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Novel mesoporous silicon sphere co-loaded medicine nano-complex and preparation method thereof

A technology of nanocomposites and mesoporous silicon spheres, applied in the field of biomedicine

Inactive Publication Date: 2018-11-16
SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report about the drug-loaded nanocomposite Ce6@MMSN / DOX / Ko143@PAsp-b-PEG-FA of the present invention

Method used

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  • Novel mesoporous silicon sphere co-loaded medicine nano-complex and preparation method thereof
  • Novel mesoporous silicon sphere co-loaded medicine nano-complex and preparation method thereof
  • Novel mesoporous silicon sphere co-loaded medicine nano-complex and preparation method thereof

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Embodiment

[0034] 1. Experimental materials

[0035] (1) Experimental equipment

[0036]

[0037] (2) Experimental reagents

[0038]

[0039]

[0040] 2. Experimental method

[0041] (1) Synthesis of mesoporous silica nanoparticles (MSN)

[0042] Adopt improved Synthesis of ordered mesoporous silica nanoparticles with dual channel core-shell structure. Weigh 1.0 g of the template agent CTAB, and dissolve it in 160 ml of deionized water in a water bath at 35° C. with stirring (300 rpm). After stirring for 15 minutes, add 3ml of concentrated ammonia water dropwise, and continue stirring for 30 minutes to fully mix to form a uniform and transparent solution. Then the solution (4ml TEOS and 20ml n-hexane) mixed in the constant pressure dropping funnel was slowly dropped into the reaction system drop by drop. The whole dropping process was about 30min, and the reaction was continued for 12h. The reaction system gradually became a uniform milky white colloid. solution, centrifu...

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Abstract

The invention discloses a novel mesoporous silicon sphere co-loaded medicine nano-complex and a preparation method thereof. The novel mesoporous silicon sphere co-loaded medicine nano-complex is Ce6@MMSN / DOX / Ko143@PAsp-b-PEG-FA; the preparation method comprises the following steps: selecting TEOS (Tetraethyl Orthosilicate) as a silicon source, CTAB (Cetyltrimethyl Ammonium Bromide) as a template agent and n-hexane as a pore expanding agent and synthesizing mesoporous silicon dioxide nanoparticles with a double-pore-channel core-shell structure; carrying out amination modification on the mesoporous silicon dioxide nanoparticles; synthesizing Fe3O4 nanoparticles by adopting an LSS (Liquid-Solid-Solution) phase transfer method and ligand exchange reaction; modifying and embedding superparamagnetic iron oxide nanoparticles on the surface of aminated MSN through nucleophilic substitution, so as to construct magnetic mesoporous silicon dioxide nanoparticles; taking DCC (Dicyclollexyl Carbodiimide) as a condensation agent and covalently binding a photosensitizer Ce6 through amidation; meanwhile, loading a BCRP (Breast Cancer Resistance Protein) inhibitor Ko143; then crossly linking a copolymer FA-PEG-b-PAsp; finally, loading an anti-tumor medicine DOX.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a drug-loading nanocomposite Ce6@MMSN / DOX / Ko143@PAsp-b-PEG-FA and a preparation method thereof. Background technique [0002] Tumor is a major disease that threatens human life and health in contemporary society. Chemotherapy is one of the important means of clinical treatment of tumor. However, currently commonly used chemotherapeutic drugs can not only kill tumor cells in the body, but also extensively kill normal tissues and cells, resulting in severe systemic side effects in patients, thereby reducing the patient's compliance with chemotherapy and clinical treatment. Effect. Therefore, the research on the precise and efficient delivery of anti-tumor drugs to the lesion site by using intelligent new tumor site-targeting and slow-controlled release drug delivery system has become a hot spot in the current medical field. [0003] With the development of nanotechnology and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/04A61K47/54A61K47/59A61P35/00A61K31/704A61K31/4985
CPCA61K31/4985A61K31/704A61K41/0071A61K47/02A61K47/54A61K47/59A61P35/00A61K2300/00
Inventor 王丹杨峰李新方徐丛剑金志军秦尚谦
Owner SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
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