63 results about "Neuroprotective drug" patented technology

The invention relates to application of a ferulic acid derivative to preparation of drugs for treating and / or preventing neurodegenerative diseases related to nerve cell injury. The neurodegenerative diseases includes but not limited Alzheimer's disease, vascular dementia, Parkinson's disease, multiple sclerosis, diabetic neuropathy, ischemia stroke and hemorrhagic stroke.

Disclosed is the use of 5α-androstane(alkyl)-3β,5,6β-triol in preparing neuroprotective drugs. The compound has significant protective effect against neuron injuries caused by cerebral ischemia, spinal cord ischemia or hypoxia and has no obvious toxic reaction within effective dose thereof.

The invention relates to the field of medicine synthesis, and discloses a long-acting PSD-95 inhibitor. The long-acting PSD-95 inhibitor is used to prepare a pharmaceutical composition for treating diseases, and the pharmaceutical composition is used in the preparation of neuroprotective drugs after ischemic brain injury.

The invention discloses a neuroprotective drug for cerebral arterial thrombosis, and belongs to the field of biotechnology drugs. The drug is prepared by taking a DNA tetrahedron as an active component and adding pharmaceutically acceptable auxiliary components. The drug disclosed by the invention can be used for effectively protecting cranial nerves and greatly reducing the infarction area caused by cerebral arterial thrombosis, and can be used for improving the behavioral capacity of patients with relatively light illness conditions; and for patients with relatively severe illness, the illness can be stabilized, and the treatment window period is prolonged.

The invention discloses a new codonopsis pilosula alkynol compound 1 extracted from codonopsis pilosula, a preparation method thereof, a pharmaceutical composition containing a new codonopsis pilosula alkynol compound and application in a neuroprotective drug, especially senile dementia. Pharmacological experiments show that the compound embodies neuroprotection activity and has good neuroprotection activity in a sodium nitroprusside injury primary neuron model and a glutamic acid-induced primary neuron toxicity model. A structural formula of the compound 1 is as shown in the specification.

The application of fennomide in the preparation of neuroprotective drugs belongs to the technical field of neuroprotective drugs. The application of fennomide in drugs for the treatment or prevention of cranial nerve injury is made by adding fennomide into pharmaceutically acceptable excipients to prepare clinically usable drugs. pharmaceutical dosage form. Specifically, the application of fennomide in the preparation of a medicament for the treatment or prevention of nerve damage caused by cerebral hemorrhage, or the application of fennomide in the preparation of a medicament for the treatment or prevention of nerve injury caused by cerebral ischemia-reperfusion. Tests have confirmed that fennomide has a neuroprotective effect, and can effectively treat or prevent nerve injury caused by cerebral ischemia-reperfusion, nerve injury caused by cerebral hemorrhage, and various neurological injuries such as Guillain-Barre.

The invention discloses the compound represented by formula (A), or its stereoisomer, or its salt, or its solvate, or its prodrug, or its metabolite. The test results show that the sesquiterpene compound provided by the invention can effectively protect nerve cells, and its protective effect is even better than that of the positive control drug. Therefore, the sesquiterpene compound provided by the present invention, or its stereoisomer, or its salt, or its solvate, or its prodrug, or its metabolite is used in the preparation of neuroprotective drugs, especially in the preparation of preventive and / Or in medicines for the treatment of neurodegenerative diseases, it has a good application prospect. The invention provides a new option for clinically screening and / or preparing neuroprotective drugs.

The present invention relates to the active ingredient of A. chinensis, which is characterized in that it comprises oleanolic acid-type triterpenoid saponins and / or phenylacetonitrile glycosides, and the structural formula of the oleanolic acid-type triterpenoid saponins is as follows: The structural formula of phenylacetonitrile glycosides is shown below: . The present invention also provides a preparation method of the active ingredient of the Fructus Arugulae. According to the experiment, the invention finds that the active components of Fructus chinensis have a good protective effect on the oxidative damage of nerve cells NSC34, and can be used for preparing neuroprotective drugs or health care products.

The invention relates to a compound (22-trans)-3beta-hydroxyl-cholester-5,22-diene-24-ketone, a preparation method and an application thereof. The compound is obtained through extraction from Caulerpa racemosa, pressure reduction and concentration, extraction, silica gel column chromatography and gel column chromatography purification; which has the structure which is measured via a rationalize constant and defined via a spectrum data analysis. Multiple in-vitro SH-SY5Y cell injury neuroprotection experiments prove that the compound has obvious protection effect to beta-amyloid protein 25-35(Abeta-25-35)injury-SY5Y cell, and can be used for preparing the neuroprotectants and medicines to prevent and treat Alzheimer's disease.

The invention relates to the technical field of traditional Chinese medicine, in particular to a biflavonoid compound extracted from Malachite flower and its preparation method and application. A kind of biflavonoid compound, molecular formula is C 33 h 24 o 16 , named as 8,8'-methylenebis(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-chromone, the chemical structure is as follows , the purposes of the described biflavonoids in the preparation of neuroprotective drugs. The preparation method adopts ethanol extraction, n-butanol extraction, silica gel column chromatography, polyamide, Sephadex LH‑20 successively, and can easily and quickly extract Isolate high-purity biflavonoid compounds, which have neuroprotective effects, and can be prepared in dosage forms such as tablets, granules, and capsules with commonly used pharmaceutical excipients, and are used to improve and treat neurological diseases such as depression. Therefore, biflavones The compounds can be used as a new class of natural products to develop traditional Chinese medicine, and have broad application prospects.