152 results about "Mucous layer" patented technology

A preparation method of an anti Helicobacter pylori active antibacterial peptide gastric mucosa nanoparticle delivery system. Helicobacter pylori is highly sensitive to the antibacterial peptide and does not generate resistance to the antibacterial peptide, and the antibacterial peptide nanoparticles have short acting time on Helicobacter pylori. Compared with an antibacterial peptide suspension, the antibacterial peptide nanoparticles stay a long time in the gastric mucosa, are not easy to be damaged by gastric acid and protease, and have very strong gastric mucous layer permeability to increase the concentration of antimicrobial peptides in the gastric mucosa, and are conducive to inhibit and kill planting Helicobacter pylori in the gastric mucosa. The antibacterial peptide nanoparticles have the function of eliminating Helicobacter pylori infection under lower amount of drug. The invention provides a novel approach and dosage form for the treatment of Helicobacter pylori.

The invention provides a method for treating sewage into reclaimed water by active organisms. The method comprises the following steps: throwing a biological antiseptic disinfectant in sewage, stirring for 10 to 60 seconds, throwing a biological activity purifying agent in the sewage, stirring to obtain recycled water on the upper layer and flocculent settling matters on the lower layer, sending the recycled water on the upper layer to a water circulating system for reuse, periodically discharging the flocculent settling matters on the lower layer, and using the flocculent settling matters as greening fertilizers. Through the addition of the biological activity purifying agent, the leading role of beneficial microorganisms is highlighted, and the capability of the beneficial microorganisms in eating a great number of nutrient substances is enhanced greatly, so that the propagation and the growth of the beneficial microorganisms are accelerated, harmful bacteria in raw wastewater are extinguished quickly due to shortage of food, organic matters in water are absorbed and degraded quickly while the propagation of the beneficial microorganisms is accelerated, lots of impurities in water are absorbed through mucous layers and the capsule structures on the surfaces of the cells of the beneficial microorganisms, and finally the sewage is purified quickly to become recycled water.

The invention relates to medicine-carried black phosphorus shell glycan composite nanospheres and a preparation method and application thereof. The medicine-carried black phosphorus shell glycan composite nanospheres are glycan nanospheres of which the surface modified with polyethylene glycol, and which are packed with black phosphorus quantum dots and medicines. The black phosphorus quantum dots, glycan and polyethylene glycol are creatively combined, the advantage of synergy is exerted, and the protective screen of a respiratory tract mucous layer and a pathogenic bacteria biomembrane can be efficiently broken through, so that the nanospheres have favorable capacity of carrying and delivering medicines, and the nanospheres are broad in application range. According to the nanospheres, various treatment medicines can be loaded, the treatment effect of the medicines can be increased, and the bad toxic and side effects can be reduced. Besides, the nanospheres have favorable biocompatibility. The medicine-carried black phosphorus shell glycan composite nanospheres provide a new strategy for treatment of respiratory diseases.

The invention discloses a preparation technology of nano-micelles for conveying anti-tumor medicines through oral administration, namely a preparation method of nano-micelles with mucous layer permeation and P-gp inhibition dual effects. Chitosan, quercetin and 6-phosphogluconic acid are used as raw materials to prepare an amphiphilic chitosan-quercetin succinate-6-phosphogluconic acid copolymer through a condensation and esterification method and a target product is synthesized through a self-assembling technology; the nano-micelles have a good mucous layer permeation capability and also has the P-gp inhibition effect; the oral administration conveying efficiency of the anti-tumor medicines can be effectively improved. The nano-micelles can be used for medical biological materials and medicine carriers and have good research and development application prospects.

The invention discloses a preparation method of short amylase-insulin or short amylase-insulin-procyanidine nanocomposite. The preparation method comprises the steps of mixing short amylase with insulin or mixing short amylase, insulin and procyanidine, and carrying out retrogradation, so as to obtain short amylase-insulin or short amylase-insulin-procyanidine nanocomposite. The short amylase-insulin or short amylase-insulin-procyanidine nanocomposite is relatively small in particle size and can tightly adhere to a membrane adhesion layer of a small intestine, so that the standing time in the stomach and intestine is prolonged, meanwhile, a mucous layer barrier, an enzyme barrier and an epithelial barrier existing in an alimentary system can be overcome, and the bioavailability of oral insulin is increased.

