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A biflavonoid compound with neuroprotective effect and its extraction and separation method

A technology of biflavonoids and compounds, applied in the fields of bisflavonoids and their preparation, antidepressant effect, and preparation of neuroprotective drugs, can solve the problems of low economic added value, achieve LDH leakage rate improvement, cell damage protection, The effect of improving the survival rate

Active Publication Date: 2022-06-03
大连五舟神草健康科技有限公司
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

At present, peacock grass is a common flower bed landscape plant, which is rarely used in China and has low economic added value. If the flowers of peacock grass can be recycled and reused after the flowering period, it can not only reduce the burden on the environment but also avoid the waste of resources

Method used

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  • A biflavonoid compound with neuroprotective effect and its extraction and separation method
  • A biflavonoid compound with neuroprotective effect and its extraction and separation method
  • A biflavonoid compound with neuroprotective effect and its extraction and separation method

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

for the test solution

NMR data of the agent.

[0028] Table 1. The nuclear magnetic data of the bisflavonoids.

[0029]

One, the preparation method of double flavonoids.

Step 1, get 8kg of dried peacock grass and cut into powder. The weight ratio of the dried medicinal powder of Malachite grass to the aqueous ethanol solution

1:8-15, reflux extraction 1-3 times, 3-10 hours each time. Preferably, 10 times the amount of 95% ethanol is refluxed for three times, and each time is 6 hours. Pass

Filter, combine the extracts and concentrate. The drug residues were extracted again with ethanol, filtered and combined. Concentrate under reduced pressure until there is no alcohol smell.

[0032] Step 2, extracting and separating the obtained extract in step 1 with 1-12L n-butanol. 10L n-butanol is preferred. Recovered reagents

Silica gel column chromatography with CH

2

Cl

2

‑CH

3

OH (100:0→75:25→75:50→50:50→25:75→0:100, volume ratio)

Gradient elution gave Fr.b.1 ...

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Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a biflavonoid compound extracted from Malachite flower and its preparation method and application. A kind of biflavonoid compound, molecular formula is C 33 h 24 o 16 , named as 8,8'-methylenebis(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-chromone, the chemical structure is as follows , the purposes of the described biflavonoids in the preparation of neuroprotective drugs. The preparation method adopts ethanol extraction, n-butanol extraction, silica gel column chromatography, polyamide, Sephadex LH‑20 successively, and can easily and quickly extract Isolate high-purity biflavonoid compounds, which have neuroprotective effects, and can be prepared in dosage forms such as tablets, granules, and capsules with commonly used pharmaceutical excipients, and are used to improve and treat neurological diseases such as depression. Therefore, biflavones The compounds can be used as a new class of natural products to develop traditional Chinese medicine, and have broad application prospects.

Description

A kind of biflavonoid compound with neuroprotective effect and its extraction and separation method technical field The present invention relates to technical field of traditional Chinese medicine, relate in particular to a kind of double flavonoids extracted from Malachite flower The preparation method thereof and the use thereof in the preparation of a neuroprotective medicine, in particular, have antidepressant effect. Background technique Malachite grass (Tagetes patula L.) is collected in " Guizhou herbal medicine " as Yi nationality medicine, it has heat-clearing properties It has the functions of detoxification, invigorating blood and clearing menstruation, relieving cough, and can effectively relieve symptoms such as toothache, oral ulcers, red eyes, swelling and pain. In South America, living People often use peacock grass as tea to achieve the purpose of lowering blood lipids, protecting liver, lowering blood pressure, preventing and treating cardiovascular ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30C07D311/40A61K31/352A61P25/00A61P25/24
CPCC07D311/30C07D311/40A61P25/00A61P25/24
Inventor 窦德强刘琳琳罗思敏窦培元蔡德成
Owner 大连五舟神草健康科技有限公司
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