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42 results about "Open field" patented technology

Developed by Calvin S. Hall, the open field test is an experimental test used to assay general locomotor activity levels, anxiety, and willingness to explore in animals (usually rodents) in scientific research. However, the extent to which behavior in the open field measures anxiety is controversial.

Application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction

The invention discloses an application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction. An open field test and an elevated plus-maze test for researching anxiety behaviors as well as a tail suspension test and a forced swimming test for researching depression behaviors show that Activin A has a therapeutical effect on neurodegeneration diseases and can effectively relieve anxiety and depression behaviors induced by cocaine withdrawal, and further, Activin A almost does not have toxic and side effects on cells, has good development prospect and is expected to be developed into novel medicine for treating the neurodegeneration diseases, particularly the novel medicine for treating withdrawal symptoms after cocaine addiction.
Owner:SOUTHERN MEDICAL UNIVERSITY

Gordon euryale seed extract with antioxidation and anti-ageing effects as well as preparation method and application thereof

The invention discloses a gordon euryale seed extract with antioxidation and anti-ageing effects as well as a preparation method and application thereof. Through system optimization of an extraction solvent, an extracting method, an extraction method and a macroporous resin separation method, an optimal preparation process is obtained to prepare the gordon euryale seed extract. An experimental result shows that the gordon euryale seed extract provided by the invention is capable of obviously improving the motion capability and the exploratory behavior of a subacute ageing mouse in an open field, the academic record and memory ability of the mouse in water maze tests and the spleen and kidney indexes of the mouse, increasing the activity and protein contents of GSH-Px (Glutathione Peroxidase) and NOS (Nitric Oxide Synthase) in brain tissues, reducing the activity of AChE (acetylcholinesterase) in the brain tissues, improving the pathological change of the brain tissues, and having excellent antioxidation and anti-ageing effects.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Application of Xinnaoxin capsule in preparation of antidepressant

ActiveCN103494946AAntidepressantDoes not interfere with spontaneous activityNervous disorderCapsule deliverySynaptic cleftMedicine
The invention discloses application of a Xinnaoxin capsule in preparation of an antidepressant. According to experimental studies, the Xinnaoxin capsule can substantially reduce dead time during tail suspension and forced swimming of behavioral despair model mice; according to open field experiments, spontaneous activities of the mice are not influenced while dead time is substantially decreased, which prompts that the Xinnaoxin capsule has a certain anti-depression effect. Meanwhile, the Xinnaoxin capsule can substantially inhibit activity of monoamine oxidase and increase the content of a monoamine neurotransmitter in a synaptic cleft, which proves that the Xinnaoxin capsule has the anti-depression effect. Moreover, the Xinnaoxin capsule can substantially antagonize decrease of body temperature of the mice caused by reserpine and apomorphine and increase exogenous toxicity given to NE, which reveals that the capsule has the anti-depression effect. The anti-depression effect of the capsule is realized through improvement of the level of the monoamine neurotransmitter in the synaptic cleft.
Owner:GANSU CHEEZHENG TIBETAN MEDICINE CO LTD

Global perceptual behavior detecting device and animal cognitive behavior testing method

The invention provides a global perceptual behavior detecting device. The global perceptual behavior detecting device comprises an open field, a display screen, a shading part and an image pick-up part, wherein the open field is of a box body structure with an open top and is composed of a bottom plate and a plurality of side plates which are connected end to end through enclosing; the display screen is arranged at the top of the open field, a display surface of the display screen faces to the surface of the bottom plate of the open field, and dynamic approach images are displayed on the display screen and comprise either images maintaining topological attributes or images transforming the topological attributes; the shading part is arranged on the surface of the bottom plate of the open field and is provided with a shading space; and the image pick-up part is arranged on the open field and is used for monitoring dynamic behaviors in the open field in real time. The behavior detectingdevice is a subconscious visual-stimulation detecting device, can be used for testing influence on animal behaviors caused by subconscious topological perceptions and can be used for reflecting relevance between the animal behaviors and global attribute perceptions to certain extent. The invention further provides an animal cognitive behavior testing method.
Owner:SHENZHEN INST OF ADVANCED TECH

