Application of 4-methoxybenzyl alcohol in preparation of neuroprotective drugs
A technology of methoxybenzyl alcohol and neuroprotection, which is applied in the field of 4-methoxybenzyl alcohol in the preparation of neuroprotective drugs, and can solve the problems of unseen neuroprotection and the like
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experiment example 14
[0026] Effect of Experimental Example 14-Methoxybenzyl Alcohol on Neuronal Growth
[0027] 1 Experimental materials
[0028] 1.1 Experimental animals
[0029] SD rats, female and male, weighing 180±220 g, were provided by the Institute of Zoology, Sichuan Academy of Medical Sciences, certificate number: 0014842.
[0030] 1.2 Experimental reagents
[0031]
[0032] 1.3 Experimental Instruments
[0033]
[0034] 1.4 Preparation of reagents
[0035] 1.4.10.01% PLL solution
[0036] The 0.1% poly-lysine solution was diluted 10 times with sterile double-distilled water to prepare a 0.01% poly-lysine solution, and placed in a 4°C refrigerator for later use.
[0037] 1.4.2 D-Hanks solution
[0038] Add 0.5ml of double antibody to the D-Hanks solution to make the final concentration 10U / ml, and store in a refrigerator at 4°C.
[0039] 1.4.3 Termination of digestive juice
[0040] The DMEM culture medium and FBS were mixed at a ratio of 9:1 to prepare a DMEM culture mediu...
experiment example 24
[0110] Experimental Example 24-Methoxybenzyl Alcohol Antigen Substitutes the Effect of OGD / Rep Injury on Cortical Neurons
[0111]After cerebral ischemia, the respiration of nerve cells is blocked, and respiratory dysfunction causes mitochondrial dysfunction and affects the energy supply of brain cells; after reperfusion, while restoring oxygen supply, it can lead to a large number of free radicals and intracellular calcium overload , a large increase in reactive oxygen species (reactive oxygen species, ROS) beyond the superoxide dismutase (superoxide dismutase, SOD) and glutathione peroxidase (GSH-Px) defense scavenging capacity, excess ROS attack mitochondria The double bonds of unsaturated fatty acids in membrane phospholipids lead to lipid peroxidation, and the content of malondialdehyde (MDA) increases, further destroying the integrity of mitochondrial membranes, loss of cell function, and brain damage.
[0112] In this experiment, the high-purity cortical neuron obtained...
experiment example 34
[0175] Experimental Example 3: Effect of 4-methoxybenzyl alcohol on the expression of neuronal apoptosis-related proteins
[0176] In the process of cerebral ischemia-reperfusion injury, the death of nerve cells in the ischemic central area is mainly necrosis, while the nerve cells in the penumbra cannot maintain their normal physiological functions, but still have metabolic vitality, and their subsequent death is mainly apoptosis , in the process of nerve cell apoptosis, the mitochondrial apoptosis pathway is extremely important. Studies have shown that the activation of mitochondrial apoptotic pathway is the initiating factor of brain nerve cell apoptosis. After cerebral ischemia, nerve cell respiration is blocked, and respiratory dysfunction reduces ATP synthesis, mitochondrial dysfunction, and affects the energy supply of brain cells; After restoration of reperfusion, while oxygen supply is restored, it can lead to a large number of free radicals and intracellular calcium ...
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