The invention provides toothpaste for inhibiting helicobacter pylori and a preparation method thereof. The toothpaste is prepared from pure herbal materials, has a simple and reasonable formula, can be used for effectively removing helicobacter pylori bred under the mucous layer of the stomach under the action of cool foods. The toothpaste has low production cost, quick response, no toxic or side effect and good bubbling effect.

The present invention presents a pharmaceutical composition for oral use with improved absorption, which comprises drug, aminoalkyl methacrylate copolymer E, and acidic substance and is obtained by bringing said 3 components together and uniformly mixing at least this polymer and this acidic substance, and a method of improving oral absorption / by using this pharmaceutical composition. Moreover, the present invention presents an agent for improving oral absorption that increases drug permeability of the digestive tract mucous membrane and / or mucous layer present on the surface of this membrane, whose active ingredient is aminoalkyl methacrylate copolymer E. In addition, the present invention presents an oral agent for improving absorption by increasing drug permeability of the digestive tract mucous membrane and / or the mucous layer distributed over this mucous membrane, whose effective component is aminoalkyl methacrylate copolymer E.

The invention discloses a vaginal substrate material and a preparation method thereof, wherein a vaginal tissue mucous layer of a pig or a cow is taken as a carrier, and is subjected to the following treatment: a, carrying out shocking treatment by adopting deionized water solution containing phenylmethylsulfonyl fluoride or Tris solution; b, carrying out shocking treatment in a water solution containing lauryl sodium sulfate or Tris-HCl buffer solution; c, carrying out shocking treatment by adopting Tris-HCl buffer solution containing Triton X-100; d, carrying out shocking treatment in Tris-HCl buffer solution containing deoxyribonuclease and ribonuclease; and e, carrying out disinfection and freeze-drying. The vaginal substrate material provided by the invention has the biological activity and the biological mechanical property more suitable for pelvic floor repairing or vagina reconstruction.

The invention relates to a uterine cavity implant as well as a preparation method and application thereof. The uterine cavity implant is characterized by having a bagged structure. The uterine cavity implant comprises a substrate material of animal small intestine submucosa subjected to decellularization treatment. An implantable medical device for preventing and treating intrauterine adhesion comprises a biological tissue substrate material. The present decellularization technology for a biological repairing material is improved; compared with the present product, the biological tissue substrate material provided by the invention has the advantages of lower DNA residual quantity, lower immunogenicity, higher anti-infection capacity and higher repairing capacity; and the uterine cavity implant is beneficial to the recovering of tissues, such as, uterine cavity base layer, submucosa and mucous layer. Besides, the invention prepares the biological repairing material into the uterine cavity built-in structure which is used for isolating wound surfaces, repairing uterine cavity tissues and reducing scar forming, so that the intrauterine adhesion problem is solved, and the accordingly generated sterility problem also can be solved.

The invention relates to a palate mouth cavity model simulation method and palate mouth cavity models for teaching. A palate skeleton and a plurality of mucous layers are adopted, wherein the palate skeleton is provided with an upper dentition and corresponding gingivae. Each mucous layer is matched with the palate skeleton in shape and provided with tooth holes corresponding to the dentition, and a symptom structure corresponding to one of palate symptoms. The mucous layers provided with the different palate symptoms are respectively connected with the dentition on the palate skeleton in a penetrating mode through the tooth holes to be in adsorbed connection to the palate skeleton, and the various corresponding palate mouth cavity models are formed. The relative soft and elastic mucous layers are arranged on the palate skeleton made of hard materials, the characteristic that the palate symptoms are mainly centralized on mucous membranes is utilized, the mucous layers and the palate skeleton are made into a separable mode, the various symptoms of the mucous membranes are arranged on the corresponding mucous layers respectively, the palate skeleton is matched with the mucous layers in a one-to-one mode, the mouth cavity models are formed, the cost of the teaching aids is greatly reduced, and meanwhile the models are quite vivid.

