63 results about "Membrane adhesion" patented technology

A pH responsive and mucoadhesive pharmaceutical dosage form for the release of a pharmaceutically active agent is described. The dosage form includes a mucoadhesive layer for site-specific mucoadhesion, a water-insoluble outer layer, and an intermediate layer including one or more pharmaceutically active agents for site-specific delivery. The different membranous layers perform different functions in order to create a drug delivery system which is able to deliver a drug to a specific site, for a particular period of time and with a specific drug release pattern. The dosage form can have two or more intermediate layers, each layer comprising an active agent. The mucoadhesive layer can also include an active agents. The dosage form is preferably an oral or buccal delivery form for release of the active agent into the gastro intestinal tract. The intermediate layer can be an electrospun fibrous membrane layer containing the active agent.

The invention relates to the technical field of medicines, and relates to adriamycin-indocyanine green bionic nanoparticles coated with platelet and neutrophil fusion membranes and an application of the adriamycin-indocyanine green bionic nanoparticles in preparation of medicines for treating tumor metastasis diseases. The bionic nanoparticle coated with the platelet and neutrophil hybrid membranecomprises adriamycin, indocyanine green, a nano carrier material, a platelet membrane and a neutrophil hybrid membrane, which is characterized by comprising the following components in percentage byweight: 8 to 10 percent of doxorubicin, 8 to 10 percent of indocyanine green, 30 to 40 percent of nano carrier material and the balance of platelet and neutrophile granulocyte hybrid membrane. The bionic nanoparticle has the capability of simultaneously capturing and removing circulating tumor cells and tumor-derived exosomes through a high-affinity membrane adhesion receptor, and effectively cutsoff the relationship between the exosomes and immune cells. The primary tumor can be completely ablated, and breast cancer metastasis can be efficiently inhibited in xenograft and in-situ breast tumor models.

The invention discloses a pH response/membrane adhesive amphiphilic block copolymer as well as a preparation method and application thereof. According to the preparation method, methacrylic acid with an isoelectric point of 5.0-6.5 is utilized as a pH response monomer, methacrylic aminoethyl ester with pH-insensitive hydrophilia is utilized as a membrane-adhesive monomer, an electron transfer activator regeneration-atom transfer free radical active polymerization method is adopted, a pH response monomer and hydrophobic monomer block copolymer is firstly prepared; and by taking the pH response monomer and hydrophobic monomer block copolymer as a macroinitiator, the membrane-adhesive monomer, namely the methacrylic aminoethyl ester is polymerized, and finally acidolysis reaction is performed, so that the pH response/membrane adhesive amphiphilic block copolymer is prepared. The pH response/membrane adhesive amphiphilic block copolymer is capable of being self-assembled to form a core-shell structure micelle in an aqueous solution, has favorable pH sensibility and membrane adhesion property, lower critical micelle concentration and relaively small micelle particle size, and can be used in drug delivery systems for oral medication application of polypeptide or proteinic drugs.

The present invention relates to a beverage bottle with storage solutes. By means of pressing the drinking pumping cylinder, the cutting membrane inner cylinder being pushed down, two cutting edges of the cutting membrane inner cylinder are provided to cut the membrane; the cutting membrane inner cylinder has a notch to constitute a membrane adhesion structure; the cutting membrane inner cylinder being pushed down, the inner sleeve being separated from the sleeve in longitudinal direction, the water outlet port is connected to the water outlet cylinder portion so as to constitute a water outlet access; the sealed cap cooperates with the central spindle to constitute a switch control structure for the water outlet access. It has the advantages of: its pressing control structure is simple and labor-saving, its cutting membrane effect is good, its solutes are released quickly and completely and it can be provided for drinking directly.

The invention discloses a special shot blast cleaning machine for a concrete mixing cylinder with a cleaning effect. The special shot blast cleaning machine for the concrete mixing cylinder comprises a rack arranged on the ground surface, and the rack is provided with a dedusting device, a shot blast device, a lifter, a separator, a longitudinal spiral conveyer and a trolley. The special shot blast cleaning machine for the concrete mixing cylinder has the advantages that surfaces of workpieces are in natural metal color; the internal stress of workpieces is eliminated; the workpiece anti-fatigue performance is improved; paint membrane adhesion force in painting the workpieces is increased; and finally the aim that the surface and internal quality of the workpieces is improved is achieved.

The invention discloses a pulmonary membrane adhesion nodule region repairing method for a pulmonary CT image threshold segmentation result. The method comprises the steps of carrying out the SIFT feature detection on the lung binary image to obtain the feature points in the image, calculating the nearest neighbor substitution points of the obtained non-boundary feature points, and after the calculated substitution points are used for replacing original non-boundary feature points, obtaining a corresponding boundary feature point set; for each boundary feature point in the boundary feature point set, extracting a support boundary based on a specific rule; segmenting the support boundaries according to the calculated connectivity of the support boundaries in the support boundary image to obtain the mutually independent support boundaries in the image; for each support boundary segment, identifying a to-be-repaired boundary by using the curvature code; using a GVF-based method to drive the smooth profile curve for the identified portion to repair the recessed region and boundary. By applying the method provided by the invention, the omissive pulmonary membrane bonding joint region inthe threshold segmentation result can be accurately repaired, and the pulmonary membrane nodule region is re-incorporated into the pulmonary parenchyma region, so that the accuracy of the pulmonary CT image lesion tissue analysis algorithm is ensured.

