99 results about "Sleep Latencies" patented technology

For a processor having a plurality of sequential stages, variable (or idiosyncratic) wake-up latencies and a method for managing power in such a processor are provided. Each sequential stage includes one or more logic blocks and one or more power switches. A power controller can measure wake-up latencies for the logic blocks and control the power switches of the logic blocks by referring to the measured wake-up latencies, respectively.

For a processor having a plurality of sequential stages, variable (or idiosyncratic) wake-up latencies and a method for managing power in such a processor are provided. Each sequential stage includes one or more logic blocks and one or more power switches. A power controller can measure wake-up latencies for the logic blocks and control the power switches of the logic blocks by referring to the measured wake-up latencies, respectively.

Apparatuses and methods to enhance sleep, reduce sleep onset latency, extend sleep duration and / or increasing the duration of deeper sleep stages relative to stage 1 sleep. In general, these apparatuses and methods apply and maintain one or more target “warm” temperatures to a subject's forehead for a time period. The target temperature may be between 25° C. and 42° C. The target temperature may be a fixed amount greater than ambient temperature. The time period may be a fixed time period or a variable time period. These methods and apparatuses may limit the application of thermal energy to the subject's forehead region.

An illumination system (1) includes a lighting device (3); a manipulation device (6) for a user to manipulate when the user intends to fall asleep; a control unit (2) for detecting a start time of measuring a sleep latency based on a manipulation time at which the manipulation device is manipulated, the sleep latency being a time period from a time at which the user intends to fall asleep to a time at which the user falls asleep; and a memory unit (14) for storing a reference time obtained based on the start time of measuring the sleep latency detected by the control unit. The control unit includes a lighting device control (15) subunit performing an illumination control to reduce the user's melatonin suppression from a preset timing before the reference time stored in the memory.

Apparatuses and methods to enhance sleep, reduce sleep onset latency, extend sleep duration and / or increasing the duration of deeper sleep stages relative to stage 1 sleep. In general, these apparatuses and methods apply and maintain one or more target “warm” temperatures to a subject's forehead for a time period. The target temperature may be between 25° C. and 42° C. The target temperature may be a fixed amount greater than ambient temperature. The time period may be a fixed time period or a variable time period. These methods and apparatuses may limit the application of thermal energy to the subject's forehead region.

The invention relates to the prediction of a sleep parameter (e.g., sleep efficiency (SE), latency to persistent sleep (LPS), wake after sleep onset (WASO), total sleep time (TST)) of an individual and the response of such an individual to a sleep inducing compound based on the individual's PER3 variable number tandem repeat (VNTR) genotype.

A sleep aiding apparatus for increasing the duration of deep sleep and / or reducing the sleep latency of a subject is disclosed. The sleep aiding apparatus comprises a pillow body and a device to play a sleep aiding music. Also disclosed herein are methods for aiding sleep, by providing the sleep aiding apparatus to a subject in need thereof.

The invention discloses a lactobacillus brevis capable of relieving anxiety and improving sleep and application of the lactobacillus brevis, and belongs to the technical field of microorganisms. The lactobacillus brevis GDMCC No.60605 can survive well in simulated gastrointestinal tract and has excellent cell adhesion and GABA production abilities. In an open-field experiment, the frequency of mice entering a central area can be significantly increased, and the time of the mice staying n the open-field central area is prolonged without affecting the total movement distance of the mice. In a high plus maze test, the number of times of the mice entering open arms can be significantly increased, the pentobarbital sodium induced sleep time can be prolonged, the pentobarbital sodium induced sleep latency can be shortened, the intestinal flora can be adjusted, and the relative abundance of Allobaculum in the intestines of the mice is significantly increased. The lactobacillus brevis GDMCC No.60605 is used for preparing a pharmaceutical composition and a fermented food capable of relieving anxiety and improving sleep, and has a very wide application prospect.

Apparatuses (including devices, kits, and systems) and methods to non-invasively and chemically (rather than thermally) activate thermoreceptors to modulate sleep. For example, described herein are apparatuses including topical compositions that stimulate thermoreceptors on the subject's skin (e.g., forehead, hands, and / or feet) for a period of time to induce a sensation of temperature (heat or cold) without significantly altering the person's actual skin temperature to improve sleep quality, including reducing sleep-onset latency, enhancing depth of sleep, and / or extending the amount of time a subject sleeps. The subject may be suffering from insomnia or some other sleep disorder.