Medicament for treating tic disorder disease

The invention relates to a medicament for treating tic disorder disease. The medicament is prepared from the following bulk drugs in parts by weight: 8-12 parts of cortex albiziae, 3-7 parts of rhizoma acori graminei, 6-8 parts of agrimonia pilosa, 3-5 parts of herba ardisiae japonicae, 8-15 parts of radix polygonati officinalis and 10-20 parts of radix rehmanniae praeparata. The medicament selects pure-natural traditional Chinese medicines, conforms to the assistance and guide principle of the traditional Chinese medicine according to the whole formula, and has obvious curative effects on stereotyped behaviors and open field activity through the pharmacological experimental verification.
Owner:太仓市胜舟生物技术有限公司

Tree shrew behavior sensitization model evaluation method and open field experiment device for evaluation

The invention discloses a tree shrew behavior sensitization model evaluation method and an open field experiment device for the evaluation, the method comprises the following steps of: inducing the tree shrew behavior sensitization by METH, detecting the tree shrew behavior science, the motion distance, the speed and the track by an open field experiment, measuring the weight change of the tree shrew and marking plate behaviors; the invention also discloses an open field experiment device for evaluating the tree shrew behavior sensitization model, which comprises a box body, a bottom plate replacement box, a moving chassis, a fixing bracket and a camera, wherein the bottom of the moving chassis is provided with universal wheel with a brake, the box body is fixed on the top of the bottom plate replacement box, the bottom plate replacement box is fixed on the moving chassis, an upright post of the fixing bracket is fixed on the moving chassis, and the camera is fixed on the fixing bracket. The device provides reference and guidance for the success of establishing the tree shrew behavior sensitization model, and is convenient for researching the addiction mechanism of lazy drugs by means of the tree shrew behavior sensitization model; the open field experiment device can conveniently replace the bottom plate after each batch of experiments are finished, thereby reducing the time for cleaning, scraping, assembling and other processes.
Owner:KUNMING MEDICAL UNIVERSITY

ConvLSTM network-based Mouse open field experiment behavior analysis method

The invention discloses a ConvLSTM network-based mouse open field experiment behavior analysis method. The method comprises the following steps: outputting a feature map containing mouse key point semantic information and position information by using a key point detection model; inputting a feature map sequence formed by adjacent frames into an identification classification model established based on a ConvLSTM network to realize behavior classification; and finally, correcting a misclassification result by using mode filtering so as to obtain behavior parameters in the mouse open field experiment. Automatic identification of animal behaviors and automatic calculation of animal behavior indexes are realized. The workload of researchers can be reduced, a quantitative behavior analysis method is provided for the researchers, and the objectivity of experiments is improved. Meanwhile, the refined behavior analysis method can help a researcher to capture some behavior modes which are difficult to perceive, and the reliability of an analysis result is improved. Meanwhile, compared with an existing mouse behavior recognition method, the method of the invention is higher in accuracy, is less affected by environment and illumination changes, and is higher in robustness.
Owner:ZHENGZHOU UNIV

Triad prediction model generation method and relationship triad extraction method and device

The embodiment of the invention provides a triad prediction model generation method, a relationship triad extraction method and device. The triad prediction model generation method comprises the stepsof obtaining a training text containing a preset relationship triad; wherein the relationship triad comprises a main entity word, a relationship word and an auxiliary entity word; wherein the training text has auxiliary entity word annotation information and relationship word annotation information corresponding to the relationship triad; and training a preset model by taking the training text and the main entity words in the relationship triad as model input and taking the auxiliary entity word annotation information and the relationship word annotation information as model output to generate a triad prediction model. Therefore, relationship triples obtained through prediction can contain various different relation types, the number of the relationship triads which can be extracted by the triad prediction model and the relationship types are expanded, and extraction of the relation triads in the open field is achieved.
Owner:BEIJING SINOVOICE TECH CO LTD

