a substituent;m and n are each independently an integer of 0 to 5;m+n is an integer of 2 to 5; and is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.

A slurry for touch-up CMP is provided, which includes water, colloidal silica having an average primary particle diameter of 5 to 60 nm, unsintered cerium oxide having an average primary particle diameter of 5 to 60 nm, a multivalent organic acid containing no nitrogen atoms, and a nitrogen-containing heterocyclic compound. The slurry has a pH of 8 to 12.

The application relates to the field of batteries, and in particular to an electrolyte and a battery containing the electrolyte. The electrolyte provided by the application comprises an organic solvent, an electrolyte and an additive, wherein the additive contains a sulfonyl nitrogen-containing heterocyclic compound and a bissulfonimide salt, and the nitrogen-containing heterocyclic ring in the sulfonyl nitrogen-containing heterocyclic compound is selected from the group consisting of at least one of a pyrazole ring, a pyrroline ring, an imidazole ring, a pyrrolidine ring, a piperidine ring and a pyridine ring. The electrolyte provided by the application can improve the properties of positive and negative interface membranes of the battery, effectively reduce the dissolution in the positive electrode and the deposition in the negative electrode of the transition metal elements in the positive electrode material, inhibit the decomposition of the electrolyte in the positive and negativeelectrodes, and ensure high temperature storage performance and high temperature cycling performance of the battery under high voltage.

The invention discloses a polymer solid electrolyte membrane and preparation method thereof. The polymer solid electrolyte membrane comprises a polymer matrix and a composite ionic liquid, and the composite ionic liquid comprises lithium salt and N-containing heterocyclic compound. According to the invention, by introducing the ionic liquid into the polymer solid electrolyte membrane, the both advantages of the ionic liquid and the the polymer solid electrolyte membrane are achieved, and the self-supporting electrolyte with independent from water, high conductivity, good security, good ionic conductivity and high mechanical property is obtained. The invention can be widely used in the fields of lithium ion battery, and has a good application prospect in the fields of electronics, medical treatment, space technology, electrochrimic technique, photoelectricity, sensors and the like.

An oil-based pigmented ink composition containing a pigment, a polymer and an organic solvent, wherein the organic solvent contains a (poly)alkylene glycol derivative in an amount of 30 to 90% by weight and a nitrogen-containing heterocyclic compound in an amount of 1 to 30% by weight, each based on the whole weight of the ink composition, and the ink composition has a flash point of at least 63° C.