The present disclosure pertains to a system and method for determining sleep onset latency in a subject. The system is configured to generate output signals conveying information related to brain activity in the subject, determine sleep stages of the subject based on the output signals, determine a sleep onset moment in the subject based on the determined sleep stages, determine a sleep intention moment for the subject by: (i) detecting eye blinks in the subject based on the output signals, and determining the sleep intention moment responsive to the detected eye blinks ceasing for a predetermined period of time; and / or (ii) determining whether brain activity power in a target frequency band has breached a threshold power level based on the output signals, and determining the sleep intention moment responsive to a breach; and determine the sleep onset latency based on the sleep onset moment and the sleep intention moment.

Disclosed is a novel use of rice, rice bran or rice hull extract as a histamine receptor antagonist. The rice, rice bran or rice hull extract may be used as a natural antihistamine to prevent or treat allergic rhinitis, inflammatory bowel disease, asthma, bronchitis, nausea, gastric and duodenal ulcer, gastroesophageal reflux disease, sleep disorder, anxiety and depression. It provides comparable or better effect of decreasing sleep latency, increasing sleep duration and increasing non-REM sleep as compared to diazepam, which is currently used as sleeping drug. Derived from the natural product rice, rice bran or rice hull, it has no side effect such as cognitive impairment, resistance or dependency even after long-term use.

The invention discloses a nattokinase and melatonin composition capable of improving sleep and a preparation method thereof, and belongs to the field of health foods. The composition is prepared fromnattokinase and melatonin, the fibrinolysis activity of the nattokinase in 1g of composition is 500-1000IU, and the content of the melatonin is 0.1mg / g. The preparation method comprises the steps: (1)preparing nattokinase fermentation liquid by using bacillus subtilis capable of producing a high yield of nattokinase, taking the supernatant liquid after centrifuging and performing ultrafiltrationconcentration, and performing vacuum drying to obtain nattokinase freeze-dried powder; and (2) mixing the nattokinase freeze-dried powder with melatonin powder, and adding auxiliary materials. The nattokinase and melatonin composition takes the nattokinase and the melatonin as raw materials, and the two components play a synergistic effect on sleep. Proven by experiments, the nattokinase and melatonin composition disclosed by the invention can obviously prolong the pentobarbital sodium sleep time and shorten the barbital sodium sleep latency, and has a function of enhancing and improving sleep.

The invention relates to the field of traditional Chinese medicines and in particular discloses a traditional Chinese medicine composition for improving sleep. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of spina date seed, 15-25 parts of lucid ganoderma, 15-20 parts of acanthopanax and 5-15 parts of schisandra chinensis. According to the traditional Chinese medicine composition disclosed by the invention, the sleep time of a pentobarbital sodium hypnosis mouse can be prolonged; the sleep onset latency of the pentobarbital sodium hypnosis mouse is shortened; and the traditional Chinese medicine composition does not have an obvious direct sleeping effect and does not have bad effect on the weight of the mouse. The invention also provides a method for preparing the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention is a pure traditional Chinese medicine preparation, does not have a toxic or side effect and has good application prospects, and the sleep can be effectively improved.

The invention discloses an application of a composition of bacillus subtilis BS01 and ganoderma lucidum spore powder in improving sleep. According to the invention, with the combination of bacillus subtilis BS01 and ganoderma lucidum spore powder, mice sleep latency time and serum MDA content can be substantially reduced. Mice sleep time, subliminal hypnotic sleep rate, CAT activity, GSH-Px activity and SOD activity are respectively improved by 54.36%, 43.75%, 98.13%, 49.27% ??and 12.61%. With the composition of bacillus subtilis BS01 and ganoderma lucidum spore powder, mice sleep quality is effectively improved. The composition can be used for preparing biological products used for improving sleep.

The invention provides agents for phase-adjusting or enhancing the amplitude of an endogenous melatonin secretion rhythm and for improving a circadian rhythm, which may be taken daily and continuously, have excellent safety, and may effectively prevent or ameliorate disorders of an endogenous melatonin secretion rhythm or of a circadian rhythm without administration of exogenous melatonin, as well as functional food containing such an agent, which may prevent or ameliorate various symptoms, such as sleep disorder or prolonged sleep latency. The agent for phase-adjusting or enhancing the amplitude of an endogenous melatonin secretion rhythm according to the invention contains whey as the active component. The functional food for improving an endogenous melatonin secretion rhythm according to the invention contains the agent for phase-adjusting or enhancing the amplitude of an endogenous melatonin secretion rhythm. The functional food for improving a circadian rhythm contains the agent for improving a circadian rhythm.