The invention discloses a processing process of natural sausage casings. The processing process comprises the steps of cleaning primitive intestines, soaking, removing mucous layers and muscle layers from intestines, flushing by high-pressure water filling, checking by water filling, measuring the size, pickling, and discharging from a bucket and storing, wherein a physical repeated freeze-thaw method is combined with a chemical bioenzyme digestion method in the process of removing the mucous layers and the muscle layers from the intestines. The processing process is simple; due to the physical repeated freeze-thaw method, cell membranes can be effectively broken, cell contents are released, and the subsequent chemical bioenzyme digestion method can be conveniently carried out, so that cell membranes and organelle structures in tissues can be broken and cells can be separated from matrixes to generate a cell removal effect; the tissues in the intestines are flushed out by adopting the high-pressure water filling process; the process is favorable for quickly removing the tissues except for the casings to obtain light, thin and transparent casings with good color and luster; in addition, the large-scale modern production of the casings can be realized, and the industry development is promoted while the production efficiency is improved.

The invention provides a preparation method of a trachea substitute. The preparation method comprises the following steps: eliminating antigens of an animal-derived tracheal tissue; compounding vascular endothelial growth factors (VEGF) with the outer wall of the trachea substitute; and compounding epidermal growth factors (EGF) with the inner wall of the substitute, wherein antigen elimination is carried out on a cartilage layer on the outer wall of a trachea and a lower muscular layer of a mucous layer on the inner wall of the trachea. The trachea substitute prepared by the method is derived from the animal tracheal tissue, has a specific C-shaped cartilaginous ring structure of a natural trachea, is formed by connecting compact connective tissues, has elasticity, can extend and contract longitudinally, and can moderately expand when gas passes through the substitute; and the prepared trachea substitute can keep the trachea unobstructed for a long time after transplantation, can notcollapse, and has good integration effect with a host without obvious rejection reaction. The preparation method has the advantages of simpleness, wide raw material source and low cost; and the medical cost can be reduced and the economic burden of patients can be lightened by means of large-scale industrial production.

The invention provides an infinity pool. The infinity pool comprises a pool body; and the pool body comprises pool walls arranged around in an enclosed mode, and pool film assemblies arranged at the bottom of the pool body and the inner sides of the pool walls. The pool walls comprise a bottom frame, inner side frames with the lower end portions fixedly connected with the front side of the bottomframe and outer side frames with the lower end portions fixedly connected with the rear ends of the bottom frame. The outer side frames comprise vertical sections and inclined sections arranged on theend portions of the vertical sections, the inclined sections are fixedly connected with the upper end portions of the inner side portions, and the height of the vertical sections is larger than the height of the inner side frames. The pool film assemblies comprise a cushion layer arranged at the bottom of the pool body and waterproof mucous layers arranged on the upper surface of the cushion layer and the inner side faces of the inner side frames. The edge portions of the waterproof mucous layers are fixed to the joint of the inner side frames and the inclined sections.

The invention belongs to the technical field of medicine, and relates to a maleimide prodrug taking mucoprotein as a target point in promotion of biological adhesion and an application of the maleimide prodrug in increasing of oral drug absorption. The maleimide prodrug has a structural formula shown in a formula (I): wherein n is 2-8, and X is O, N. The prodrug has the advantages of high compounddrug loading, good stability, and safety, and can be used for oral administration. The carried maleimide group can be specifically combined with mucoprotein in a mucous layer in gastrointestinal tract, a mucoprotein-prodrug compound is formed, detention time of the prodrug in the gastrointestinal tract is prolonged, concentration gradient of an adsorption-absorption part is increased, passive diffusion is promoted, and oral absorption is promoted. The invention provides the novel maleimide prodrug having the biological adhesion effect for oral absorption of the drug.

