The invention discloses a preparation method of a nose bridge prosthesis for plastic surgery, relates to the field of orthopedic medical technology, and aims to solve the problem that the existing silicone rubber nose bridge prosthesis is easy to shift and to be worn after being implanted. The preparation method comprises the following steps: a, pressing a nose back part substrate and a nose tip part substrate; b, surface treating of the nose back part substrate; and c, connecting the nose back part substrate and the nose tip part substrate. The surface treating of the nose back part substrate comprises the following steps: (1), preparation, preparing casting feed liquid; (2), infusion, submerging the nose back part substrate totally into the feed liquid and drying after taking out; (3), sanding, performing sanding operation to the nose back part substrate after submerging; and (4), vulcanization, vulcanizing, cleaning and drying the nose back part substrate after sanding. The invention is especially suitable for manufacturing the nose bridge prosthesis.