108 results about "Superparamagnetic iron oxide nanoparticles" patented technology

The invention relates to a method for preparing magnetic oxide iron Fe21.333O32, which comprises the following steps: (a) mixing solid soluble ferrous salt and solid hydroxid according to a molar ratio of iron to hydroxyl being between 1:2 and 1:3; (b) completing reaction of a mixed material prepared in step (a) by kneading, and controlling the temperature of the material not to exceed 70 DEG C in the kneading process; (c) drying a reaction product obtained in step (b) in air; (d) washing and filtering a material obtained in step (c); (e) naturally drying or baking a solid obtained in step (d); and (f) roasting a product obtained in step (e) at a temperature of between 150 and 500 DEG C. The invention further discloses a magnetic oxide iron Fe21.333O32 desulfurizer prepared by the preparation method. Tests show that the desulfurizer has high sulfur capacity reaching 62.0 percent.

The invention relates to the technical field of sewage treatment, and in particular to preparation method of magnetic biochar loaded photosynthetic bacteria material and a sewage treatment method. The preparation method comprises the steps of: preparing a magnetic nano iron oxide material by a chemical coprecipitation method, conducting activation and expansion culture on photosynthetic bacteria, loading the nano iron oxide particles on the surface of biological carbon material through a self-assembly method to form a magnetic biochar; and loading the photosynthetic bacteria on the surface of the magnetic biochar through a co-incubation method, so as to obtain the magnetic biochar loaded photosynthetic bacteria material. The magnetic biochar loaded photosynthetic bacteria material is co-incubated with sewage for a period of time, so as to realize degradation of COD, ammonia nitrogen and phosphate radical in the sewage. The invention employs the electrostatic binding of high specific surface of the nano magnetic iron oxide and the bacteria with charge on the surface to achieve immobilization of strains, and magnetic iron oxide material has activation on strain enzyme, thereby enhancing the degradation of COD, ammonia nitrogen and phosphate radical by microbes.

A magnetic toner for developing an electrostatic latent image has magnetic toner particles containing at least a binder resin, a magnetic powder and a wax component. The magnetic powder has magnetic iron oxide particles the particle surfaces of which have been coat-treated with an organic surface modifying agent. The magnetic iron oxide particles contain silicon element (Si) in an amount of from 0.4 to 2.0% by weight based on the weight of iron element (Fe) and the magnetic iron oxide particles have an Fe / Si atomic ratio of from 1.0 to 4.0 at their outermost surfaces. The magnetic toner particles have shape factors SF-1 and SF-2 as measured by an image analyzer, with a value of SF-1 of from 100 to 160, a value of SF-2 of from 100 to 140 and a value of (SF-2) / (SF-1) of not more than 1.0.

The invention relates to a method for producing biological degradable magnetic nanometer particles, wherein said particle has corn and frame; the corn layer is magnetic ferric oxide; the frame is natural macromolecule materials as liposome, blood albumin, dope, starch, or chitose; its diameter is 1-100nm; the nanometer particles is prepared by reverse-phase micro emulsion method. The inventive particle has wide application.

The invention relates to d-glucosamine-modified iron oxide nanoparticles used as a tracer for magnetic resonance, a preparation method of lyophilized powder thereof and use thereof. The d-glucosamine-modified iron oxide nanoparticles comprise superparamagnetic iron oxide nanoparticles, wherein the surfaces of the superparamagnetic iron oxide nanoparticles are modified by a substance having carboxyls; the carboxyls react with the aminos of the d-glucosamine to form amido bonds; and thus a structure that the surfaces of the superparamagnetic iron oxide nanoparticles are modified by the d-glucosamine is formed. The invention provides a novel tumor-targeted MRI contrast agent which has high selectivity of tumors for the tumor targeted magnetic resonance diagnostic tests and clinic tumor diagnosis. By preserving the d-glucosamine-modified superparamagnetic iron oxide nanoparticles in form of the lyophilized powder, the unstable problem of the d-glucosamine-modified superparamagnetic iron oxide nanoparticles is solved. The d-glucosamine-modified iron oxide nanoparticles are sterile, anhemolytic and free from vascular stimulation and can meet the requirements of tests of cells, animals and the like.

