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Preparation method of spaceflight depression syndrome animal model

An animal model and technology of stagnation syndrome, which is applied in the field of preparation of spaceflight stagnation syndrome animal models, can solve problems affecting physical and mental health, increase the mental burden of astronauts, and achieve the effect of preventing related things from happening

Inactive Publication Date: 2021-01-05
63919 TROOPS PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These will increase the mental burden of astronauts to varying degrees and affect their physical and mental health. On the other hand, staying in space for a long time, monotonous and repetitive work will also make astronauts feel depressed

Method used

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  • Preparation method of spaceflight depression syndrome animal model
  • Preparation method of spaceflight depression syndrome animal model
  • Preparation method of spaceflight depression syndrome animal model

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Embodiment Construction

[0016] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0017] 1. Preparation of an animal model of aerospace depression syndrome

[0018] 2.1.1 Materials and methods

[0019] a. Reagents and equipment

[0020] The computer image real-time detection, analysis and processing system for the open field experiment (jointly developed by the Institute of Medicinal Plants, Chinese Academy of Medical Sciences, the Chinese Astronaut Research and Training Center, and Beijing Sunway Tuomeng Digital ...

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Abstract

The invention belongs to the technical field of animal model preparation, and particularly relates to preparation method of a spaceflight depression syndrome animal model. The method comprises the steps of S1, spaceflight depression syndrome model molding, namely adopting closed isolated culture, simulated weightlessness, noise and circadian rhythms to verify the condition of accepting simulated spaceflight stress stimulation of adult SD male rats; and S2, spaceflight depression syndrome model behavioristics evaluation, namely detecting a depression syndrome state condition through a sweet water preference experiment, an open field experiment, a Morris water maze experiment, a step-down experiment and a forced swimming experiment. According to the simulated weightlessness manner, a Chen Jie improved tail crane is adopted, and an angle of 30 degrees is formed between the body and the horizontal plane; for day and night rhythm change, day and night alternation of space flight in 90 minutes in a light and shade period is simulated through light control; and for the step-down experiment, an electrified copper grid is laid at the bottom of a reaction box, animals are shocked by electricshock, and for a normal reaction, the animals jump onto an insulating platform in the box to avoid harmful stimulation. Through model establishment, the influence of different conditions on the depression syndrome of an astronaut is studied.

Description

technical field [0001] The invention belongs to the technical field of animal model preparation, and in particular relates to a preparation method of an animal model of aerospace depression syndrome. Background technique [0002] In the process of space flight, astronauts face a special and complex space environment, including the influences caused by overweight, weightlessness, noise, vibration, shock, and curve acceleration of the vehicle and the spacecraft, and the internal and external environment of the spacecraft. The influence of factors, such as the small environment in the cabin, atmospheric pressure, harmful gases, radiation, meteors, meteorites, etc., all of these factors can affect the body and mind of the human body individually, comprehensively, indirectly or directly. These will increase the mental burden of astronauts to varying degrees and affect their physical and mental health. On the other hand, staying in space for a long time and monotonous and repetiti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A01K29/00
CPCA01K67/02A01K29/005A01K2267/03
Inventor 李勇枝刘军莲范全春武晓瑞赵爽高建义王佳平刘宇
Owner 63919 TROOPS PLA
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