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Novel usage of rice, rice bran, or chaff extract as histamine receptor antagonist

A technology of histamine receptors and extracts, applied in the field of histamine receptor antagonists, can solve problems such as not knowing

Inactive Publication Date: 2014-02-05
KOREA FOOD RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the relationship between rice, rice bran or rice husk and histamine receptor antagonists or between allergic diseases such as allergic rhinitis or asthma, diseases related to hyperacid secretion, sleep, anxiety or depression relationship is not yet known

Method used

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  • Novel usage of rice, rice bran, or chaff extract as histamine receptor antagonist
  • Novel usage of rice, rice bran, or chaff extract as histamine receptor antagonist
  • Novel usage of rice, rice bran, or chaff extract as histamine receptor antagonist

Examples

Experimental program
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Embodiment

[0068] Examples and experiments will now be described. The following examples and experiments are for illustrative purposes only and are not intended to limit the scope of the present disclosure.

[0069] [experimental method]

[0070] experimental animals

[0071] ICR mice (18 g to 22 g, male) and SD rats (200 g to 250 g, male) were obtained from Koatech and Orient Bio, respectively, and allowed to acclimatize in a cage for 1 week before performing experiments. Animals were housed at 23±1° C., humidity 55±5%, 12 / 12 hour light / dark cycle (light from 9 am to 9 pm, 3000 Lux), and provided food and water without restriction. All animals were managed in accordance with the guidelines of the Korea Food Research Institutional Animal Care and Use Committee (KFRI-IACUC).

[0072] pentobarbital-induced sleep test

[0073] Pentobarbital-induced sleep tests were performed at fixed times between 1pm and 5pm. Ten (n=10) mice per group were fasted for 24 hours prior to testing. All te...

preparation Embodiment 1

[0076] Preparation Example 1: Preparation of Rice Extract

[0077] Rice water extract (RWE) was prepared by adding distilled water (1 L) to powdered rice (100 g) and heating at 100 °C for 1 hour by adding 10-fold (w / v) 70% ethanol to powdered rice The rice ethanol extract (REE) was prepared by extracting in a 50°C incubator for 1 day, followed by ultrasonic treatment 3 times for 90 minutes each time. The resulting extract was filtered, concentrated under reduced pressure, lyophilized and prepared into a powder. The yield of RWE was 1.16% by weight and that of REE was 0.19% by weight.

preparation Embodiment 2

[0078] Preparation Example 2: Preparation of rice husk extract.

[0079] Rice husk water extract (HWE) was prepared by adding distilled water (1 L) to powdered rice husk (100 g) and heating at 100 °C for 1 hour, and by adding 10 times (w / v) The rice husk ethanol extract (HEE) was prepared by using 70% ethanol and extracting in a 50°C incubator for 1 day, followed by ultrasonic treatment 3 times for 90 minutes each time. The resulting extract was filtered, concentrated under reduced pressure, lyophilized and prepared into a powder. The yield was 5% for HWE and 0.96% for HEE.

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Abstract

Disclosed is a novel use of rice, rice bran or rice hull extract as a histamine receptor antagonist. The rice, rice bran or rice hull extract may be used as a natural antihistamine to prevent or treat allergic rhinitis, inflammatory bowel disease, asthma, bronchitis, nausea, gastric and duodenal ulcer, gastroesophageal reflux disease, sleep disorder, anxiety and depression. It provides comparable or better effect of decreasing sleep latency, increasing sleep duration and increasing non-REM sleep as compared to diazepam, which is currently used as sleeping drug. Derived from the natural product rice, rice bran or rice hull, it has no side effect such as cognitive impairment, resistance or dependency even after long-term use.

Description

technical field [0001] The present disclosure relates to novel uses of rice, rice bran or rice husk extracts as histamine receptor antagonists. Also relates to extracts comprising rice, rice bran or rice husk as an active ingredient for the prevention or treatment of allergic rhinitis, inflammatory bowel disease, asthma, bronchitis, nausea, gastric and duodenal ulcers, gastroesophageal reflux disease, Composition of sleep disorders, anxiety and depression. Background technique [0002] 1 / 3 of the average person's life is spent in sleep. Sleep is the most basic and essential physiological process, important for the maintenance of health and mental stability. Chronic sleep deficits and disorders have negative impacts on physical and mental health, including cardiovascular disease and hypertension, memory and learning, metabolic regulation and body weight, immunity and resistance to cancer, diabetes, neglect accidents, mood, and more. Currently, it is estimated that 30% of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P37/08A61P25/24A61P11/06
CPCA61K2236/13A61K36/899A61P1/04A61P1/08A61P11/00A61P11/02A61P11/06A61P25/00A61P25/20A61P25/22A61P25/24A61P37/08A61P43/00
Inventor 曹承睦韩大锡金铜洙白南仁陈映昊韩镇圭成在英金仁镐李昌镐
Owner KOREA FOOD RES INST
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