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Application of metabolic marker in diagnosis of ADHD combined tic disorder in children

A technology of metabolic markers and metabolites is applied in the application field of urinary metabolic markers in children with attention deficit hyperactivity disorder combined with tic disorder, which can solve problems such as deficiency and achieve the effect of high specificity and sensitivity

Active Publication Date: 2022-01-21
BEIJING CHILDRENS HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some researchers have found that there are some ADHD disease-related differentially expressed metabolites in plasma[13], but there is still a lack of urine metabolomics-related research on children with ADHD and tic disorders, and the metabolic markers in urine need further research. explore

Method used

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  • Application of metabolic marker in diagnosis of ADHD combined tic disorder in children
  • Application of metabolic marker in diagnosis of ADHD combined tic disorder in children
  • Application of metabolic marker in diagnosis of ADHD combined tic disorder in children

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Screening and identification of metabolites related to ADHD combined with tic disorder in children's urine

[0042] The inventors used liquid chromatography-high resolution mass spectrometry (LC-MS) to detect metabolites in urine through full-scan mode, and screened metabolites related to ADHD combined with tic disorder through multivariate statistical analysis. The identification of metabolic markers is carried out by the matching or analysis of the secondary fragments using the secondary targeted analysis method.

[0043] 1. Materials and Reagents

[0044] 1) Instruments: Waters H-class liquid chromatograph (Waters Company) LTQ-Orbitrap mass spectrometer (Thermofisher Scientific Company).

[0045] 2) Main reagents: acetonitrile (Thermofisher Scientific Company); C18 reverse-phase chromatographic column (3.0 mm×100 mm, C18, 1.7 μm, Waters Company).

[0046] 3) Sample: 21 children with ADHD combined with tic disorder and 46 age- and gender-matched healthy ch...

Embodiment 2

[0068] Example 2 verification group

[0069] The inventor collected the urine of 11 children with ADHD combined with tic disorder and 17 healthy children, and used liquid chromatography-high resolution mass spectrometry (LC-MS) to detect N-acetylaspartyl glutamine in the samples through full-scan mode detection ROC curve was used to evaluate the diagnostic effect of five metabolite combinations on ADHD complicated with tic disorder. The results showed that the AUC value of five metabolite combination diagnosis was 0.918 (95% CI, 0.75 to 1) ( Figure 4 ), and further, it was verified that these five metabolites have good diagnostic effects.

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Abstract

The invention discloses a group of metabolic markers for diagnosing attention deficit hyperactivity disorder combined with tic disorder, and the metabolic markers comprise one or more of FAPy-adenine, N-acetyl aspartyl glutamic acid, dopamine 4-sulfate, aminocaproic acid and asparagine-leucine, and the metabolic markers comprise one or more of FAPy-adenine, N-acetyl aspartyl glutamic acid, dopamine 4-sulfate, aminocaproic acid and asparagine-leucine, and are used for preparing an early screening and diagnosis product for attention deficit hyperactivity disorder and tic disorder; when the metabolic marker is used for early screening and diagnosis of attention deficit hyperactivity disorder and tic disorder, high specificity and sensitivity are achieved, and the metabolic marker has guiding significance on development of follow-up clinical application research.

Description

technical field [0001] The invention relates to the field of biological detection, in particular to the application of urine metabolic markers in children's attention deficit hyperactivity disorder combined with tic disorder. Background technique [0002] Attention deficit hyperactivity disorder (ADHD), also known as ADHD, is the most common neurodevelopmental disorder in children and adolescents. [0003] ADHD is a behavioral disorder characterized by attention deficit, impulsivity, and hyperactivity that is out of proportion to a child's development and is associated with immature brain function [1;2]. At present, the prevalence of ADHD in children and adolescents worldwide is about 5% [1]. The latest population-based cross-sectional survey in the United States shows that the prevalence of ADHD has continued to rise in the past two decades [3]. Meta-analysis of ADHD among children in my country reported that the overall prevalence rate was as high as 5.6% [4] to 6.26% [5]...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N27/62G01N24/08G01N33/68
CPCG01N30/02G01N27/62G01N24/08G01N33/6848
Inventor 田晓怡宋文琪
Owner BEIJING CHILDRENS HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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