The present invention relates to a magnetic carrier for an electrophotographic developer comprising spherical magnetic composite particles comprising a phenol resin as a binder and ferromagnetic iron oxide particles bonded to each other through the phenol resin, wherein the spherical magnetic composite particles have a ten-point mean roughness Rz of 0.3 to 2.0 μm. The magnetic carrier for an electrophotographic developer according to the present invention exhibits an excellent durability against peeling-off and abrasion of coating resins formed thereon and a high stability to mechanical stress exerted onto the carrier, is free from occurrence of spent toner, can be stably held over a long period of time without occurrence of fogging and unevenness in density of toner images, and can keep high-quality images with an excellent gradation for a long period of time.

The invention discloses a Fe3O4@SiO2@P4VP-PDMS-P4VP hybrid nanoparticle with pH and magnetic responsiveness and a preparation method thereof and an application of the hybrid nanoparticle in a nano oil-water separation emulsion. The Fe3O4@SiO2@P4VP-PDMS-P4VP hybrid nanoparticle is obtained by coupling reaction of a pyridine group on a P4VP block in a P4VP-PDMS-P4VP triblock copolymer with pH responsiveness with a C-I active group on the superparamagnetic iron oxide nanoparticles Fe3O4@SiO2 surface and bonding the P4VP-PDMS-P4VP triblock copolymer into the Fe3O4@SiO2 nanoparticle surface. The invention further specifically discloses the preparation method of the Fe3O4@SiO2@P4VP-PDMS-P4VP hybrid nanoparticle and the application of the Fe3O4@SiO2@P4VP-PDMS-P4VP hybrid nanoparticle in the nano oil-water separation emulsion. Due to the action of the central Fe3O4magnetic nanoparticle, the hybrid nanoparticle absorbing oil content can be easily separated from an aqueous system, and the oil absorbed hybrid nanoparticle can be recycled in an acid aqueous solution after absorption.

The invention discloses a novel mesoporous silicon sphere co-loaded medicine nano-complex and a preparation method thereof. The novel mesoporous silicon sphere co-loaded medicine nano-complex is Ce6@MMSN / DOX / Ko143@PAsp-b-PEG-FA; the preparation method comprises the following steps: selecting TEOS (Tetraethyl Orthosilicate) as a silicon source, CTAB (Cetyltrimethyl Ammonium Bromide) as a template agent and n-hexane as a pore expanding agent and synthesizing mesoporous silicon dioxide nanoparticles with a double-pore-channel core-shell structure; carrying out amination modification on the mesoporous silicon dioxide nanoparticles; synthesizing Fe3O4 nanoparticles by adopting an LSS (Liquid-Solid-Solution) phase transfer method and ligand exchange reaction; modifying and embedding superparamagnetic iron oxide nanoparticles on the surface of aminated MSN through nucleophilic substitution, so as to construct magnetic mesoporous silicon dioxide nanoparticles; taking DCC (Dicyclollexyl Carbodiimide) as a condensation agent and covalently binding a photosensitizer Ce6 through amidation; meanwhile, loading a BCRP (Breast Cancer Resistance Protein) inhibitor Ko143; then crossly linking a copolymer FA-PEG-b-PAsp; finally, loading an anti-tumor medicine DOX.

A magnetic toner is formed of magnetic toner particles each comprising at least a binder resin and a magnetic iron oxide. The magnetic toner is provided with improved developing performances by realizing an appropriate surface-exposure state of the magnetic iron oxide, which is represented by a wettability characteristic in methanol / water mixture liquids of the magnetic toner such that it shows a transmittance of 80% for light at a wavelength of 780 nm at a methanol concentration in a range of 65-75% and a transmittance of 20% at a methanol concentration in a range of 66-76%.