Application of phloretin in preparation of antidepressant drug

The invention discloses application of phloretin in preparation of antidepressant drugs, and belongs to the technical field of medicines. A mouse depression model is established through chronic unpredictable mild stimulation, the anti-depression effect of the phloretin is evaluated through behavioral detection means such as an open field experiment, a sweet water preference experiment, a tail suspension experiment and a forced swimming experiment, and it is proved through an immunofluorescence experiment and ELISA kit detection that the phloretin can inhibit microglial cell activation; the compound can relieve neuroinflammation and play a neuroprotective role, and can be used for preparing anti-depression drugs.
Owner:NANTONG UNIVERSITY

Table-based question and answer method, device and computer equipment

The invention provides a table-based question and answer method, a device and computer equipment, and relates to the technical field of artificial intelligence, in particular to natural language treatment.The method comprises the steps of obtaining a plurality of question templates used for questioning information points in an information table, analyzing the received question information to obtain the part information of the question information; generating at least one replacement question semantically matched with the part information according to a plurality of question templates; responding to a selection operation on the at least one replacement question, and replying the selected replacement question according to information points in the information table; by analyzing the question information and combining the question template of the information table, the user is guided to select the replacement question and obtain the reply result of the selected replacement question, so that the method is simple and efficient, the strong correlation of the question information is ensured, the probability of accurately replying the question information is improved. Meanwhile, the method is suitable for the open field andlarge-scale table data .
Owner:BEIJING BAIDU NETCOM SCI & TECH CO LTD

Behavior detection device

ActiveCN111034682AFacilitate path analysisPrevent drilling gapsTelevision system detailsColor television detailsInstinctSimulation
The invention belongs to the technical field of behavior research, and particularly relates to a behavior detection device. An existing behavior detection device has the problems of training sugar reward smell interference, time consumption and individual learning ability difference, influences on insects are large, and insect conscious selection is needed, the existing behavior detection device is less suitable for insects. The invention provides a behavior detection device which comprises an open field, the open field is connected with a display screen, the display screen is connected with an intelligent terminal, and the intelligent terminal comprises a danger signal stimulation module; a camera is arranged in the open field; the open field is of an integrally-formed structure. The device can be used for untrained insects, so that the experiment time and cost are greatly saved, other factors such as sugar reward smell are reduced, the influence on an experiment object is reduced, and the consistency of experiment conditions is kept; through short-time stimulation and instinct contact operation, the obtained behavior data is of a subconscious level, and the priority of overall attribute perception can be better explained.
Owner:SHENZHEN INST OF ADVANCED TECH

Oxidized isoaporphine alkaloid derivative as well as preparation method and anti-depression application thereof

The invention discloses an oxidized isoaporphine alkaloid derivative with a structure as shown in a formula I, wherein R1 and R2 are independently selected from H, F, Cl and methoxyl respectively; and n is an integer of 2-6. An in-vitro activity experiment shows that the oxidized isoaporphine alkaloid derivative has relatively good protection activity on corticosterone-induced PC12 cell injury, which indicates that the corticosterone-induced PC12 cell injury has a neuroprotection function; in-vivo anti-depression drug effect evaluation shows that the oxidized isoaporphine alkaloid derivative can remarkably increase the moving distance and the moving speed in an open field experiment and remarkably shorten the immobility time in a tail suspension experiment and a forced swimming immobility experiment, which indicates that the oxidized isoaporphine alkaloid derivative can remarkably improve the depression state. The invention also discloses an application of the oxidized isoaporphine alkaloid derivative in preparation of an antidepressant drug. The invention also discloses an application of the oxidized isoaporphine alkaloid derivative in preparation of a neuroprotective drug.
Owner:CHINA PHARM UNIV

