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76 results about "Chronic injury" patented technology
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Apparatus and method for detecting swallowing activity
An apparatus and method for detecting swallowing activity is provided. In an embodiment, a method includes receiving an electronic signal from an accelerometer that represents swallowing activity, extracting at least two features from the signal, classifying the signal as a type of swallowing activity based on the extracted features, and generating an output of the classification. Exemplary activities include swallows, aspirations, movement and vocal artifacts. By indicating whether an activity is a swallow or an aspiration, the manner in which a patient afflicted with an increased likelihood for aspirations is fed can be adjusted to increase the likelihood of achieving a swallow instead of an aspiration during feeding. In turn this could reduce hospitalizations for aspiration pneumonia in patients with acute or chronic injury.
Owner:BLOORVIEW KIDS REHAB
System and Method for Detecting Swallowing Activity
A system and method for detecting swallowing activity is provided. In an embodiment, a method includes receiving an electronic signal from an acceleronic signal from an accelerometer that represents swallowing activity, extracting at least two features from the signal, classifying the signal as a type of swallowing activity based on the extracted features, and generating an output of the classification. Exemplary activities include swallows, aspirations, movement and vocal artifacts. By indicating whether an activity is a swallow or an aspiration, the manner in which a patient afflicted with an increased likelihood for aspirations is fed can be adjusted to increase the likelihood of achieving a swallow instead of an aspiration during feeding. In turn this could reduce hospitalizations for aspiration pneumonia in patients with acute or chronic injury.
Owner:HOLLAND BLOORVIEW KIDS REHABILITATION HOSPITAL
Methods for treating neural disorders and conditions, and compounds useful therefor
In accordance with the present invention, there are provided novel compounds that protect neurons and / or promote neuroregeneration and / or promote memory formation. Such compounds are useful for treatment of a variety of neural disorders and conditions. In another aspect of the present invention, there are also provided formulations containing one or more of the above-described compounds, optionally further containing additional neurologically active compound(s) and / or adjuvants to facilitate delivery thereof across the blood / brain barrier. In still another aspect of the present invention, there are further provided methods for treating a wide variety of neurological indications, e.g., acute neural injuries, chronic injuries, promoting memory formation, and the like.
Owner:SALK INST FOR BIOLOGICAL STUDIES
Apparatus and method for detecting aspiration
Owner:BLOORVIEW KIDS REHAB
Specific inhibitors of protein p21 as therapeutic agents
The present invention relates to novel inhibitors of p21. These inhibitors are useful as therapeutic agents for promot ing cell regeneration and in the treatment of cancer. Improvement of cell regeneration is particularly desirable in patients of old age or in patients suffering from chronic diseases, acute or chronic injuries.
Owner:LEIBNIZ INSTITUT FUR ALTERSFORSCHUNG
Methods for treating a variety of diseases and conditions, and compounds useful therefor
In accordance with the present invention, there are provided novel compounds that have a variety of properties, i.e., antioxidant, anti-inflammatory, antiviral, antibacterial, and antifungal properties. Invention compounds, therefore, have the ability to impart a variety of beneficial physiological effects, e.g., to protect neurons and / or to promote neuroregeneration and / or to promote memory formation and / or to act as protein phosphatase or kinase inhibitors and / or to act as lipoxygenase inhibitors. Such compounds are useful for treatment of a variety of indications, including neurodegenerative diseases and conditions, diabetes, ischemia associated with heart disease, and memory deficit. In another aspect of the present invention, there are also provided formulations containing one or more of the above-described compounds, optionally further containing additional neurologically active compound(s) and / or adjuvants to facilitate delivery thereof across the blood / brain barrier. In still another aspect of the present invention, there are further provided methods for treating a wide variety of neurological indications, e.g., acute neural injuries, chronic injuries, promoting memory formation, and the like.
Owner:SALK INST FOR BIOLOGICAL STUDIES
System and method for detecting swallowing activity
A system and method for detecting swallowing activity is provided. In an embodiment, a method includes receiving an electronic signal from an acceleronic signal from an accelerometer that represents swallowing activity, extracting at least two features from the signal, classifying the signal as a type of swallowing activity based on the extracted features, and generating an output of the classification. Exemplary activities include swallows, aspirations, movement and vocal artifacts. By indicating whether an activity is a swallow or an aspiration, the manner in which a patient afflicted with an increased likelihood for aspirations is fed can be adjusted to increase the likelihood of achieving a swallow instead of an aspiration during feeding. In turn this could reduce hospitalizations for aspiration pneumonia in patients with acute or chronic injury.
