40 results about "Tic disorder" patented technology

The present invention relates to a method of treating disorders including cognition impairment, generalized anxiety disorder, acute stress disorder, social phobia, simple phobias, pre-menstrual dysphoric disorder, social anxiety disorder, major depressive disorder, eating disorders, obesity, anorexia nervosa, bulimia nervosa, binge eating disorder, substance abuse disorders, chemical dependencies, nicotine addiction, cocaine addiction, alcohol addiction, amphetamine addiction, Lesch-Nyhan syndrome, neurodegenerative diseases, late luteal phase syndrome, narcolepsy, psychiatric symptoms anger, rejection sensitivity, movement disorders, extrapyramidal syndrome, Tic disorder, restless leg syndrome, tardive dyskinesia, sleep related eating disorder, night eating syndrome, stress urinary incontinence, migraine, neuropathic pain, diabetic neuropathy, fibromyalgia syndrome, chronic fatigue syndrome, sexual dysfunction, premature ejaculation, and male impotence. This method involves administering to a patient in need of such treatment a therapeutically effective amount of a disclosed compound. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.

The present invention relates to a method of treating disorders including cognition impairment, generalized anxiety disorder, acute stress disorder, social phobia, simple phobias, pre-menstrual dysphoric disorder, social anxiety disorder, major depressive disorder, eating disorders, obesity, anorexia nervosa, bulimia nervosa, binge eating disorder, substance abuse disorders, chemical dependencies, nicotine addiction, cocaine addiction, alcohol addiction, amphetamine addiction, Lesch-Nyhan syndrome, neurodegenerative diseases, late luteal phase syndrome, narcolepsy, psychiatric symptoms anger, rejection sensitivity, movement disorders, extrapyramidal syndrome, Tic disorder, restless leg syndrome, tardive dyskinesia, sleep related eating disorder, night eating syndrome, stress urinary incontinence, migraine, neuropathic pain, diabetic neuropathy, fibromyalgia syndrome, chronic fatigue syndrome, sexual dysfunction, premature ejaculation, and male impotence. This method involves administering to a patient in need of such treatment a therapeutically effective amount of a disclosed compound. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.

The present invention describes a novel treatment for movement disorders, including tardive dyskinesia, tic disorders, Tourette's syndrome, and blepharospasm, and other focal dystonias. The treatment of the present invention utilizes agents that simultaneously act as NMDA-type glutamate receptor antagonists and GABA-A receptor agonists. Preferably these two activities are characteristic of a single agent, for example acamprosate. Alternatively, separate agents having these activities can be combined and administered together. The invention also provides a third agent that acts as a non-competitive NMDA-receptor blocking agent or ion channel blocker that augments the effect of the primary treatment. A particularly preferred ion channel blocking agent is magnesium. Alternatively, magnesium can be administered alone for prevention and treatment of movement disorders.

The present invention provides a method of treating attention deficit / hyperactivity disorder (AD / HD) and associated tic disorders in an animal subject comprising administering an effective amount of an anti-AD / HD compound or a pharmaceutically acceptable salt thereof. The anti-AD / HD compound useful in the present invention is characterized by ant-AD / HD and anti-tic properties and exhibits at least two distinct pharmacological activities. In particular, the use of milnacipran to treat AD / HD and comorbid tic and psychiatric disorders is disclosed.

The present invention relates to (−)-1-(3,4-dichlorophenyl )-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing a disorder alleviated by inhibiting dopamine reuptake. In certain embodiments the methods and compositions of the invention are effective for treating attention-deficit disorder, depression, obesity, Parkinson's disease, a tic disorder, and / or an addictive disorder. In more detailed embodiments, methods and compositions of the invention are provided for treating an alcohol-related addictive disorder, for example alcohol abuse, alcohol dependence, excess alcohol consumption, and / or alcohol withdrawal. The (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof may be employed within the methods and compositions of the invention in a form or composition that is substantially free of its corresponding (+)-enantiomer.