A toner showing a high transferability and suitable for use in cleanerless image forming system is formed of toner particles comprising at least a binder resin and magnetic iron oxide. The toner is characterized by a specific circularity distribution relative to its weight-average particle size and a controlled degree of surface-exposed magnetic iron oxide providing an extract solution with hydrochloric acid showing an absorbance of 1.0-2.5 at a wavelength of 340 nm. The toner is suitably produced by a production system including a rotary mechanical pulverizer and a one-pass surface treatment apparatus for continuously applying a mechanical impact force to pulverized toner particles therein.

The invention provides a contrast medium used for glioma targeted magnetic resonance and fluorescence dual modality imaging, and a preparation method thereof. The contrast medium is composed of an acrylamide monomer, an allyl monmer containing sulfhydryl or carboxyl or amidogen, superparamagnetic iron oxide nanoparticles, a fluorochrome and lactoferrin. The preparation method comprises following steps: the acrylamide monomer and the allyl monmer containing sulfhydryl or carboxyl or amidogen are subjected to polymerization reaction so as to obtain a copolymer nanogel; the superparamagnetic iron oxide nanoparticles are added in polymerization reaction process so as to obtain a superparamagnetic copolymer nanogel; the fluorochrome and lactoferrin and combined via covalent bonds so as to obtain fluorochrome labeled lactoferrin; and the superparamagnetic copolymer nanogel and fluorochrome labeled lactoferrin are combined via covalent bonds so as to obtain the contrast medium used for glioma targeted magnetic resonance and fluorescence dual modality imaging. The contrast medium possesses characteristics such as high specificity, selectivity and contrast effect, and low toxic and side effect; and is capable of realizing dual modality imaging.

The present invention provides the synthetic method and superparamagnetic iron oxide nanoparticles capable of targeting to the folic acid receptors existing on the cell membranes and with high relaxivity. The iron oxide nanoparticles of the present invention can further be used as the contrast agents for magnetic resonance imaging (MRI).

The invention discloses a folic acid mediated antitumor drug superparamagnetic tumor targeted nanoparticle. A superparamagnetic iron oxide nanoparticle is adopted as the carrier, and high temperature thermal decomposition method is employed to synthesize polyethylene glycol-polyethyleneimine modified uperparamagnetic iron oxide nanoparticle, then a folic acid ligand is grafted on the surface of iron oxide by chemical method, and then an antitumor drug is loaded into the iron oxide nanoparticle by electrostatic adsorption and hydrogen bonding, thus obtaining the folic acid mediated antitumor drug superparamagnetic tumor targeted nanoparticle. According to the invention, the dual targeting effect can strengthen the anti-tumor effect of the antitumor drugs, and the folic acid mediated antitumor drug superparamagnetic tumor targeted nanoparticle has small toxic and side effect, thus being a tumor treatment nanoparticle preparation with substantial development value.

A process for preparing the high-purity iron oxide used as soft-magnetic material from the copperas, which is the by-product of Ti white powder, and ferrous sulfate includes such steps as removing impurities, two-step neutralizing, two-step oxidizing to obtain Fe3O4, filtering, baking and calcining. The technological parameters for said neutralizing and oxidizing steps are also disclosed.

The invention discloses a sewage treatment microbial carrier, which consists of a magnetic carbon fiber bracket and a polypyrrole film layer, wherein microorganisms are fixed on the surface of the polypyrrole film layer; wherein the magnetic carbon fiber bracket is formed by weaving composite fiber bundles, and is obtained through pre-oxidation and carbonization treatment; the composite fiber is apolyacrylonitrile fiber doped with graphene, and magnetic iron oxide nanoparticles are uniformly distributed on the surface and inside the composite fiber. The iron oxide nanoparticles generated in situ have good photocatalytic activity, and can promote local graphitization of the carbon fibers and cooperate with graphene to improve the conductivity of the carbon fibers; the magnetic carbon fiberbracket is used as a working electrode; a polypyrrole film is electrochemically deposited on an iron oxide photocatalyst, so that microorganisms are effectively fixed and cannot be embedded, microorganism loading and proliferation are facilitated, the iron oxide photocatalyst and the microorganisms can be in full contact with pollutants in sewage, photocatalytic degradation and microorganism treatment are synchronously carried out, and the sewage treatment efficiency is greatly improved.

