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Application of single use of tenuigenin or combination of tenuigenin and hydroxysafflor yellow A in preparation of medicine for improving cognitive impairment after cerebral arterial thrombosis

A technology of ischemic stroke and polygala saponin, which is applied in the field of medicine to achieve the effect of reducing the proportion of rest time and increasing the proportion of fast exercise time

Active Publication Date: 2021-09-07
SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, there is no report on improving cognitive impairment after ischemic stroke with polygala saponin alone or in combination with hydroxysafflower yellow A.

Method used

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  • Application of single use of tenuigenin or combination of tenuigenin and hydroxysafflor yellow A in preparation of medicine for improving cognitive impairment after cerebral arterial thrombosis
  • Application of single use of tenuigenin or combination of tenuigenin and hydroxysafflor yellow A in preparation of medicine for improving cognitive impairment after cerebral arterial thrombosis
  • Application of single use of tenuigenin or combination of tenuigenin and hydroxysafflor yellow A in preparation of medicine for improving cognitive impairment after cerebral arterial thrombosis

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Effect test

Embodiment 1

[0026] 1. Experimental purpose: To explore the improvement effect of polygala saponin combined with hydroxysafflor yellow A on cognitive impairment after ischemic stroke.

[0027] 2. Experimental materials

[0028] 2.1 Experimental animals

[0029] Healthy SPF grade male SD rats, aged 9-11 weeks, weighing 250-290 g, were purchased from Shanghai Slack Experimental Animal Company. The feeding and experimental process complied with the relevant working regulations of the Animal Ethics Committee (animal ethics committee review approval number: r20160302).

[0030] 2.2 Reagents and consumables

[0031] Chloral hydrate (Sinopharm Group), TTC staining agent (Beijing Xinong Science and Technology Co., Ltd.), MCAO silicone thread plug (A4) (Beijing Xinong Science and Technology Co., Ltd.), carotid artery injection syringe (Beijing Xinong Science and Technology Co., Ltd.), stainless steel Brain slicing blade (Beijing Xinong Technology Co., Ltd.).

[0032] 2.3 Instruments and equipme...

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Abstract

The invention relates to application of single use of tenuigenin or combination of the tenuigenin and hydroxysafflor yellow A in preparation of a medicine for improving cognitive impairment after cerebral arterial thrombosis. Specifically, animal experiments find that when the tenuigenin is singly used or combined with hydroxysafflor yellow A, the movement distance and the number of times of passing through a central area in an MCAO rat open field experiment can be remarkably increased, the proportion of rapid movement time is increased, the proportion of rest time is reduced, the time of entering a dark box in an MCAO rat passive avoidance experiment is increased, and the specific value of P-JAK2 / JAK2 and P-STAT3 / STAT3 of the brain tissue of the MCAO rat and the expression of SOCS3 are improved. The invention provides a new medicine for preventing and treating cognitive impairment after cerebral arterial thrombosis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of polygala saponin alone or in combination with hydroxysafflor yellow A in the preparation of drugs for improving cognitive impairment after ischemic stroke. Background technique [0002] Cognitive impairment after ischemic stroke refers to cognitive impairment that meets or fails to meet the diagnostic criteria for dementia after the first or recurrent ischemic stroke. Studies have shown that 6% to 55% of patients with ischemic stroke may suffer from cognitive decline after onset; among patients with recurrent stroke, more than 1 / 3 will eventually develop dementia. Cognitive impairment after stroke mainly involves executive function, attention, processing speed, and spatial memory. Executive dysfunction includes impairment of working memory, abstract reasoning ability, language fluency, and cognitive flexibility, which can lead to poor long-term outcome of stroke. Good,...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K31/351A61P9/10A61P25/28
CPCA61K31/56A61K31/351A61P9/10A61P25/28A61K2300/00
Inventor 俞璐张成张秋娟刘知理赵政曹晓华陶杰段燕红
Owner SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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