Folic acid mediated antitumor drug superparamagnetic tumor targeted nanoparticle and preparation method thereof
An anti-tumor drug and tumor-targeting technology, applied in the field of medicine, achieves the effect of less operation steps, convenient separation, and favorable promotion and application
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Embodiment 1
[0034] The folic acid-mediated antitumor drug superparamagnetic tumor-targeting nanoparticles of the present invention comprises the following steps:
[0035] A. Mix 12g of polyethylene glycol and 0.1g of polyethyleneimine evenly, and heat up to 78°C within 8 minutes to obtain a mixed solution; add 0.5g of iron acetylacetonate to the mixed solution, and continue stirring at 78°C for 8 minutes , heated to 250°C, kept warm for 0.5h, stopped heating, cooled to 50°C, obtained a mixed solution containing iron oxide nanoparticles, removed unreacted organic matter, collected iron oxide nanoparticles, dispersed them in deionized water to obtain oxidation Iron nanoparticle solution; the whole process is carried out under magnetic stirring, and argon gas is introduced to remove oxygen;
[0036]B. Mix 18mg of folic acid, 3mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 1mg of N-hydroxysuccinimide with 3g of deionized water, adjust with NaOH pH to 9, stirring in a dark...
Embodiment 2
[0040] The folic acid-mediated antitumor drug superparamagnetic tumor-targeting nanoparticles of the present invention comprises the following steps:
[0041] A. Mix 13g of polyethylene glycol and 0.2g of polyethyleneimine evenly, and heat up to 79°C within 9 minutes to obtain a mixed solution; add 0.6g of iron acetylacetonate to the mixed solution, and continue stirring at 79°C for 9 minutes , heated to 255°C, kept warm for 0.8h, stopped heating, cooled to 52°C, obtained a mixed solution containing iron oxide nanoparticles, removed unreacted organic matter, collected iron oxide nanoparticles, dispersed them in deionized water to obtain oxidation Iron nanoparticle solution; the whole process is carried out under magnetic stirring, and argon gas is introduced to remove oxygen;
[0042] B. Mix 19mg of folic acid, 3.2mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 2mg of N-hydroxysuccinimide with 4g of deionized water, and wash with NaOH Adjust the pH to 10, s...
Embodiment 3
[0046] The folic acid-mediated antitumor drug superparamagnetic tumor-targeting nanoparticles of the present invention comprises the following steps:
[0047] A. Mix 14g polyethylene glycol and 0.3g polyethyleneimine evenly, and heat up to 80°C within 10min to obtain a mixed solution; add 0.7g iron acetylacetonate to the mixed solution, and continue stirring at 80°C for 10min , heated to 260°C, kept warm for 1h, stopped heating, cooled to 54°C, obtained a mixed solution containing iron oxide nanoparticles, removed unreacted organic matter, collected iron oxide nanoparticles, and dispersed them in deionized water to obtain iron oxide Nanoparticle solution; the whole process is carried out under magnetic stirring, and argon gas is introduced to remove oxygen;
[0048] B. Mix 20mg of folic acid, 3.5mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 3mg of N-hydroxysuccinimide and 5g of deionized water, and wash with NaOH Adjust the pH to 10, stir in a dark room a...
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