Tic disorders can be improved by administering theanine, an amino acid that crosses the blood-brain barrier, or a dipeptide consisting of theanine and a different amino acid. In addition, these compositions can be added to foods and drinks or pharmaceuticals.

The invention relates to a Chinese traditional medicine for curing multiple tic disorder, including 5 to 10 parts of processed rehmanniae, 1 to 7 parts of white paeony root, 1 to 5 parts of rhizoma gastrodiae, 2 to 6 parts of acori graminei rhizoma, 2 to 8 parts of nacre, and 2 to 8 parts of thinleaf milkwort root according to the weight proportion. The medicine can be made into pills, capsules, grains and oral liquid preparation and has the functions of calming liver wind and eliminating phlegm for resuscitation and can well control the unconscious tics and vocalization, with the total cure rate over 92 percent.

The present invention relates to (-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing a disorder alleviated by inhibiting dopamine reuptake. In one embodiment, the disorder is attention-deficit disorder, depression, obesity, Parkinson's disease, a tic disorder, or an addictive disorder. The (-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof is preferably substantially free of its corresponding (+)-enantiomer.

The present invention describes a novel treatment for movement disorders, including tardive dyskinesia, tic disorders, Tourette's syndrome, and blepharospasm, and other focal dystonias. The treatment of the present invention utilizes agents that simultaneously act as NMDA-type glutamate receptor antagonists and GABA-A receptor agonists. Preferably these two activities are characteristic of a single agent, for example acamprosate. Alternatively, separate agents having these activities can be combined and administered together. The invention also provides a third agent that acts as a non-competitive NMDA-receptor blocking agent or ion channel blocker that augments the effect of the primary treatment. A particularly preferred ion channel blocking agent is magnesium. Alternatively, magnesium can be administered alone for prevention and treatment of movement disorders.

The invention discloses a medicinal composition for treating children with tic disorders and a preparation method thereof, aiming at solving the problem on treating the children with tic disorders. The medicinal composition is characterized by comprising the following raw medicinal materials in weight proportion: 10-30 parts of prepared rehmannia root, 6-12 parts of common macrocarpium fruit, 3-10 parts of pinellia tuber, 6-12 parts of bamboo shavings, 3-10 parts of fruit of immature citron, 6-12 parts of common yam rhizome, 6-12 parts of tangerine peel, 6-12 parts of oriental waterplantain rhizome, 6-12 parts of moutan bark, 9-15 parts of poria cocos, 3-10 parts of prepared licorice, 15-30 parts of drgon's bones, 15-30 parts of oyster, 6-15 parts of earthworm, 5-9 parts of stiff silkworm, 6-12 parts of uncaria, 6-12 parts of cicada slough, 3-9 parts of grassleaf sweelflag rhizome, and 10-25 parts of nacre. Clinical experiments prove that the medicinal composition has the characteristics of good curative effect and higher safety for treating the children with tic disorders and is worthy of clinical application and popularization.

The invention relates to a medicament for treating tic disorder diseases. An effective medicament for treating tic disorder diseases is mainly prepared from the following Chinese herbal medicines in part by weight: 6 to 10 parts of tall gastrodia tuber, 6 to 10 parts of gambir plant and 1 to 5 parts of scorpion; and a quick-acting medicament for treating tic disorder diseases is mainly prepared from the following Chinese herbal medicines in part by weight: 10 to 50 parts of scorpion and 1 to 3 parts of borneol. The invention also provides application of the effective medicament and the quick-acting medicament for treating tic disorder diseases. The medicaments are mixed on the basis of the principle of 'monarch, minister, assistant and guide' of Chinese medicines, and pharmacodynamic experiments prove that the medicaments have obvious curative effect and small toxic and side effects.

