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Application of superparamagnetic iron oxide nanoparticles in preparation of nerve magnetic stimulation enhancers for treating neurogenic diseases

A nanometer and superparamagnetic technology of iron oxide, which is applied in the direction of nervous system diseases, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of inaccurate correspondence and achieve good biocompatibility , long blood circulation time, avoid damage effect

Active Publication Date: 2018-11-23
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The difference in size between the human brain and the brain of experimental animals, in vitro research and animal experiments can only be compared with human TMS research and cannot be accurately corresponded

Method used

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  • Application of superparamagnetic iron oxide nanoparticles in preparation of nerve magnetic stimulation enhancers for treating neurogenic diseases
  • Application of superparamagnetic iron oxide nanoparticles in preparation of nerve magnetic stimulation enhancers for treating neurogenic diseases
  • Application of superparamagnetic iron oxide nanoparticles in preparation of nerve magnetic stimulation enhancers for treating neurogenic diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Preparation of superparamagnetic iron oxide nanoparticles

[0022] With reference to the method of Example 1 in WO2016 / 078576, using dextran T10 as a raw material, after reducing dextran T10, carry out carboxymethyl (-CH 2 COOH) substitution, polyglucose sorbitol carboxymethyl ether (sodium salt form) can be prepared.

[0023] Add 400 mg of polydextrose sorbitol carboxymethyl ether (sodium salt form) and 3 mL of distilled water to the reaction flask, and mechanically stir at room temperature to fully dissolve the raw materials; after blowing nitrogen gas and stirring for 5 min, add 6 mL of aqueous solution (300 mg of trihydrate hexahydrate) to the reaction flask. ferric chloride and 150 mg of ferrous chloride tetrahydrate), stirred for 15 min; the nitrogen gas was removed, and ammonia water (1 mL of concentrated ammonia water with a mass concentration of 28% was diluted with 1 mL of water) was added dropwise, and the pH value was adjusted to 11. Start the ...

Embodiment 2

[0024] Example 2 Effect of Superparamagnetic Iron Oxide Nanoparticles on Behavioral Hopelessness and Depression Model Mice under the Effect of External Magnetic Field

[0025] (1) Experimental animals and groups

[0026] 5-6 week old male C57BL / 6 mice (C57BL / 6J JAX TM mice strain), weighing about 15-18g, purchased from the Comparative Medicine Center of Yangzhou University, animal production license number: NO.SCXK (Su) 2017-2007. Before the experiment, the mice were placed in a normal experimental environment (constant temperature 23±1°C; constant humidity 55±10%) for adaptive feeding, eating and drinking independently, and ensuring a 12h light cycle. Magnetic iron oxide nanoparticle group (prepared in Example 1) and control group (injection of equal amount of normal saline), 6 mice in each group, after 5 days of external magnetic field, adopt open field and tail suspension test to evaluate the effect of magnetic nanoparticles on small Effects on depressive-like behavior in...

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Abstract

The invention discloses application of superparamagnetic iron oxide nanoparticles in preparation of nerve magnetic stimulation enhancers for treating neurogenic diseases. On the basis of magnetic nanomaterials and the action of a magnetic field, method and system construction for magnetic stimulation of deep brain nerves are realized. The application has the advantages that the high compatibilityand magnetic field response characteristics of the superparamagnetic iron oxide nanoparticles are utilized to feed the superparamagnetic iron oxide nanoparticles to a specific brain region, the magnetic nanoparticles amplify the magnetic field effect under the action of a specific external magnetic field, surrounding nerve cells are stimulated, activation of neural circuits is realized, and accordingly, some neurogenic diseases can be treated.

Description

technical field [0001] The invention relates to the application of magnetic nanoparticles, in particular to the application of superparamagnetic iron oxide nanoparticles in the preparation of nerve magnetic stimulation enhancers for treating neurological diseases. Background technique [0002] The modulation of nerve function caused by electromagnetic stimulation has been successfully applied in the clinical treatment of various neurogenic diseases. For example, brain nerve stimulation can effectively control cognitive impairment diseases, and has unique advantages such as adjustable and reversible. , Improve or even eliminate corresponding symptoms, so that patients can better maintain their daily life functions and improve their quality of life. As a non-invasive physical factor, magnetic field can directly act on organisms, thereby producing corresponding biological effects. When the magnetic field where the body is located changes, it will affect the activity of cell mo...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/36A61K33/26A61K41/00A61P25/00A61P25/24A61P25/18
CPCA61K9/5161A61K33/26A61K41/00A61P25/00A61P25/18A61P25/24
Inventor 孙剑飞李暖陆清波张志珺顾宁
Owner SOUTHEAST UNIV
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