Owner:HOLLAND BLOORVIEW KIDS REHABILITATION HOSPITAL
Occlusive device for treating septal defect of congenital heart disease
InactiveCN1875894ALess chronic damageSmall mechanical propertiesSurgeryProsthesisHeart septal defectHeart disease
The invention relates the congenital heart disease plugging device, comprising the bevel support 1 and polyester fibre 2. The bevel support 1 is weaved by the nickel-cemented tantalum carbide, and the diameter of 1 is between 0.002-0.003 inch, the 1 is filled with 2, and around the metal wire of 1 there is polydactyl acid, silica gel, polyurethane or other degradable consistency high polymer materials. The invention has the advantages of reducing heavy metal toxicity, low vessel chronic injury and mechanical stimulation, and safety.
Owner:何健峰
Use of Stem Cells to Prevent Neuronal Dieback
PendingUS20110293578A1Reduce retractionReduce harmBiocideNervous disorderNervous systemNeuronal damage
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth / regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and / or promote growth / regeneration of axons.
Owner:ABT HOLDING COMPANY +1
Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system
Proteins that are differentially expressed or elevated in tissue and biofluids after central nervous system injuries are described. Elevated or reduced levels of the proteins, alone or in various combinations or ratios, can be used to assess severity of central nervous system injury (CNS injury) including traumatic brain injury (TBI), traumatic spinal cord injury (SCI) and chronic traumatic encephalopathy (CTE). Time course measurements post CNS-injury of these proteins can be used to monitor progress or recovery over periods up to several months. Differentiation of acute, subacute and chronic injury can be diagnosed by comparing the protein levels in CNS-injury patients at days 1-3, day 4-10 with levels at day 30-180 in comparison with normal controls.
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK +1
Methods for treating neural disorders and conditions, and compounds useful therefor
Owner:SALK INST FOR BIOLOGICAL STUDIES
Pharmaceutical Compositions and Methods
ActiveUS20170128465A1Reduce intensityAvoid adjustmentOrganic active ingredientsNervous disorderDiseaseHydrocortisone
This invention relates the use of cortisol blockers (e.g., glucocorticoid receptor [GR] antagonists) for the treating or preventing viral infections, treating or preventing treatment resistant prostate cancer, treating or preventing neoplasia, and treating or preventing infection related to acute or chronic injury or disease.
Owner:POP TEST ONCOLOGY LIMITED LIABILITY
Pharmaceutical compositions and methods
ActiveUS20170051007A1Good chemical resistanceInhibition of activationOrganic active ingredientsSugar derivativesDiseaseProstate cancer
This invention relates the use of cortisol blockers (e.g., glucocorticoid receptor [GR] antagonists) for the treating or preventing viral infections, treating or preventing treatment resistant prostate cancer, treating or preventing neoplasia, and treating or preventing infection related to acute or chronic injury or disease.
Owner:POP TEST ONCOLOGY LIMITED LIABILITY
External-use drug for treating pain in waist and lower extremities, process and application
InactiveCN105902969AReduce inflammationReduce adhesionAntipyreticAnalgesicsMyrrhCervical spondylosis
The invention relates to the field of drugs, in particular to an external-use drug for treating pain in waist and lower extremities, a process and application. The external-use drug is prepared from radix clematidis, rhizoma et radix notopterygii, radix angelicae pubescentis, rhizoma curcumae, radix notoginseng, radix aconiti, radix aconiti kusnezoffii, black pepper, radix angelicae dahuricae, herb of tuberculate speranskia, frankincense, myrrh, unprocessed rhizoma pinelliae, unprocessed arisaema cum bile, herbal asari, rhizoma drynariae, radix dipsaci, semen strychni, sophorra flavescens, cortex dictamni and fructus kochiae. The external-use drug can efficiently and rapidly treat cervical spondylosis, protrusion of lumbar intervertebral disc, lumbar muscle degeneration, chronic injury diseases and multiple kinds of internal and external rheumatic arthritis, and is wide in disease adaptation range.
