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Application of dendrobium officinale in preparation of product for preventing or treating endoxemia

A technology of endotoxemia and Dendrobium candidum, applied in the field of medicine, can solve problems such as damage, clinical application limitations, and large toxic and side effects, and achieve the effects of reducing inflammatory damage, reducing intestinal mucosal damage, and inhibiting secretion

Inactive Publication Date: 2019-06-14
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reliability and durability of the clinical efficacy of lactulose and bile salts need to be further confirmed. Although polymyxin B can neutralize or inactivate the toxicity of endotoxin, it has serious side effects, especially damage to the nervous system and kidneys. make clinical application limited

Method used

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  • Application of dendrobium officinale in preparation of product for preventing or treating endoxemia
  • Application of dendrobium officinale in preparation of product for preventing or treating endoxemia
  • Application of dendrobium officinale in preparation of product for preventing or treating endoxemia

Examples

Experimental program
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Effect test

Embodiment 1

[0013] Example 1 Study on the preventive effect of Dendrobium candidum on endotoxemia

[0014] 40 C57BL / 6J male mice were randomly divided into 4 groups according to body weight statistics after 7 days of adaptive feeding: G1 normal group (NC), G2 model group (MC), G3 Dendrobium officinale broken wall powder suspension group 0.2 g / kg group (DSP-L) and G4 Dendrobium candidum broken wall powder suspension group 0.4g / kg group (DSP-H), 10 in each group. After grouping, intragastric administration was started for 7 consecutive days. After 7 days, G2, G3 and G4 were intraperitoneally injected with LPS at 5 mg / kg to simulate endotoxemia, and the normal control group was given an equal volume of normal saline as a control. Six hours after the injection, blood was collected from the orbit, centrifuged, and plasma was collected. The mice were sacrificed by cervical dislocation, and the jejunum and colon were quickly removed. After being fixed in neutral formalin, the paraffin sections...

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Abstract

The invention relates to a new purpose of dendrobium officinale, in particular to application of dendrobium officinale in preparation of a product for preventing or treating endoxemia. The dendrobiumofficinale can inhibit a body inflammatory reaction mediated by endotoxin, and relieve mucosal injuries and intestinal barrier functions caused by the endotoxin. Genesis and development of endoxemia can be interdicted from the links of inhibiting inflammatory injuries mediated by the endotoxin and reducing endotoxin displacement. By means of the modern preparation technology, the dendrobium officinale can be further used for preparing medicine or healthcare food or special medical purpose formula food or common food for treating endoxemia.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of dendrobium candidum in the preparation of products for preventing or treating endotoxemia. Background technique [0002] Detectable endotoxin in circulating blood is called endotoxemia. Endotoxemia can occur in a variety of diseases, and severe cases can lead to fatal septic shock, multiple organ failure, disseminated intravascular coagulation, etc., and the fatality rate is extremely high. Many critically ill patients with non-gram-negative bacterial infections and patients in stressful states such as trauma, burns, radiation injuries, hemorrhagic shock, chemotherapy, and major cardiovascular surgery are prone to it. Endotoxin in plasma mainly comes from the absorption of intestinal endotoxin, so intestinal endotoxemia is the main cause of death in patients with acute endotoxemia. The cellular damage of endotoxin and its induced inflammatory cyt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P7/00A61P31/04A23L33/105
Inventor 颜美秋吕圭源陈素红楼招欢苏洁杨志远俞静静
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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