48 results about "Intestinal submucosa" patented technology

The present disclosure provides a regenerative peripheral nerve interface (RPNI) for a subject comprising an insulating substrate, at least one metallic electrode deposited onto the insulating substrate forming a thin-film array; a portion of the at least one metallic electrode surface having a layer of a first conductive polymer and a layer of decellularized small intestinal submucosa (SIS) coating a portion of the electrode, wherein a second conductive polymer is electrochemically polymerized through the SIS to form the regenerative peripheral nerve interface. The present disclosure also provides that a layer of muscle tissue contacts the regenerative peripheral nerve interface.

A tissue graft composition is described herein that includes a segment of small intestinal submucosa having at least one nanoparticle incorporated therein such that the permeability of the segment of small intestinal submucosa is altered, thereby providing the segment of small intestinal submucosa with a more substantially uniform structure for cell migration and proliferation. The tissue graft composition may further comprise at least one macromolecule incorporated into the nanoparticle. The tissue graft composition may be utilized in seeded or unseeded methods of tissue repair.

A tissue graft composition is described herein that includes a segment of small intestinal submucosa having at least one nanoparticle incorporated therein such that the permeability of the segment of small intestinal submucosa is altered, thereby providing the segment of small intestinal submucosa with a more substantially uniform structure for cell migration and proliferation. The tissue graft composition may further comprise at least one macromolecule incorporated into the nanoparticle. The tissue graft composition may be utilized in seeded or unseeded methods of tissue repair.

The invention provides a mold for preparing an accellular small intestine submucosa matrix material, which is composed of a base, a pressure frame and a pressure screen, wherein the base is a square plate with bolt holes at four corners; the pressure frame is a hollow square frame with bolt holes at four corners; the pressure screen is a square frame with a square frame structure or reticular structure inside; the bolt holes in the base are corresponding to the bolt holes in the pressure frame one by one; the external diameter of the pressure frame is the same as the dimension of the base; and the inner diameter of the pressure frame is the same as the dimension of the pressure screen. When being used for preparing the accellular porcine small intestine submucosa matrix material, the mold can not compress the space structure of the accellular porcine small intestine submucosa matrix material or destroy the three-dimensional structure of the natural extracellular matrix, and can ensure the porosity of the prepared accellular porcine small intestine submucosa matrix material.

The invention provides a small intestinal submucosa-based vascularization promoting thermosensitive material. The small intestinal submucosa-based vascularization promoting thermosensitive material is prepared by packaging a small intestinal submucosa matrix and a dissolving solution, respectively, wherein the small intestinal submucosa matrix is obtained through the following steps: performing enzymatic hydrolysis, acid dissolution and freeze-drying on the small intestinal submucosa, and then crushing and sterilizing the small intestinal submucosa to obtain a sterile powdery or flocculent small intestinal submucosa matrix material; the dissolving solution consists of phosphate buffer containing NaOH or normal saline. According to the invention, the two matrixes of the small intestinal submucosa-based vascularization promoting thermosensitive material both can be preserved for a long time and are mixed in an appropriate ratio before in use; the thermosensitive material has excellent injectability and is capable of forming a stable gel at 37 DEG C without cross-linking polymerization; the thermosensitive material is proven to have the effect of promoting vascularization by both experiments in vitro and vivo.

The invention provides a mold for preparing an accellular small intestine submucosa matrix material, which is composed of a base and a pressure screen, wherein the base is a square plate with pins on four sides, and the pins are perpendicular to the square plate; the pressure screen is a square frame with a square frame structure or reticular structure inside; and the length of the four sides of the pressure screen is 1-3 cm smaller than that of the base. When being used for preparing the accellular porcine small intestine submucosa matrix material, the mold can not compress the space structure of the accellular porcine small intestine submucosa matrix material or destroy the three-dimensional structure of the natural extracellular matrix, and can ensure the porosity of the prepared accellular porcine small intestine submucosa matrix material.