Preparation method of spaceflight depression syndrome animal model

The invention belongs to the technical field of animal model preparation, and particularly relates to preparation method of a spaceflight depression syndrome animal model. The method comprises the steps of S1, spaceflight depression syndrome model molding, namely adopting closed isolated culture, simulated weightlessness, noise and circadian rhythms to verify the condition of accepting simulated spaceflight stress stimulation of adult SD male rats; and S2, spaceflight depression syndrome model behavioristics evaluation, namely detecting a depression syndrome state condition through a sweet water preference experiment, an open field experiment, a Morris water maze experiment, a step-down experiment and a forced swimming experiment. According to the simulated weightlessness manner, a Chen Jie improved tail crane is adopted, and an angle of 30 degrees is formed between the body and the horizontal plane; for day and night rhythm change, day and night alternation of space flight in 90 minutes in a light and shade period is simulated through light control; and for the step-down experiment, an electrified copper grid is laid at the bottom of a reaction box, animals are shocked by electricshock, and for a normal reaction, the animals jump onto an insulating platform in the box to avoid harmful stimulation. Through model establishment, the influence of different conditions on the depression syndrome of an astronaut is studied.
Owner:63919 TROOPS PLA

New application of bacteroides fragilis zwitterionic capsular polysaccharide or/and modified zwitterionic capsular polysaccharide

The invention provides novel application of bacteroides fragilis zwitterionic capsular polysaccharide or / and modified zwitterionic capsular polysaccharide. Mainly relates to application of the capsular polysaccharide extract of bacteroides fragilis in preparation of anti-anxiety drugs, the preservation number of the bacteroides fragilis is CGMCC NO.10685, and the capsular polysaccharide extract is an extract of capsular polysaccharide A. The invention further relates to application of the capsular polysaccharide extract of bacteroides fragilis in preparation of anti-anxiety drugs. Compared with the prior art, the invention has the following beneficial effects: the inventor of the invention finds that the capsular polysaccharide A extract of Bacteroides fragilis ZY312 has an obvious effect on anxiety disorder, and the effect is verified by carrying out elevated cross maze behavioral determination and open field experiments on a rat model.
Owner:GUANGZHOU ZHIYI PHARMA INC

Animal posture experiment system

The animal posture experiment system comprises an experiment device, the experiment device comprises a gait experiment module, a maze training module and an open field experiment module, and any one of the gait experiment module, the maze training module and the open field experiment module is selected for an experiment; the pressure monitoring device is used for collecting pressure information of the limb tail end of the animal to be experimented; the image monitoring device is used for shooting posture image information of the to-be-experimented animal in the experimental device; the electrophysiological signal monitoring device is used for collecting electroencephalogram information of the animal to be experimented and applying an electrical stimulation signal to the animal to be experimented; the processing device is used for acquiring the electroencephalogram information, the pressure information and the posture image information. According to the animal posture experiment system, the gait experiment module, the labyrinth training module and the open field experiment module are arranged to obtain the pressure information, the posture image information and the electroencephalogram information of the animal to be experimented, comprehensive analysis in multiple aspects can be achieved, and therefore the accuracy of the analysis result is improved.
Owner:北京宁矩科技有限公司

Method for preparing neurodevelopmental defect rat model through 3-MA treatment in weaning period of rats

The invention provides a method for preparing a neurodevelopmental defect rat model through treatment with 3-MA in a weaning period of rats, which comprises the following steps: performing intraperitoneal injection of an autophagy inhibitor 3-MA on the rats in a normal weaning period continuously for 7 days to prepare a rat model for inhibiting autophagy generation, and detecting autophagy generation through immunoblotting. Then verifying social barriers through a three-box social experiment, verifying whether the anxiety level of the rat model is increased through an open field experiment, an elevated cross labyrinth experiment and a black and white box experiment, verifying whether the rat model has memory impairment through a Y labyrinth experiment and a passive avoidance experiment, and performing Golgi body staining on the rat model and a control group; and the neuron and synaptic morphology of the hippocampus and the frontal lobe Through multiple experiments, it is found that in the weaning period, 3-MA treatment for preparing the rat model with the neurodevelopment defect has the advantages of being low in cost, short in modeling period, more obvious in model behavior abnormality and better in stability, and can be used for research of diseases such as schizophrenia and autism and research and development of new drugs.
Owner:河南省精神病医院

A behavior detection device for overall perception and a method for testing cognitive behavior of animals

