65results about How to "Reduce inflammatory damage" patented technology

The invention relates to application of a ferulic acid derivative to preparation of drugs for treating and / or preventing neurodegenerative diseases related to nerve cell injury. The neurodegenerative diseases includes but not limited Alzheimer's disease, vascular dementia, Parkinson's disease, multiple sclerosis, diabetic neuropathy, ischemia stroke and hemorrhagic stroke.

The invention relates to a traditional Chinese medicine composition used for treating respiratory diseases and related inflammatory conditions, and a preparation method and use of the traditional Chinese medicine composition. The traditional Chinese medicine composition contains traditional Chinese medicine active extracts. The respiratory diseases include pneumonia, trachitis, bronchitis, chroniccough, asthma, chronic obstructive pulmonary diseases and the like. The traditional Chinese medicine composition in the invention is particularly suitable for treating viral pneumonia and related inflammatory conditions, in particular coronavirus pneumonia, such as novel coronavirus pneumonia (COVID-19).

The invention discloses a naphthalene sulfonamide compound and preparation methods and applications thereof. The naphthalene sulfonamide compound provided by the invention can interfere with Keap1-Nrf2 binding and activate Nrf2 so as to alleviate inflammatory damage and improve inflammatory microenvironment, has potential anti-inflammatory activity, and can be used for preparing anti-inflammatory medicine for the inflammatory damage of many inflammation-related diseases. The diseases include chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, intestinal inflammation, rheumatoid arthritis and the like.

The invention discloses application of L-fucose in medicines and health-care products for treating gastrointestinal lesions. The L-fucose is used for treating the gastrointestinal lesions, such as inflammatory bowel disease, functional gastrointestinal disorder and irritable bowel syndrome. The medicine is a carbohydrate medicine, since the adverse effect is less, and the tolerance of a patient is good, so that the medicine can be widely applied into clinic. The medicine has the advantages that the L-fucose is used in an early period of the gastrointestinal lesions, the activation of mesenteric lymph node Treg cells is regulated by DC cells, the differentiation potential of colons Th1 and Th17 is inhibited, the generation of bile acid is inhibited by regulating the intestinal flora, the function of inhibiting the contraction and spasm of intestinal muscles is realized by an nNOS path, the intestinal inflammation and weight-losing conditions are improved, and the patient can obtain an obvious long-term prognosis benefit; because of limitations of related existing therapy medicines, namely multiple medicine types, large side effect and poor compliance, a new therapy strategy for treating the patients with the gastrointestinal lesions, such as the inflammatory bowel disease, the functional gastrointestinal disorder and the irritable bowel syndrome, is provided.

The invention relates to the field of biological preparations, and particularly discloses bifidobacterium animalis and application of a compound bacterium preparation prepared from the bifidobacteriumanimalis in preparation of a medicine for treating or preventing avian influenza virus infection. The invention discovers that the bifidobacterium animalis ATCC 25527 can be used for treating animalsinfected by H7N9, and after the bifidobacterium animalis ATCC 25527 is compounded with bifidobacterium pseudolongum ATCC 25526, the effect is better; the compound preparation can regulate the body immune response, remarkably improve weight loss and lung tissue injury caused by H7N9 influenza virus infection, and obviously increase the survival rate of mice infected by the H7N9 influenza virus. The compound probiotic preparation provided by the invention has a remarkable effect of resisting the H7N9 influenza virus infection, and can be effectively used for preventing and treating the avian influenza virus infection.

The invention discloses a sulfonamide compound with tetrahydroquinoline as a core and a preparation method and application of the sulfonamide compound. The sulfonamide compound with tetrahydroquinoline as the core is novel in structure and simple in preparation method, is capable of reducing mature secretion of interleukin IL-1beta by specifically inhibiting activation of NLRP3 inflammasome, thenalleviating inflammatory injury and improving inflammatory microenvironments, has remarkable anti-inflammation activity, and meanwhile has no conspicuous toxicity for THP-1 cells. The compound disclosed by the invention can be prepared as an anti-inflammation medicine for treating inflammation related diseases, including purpurin-related periodic syndromes, inflammatory intestine problems, chronicretardant lung diseases, diabetes, rheumatic arthritis, rheumatoid arthritis, gout, non-alcoholic fatty liver diseases, chronic kidney diseases, atherosclerosis, neurodegenerative diseases and the like.