Owner:张文
Method for identifying kidney allograft recipients at risk for chronic injury
A method for identifying a renal allograft recipient at risk for chronic allograft damage or interstutial fibrosis and tubular atrophy (IF / TA) by comparing the transcription level of a preselected gene signature set with the transcription level of a comparison standard, and diagnosing the recipient as being at risk for chronic allograft damage if the transcription level of the preselected gene signature set is significantly higher than the transcription level of the comparison standard.
Owner:WESTERN SYDNEY LOCAL HEALTH DISTRICT +1
Apparatus and Method for Detecting Aspiration
An apparatus and method for detecting swallowing activity is provided. In an embodiment, a method includes receiving an electronic signal from an accelerometer that represents swallowing activity, extracting at least two features from the signal, classifying the signal as a type of swallowing activity based on the extracted features, and generating an output of the classification. Exemplary activities include swallows, aspirations, movement and vocal artifacts. By indicating whether an activity is a swallow or an aspiration, the manner in which a patient afflicted with an increased likelihood for aspirations is fed can be adjusted to increase the likelihood of achieving a swallow instead of an aspiration during feeding. In turn this could reduce hospitalizations for aspiration pneumonia in patients with acute or chronic injury.
Owner:BLOORVIEW KIDS REHAB
Application of nicotinamide phosphoribosyltransferase in preparation of neuroprotective drugs
InactiveCN103961691AStimulate or enhance regenerationPromote repairNervous disorderPeptide/protein ingredientsBrain HypoxiaRisk stroke
Belonging to the pharmaceutical field, the invention relates to application of nicotinamide phosphoribosyltransferase (NAMPT) in preparation of neuroprotective and rehabilitation drugs. Experiments of the invention show that NAMPT recombinant protein can penetrate the blood-brain barrier to significantly reduce the volume of ischemic brain injury and alleviate white matter injury after ischemic brain injury; the NAMPT recombinant protein can significantly improve long-term behaviors after ischemic brain injury; the NAMPT recombinant protein can raise revascularization related factors to enhance revascularization after brain hypoxia and neuron regeneration after brain hypoxia, and promote post-injury neurologic function reestablishment; and by mediating oligodendrocyte regeneration and alleviating the demyelination effect of local lysolecithin, the NAMPT recombinant protein can promote restoration of white matter after injury and strengthen post-injury neurologic function reestablishment. Results show that the NAMPT recombinant protein plays a long-term neuroprotective role in drugs treating cerebral stroke, traumatic brain injury and multiple sclerosis, and can be used as a neuroprotective drug to treat acute and chronic injury caused by brain stroke.
Owner:FUDAN UNIV
Implanted titanium mesh realizing temperature self-adjustment and preparation method of implanted titanium mesh
ActiveCN105797209ALess discomfortReduce chronic damageCoatingsMicrocapsulesMaterials scienceThermal protection
The invention discloses an implanted titanium mesh realizing temperature self-adjustment. The implanted titanium mesh comprises a titanium mesh, wherein a phase-change microcapsule layer is formed on the surface of the titanium mesh in a chemical bonding manner. Preferably, the surface of the titanium mesh is treated with acid or alkali in advance, active hydroxyl groups are introduced, the titanium mesh is directly chemically bonded with phase-change microcapsules or chemically bonded with phase-change microcapsules through a coupling agent; the coupling agent is used for introducing reactive active chemical groups, and the active chemical groups comprise one or more of hydroxyl groups, carboxyl groups, amino groups and halogen substituent groups. According to the implanted titanium mesh realizing temperature self-adjustment, the phase-change microcapsule layer can absorb, store and release a large amount of latent heat of phase change and, accordingly, has the functions of energy storage, environmental temperature adjustment, thermal protection and the like, due to existence of the phase-change microcapsule layer, the implanted titanium mesh cannot be influenced or is seldom influenced by external temperature difference, and chronic injuries to cerebral tissue and subcutaneous exudate are reduced.
Owner:THE SECOND PEOPLES HOSPITAL OF SHENZHEN
Use of stem cells to prevent neuronal dieback
InactiveUS20150093364A1Reduced and prevented adhesionIncreased neurite outgrowth/regenerationBiocideNervous disorderNervous systemNeuronal damage
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth / regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and / or promote growth / regeneration of axons.