The invention provides a dextrorotatory oxiracetam oral membrane which is prepared from a membrane forming material containing acrylate together with a plasticizer, a filler, a corrigent and dextrorotatory oxiracetam by a coating method. Since the membrane forming material containing acrylate is mixed with a particular quantity of raw materials such as dextrorotatory oxiracetam, the filler and theplasticizer to achieve an synergistic effect, the stripping performance is improved while problems such as membrane adhesion and soft texture are solved, and thus, quality of the product is improved.The dextrorotatory oxiracetam oral membrane has uniform and complete appearance, uniform color, and consistent thickness, stable physical and chemical properties, short time for disintegration, quickdissolving and quick action; the preparation method is simple, can be implemented without any large-size industrial equipment, and is suitable for industrial production.

The invention discloses engineered platelets of nanogel internally loaded with chemotherapeutic drugs and externally carried with immune checkpoint inhibitors as well as a preparation method and application of engineered platelets, and belongs to the technical field of drugs. The preparation method of the engineered platelets includes the following steps: crosslinking the nanogel carried with an immune checkpoint inhibitor, to extract and purified the platelets, and loading a chemotherapeutic drug and the nanogel onto the platelets, and the like. The engineered platelets deliver the chemotherapeutic drug and the immune checkpoint inhibitor to postoperative tumor remaining parts by efficiently targeting damaged vascular endothelium, circulating tumor cells are captured and cleared through a high-affinity membrane adhesion receptor, and the engineered platelets are activated in situ on the surfaces of the tumor cells, and the chemotherapeutic drug and the immune checkpoint inhibitor are released to trigger the T-cell-mediated anti-tumor immune response, so that the tumor is ablated, and the postoperative tumor recurrence and metastasis are effectively avoided.

The invention belongs to the field of biological medicines, and relates to a bladder irrigation solution which is used for treating the effective concentration of nonbacterial cystitis, is in contact with the internal surface epithelium and relevant structures of the bladder of a patient suffering from the nonbacterial cystitis to prevent and treat the nonbacterial cystitis and contains sodium hyaluronate. The bladder irrigation solution comprises a water-soluble mucous membrane adhesive material, an active component and a medically acceptable carrier and/or an additive. The water-soluble mucous membrane adhesive material is prepared from hyaluronic acid-cysteine and salt thereof, and the molecular weight is not less than 50,000 Dalton, and the use amount is smaller than 1 percent; the active component comprises glycosaminoglycan and/or amino monosaccharide; glycosaminoglycan is one or a combination of several of salt, chondroitin sulfate and dermatan sulfate of any proportion; amino monosaccharide is a combination of one or two of glucosamine and acetylglucosamine of any proportion. The irrigation solution contains the medically acceptable carrier and/or an additive which comprises an osmotic pressure adjusting agent, a pH adjusting agent, a preservative and water.

The invention discloses a preparation method of a trauma auxiliary material, and belongs to the technical field of medical trauma auxiliary materials. The trauma auxiliary material is composed of twolayers, wherein the upper layer is a silicone membrane, and the lower layer is a PEG/PLGA composite nanofiber membrane. The preparation method of the PEG/PLGA composite nanofiber membrane comprises the following steps: 1) preparing a PEG/PLGA mixed spinning solution; 2) preparing a silicone membrane; 3) adhering the silicone membrane to an aluminum foil, fixing the aluminum foil on a roller receiver of an electric spinning machine, and performing electrostatic spinning on the mixed spinning solution obtained in the step 1); and 4) drying samples for a certain time after spinning. Through preparation of the double-layer membrane auxiliary material formed by combining the silicone membrane and the PEG/PLGA composite nanofiber membrane, the auxiliary material has moisturizing and antibacterial properties, the flexibility and mechanical properties of the auxiliary material can be remarkably improved, and the action time of drug properties of the auxiliary material is prolonged.

Stannous fluoride polyol solid solutions combine three complimentary, biochemical mechanisms attributed to Sn⁺⁺, F⁻ and Polyol, respectively to reduce growth and metabolism of Streptococcus mutans while effecting superior Bioactivity Quotients. The stannous fluoride polyol solid solution particulate compositions of the present invention comprise:

• • (a) stannous fluoride at between about 0.01 and about 0.8% by weight;
  • (b) a polyol at between about 0.1 and about 30% by weight;
  • (c) an astringency neutralizer at between about 0.01 and about 0.4% by weight, where the ratio of astringency neutralizer to stannous fluoride is from between about 0.01 and about 0.2;
  • (d) a mucoadhesive at between about 1.5 and about 70% by weight, wherein the ratio of mucoadhesive to stannous fluoride polyol is from between about 7 to 1 and about 25 to 1;
  • (e) a pH stabilizer, selected from the group consisting of malic, fumaric, citric acid and combinations thereof, wherein the ratio of pH stabilizer to stannous fluoride polyol is from between about 0.03 and 5 and preferably from between about 0.1 and about 3; and

(f) optional flavorants, stabilizers, preservatives, conditioners, and oral care adjuncts.

The invention discloses a test device, which is simple in structure, safe and convenient to operate, and capable of testing the membrane adhesion fastness of a membrane-coated air filter felt and discloses a test method. The test device comprises a gas source switch (1), an air-pressure regulating valve (2), a pressure transducer (3), a test chamber (4), a microprocessor (6) and a computer (7). The gas source switch (1), the air-pressure regulating valve (2), the pressure transducer (3) and the test chamber (4) communicate with each other in sequence; the pressure transducer (3) is connected to the computer (7) through the microprocessor (6), and signals can be transmitted in the connection; and the computer (7) draws a pressure-time curve based on signals received from a microprocessor (5). The air-pressure regulating valve is gradually regulated, and the pressure of air in the test chamber is gradually increased, so that via the microprocessor, values tested by the pressure transducer form the pressure-time curve on the computer through drawing. When the pressure-time curve deviates from the variation trend of an original curve, the pressure corresponding to the change is the membrane adhesion fastness of a tested membrane-coated air filter felt.