The invention discloses a preparation method for a high-sensitivity bimodal magnetic resonance contrast agent. According to the preparation method, by means of a method for preparing ferric oleate andmanganese chloride through thermal decomposition, a high-boiling-point solvent is adopted as a reaction medium, oleic acid and oleylamine are used as stabilizers, and therefore manganese oxide embedded iron oxide nanoparticles with narrow particle size distribution and high degree of crystallinity are obtained. The invention particularly relates to a preparation method for modifying the manganeseoxide embedded iron oxide nanoparticles by utilizing the oleic acid / the oleamine, or a preparation method for the biocompatible and water-soluble manganese oxide embedded iron oxide nanoparticles. The preparation method for the high-sensitivity dual-mode magnetic resonance contrast agent has the advantages that the requirements of magnetic resonance imaging for the contrast agent and the characteristics of the Nanotechnology are combined, by means of regulation and control over chemical synthesis, manganese oxide with the T1 contrast capability and superparamagnetic iron oxide nanoparticles with the T2 contrast capability are combined so as to form the manganese oxide embedded iron oxide nanoparticles, and therefore the cooperatively-enhancing dual-mode magnetic resonance contrast effectcan be achieved between the two imaging modes, namely, the T1 imaging mode and the T2 imaging mode.

A developing apparatus is provided which can suppress a fluctuation in image density in a discontinuous printing mode provided with a pause period. The developing apparatus includes a developer for developing an electrostatic latent image on a photosensitive drum, a developer bearing member for carrying and conveying the developer and a developer layer thickness-regulating unit placed close to the developer bearing member for regulating the amount of the developer carried and conveyed by the developer bearing member, the developer layer thickness-regulating unit being. As the developer, a negatively chargeable, one-component, magnetic toner is used having magnetic toner particles containing a binder resin and a magnetic iron oxide particle, and has a specific saturation magnetization, specific weight-average particle diameter and specific composition. The developer bearing member includes a surface layer containing a binder resin, a quaternary ammonium salt, graphitized particles, and conductive, spherical resin particles, and has a specific surface shape.

The invention relates to magnetic black iron oxide. A preparation process of the magnetic black iron oxide comprises the following steps of: (1), putting the mixture of ferric salt and ferrite into a container, adding a certain amount of water, and preparing a solution with the iron ion concentration of 1.0-2.0 mol / L; (2), adding ethanol and oleic acid into the container; (3), adjusting the pH of the solution in the container by using ammonia water till the pH is 1.0-1.4, and then, adjusting the pH by using liquid caustic soda till the pH is 7.4-8.1; (4), increasing the temperature of the container filled with a mixed solution after adjusting the pH; (5), filter-pressing, rinsing, drying and crushing at the beginning of increasing the temperature after reacting for 0.8-1.5 hours, and then obtaining the finished product. Because of adopting the technical scheme, the preparation process is lower in reaction temperature and shorter in process period; furthermore, the prepared finished product is higher in purity; the production energy consumption is reduced; the production cost is saved.

The invention discloses a siRNA conveying carrier. The active ingredient of the conveying carrier is nanaparticles formed by coupling superparamagnetic iron oxide nanoparticles and polyethylene glycol-polyethyleneimine. In addition, the invention also discloses a eukaryotic cell transfection liquid which comprises a composite made from siRNA and the siRNA conveying carrier. The siRNA conveying carrier provided by the invention has the physical and chemical properties of small particle size and suitable surface potential, has good siRNA compounding ability, low cell toxicity and high transfection rate, is a safe and efficient nano carrier with siRNA conveying function and has broad application prospect in siRNA conveying and disease treatment based on RNA interference.