The present invention provides a behavior detection device for overall perception, comprising: an open field, which is a box structure with an open top, and the open field is surrounded by a bottom plate and a plurality of side plates connected end to end; a display screen, It is arranged on the top of the open field, the display surface of the display screen faces the bottom plate surface of the open field, and a dynamic approaching image is displayed on the display screen, and the dynamic approaching image includes an image maintaining topological properties and transforming topological properties at least one of the images; the shielding part is arranged on the bottom plate surface of the open field, and the shielding part is provided with a shielding space; the camera part is arranged on the open field for real-time monitoring of the open field Dynamic. The behavior detection device is a subconscious visual stimulus detection device, which can be used to test the influence of subconscious topology perception on animal behavior, and can reflect the correlation between animal behavior and overall attribute perception to a certain extent. The invention also provides a method for testing animal cognitive behavior.
Owner:SHENZHEN INST OF ADVANCED TECH

Application of epilupinine and derivative thereof in preparation of medicine for treating depression

The invention provides application of epilupinine (1-EPILLUPININE) and a derivative of the epilupinine (1-EPILLUPININE) in preparation of a medicine for treating depression. The application dosage is 0.01-30 mg of epilupinine or the derivative thereof per kilogram of body weight, and the anti-depression effect can be achieved within 60 minutes after administration. After the medicine is administrated for 5 days, the obvious anti-depression effect is generated in the low dosage and the high dosage. Research results show that in a mammal mouse tail suspension experiment, the epilupinine or the derivative thereof has a rapid anti-depression effect, and is more effective than a conventional anti-depression drug imipramine. According to the method, a forced swimming experiment and a mouse tail suspension experiment are adopted as drug screening experiments, and meanwhile, an Open field test is carried out, so that the autonomous activity of a mouse is detected, and interference of central excitants is avoided. The anti-depression drug has the advantages of being remarkable in anti-depression effect, quick in effect taking, small in dosage, small in side effect and the like, and is expected to become a new anti-depression drug which is quick, efficient and novel in mechanism.
Owner:BEIJING ANDING HOSPITAL CAPITAL MEDICAL UNIV +1

A method for analyzing the movement behavior of mice in open field experiments based on key point detection

The invention discloses a method for analyzing the movement behavior of mice in an open field experiment based on key point detection, comprising: (a) collecting experimental videos and determining the experimental area; (b) a mouse key point detection model based on a convolutional neural network, Detect the nose tip, left ear, right ear and tail root of the mouse in the video image, and return the coordinates of the key points; (c) calculate the movement distance of the key points between adjacent frames, and filter out the abnormal key points with the distance threshold; (d) check the key points The coordinates are cleaned, and the Kalman filter is used to predict the trajectory to eliminate the influence of measurement errors; (e) determine the movement parameters in the mouse open field experiment from the calculated key point coordinates, and generate relevant graphical reports. The method for analyzing the movement behavior of mice in open-field experiments based on key point detection in the present invention has strong robustness, and has strong anti-interference ability against changes in the environment and light, and greatly simplifies the process of analyzing behavioral indicators. Behavioral analysis means are convenient, comprehensive and precise.
Owner:郑州布恩科技有限公司

Application of single use of tenuigenin or combination of tenuigenin and hydroxysafflor yellow A in preparation of medicine for improving cognitive impairment after cerebral arterial thrombosis

ActiveCN113350358AIncrease distanceIncrease the number of passes through the central areaOrganic active ingredientsNervous disorderPassive avoidancePharmaceutical drug
The invention relates to application of single use of tenuigenin or combination of the tenuigenin and hydroxysafflor yellow A in preparation of a medicine for improving cognitive impairment after cerebral arterial thrombosis. Specifically, animal experiments find that when the tenuigenin is singly used or combined with hydroxysafflor yellow A, the movement distance and the number of times of passing through a central area in an MCAO rat open field experiment can be remarkably increased, the proportion of rapid movement time is increased, the proportion of rest time is reduced, the time of entering a dark box in an MCAO rat passive avoidance experiment is increased, and the specific value of P-JAK2 / JAK2 and P-STAT3 / STAT3 of the brain tissue of the MCAO rat and the expression of SOCS3 are improved. The invention provides a new medicine for preventing and treating cognitive impairment after cerebral arterial thrombosis.
Owner:SHANGHAI PUTUO DISTRICT CENT HOSPITAL