A combination of (S)—N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide with a medicine capable of prolonging a slow-wave sleep time provides a preventive or therapeutic agent for sleep disorder that induces natural sleep, shortens sleep latency, increases deep sleep, excels in sleep maintenance and ensures an appropriate sleep time.

The invention relates to the field of medicines, and discloses new application of 5,6,4'-trihydroxyl flavone-7-O-beta-D-glucuronide methyl ester to the field of pharmacy and a medicinal composition as well as a preparation thereof. The 5,6,4'-trihydroxyl flavone-7-O-beta-D-glucuronide methyl ester has the effects of improving sleep, such as prolonging sleep time, improving sleep incidence rate, shortening sleep latency and delaying aging, and can be used for preparing medicaments or health-care products for improving sleep and delaying aging.

The invention discloses a milk-derived polypeptide protein beverage capable of relieving pressure and helping sleep. The milk-derived polypeptide protein beverage comprises the following main components: raw milk, hydrolyzed casein powder, casein phosphopeptides, whey protein hydrolysate, gamma-aminobutyric acid, coconut powder, passion flower concentrated juice, concentrated pear juice and asparagus powder. The invention further discloses a preparation method of the polypeptide protein beverage. The prepared polypeptide protein beverage has the functions of shortening the sleep incubation period, reducing sleep interference, reducing body disorder, improving the conscious sleep quality, prolonging the sleep time and improving the sleep efficiency, and achieves the effects of relieving pressure and improving sleep.

The invention discloses a traditional Chinese medicine composition for treating insomnia, which is mainly prepared from the following raw material drugs in portion by weight: 5 to 15 portions of dactylicapnos root, 3 to 10 portions of grassleaf sweelflag rhizome, and 1 to 5 portions of Szechuan lovage rhizome. The invention also discloses a method for preparing crude drug powder, active component liquid medicine and dry extract powder of the traditional Chinese medicine composition. The traditional Chinese medicine composition has a simple formulation, and has the efficacies of tranquilizing and allaying excitement, activating blood and promoting Qi. Pharmacodynamics research results show that the traditional Chinese medicine composition applied by lavage can remarkably shorten the sleep latency of mice induced by sodium pentobarbital of threshold dosage, prolong sleep time, strengthen the hypnotic effects of the sodium pentobarbital of the threshold dosage, induce the mice given with the sodium pentobarbital of the sub-threshold dosage, and strengthen the hypnotic effects of the sodium pentobarbital of the sub-threshold dosage.

The invention discloses a sleep quality evaluation method. The method comprises the following steps: S1, monitoring all-night sleep of a subject to obtain an all-night sleep staging chart; S2, analyzing the all-night sleep staging chart, calculating seven index values including the total sleep duration, the sleep latency, the awakening frequency, the total awakening duration ratio, the REM period ratio, the light sleep period ratio and the deep sleep period ratio, and then dividing the four indexes including the total sleep duration, the REM period ratio, the light sleep period ratio and the deep sleep period ratio into first-type indexes, dividing the sleeping latency, the awakening frequency and the awakening total duration proportion are divided into second-type indexes; S3, calculating single scores of the seven indexes respectively; S4, comprehensively weighting the scores of the indexes to obtain a total score; evaluating the sleep quality according to the obtained total score, if the total score is larger than or equal to 80, indicating the sleep quality is good, wherein the higher the score is, the better the sleep quality is; and if the total score is lower than 80, indicating the sleep quality is poor.

The invention relates to a sleep-aiding small molecule peptide solid beverage and a preparation method and application thereof. The sleep-aiding small molecular peptide solid beverage comprises sturgeon skin oligopeptide, wheat oligopeptide, chinese walnut oligopeptide, cow milk oligopeptide, gamma-aminobutyric acid, N-acetylneuraminic acid and composite vitamins. The sleep-aiding small molecularpeptide solid beverage is green and natural in raw materials, fine and mellow in taste and obvious in sleep-aiding effect, the sleep latency time can be greatly shortened, the sleep validity time is prolonged, and the defects of unobvious effect and great side effect of an existing sleep-aiding product are overcome to a great extent.

The present disclosure pertains to a system and method for providing sleep positional therapy and paced breathing to a user for a sleep session. The system and method may be used to treat positional obstructive sleep apnea, positional snoring, and / or other conditions to improve sleep onset latency, relaxation, reduce blood pressure, and / or improve other physiological characteristics. The system includes a posture sensor, a sensory stimulator, a controller, and / or other components. The system is configured to generate information related to a posture of the user, determine whether the posture of the user has breached a posture threshold, provide vibrations to the user to prompt the user to change posture, and lead the user through a paced breathing exercise to help the user fall asleep.