The invention discloses a composition for treating an inflammatory bowel disease and belongs to the field of medicines. The composition comprises ganoderma lucidum, salvia miltiorrhiza, poria cocos, threonine, serine and cysteine. The ganoderma lucidum, the salvia miltiorrhiza and the poria cocos have the effects of enhancing blood supply and oxygen supply for a human body. The threonine, the serine and the cysteine are the constituent parts of mucoprotein. The composition provides nutrients, oxygen and raw materials for development, update and repair of goblet cells and composition of an intestinal tract surface mucous layer barrier by goblet cell secretory mucoprotein. The composition has the obvious effects of eliminating inflammation, repairing intestinal tissues and establishing the normal intestinal tract surface mucous layer barrier of the human body and is an effective formula for treatment of the inflammatory bowel disease.

The invention discloses an antibacterial styrene-acrylic emulsion, and a preparation method and the application thereof. The emulsion is prepared from the following components in parts by weight: 40 to 60 parts of deionized water, 15 to 20 parts of styrene, 15 to 20 parts of butyl acrylate, 3 to 5 parts of an emulsifier, 1 to 2 parts of a water-soluble initiator, 0.5 to 1 part of an oxidation-reduction system initiator, 2 to 7 parts of an antibacterial monomer, 0.1 to 0.3 part of a pH value regulator and 3 to 5 parts of other auxiliaries. By taking a main measure of adding a monomer having the antibacterial function for participation in polymerization reaction during synthesis of the styrene-acrylic emulsion, the styrene-acrylic emulsion has an antibacterial function, and no antibacterial auxiliary is needed; moreover, the styrene-acrylic emulsion is uniform in dispersion and difficult to seep. The antibacterial styrene-acrylic emulsion has the characteristics that the styrene-acrylic emulsion is high in efficiency and low in toxicity, is hardly affected by the change of the pH value, and is convenient to use, has a relatively strong stripping function for a mucous layer, is stable in chemical property, and has relatively good dispersion and corrosion inhibition effects.

The invention relates to a ketoconazole vaginal suppository as well as a preparation method and a detection method thereof. The suppository comprises a drug-containing base formed of ketoconazole and a base, a drug-containing mucous layer formed of ketoconazole and a mucous layer, and a swelling carrier. The oleaginous base and water soluble base are added, thereby ensuring that the whole body absorption and application risk of ketoconazole are reduced and the concentration and bioavailability of ketoconazole are effectively improved, so as to take full play of the efficacy of ketoconazole; an absorption promoting agent and chitosan are added, the absorption of a human body to ketoconazole is promoted; the solid disperse carrier can be used for improving the dissolution of ketoconazole, and further promoting absorption of the human body; the drug-containing mucous layer can be adsorbed on vaginal skin to promote skin absorption and can be used for further improving the bioavailability of ketoconazole. The ketoconazole vaginal suppository provided by the invention adopts six original advanced techniques, and has the beneficial effects of drug liquid outflow prevention, good human body absorption, high bioavailability, lasting curative effect, secondary infection prevention, and the like.

The present invention relates to nanomicelles composed of a complex of a lipophilic compound and a poly-gamma-glutamic acid wherein a portion of carboxyl groups are substituted with an amine group, and more particularly, to nanomicelles composed of a complex of a lipophilic compound and a poly-gamma-glutamic acid wherein a portion of carboxyl groups are substituted with an amine group, a preparation method thereof, and a drug delivery system employing the mucous membrane-adhesive property of the nanomicelles. According to the present invention, the nanomicelle drug delivery system based on poly-gamma-glutamic acid that is a natural biopolymer can be used for the delivery of a drug to mucous membranes to thereby increase the in vivo stability and effectiveness of the drug.

