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130 results about "Monomethoxypolyethylene glycol" patented technology

Method of preparing branched polyethylene glycol

InactiveCN1461762ANo need to control pHLow priceMonomethoxypolyethylene glycolMedicinal chemistry
A process for preparing branched polyethylene glycol used to modify macromoleculae and micromoleculae includes such steps as respectively preparing the amino acid's ethylester hydrochloride and carboxymethylated monomethoxy polyethanediol, mixing, sequentially adding TEA, DCC and NHS, reaction, removing protector, and gel separation. Its advantages are simple process, low cost, and high output rate up to 65%.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI

Double-pH-response amphiphilic copolymer and preparation method and application thereof

The invention relates to double-pH-response amphiphilic copolymer, the molecular formula of the double-pH-response amphiphilic copolymer is MPEG-Dliable-PAE-g-Chol, and the structure of the double-pH-response amphiphilic copolymer is as shown in formula I. The double-pH-response amphiphilic copolymer is copolymerized by hydrophilic block methoxy polyethylene glycol, hydrophobic cholesterol and pH response block poly(beta-amino ester). The double-pH-response amphiphilic copolymer has the advantages that the double-pH-response amphiphilic copolymer can self-assemble in an aqueous solution to obtain a nanoscale micellar system, the inner layer of the nanoscale micellar system is a hydrophobic core modified by cholesterol, the middle of the nanoscale micellar system is a pH-sensitive-response PAE layer, the shell of the nanoscale micellar system is hydrophilic block MPEG, the hydrophilic shell is connected sensitive middle layer through a pH-sensitive benzimide bond, the cell intake of a micelle drug-loading system is increased effectively while the requirements of high entrapment performance, stable system structure, long in-vivo circulation time, stability under neutral conditions and controllable drug release under weak acid conditions of hydrophobic drugs are satisfied, and accordingly drug bioavailability is increased, and a tumor treatment effect is optimized.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA

Modified glutathione peroxidase and preparation method thereof

The invention belongs to the technical field of biology, relating to a modified glutathione peroxidase and a preparation method thereof. The preparation method comprises the following steps of: reacting single-chain monomethoxypolyethylene glycol (mPEG1) with amino-groups of glutathione peroxidase through free chlorine atoms so as to connect the mPEG1 to the glutathione peroxidase, wherein the activated single-chain mPEG1 is used as a modifier to react with the glutathione peroxidase at 4-37 DEG C with a pH value of 7.0-10.0, and the mass ratio of the single-chain mPEG1 to the glutathione peroxidase is (20-100):1; adding glutathione (GSH) by a proportion of 1:1 of the modifier to the GSH used as a terminator to terminate the reaction after reacting for 15-60min; and then removing the terminator by using 30 thousands of ultrafiltration membranes for ultrafiltering to obtain the modified glutathione peroxidase. The amino-group modification rate of the modified glutathione peroxidase is controlled to be 40-45 percent, and the enzymatic activity retention rate exceeds 100 percent.
Owner:SOUTH CHINA AGRI UNIV

Prodrug of oridonin with polyethylene glycol serving as vector and preparation method thereof

The invention discloses a prodrug of oridonin with polyethylene glycol serving as a vector. The prodrug has the structural formula shown in the specification, wherein n is an integer from 110 to 910. The preparation method comprises the following steps: (1) preparing carboxylation oridonin: performing reaction to oridonin and succinic anhydride, thus obtaining carboxylation oridonin; and (2) synthesizing prodrug of oridonin modified via methoxypolyethylene glycol amine: reacting the mono-methoxypolyethylene glycol amine with carboxylation oridonin, thus obtaining the prodrug of oridonin which is in form of white solid. According to the prodrug of oridonin with polyethylene glycol serving as the vector disclosed by the invention, the succinic acid serves as a joint arm for combining the oridonin with the hydrophilic polyethylene glycol derivative, so that the dissolubility of the oridonin is improved, the performance of the medicine is enhanced and improved, and the stability of the oridonin is improved; and the prodrug can be decomposed and fallen at a proper environment, so as to release the oridonin, so that the acting time in the organism can be increased, and the purpose of long circulation can be achieved.
Owner:山东希力药业有限公司

Polyglycol modifying ferric iron deuterohemin short peptide compound and production method thereof

The invention belongs to the biotechnology field, which particularly relates to a deuterohemin short peptide compound modified by the Monomethoxy-Polyethylene Glycol Succinimidyl Ester derivatives and the preparation method for the compound, which adds phosphate buffer into the water solution prepared by a deuterohemin 6-mer peptide, and then reacts by adding the solid powder of active Polyethylene Glycol derivatives or the acetonitrile solution of the Polyethylene Glycol derivatives and obtains the deuterohemin 6-mer peptide modified by the Polyethylene Glycol by chromatographic separating of the reaction mixture with the reversed-phase high performance Liquid Chromatography. The deuterohemin 6-mer peptide modified by the Polyethylene Glycol of the invention can basically maintain the biological activity of the deuterohemin 6-mer peptide, and has better stability than the deuterohemin 6-mer peptide without any modification. The preparation method of the deuterohemin 6-mer peptide modified by the Polyethylene Glycol of the invention is simple and easy to operate, while the structure general formula of the deuterohemin 6-mer peptide modified by the Polyethylene Glycol is shown on the right, wherein, R stands for a DhHP-6 molecule eliminating an NH2.
Owner:JILIN UNIV
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