The invention discloses an application of an andrographolide compound in preparation of a medicine for radiation injury. The andrographolide compound comprises the andrographolide compound, its isomer, a prodrug, a solvate or pharmaceutically acceptable salt; The andrographolide compound has good effect for treating radiation injury.

The invention relates to an anti-oxidation repair mask and a preparation method thereof and belongs to the technical field of cosmetics. Through the high-efficiency antibacterial property of oxidizedsodium alginate, bacteria are killed, a suitable environment is provided for new cells, the production of new collagen elastin and collagen is promoted, cell growth is promoted, the repair of inflammatory aging skin is realized, a protective film is formed on the surface of the cell to reduce the evaporation of moisture on the surface of the skin, water is freely diffused to the stratum corneum, the functions of effectively moisturizing the skin and protecting the cell membrane are obtained, a protective film is formed in the extracellular matrix and the evaporation of water on the skin surface is reduced so that the effect of moisturizing and moistening the skin is obtained. Under strong ultraviolet rays, a special protective film is formed on the cell surface to prevent sunburn, reduce melanin precipitation, effectively prevent aging, relieve local inflammatory reaction of facial hormone-dependent dermatitis and improve facial discomfort so that the facial skin barrier function of the patient is slowly recovered.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine component composition for treating and / or preventing liver and gall diseases. The composition is composed of chlorogenic acid, gallic acid, rhubarb polysaccharide and total saponins of astragalus membranaceus, and the weight part ratio of the chlorogenic acid to the gallic acid to the rhubarb polysaccharide to the total saponins of astragalus membranaceus, is 1:0.2:0.2:0.2 to 1:10:20:30. The invention has the advantages that: the CRGA component medicine can effectively improve the liver function of chronic cholestasis serum, reduce the content of hydroxyproline in liver tissue, and relieve inflammatory injury of liver tissue, interlobular biliary duct hyperplasia and collagenous fiber deposition, the curative effect is superior to that of a combination formula of raw medicinal materials, the medicine components are clear, and the quality is easy to control.

The invention discloses an islet organ with an immune tolerance function as well as a preparation method and an application thereof. The preparation method comprises the following steps: mixing islet-containing cell clusters, mesenchymal stem cells, an immunosuppressant and a scaffold material according to a volume ratio of 1: 1: 0.5: 2.5 to prepare a hydrogel material, and carrying out a cross-linking reaction for 1 h; the islet organ prepared by the invention can well solve the problems of immunological rejection and early ischemia of a host, prolong the function and survival time of an islet graft, improve the effect of clinical islet transplantation, and relieve the pain of patients suffering from type I diabetes in need of long-term insulin treatment.

The invention relates to a new purpose of dendrobium officinale, in particular to application of dendrobium officinale in preparation of a product for preventing or treating endoxemia. The dendrobiumofficinale can inhibit a body inflammatory reaction mediated by endotoxin, and relieve mucosal injuries and intestinal barrier functions caused by the endotoxin. Genesis and development of endoxemia can be interdicted from the links of inhibiting inflammatory injuries mediated by the endotoxin and reducing endotoxin displacement. By means of the modern preparation technology, the dendrobium officinale can be further used for preparing medicine or healthcare food or special medical purpose formula food or common food for treating endoxemia.

The present invnetion relates to a Chinese medicine for curing chronic bronchitis, and is made up by using 16 Chinese medicinal materials of bupleurum root, peach kernel, bitter organe, safflower, white peony root, Chinese angelica root, lygusticum root and others. Said Chinese medicine is a kind of honey pill preparation, and possesses the functions of promoting blood icrculation, removing stasis, moistening the lung, transforming phlegm and raising immunity of human body. Its total effective rate is 98.68%, and ita has no obvious toxic side effect.