The invention relates to a tic disorder illness monitoring method and system based on a vision and voice fusion technology. Image and sound information of a monitored person is continuously obtained,real-time judgment is performed on movement and sound production tic of the monitored person, the obtained tic information is stored in a database according to a judgment result, then a diagnosis result is fed back to related personnel in time after database information of the monitored person is analyzed and diagnosed, and continuous monitoring is performed. According to the invention, the illness state of the monitored person can be found in a natural state without attracting attention of the monitored person, and the monitored person is reminded of timely treatment and correction accordingto the serious illness state. The problems that when manual monitoring is relied on, intentional self-control of the monitored person is likely to be caused, the illness state is insufficient to show,and the morbidity situation of a patient suffering from dysphagia cannot be monitored in real time for a long time are solved, and more accurate adjuvant therapy information can be provided for medical staff.

The present invention relates to the use of a composition made from Clerodendrum for treating tic disorder or sensorimotor gating deficits, wherein the composition is particularly made from the leaves of the plant.

The invention relates to a medicament for treating tic disorder disease. The medicament is prepared from the following bulk drugs in parts by weight: 8-12 parts of cortex albiziae, 3-7 parts of rhizoma acori graminei, 6-8 parts of agrimonia pilosa, 3-5 parts of herba ardisiae japonicae, 8-15 parts of radix polygonati officinalis and 10-20 parts of radix rehmanniae praeparata. The medicament selects pure-natural traditional Chinese medicines, conforms to the assistance and guide principle of the traditional Chinese medicine according to the whole formula, and has obvious curative effects on stereotyped behaviors and open field activity through the pharmacological experimental verification.

The invention relates to a medicine for curing epilepsy, belonging to the technical field of Chinese traditional medicine. The medicine is made by the following raw materials by weight: 1 to 30 parts of bezoar, 1 to 30 parts of muskiness, 1 to 30 parts of pearl, 1 to 50 parts of cinnabar, 1 to 30 parts of amber, 1 to 50 parts of bulbus fritilariae, 1 to 100 parts of talc,1 to 100 parts of pure gold, 0 to 10 parts of rhino horn and 0 to 15 parts of antelope horn, powder is preferential. The invention has simple composition, precise component, convenient production, good and rapid efficacy and is mainly used for curing epilepsy of childhood, acute and chronic infantile convulsion, anonymous high fever, hyperactivity, tic disorder and noctambulism, with the effective rate of 100percent, cure rate of 98percent, taking effect 1 to3 days later. According to the illness state and age, the patient can be healed in 100 to 180 days.

The invention discloses a medicinal composition for treating children with tic disorders and a preparation method thereof, aiming at solving the problem on treating the children with tic disorders. The medicinal composition is characterized by comprising the following raw medicinal materials in weight proportion: 10-30 parts of prepared rehmannia root, 6-12 parts of common macrocarpium fruit, 3-10 parts of pinellia tuber, 6-12 parts of bamboo shavings, 3-10 parts of fruit of immature citron, 6-12 parts of common yam rhizome, 6-12 parts of tangerine peel, 6-12 parts of oriental waterplantain rhizome, 6-12 parts of moutan bark, 9-15 parts of poria cocos, 3-10 parts of prepared licorice, 15-30 parts of drgon's bones, 15-30 parts of oyster, 6-15 parts of earthworm, 5-9 parts of stiff silkworm, 6-12 parts of uncaria, 6-12 parts of cicada slough, 3-9 parts of grassleaf sweelflag rhizome, and 10-25 parts of nacre. Clinical experiments prove that the medicinal composition has the characteristics of good curative effect and higher safety for treating the children with tic disorders and is worthy of clinical application and popularization.

The invention relates to a quick-acting medicament for curing a tic disorder disease. The medicament is mainly prepared from the following raw material medicaments in part by weight: 10 to 50 parts of scorpion and 1 to 3 parts of borneol. The medicament is mainly prepared from the following raw material medicaments in part by weight: 27 parts of scorpion and 2 parts of borneol. The invention also provides application of the quick-acting medicament for curing the tic disorder disease in preparing medicaments for preventing and curing acute exacerbation of the tic disorder disease. The quick-acting medicament for curing the tic disorder disease can quickly control involuntary behaviors of patients, and experiments show that the effecting time of a quick-acting wind dispelling and action stopping No. 1 formula and a quick-acting No. 2 formula is about 5 minutes.