The invention relates to a biological periosteum repair material and a preparation method thereof, and particularly relates to an acellular dermis matrix material and a preparation method and application thereof to periosteum repair. The preparation method comprises: (1) taking a jejunum segment of a pig small intestine, cleaning up, radially cutting open, removing a mucous layer, a myolemma layerand a serosal layer and obtaining a pig small-intestine mucous lower-layer tissue membrane; (2) sequentially carrying out the following processing on the obtained pig small-intestine mucous lower-layer tissue membrane: firstly, placing in peracetic acid solution to soak and cleaning up; then placing in sodium hydroxide solution to soak and cleaning up; finally, placing in acetone solution to soak, cleaning and obtaining a pig small-intestine mucous lower-layer tissue acellular matrix. The biological periosteum repair material is high in biological safety, low in immunogenicity and cytotoxicity, good in biocompatibility, can promote multiplication of cells adhered to the biological periosteum repair material, is applicable to use as a biological repair material and is particularly suitablefor periosteum repair.

The invention provides a method for preparing a natural tubular small intestine acellular matrix membrane and belongs to the technical field of medical biological materials. The method comprises the following steps: cleaning small intestines cut from animals; adding the cleaned small intestines into a closed container, rapidly freezing in liquid nitrogen at the temperature of 80 DEG C below zero,taking out within half an hour, unfreezing, sleeving on an annular tubular scaffold, destroying the serosa by scissors, cutting off the serosa of the small intestines, scraping the destroyed serosa ofthe small intestines by organic glass, turning over the small intestines, scraping the mucous layer, submucosa and muscular layer of the small intestines, and removing the basal cells of the small intestines, thereby obtaining the single-layer tubular small intestine acellular matrix membrane; and performing freeze-dried seal and sterilizing preservation on the obtained single-layer and multilayer tubular small intestine acellular matrix membranes, thereby obtaining the natural tubular small intestine acellular matrix membranes of different thicknesses. The preparation method disclosed by theinvention is simple, and the prepared small intestine acellular matrix membrane is natural tubular.

An object of the present invention is to provide a method for non-invasively diagnosing invasiveness or degree of invasion of colorectal tumors.The present invention is characterized in that it enables to obtain a specimen that can be used to detect invasive colorectal tumors by spraying a washing fluid onto the colonic mucous layer of a subject to detach the mucus from the mucous layer, and collecting the detached mucus together with the washing fluid.

The invention relates to a system and method for automatically judging eating, relates to the technical field of medical care treatment, and solves the problems that in the prior art, the treatment ofgastroenteric electrostimulation is mainly started before the eating of a user at present, so that the satiety of the user before the eating is effectively improved, when the user really starts to eat, the food intake is reduced, but in the practical application process, the situation that the user forgets to start gastroenteric electrostimulation equipment before eating is often generated, and the treatment effect of the user is seriously influenced. The system comprises a gastroenteric electrographic recording electrode and a signal processing module, wherein the gastroenteric electrographic recording electrode is transplanted to a mucous layer or a serosal layer of the stomach to record a gastroenteric electrical signal; and the signal processing module is connected to the gastroenteric electrographic recording electrode to receive the gastroenteric electrical signal and to be in response to the gastroenteric electrical signal to analyze and judge whether a human body eats or not.Through the adoption of the method disclosed by the invention, whether a patient eats or not can be effectively analyzed and judged, and the gastroenteric electrostimulation equipment can be started when the situation that the user really starts to eat is judged, so that the effect of gastroenteric electrostimulation treatment of the user is improved.

The invention discloses a biological membrane oxygen-increasing aeration plate, an aeration device and an algae biological acclimation method. According to the method, nitrogen fixation biological membrane materials are laid on the aeration plate, nitrogen and oxygen in the air exhausted by the aeration device are separated according to the characteristics of nitrogen fixation algae, and a mucous layer for preventing oxygen from passing through is formed, so that oxygen in the lower layer makes full contact with microorganisms in sewage, the oxygen concentration in a water body is increased, and purification of the sewage is achieved; meanwhile, dissolved oxygen monitoring equipment is adopted for carrying out real-time monitoring on the oxygen concentration in the water body, and the dosage of a biological nutrient solution and the stay time of the sewage are regulated in real time according to the growing conditions of the nitrogen fixation blue-green algae, so that aeration efficiency is improved, and hydraulic stay time is shortened.