The invention discloses application of superparamagnetic iron oxide nanoparticles in preparation of nerve magnetic stimulation enhancers for treating neurogenic diseases. On the basis of magnetic nanomaterials and the action of a magnetic field, method and system construction for magnetic stimulation of deep brain nerves are realized. The application has the advantages that the high compatibilityand magnetic field response characteristics of the superparamagnetic iron oxide nanoparticles are utilized to feed the superparamagnetic iron oxide nanoparticles to a specific brain region, the magnetic nanoparticles amplify the magnetic field effect under the action of a specific external magnetic field, surrounding nerve cells are stimulated, activation of neural circuits is realized, and accordingly, some neurogenic diseases can be treated.

The present invention relates to: a magnetic carrier for electrophotographic developers which comprises spherical composite core particles that comprise fine ferromagnetic iron oxide particles and a cured phenolic resin and that have an average particle diameter of 20-60 µm, wherein (sigma1-sigma0) is in the range of -2 to 0, where sigma0 is the saturation magnetization (Am2 / kg) of carrier particles that have a particle diameter approximately equal to the average particle diameter of the magnetic carrier for electrophotographic developers and sigma1 is the saturation magnetization (Am2 / kg) of carrier particles having a particle diameter smaller than 20 µm; and a two-component developer obtained using the magnetic carrier. This two-component developer comprises a toner and a magnetic carrier for use in electrophotographic developers which have durability, cause no carrier adhesion, and enable long-term formation of high-quality images.

An object of the present invention is to provide a toner excellent in ability to prevent electrostatic offset and fixation tailing. Provided is a toner including toner particles each containing at least a binder resin, a wax, and a magnetic iron oxide, and inorganic fine particles, in which the magnetic iron oxide contains at least a Ti component, an Al component, an Si component, and an Fe component; and the each component has some particular characteristics.

An immuno-therapy for treatment of a tumor is provided. An effective dose of a composition containing a low dose of superparamagnetic iron oxide nanoparticle is administered to a tumor. Once the composition has been administered, it is recommended to avoid any means that would cause direct cytotoxic effects to the cancer cells and to normal / healthy tissue. The combination of composition-administered cancer cells with the avoidance of direct cytotoxic effects has been shown to be successful to inhibit the growth of the cancer cells or result in aptosis of the cancer cells. Additional dose(s) can be administered when it is determined that: (i) the tumor starts to grow and / or (ii) the remaining composition falls below a threshold. The immuno-therapy method is a safe, clinically applicable, ready-to-use theranostic approach for cancer patients who are unable to start chemoradiotherapy in a timely manner, i.e. an effective interim or adjunctive treatment for patients.

The present invention relates to a magnetic carrier for an electrophotographic developer comprising spherical composite particles comprising spherical composite core particles comprising at least ferromagnetic iron oxide fine particles and a cured phenol resin and having an average particle diameter of 1 to 100 μm, and a melamine resin coating layer formed on the respective core particles, wherein a ratio of R100 to R300 (R100 / R300) in which R100 is an electric resistance value as measured when applying a voltage of 100 V to the magnetic carrier; and R300 is an electric resistance value as measured when applying a voltage of 300 V to the magnetic carrier, is controlled to lie within the range of 1 to 50. The magnetic carrier according to the present invention is capable of maintaining an adequate electric resistance value upon development, providing images having an excellent image quality, exhibiting a good durability, obtaining a good reproducibility of uniform solid image portions having a high image density, and keeping high quality images having an excellent gradation for a long period of time.

A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a magnetic iron oxide nanoparticle, a hydrophobic protection structure including at least an amphiphilic copolymer, wherein the hydrophobic protection structure encapsulates the magnetic iron oxide nanoparticle, and at least one amino-terminal fragment (ATF) peptide or epidermal growth factor receptor (EGFR) antibody conjugated to the amphiphilic copolymer.