The invention discloses a medicine for improving sleep and a preparation method thereof. The medicine is mainly prepared from rhizoma polygonati, rhizoma gastrodiae, radix polygalae, radix pseudostellariae, lucid ganoderma and poria cocos. The medicine has effects of shortening sleep latency and prolonging sleep period, simultaneously prolonging convulsion latency and reducing convulsion death rate, has the advantages of safety and no side effects, and can be taken for a long time.

The invention discloses a melatonin preparation for improving sleeping and a preparation method thereof. The melatonin preparation is prepared from the following raw materials in parts by weight: 1 to 3 parts of melatonin, 130 to 170 parts of starch, 100 to 156 parts of white granulated sugar, 70 to 144 parts of dextrin, 2 to 6 parts of talcum powder, 2 to 6 parts of magnesium stearate and 0.2 to 2 parts of sodium carboxymethylcellulose. The melatonin preparation for improving sleeping has the characteristics of safety, no toxicity, good taste, less dose and no dependence. Tests show that the melatonin preparation has the advantages that the sleeping time of nembutal can be obviously extended, the hypnotic effect of subthreshold dose of the nembutal is cooperated, the sleep latency of the nembutal is shortened, and a function of obviously improving sleeping is realized.

The invention discloses an application of Naqu 4580 probiotics in a food for improving the sleep quality, and belongs to the technical field of microorganisms. The sleep conditions of people of different age groups are obviously improved within two weeks after taking of the Naqu 4580, and along with the prolonging of the time of taking the Naqu 4580, the improvement effect is more obvious and theimprovement rate is 93% or above; and the number of effective days of taking is intensively 3-4, and the symptoms are more obviously improved, namely, the sleeping latency is shortened, the sleeping time is prolonged, and the symptom of awakening at midnight is improved.

The invention belongs to the technical field of biological medicines, and discloses a beta-sitosterol derivative as well as a preparation method and application thereof. The beta-sitosterol derivativecan be assembled with avidin to form nanoparticles. Animal tests prove that the beta-sitosterol derivative and the nano-drug thereof can obviously reduce the sleep latency time of mice, significantlyimprove the sleep time and the subthreshold hypnotic sleep rate of the mice, can effectively improve the sleep quality of the mice, and can be used for further preparing drugs or health products forimproving the sleep quality.

The invention discloses an application of Bacillussubtilis BS01 fermented ganoderma lucidum spore powder in sleep improvement. The Bacillussubtilis BS01 fermented ganoderma lucidum spore powder has the functions of obviously reducing the sleep latency time of mice and MDA (methane dicarboxylic aldehyde) content of serum. The sleeping time, the subliminal sleeping rate, the T-AOC (total antioxidative capacity) activity, the SOD (superoxide dismutase) activity, the CAT (catalase) activity and the GSH-Px (glutathione peroxidase) activity of mice are respectively enhanced by 41.44%, 66.67%, 24.66%, 19.49%, 55.68% and 31.27%. The Bacillussubtilis BS01 fermentation ganoderma lucidum spore powder effectively improves the sleeping quality of mice, enhances the antioxidant ability of serum, and can be used for preparing microecologics for sleeping improvement.

The invention relates to a detailed classifying system for sleep incubation period. Existing detailed classifying systems for sleep incubation period are complex in calculation process and low in classification precision. The system comprises a processor and a basic data collector, the processor collects the basic data of a user through the basic data collector, and acquires the detailed sleep state of the user in the sleep incubation period through calculation. The system can provide an operation basis for subsequent sleep aiding equipment, simplify the system structure, improve the calculation efficiency and operation energy consumption, improve the wearing comfort, and improve the use experience.

The invention discloses a tortoise small peptide. The tortoise small peptide has any one of the following amino acid sequences: W-W-Y-W-R-Hex; W-G-P-G-B; W-R-W-X-H-T-H-N-W. The invention further discloses a preparation method and application of the tortoise small peptide. The tortoise small peptide can significantly shorten the sleep latency period of mice and prolong the sleep time, has a good sleep promoting effect, is clear in structural composition, stable in physical and chemical properties, more controllable in quality and easier to guarantee in efficacy compared with existing polypeptides, can be prepared by a synthesis method, and is beneficial to reducing resource waste and lowering the production cost.