The present invention discloses a transcranial nerve regulation tic disorder treatment instrument and a method for preventing from misoperation. The method comprises the following steps of: S4: changing an intensity gear of a current from a first gear to a second gear; S6: determining whether the step S4 is a misoperation or not; and S8: when determining that the step S4 is not the misoperation, changing the current intensity from a first intensity to a second intensity, and when determining the step S4 is the misoperation, allowing the current intensity not to be changed from the first intensity to the second intensity. A misoperation determination module is employed to determine whether current change of a treatment instrument is operated by operators or operated by mistake, and the current change of a treatment instrument is operated by mistake, the motion of current change is not executed so as to avoid the damaging for patients caused by current change due to misoperation.

The invention surprisingly found that Lactobacillus plantarum subsp. plantarum PS128 provides an advantageous effect in treatment or prevention of tic disorders and basal ganglia disorders. Accordingly, the invention provides a method of treating or preventing a movement disorder in a subject, comprising administering to a subject an effective amount of cells of a Lactobacillus plantarum subsp. plantarum PS128, which is deposited under DSMZ Accession No. DSM 28632.

The invention discloses an auxiliary screening system for tic disorder based on video data, which uses video data to automatically identify tic symptoms, uses a three-dimensional convolutional neural network based on multi-instance learning, and uses a combination of three-dimensional channel attention and three-dimensional spatial attention modules to The features learned by the three-dimensional convolutional neural network are optimized, and the loss function is optimized by using time smoothing constraints, which can improve the model's ability to detect tics, and combine the health information questionnaire data transformed from clinical inquiries to form an auxiliary screening system for tics, which improves Screening and identification efficiency, and reduce the stress and discomfort of patients in unfamiliar environments through non-direct contact. The present invention simplifies the most time-consuming symptom observation process through video data collection and twitch detection, and through data fusion analysis and visualization, provides screening patients with preliminary cognition of diseases, and also provides references for doctors' follow-up diagnosis and treatment and basis.

The invention belongs to the technical field of traditional Chinese medicine and particularly relates to traditional Chinese medicine for treating children tic disorder and a preparing method thereof. By weight, the traditional Chinese medicine for treating children tic disorder is prepared by the following traditional Chinese medicine active ingredients: 10-20 parts of polygonatum odoratum, 7-11 parts of cinnamon, 4-8 parts of radix pseudostellariae, 4-8 parts of roasted rhizoma atractylodis macrocephalae, 4-8 parts of astragalus membranaceus, 4-8 parts of hawthorn, 2-4 parts of fresh ginger, 2-4 parts of medicated leaven and 2-4 parts of malt. The traditional Chinese medicine for treating children tic disorder can be prepared into paste through extraction, has the efficacy of warming and dredging the channels, moistening dryness and nourishing the muscle and tendon, and spasmolysis, and is used for clinic treatment of children tic disorder. The traditional Chinese medicine for treating children tic disorder has the advantages of being high in the cure rate and the effective rate, free of untoward effect and good in long-term efficacy.

The invention provides a traditional Chinese medicine composition for treating epilepsy, tic and ADHD, and belongs to the technical field of traditional Chinese medicine formulas. It includes the following traditional Chinese medicine components in parts by weight: 3-10 g of Chuan Fritillaria, 5-10 g of Pinellia, 3-6 g of Poria cocos, 5-10 g of Fushen, 3-6 g of Dannanxing, 3-6 g of Shichangpu g, 3-6 g of licorice, 5-15 g of salvia miltiorrhiza, 5-15 g of Ophiopogon japonicus, 10-15 g of keel, 10-30 g of oysters, and 5-10 g of polygala. The components of various Chinese medicines are mixed in proportion, and the traditional Chinese medicine decoction or Chinese medicine drink can be prepared according to the conventional method. The invention adopts pure traditional Chinese medicine preparation, which is safe and has no side effects. It adopts the treatment methods of treating both symptoms and root causes, different diseases with the same treatment, and treating the root of the disease. Through the reasonable proportioning of various Chinese medicines, the whole prescription has the functions of eliminating phlegm, calming epilepsy, calming wind and relieving spasm, It can effectively control the onset of epilepsy, tics and hyperactivity, and achieve effective control of the onset of the disease, cure and eradicate the disease. the goal of.