Owner:ABT HOLDING COMPANY +1
Composition for neuronal regeneration comprising myelin-specific antibodies and complement proteins
Novel compositions are described comprising the combined administration of serum complement proteins with complement-fixing antibodies. The antibodies specifically bind to one or more epitopes of myelin, and complement proteins. These compositions are useful for promoting regrowth, repair, and regeneration of neurons in the CNS of a mammalian subject. The compositions and method can be used following immediate or chronic injury.
Owner:THE UNIV OF BRITISH COLUMBIA
Small square type rheumatoid swelling diminishing and pain eliminating plaster and preparation method thereof
ActiveCN102416049APromote absorptionHydroxy compound active ingredientsAntipyreticMonkshoodsSide effect
The invention discloses a small square type rheumatoid swelling diminishing and pain eliminating plaster, and belongs to the field of Chinese medicinal preparations. The plaster includes Chinese medicinal ingredients, a matrix and a carrier, and is characterized in that: the Chinese medicinal ingredients are mainly prepared through compatibility of processed kusnezoff monkshood root, processed monkshood, Chinese wild ginger, cinnamon, corydalis tuber, paniculate swallowwort root, frankincense, myrrh, borneol, wild celery, notopterygium root, angelica, ephedra, szechuan lovage rhizome, acanthopanax bark, bark of eucommia, divaricate saposhnikovia root, root of largeleaf gentian, loose knot and the like, and has the effects of promoting blood circulation and removing obstruction in channels, dispelling wind-evil, eliminating pain and diminishing swelling. The plaster has a better curative effect on neck and shoulder pain, lumbocrural pain, rheumatoid pain, hyperostosis and acute and chronic injury of soft tissues. The plaster has the advantages of quickly relieving pain and promoting local blood circulation, along with durable efficacy, less allergy, good clinical curative effect, no toxic or side effect, obvious effect, effectiveness ratio of 81.3-94.4 percent and broad market prospect.
Owner:常西海
Method for identifying kidney allograft recipients at risk for chronic injury
ActiveUS10941446B2Microbiological testing/measurementFermentationCardiac allograftAllotransplantation
A method for identifying a renal allograft recipient at risk for chronic allograft damage or interstutial fibrosis and tubular atrophy (IF / TA) by comparing the transcription level of a preselected gene signature set with the transcription level of a comparison standard, and diagnosing the recipient as being at risk for chronic allograft damage if the transcription level of the preselected gene signature set is significantly higher than the transcription level of the comparison standard.
Owner:WESTERN SYDNEY LOCAL HEALTH DISTRICT +1
Specific modulators of connexin hemichannels
Owner:PONTIFISIA UNIVERSIDAD KATOLIKA DE CHILE
Method for repair of acute and chronic injury, such as burned and photodamaged skin
InactiveUS20130202540A1Improve permeabilityFast penetrationCosmetic preparationsToilet preparationsDiazolidinylureaSide chain
A chemical compound and a method for its use as a topical medication that can reverse the effects of sun-damage, reverse the signs of aging, demonstrate anti-scarring properties and allow for the treatment of acne while still permitting the patient the ability to simultaneously expose the affected area to the sun without damage that includes a combination of curcumin, alcohol, carbomer, diazolidinylurea, additional penetration enhancer—such as alliin, additional agent capable of blocking both UVA and UVB such as pearl powder, anti-inflammatory agent such as aloe vera, water, glycerin and preservative as needed, and an acidifying agent to product the correct pH. Allinin is used as an s-allyl side chain to increase the penetration of curcumin into the cells. Pearl powder is used to block the effects harmful UVA and UVB.
Owner:HENG MADALENE C Y
Safety cone placing device and method
InactiveUS20090274541A1Easy resistanceImprove securityRefuse receptaclesTraffic signalsMobile vehicleEngineering
Automatic placement of safety cones from a moving vehicle is provided. The preferred safety cone would have a flexible cone part. A receptacle holds a plurality of safety cones either with the flexible cone part in non-compressed position or in spring-loaded position. The receptacle is removably attached to the vehicle. A releasing means that is attached to the receptacle is controlled and advances the safety cones in an automatic and controlled fashion, one-by-one, to different locations on a ground surface from a moving vehicle. The advantage is that it automatically handles the placement of a plurality of safety cones while driving. There would be no more need for a person to manually place the safety cones. It provides for increased road safety since it decreases or even eliminates the number of fatal or non-fatal accidents as well as chronic injuries of road-workers that are involved in placing safety cones.