Kit for detecting rat peripheral blood HDAC5 expression level, and use method of kit

The invention provides a kit for detecting a rat peripheral blood HDAC5 expression level, and a use method of the kit. Through the kit, a pregnant infection adolescent offspring rat of which the peripheral blood monocyte HDAC5 expression quantity is obviously up-regulated is screened to be continuously raised to an adult stage to carry out behavior detection (an open field test, a Y maze experiment and prepulse inhibition (PPI)). A result shows that the adult stage of the rat of which the HDAC5 obviously rises is obviously abnormal, for example, an anxiety level is increased, memory deficits are in the presence, sensory gating dysfunctions are in the presence and the like. Therefore, on the basis of the above inference, the kit can effectively evaluate the model quality of a pregnant infection adolescent offspring and can be used for subsequent researches.
Owner:河南省精神病医院

Use of Mouse Models in Assessing Intelligence Levels

ActiveCN111631190BEasy to filterFacilitate/or prepareOther apparatusWater mazeWild type
The present application relates to the application of a mouse model in evaluating changes in intelligence level, the mouse model is a mouse model of high intelligence level, and the chromosomes of the mice in the high intelligence level mouse model include at least wild-type mice All or part of chromosome 1 from which the evaluation consists of performing a test selected from the group consisting of the Open Field Test, the Sugar Preference Test, the Water Maze Test, the Spatial Exploration Y-Maze Test, the Active Avoidance Y-Maze Test, and the Fatigue Spin-Rod Test .
Owner:GEMPHARMATECH CO LTD

An open field experiment data analysis method, system and terminal equipment

The present application is applicable to the technical field of data processing, and in particular relates to an open field experiment data analysis method, system and terminal equipment. The open field experiment data analysis method comprises: obtaining an experiment video containing a target open field, and extracting each video frame corresponding to the experiment video; converting each video frame into a corresponding binary image, and extracting each video frame corresponding to the experiment video; Intercept the area image corresponding to the target open field in the binary image; obtain the first coordinates corresponding to the pixels of the experimental animals in each of the area images, and determine each of the pixels according to the first coordinates corresponding to the pixels. The second coordinates corresponding to the center of mass of the experimental animal in the area image; establish a coordinate system according to the contour boundary of the target open field in the area image, and set the coordinate system in the coordinate system according to the second coordinates corresponding to each of the center of mass The movement track of the experimental animal is drawn to reduce the time cost in the data analysis of the open field experiment and improve the analysis efficiency and accuracy of the data analysis of the open field experiment.
Owner:SHENZHEN INST OF ADVANCED TECH

Modeling and evaluation method for mice with depression and liver depression fire syndrome

The invention discloses a modeling method for mice suffering from depression and liver depression fire syndrome diseases, and relates to the field of animal model construction methods, the modeling method comprises the following steps: performing continuous sleep deprivation stimulation on healthy mice for 2-30 days, and simultaneously performing light irradiation daily stimulation and next-day grain stimulation every day, the obtained model mouse has symptomatic manifestation of depression, and meanwhile, the characteristic that the model has the syndrome of liver depression transforming into fire is judged through a traditional Chinese medicine syndrome diagnosis method. The depression mouse model established by the invention not only has clinical liver depression transforming into fire and depression states in general signs, but also can be used for treating depression through weight, total distance of open field activities, time, times and average speed of entering the center of the open field, times and time of entering an open arm in an elevated cross labyrinth, water intake and forced swimming immobile time. The model accords with the characteristics of liver depression transforming into fire in traditional Chinese medicine, and can be used for further research on pathogenesis and treatment of the syndrome of liver depression transforming into fire of depression.
Owner:JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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