The invention discloses a composition for treating an inflammatory bowel disease and belongs to the field of medicines. The composition comprises ganoderma lucidum, poria cocos, threonine, serine, cysteine, vitamins C, E and A and beta-carotene. The ganoderma lucidum and the poria cocos have the effects of enhancing blood supply and oxygen supply for a human body. The threonine, the serine and the cysteine are the constituent parts of mucoprotein. The vitamins C, E and A and the beta-carotene have the effects of inhibiting the oxygen free radical activity, removing oxygen free radicals and protecting human body cells. The composition provides nutrients, oxygen and raw materials for development, update and repair of goblet cells and composition of an intestinal tract surface mucous layer barrier by goblet cell secretory mucoprotein. The composition has the obvious effects of eliminating inflammation, repairing intestinal tissues and establishing the normal intestinal tract surface mucous layer barrier of the human body and is an effective formula for treatment of the inflammatory bowel disease.

The invention discloses a composition for treating inflammatory bowel disease, and belongs to the field of drugs. The composition follows principles of reinforcing intestinal epithelial goblet cells, building a normal intestinal surface mucous layer barrier, preventing an antigen approaching, touching, adhering to and entering an intestinal wall, and then blocking an abnormal immune response and the occurrence of inflammation. In the composition, ganoderma and radix salviae miltiorrhizae have efficacies of strengthening blood supply and oxygen supply to the human body; threonine is a component of mucoprotein; glutamine is a main energy source of intestinal mucosa. The composition provides nutrition, oxygen and raw materials for generation, renewal and repairing of the goblet cells as well as forming of an intestinal surface mucous layer barrier by utilizing mucoprotein secreted by the goblet cells, has obvious effects of building the normal intestinal surface mucous layer barrier for the human body, eliminating inflammation and repairing intestinal tissues, and is used for effectively treating the inflammatory bowel disease.

The invention discloses a composition for treating inflammatory bowel disease, and belongs to the field of drugs. The composition follows principles of reinforcing intestinal epithelial goblet cells, building a normal intestinal surface mucous layer barrier, preventing an antigen approaching, touching, adhering to and entering an intestinal wall, and then blocking an abnormal immune response and the occurrence of inflammation. In the composition, ganoderma has efficacies of strengthening blood supply and oxygen supply to the human body; glutamine is a main energy source of intestinal mucosa; vitamin C, vitamin E, vitamin A and beta-carotene have functions of inhibiting the activity of oxygen free radicals, scavenging the oxygen free radicals, and protecting human cells. The composition provides nutrition, oxygen and raw materials for generation, renewal and repairing of the goblet cells as well as forming of an intestinal surface mucous layer barrier by utilizing mucoprotein secreted by the goblet cells, has obvious effects of building the normal intestinal surface mucous layer barrier for the human body, eliminating inflammation and repairing intestinal tissues, and is used for effectively treating the inflammatory bowel disease.

The invention relates to a sugar alcohol in-vitro intestinal microorganism evaluation method. Through an in-vitro mixed bacteria evaluation device, physical regulation and control, a pH and OD double-feedback system and mucous membrane globules are utilized to simulate a mucous layer of a human body, so that a more real colon environment can be simulated, and the quantity and variety composition of microorganisms have high similarity in the colon of the human body. A metabolism estimation model is realized by adopting single double-three-bacterium culture, and a plurality of more important florae in sugar alcohol metabolism are selected for single double-three-bacterium instead of simply selecting lactic acid bacteria or bifidobacteria for experiment by performing correlation analysis anda random number forest method on data obtained by an in-vitro simulated fermentation system CDMN model. Such a method enables more realistic and efficient data to be obtained. In addition, data of symbiotic nourishing of the intestinal microbial flora by utilizing sugar alcohol can be explored and obtained in double-three-bacterium culture, so that the defects of a single-bacterium experiment areovercome, and a more real metabolism estimation model is more favorably realized.