The invention discloses a group of metabolic markers for diagnosing attention deficit hyperactivity disorder combined with tic disorder, and the metabolic markers comprise one or more of FAPy-adenine, N-acetyl aspartyl glutamic acid, dopamine 4-sulfate, aminocaproic acid and asparagine-leucine, and the metabolic markers comprise one or more of FAPy-adenine, N-acetyl aspartyl glutamic acid, dopamine 4-sulfate, aminocaproic acid and asparagine-leucine, and are used for preparing an early screening and diagnosis product for attention deficit hyperactivity disorder and tic disorder; when the metabolic marker is used for early screening and diagnosis of attention deficit hyperactivity disorder and tic disorder, high specificity and sensitivity are achieved, and the metabolic marker has guiding significance on development of follow-up clinical application research.

The invention discloses a blood plasma metabolic marker related to the diagnosis of Tourette syndrome (TS) in children and its application. The markers are L-arginine and D-pipericolic acid. The markers of the present invention can diagnose the risk of TS in children from the perspective of metabolites, and the results are accurate, objective and reliable, can well distinguish the TS group from the normal group, can accurately and sensitively evaluate the risk of TS, and only need to provide blood samples It can be carried out without other tissue samples, greatly improving the possibility and feasibility of clinical application, and providing guidance for clinicians to formulate early diagnosis and intervention plans.

The invention relates to the field of medical instruments, and provides a device for treating tic disorder placed in an oral cavity, which comprises a fixing part sleeving teeth of an upper and / or lower jaw, wherein the fixing part comprises an outer side wall positioned at the outer side of the teeth, an inner side wall positioned at the inner side of the teeth and an occlusal surface positionedat the end part of the teeth and connected with the outer side wall and the inner side wall respectively; the inner side wall can wrap the edge of the front part of a tongue; and a plurality of contacts are arranged at the outer side of the outer side wall and the inner side of the inner side wall. When the oral cavity is still, the stimulation formed by the contacts continuously regulates the degree of muscle tension innervated by the brain; when the oral cavity moves, the stimulation signal increases the regulation of the degree of muscle tension of the brain so as to reduce the occurrence of transient, rapid and repeated muscle tic; through the bite force of the upper jaw and the lower jaw and the motion of oral bones, muscles, tendons and mucous membranes are excited to excite the brain center, the output of neural information is actively fed back and adjusted, and the motion tension of the mouth is adjusted, so that the occurrence of involuntary tic is reduced.

The present invention refers to the use of a medicament for the paediatric treatment of RLS and / or Tic Disorder and / or Tourette's Syndrom.

The invention discloses a traditional Chinese medicine preparation for treating multiple tic disorders in children. The traditional Chinese medicine preparation has effects of calming the liver and suppressing yang, clearing heat and calming the liver, and extinguishing wind and relieving convulsion. The treatment effect on the multiple tic disorders in children is good, and the traditional Chinese medicine preparation takes effect quickly and has no toxic and side effects. The medicinal active ingredients of the traditional Chinese medicine preparation are made of 3-12 parts of uncaria, 4.5-9parts of szechwan chinaberry fruit, 3-15 parts of raw abalone shell, 6-12 parts of wolfberry, 6-9 parts of tribulus terrestris, 10-15 parts of radix rehmanniae, 10-30 parts of prepared rehmannia root, 4.5-9 parts of earthworm prepared with wine, 3-6 parts of scorpion, 3-10 parts of cicada slough and 3-9 parts of licorice root. The raw materials are weighed according to the component ratio, all medicines except the uncaria are placed in a medicine decocting appliance for decoction for 1-5 times, and liquid medicines are combined; and the uncaria is placed in the combined liquid medicines for continuing to be decocted for 15-20 min, to obtain the liquid medicines.