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Anti-coronavirus traditional Chinese medicine composition and use thereof in treatment of inflammation

A composition and technology of traditional Chinese medicine, applied in the field of novel coronavirus pneumonia, can solve the problems of no disclosure of decoction decoction or preparation method, unsatisfactory, no disclosure of the influence of inflammatory state, etc., achieve significant curative effect, reduce inflammatory response, The effect of reducing common sequelae

Active Publication Date: 2020-11-06
SHANDONG BUCHANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the traditional Chinese medicine formula used to treat patients with new coronary pneumonia whose TCM syndrome is manifested by dampness and stagnation in the lungs, the formula is taken in the form of decoction (water decoction), but the decoction or preparation method of the decoction is not disclosed in the prior art. No disclosure of its effect on the inflammatory state associated with viral pneumonia
[0005] Therefore, there is an unmet need for traditional Chinese medicine compositions that can effectively treat respiratory diseases such as pneumonia and the inflammatory states associated therewith, especially viral pneumonia such as novel coronavirus pneumonia

Method used

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  • Anti-coronavirus traditional Chinese medicine composition and use thereof in treatment of inflammation
  • Anti-coronavirus traditional Chinese medicine composition and use thereof in treatment of inflammation
  • Anti-coronavirus traditional Chinese medicine composition and use thereof in treatment of inflammation

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preparation example Construction

[0088] In the preparation process of the Chinese medicine active extract of the present invention, the obtained extract is preferably filtered, for example, through a 100-300 mesh sieve, and centrifuged using methods and equipment commonly used in the art.

[0089] Those skilled in the art know that in any embodiment of this aspect, the amount of water added, the extraction time and the number of extractions are not absolute, that is, the corresponding parameter values ​​outside the range and close to the end values ​​of the range are used. It is also possible to achieve the object of the present invention. All obvious variations of the above-described embodiments are therefore intended to be within the scope of the invention.

[0090] According to the Chinese medicine composition of the present invention, besides comprising the Chinese medicine active extract of the present invention involved in any form of the above aspects, it may also contain pharmaceutically acceptable auxi...

Embodiment 1

[0128] The preparation of Chinese medicine composition (granule) of the present invention

[0129] Recipe composition:

[0130] Ephedra 150g, Bitter almond 375g, Gypsum 750g, Coix seed 750g, Atractylodes 250g, Patchouli 375g, Verbena 750g, Polygonum cuspidatum 500g, Reed root 750g, Tinglizi 375g, Huajuhong 375 grams, Artemisia annua 300 grams and licorice 250 grams. Preparation of active extract of traditional Chinese medicine:

[0131] The above thirteen flavors are decocted with licorice alone, and the rest of the medicinal flavors are first extracted with gypsum in ten times the amount of water or alcohol solution for 30 minutes. Filter the filtrate, add Artemisia annua and Huoxiang to the dregs, then add six times the amount of water to extract for 30 minutes, combine the extracts, and concentrate below 60°C; add 10 times the amount of water to extract licorice twice, each time for one hour, and concentrate the filtrate to an appropriate amount The relative density of t...

Embodiment 2

[0135] The preparation of Chinese medicine composition (granule) of the present invention

[0136] Recipe composition:

[0137] 240 grams of ephedra, 600 grams of bitter almonds, 1,200 grams of raw gypsum, 1,200 grams of coix seed, 400 grams of herb, 600 grams of patchouli, 1,200 grams of verbena, 800 grams of knotweed, 1,200 grams of reed root, 600 grams of Tinglizi, and red orange 600 grams, 480 grams of Artemisia annua and 400 grams of licorice.

[0138] Preparation of active extract of traditional Chinese medicine:

[0139] Take the indicated amount of decoction pieces (except licorice) for each batch, decoct twice, add 10 times the water once decocting, first decoct raw gypsum for 30 minutes, then decoct other herbal flavors (except artemisia annua and patchouli) for 60 minutes, filter Get the first decoction extract, add Artemisia annua and patchouli, add 6 times the water along with the first decoction residue, decoct the second decoction for 30 minutes, filter the ex...

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Abstract

The invention relates to a traditional Chinese medicine composition used for treating respiratory diseases and related inflammatory conditions, and a preparation method and use of the traditional Chinese medicine composition. The traditional Chinese medicine composition contains traditional Chinese medicine active extracts. The respiratory diseases include pneumonia, trachitis, bronchitis, chroniccough, asthma, chronic obstructive pulmonary diseases and the like. The traditional Chinese medicine composition in the invention is particularly suitable for treating viral pneumonia and related inflammatory conditions, in particular coronavirus pneumonia, such as novel coronavirus pneumonia (COVID-19).

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, which can be used to treat respiratory diseases such as pneumonia and related inflammatory states, such as coronavirus pneumonia, especially novel coronavirus pneumonia (COVID-19) . Background technique [0002] Coronaviridae viruses are a large class of viruses widely existing in nature, infecting vertebrates, such as humans, mice, pigs, cats, dogs, wolves, chickens, cattle, and birds. The new coronavirus (SARS-CoV-2) belongs to the β-coronavirus in the Coronaviridae family, and its genetic characteristics are significantly different from those of SARSr-CoV and MERSr-CoV. Viruses are sensitive to ultraviolet light and heat. Lipid solvents such as ether, 75% ethanol, chlorine-containing disinfectant, peracetic acid and chloroform can effectively inactivate the virus at 56°C for 30 minutes. Based on the current epidemiologic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P11/00A61P11/06A61P11/14A61P29/00A61P31/14A61K33/06
CPCA61K36/17A61K36/736A61K33/06A61K36/8994A61K36/284A61K36/532A61K36/704A61K36/85A61K36/899A61K36/31A61K36/752A61K36/282A61K36/484A61P31/14A61P11/00A61K2300/00Y02A50/30
Inventor 张伯礼刘清泉高秀梅张俊华宋新波张磊王毅杨丰文郑文科王涛王跃飞张晗黄宇虹王苹刘二伟刘岱琳张静泽黄明
Owner SHANDONG BUCHANG PHARMA
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