Owner:WORLDWIDE SAFETY
Compositions for the debridement, granulation and reepithelialization of wounds in man
InactiveUS20140030365A1Stimulate and assist processStimulate and assist and recoveryBiocideUnknown materialsEtiologyNatural product
Compositions for topical application based on natural products, specifically dried pulverized plants suspended in bees honey, in which the ingredients are combined in proportions predetermined to provide three different types of preparations to be applied at various stages of repair and regeneration of injured tissues. The application of the compositions shortens the stages of healing in the treatment of acute and chronic injuries of any degree of depth and breadth, and of any etiology.The properties of the preparations include an hemorheological and systemic vascular activity which extends for a certain period even after the end of topical treatment.
Owner:ANGULO BORJA VICTOR HUGO
Pharmaceutical composition for treating or preventing nerve damage
ActiveCN110075274AEasy to passFunction increaseOrganic active ingredientsNervous disorderMuscle strengthLeontopodium alpinum extract
The invention provides a pharmaceutical composition for treating or preventing nerve damage. The pharmaceutical composition comprises the following components: asiaticoside, an Aloe vera extract, a sweetsop seed extract, a leontopodium alpinum extract, and a vascular endothelial growth factor (VEGF). The pharmaceutical composition of the invention is useful for inducing neurite outgrowth, for promoting stem cell function, and / or for promoting functional recovery and enhancing synapse formation and synaptic plasticity in damaged and / or injured neurons in acute and chronic injury, and can significantly alleviate impaired sciatic nerve function, increase nerve conduction velocity, increase axon count, and repair axons. Clinical studies show that the pharmaceutical composition of the inventioncan improve muscle strength, accelerate repair of damaged nerve tissue, and improve nerve tissue transmission and metabolic disorders in patients with peripheral nerve injury.
Owner:GUANGDONG MEDICAL UNIV +1
Use of Stem Cells to Prevent Neuronal Dieback
InactiveUS20140186307A1Reduced and prevented adhesionIncreased neurite outgrowth/regenerationBiocideNervous disorderNervous systemNeuronal damage
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth / regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and / or promote growth / regeneration of axons.
Owner:CASE WESTERN RESERVE UNIV +1
External application type traditional Chinese medicine and application method thereof
InactiveCN108310347AImprove body immunityTo achieve the function of health careNervous disorderAntipyreticCannabisSciatica
The invention discloses an external application type traditional Chinese medicine and an application method thereof. The external application type traditional Chinese medicine is prepared from the following medicines in parts by mass: 3 to 8 parts of flos caryophylli, 2 to 10 parts of cortex cinnamomi, 2 to 10 parts of fennel, 2 to 10 parts of rhizoma zingiberis recens, 1 to 10 parts of rhizoma zingiberis, 2 to 10 parts of fructus chaenomelis, 2 to 10 parts of semen sinapis albae, 2 to 10 parts of rhizoma polygonati, 2 to 10 parts of fructus mume, 3 to 8 parts of fructus cannabis, 1 to 3 partsof semen pruni, 3 to 8 parts of Chinese prickly ash, 3 to 8 parts of fructus alpiniae oxyphyllae, 1 to 2 parts of semen persicae, 2 to 10 parts of radix angelicae dahuricae, 2 to 8 parts of orange peel and 2 to 10 parts of raspberry fruit. The external application type traditional Chinese medicine can be used for improving the body immunity, has health-maintenance and health-care functions, has the effects of strengthening muscles and bones and warming waist and knees and has prevention and health-care effects on back pain, lumbar disc herniation, bone spur, belly flatulence, irregular menstruation, dysmenorrhea, cold wombs, pelvic inflammation, appendagitis, osteoproliferation, knee aching and limp, knee crymodynia and sounds, dropsy, pains, ache and swelling, numbness, synovitis, meniscus injuries, gonitis, knee chronic injuries, sciatica and the like.
Owner:丹阳市上古本真健康科技有限公司
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