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Preparation method of hydrogel

A hydrogel and aqueous solution technology, which is applied in the field of gel material synthesis, can solve the problems of lack of in vivo drug delivery characteristics, less β-CD, and inapplicability, and achieve good biocompatibility, fast cross-linking speed, and improved Effects of mechanical strength and viscoelasticity

Active Publication Date: 2018-12-25
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the technical solution disclosed in the report, the electrostatic driving force for fiber formation is generally weak, and less β-CD is introduced, and the prepared material does not have good drug delivery properties in vivo, and is not suitable for hydrogels, etc. Preparation of Biomaterials

Method used

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  • Preparation method of hydrogel
  • Preparation method of hydrogel
  • Preparation method of hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Preparation of cellulose nanofibril membrane:

[0026] Take an appropriate amount of TEMPO oxidized cellulose nanofibrils and add them to water, stir rapidly at 40°C until they are completely dissolved, then add glycerin and continue to stir rapidly at 40°C until the solution is uniform and transparent, then the solution is subjected to centrifugal defoaming and ultrasonic defoaming treatment, degassing The soaked solution is dried in an oven at 55°C for 6-12 hours to obtain a cellulose nanofibril film.

[0027] The parts by mass of each raw material added in the reaction system are: 1.5 parts of TEMPO oxidized cellulose nanofibrils, 6 parts of glycerin, and the balance of water.

[0028] 2. Preparation of hydrogel:

[0029] Dissolve the water-soluble cationic β-CD polymer in water to prepare a solution with a concentration of 20%, and then take an appropriate amount of Ag-NH 2 NPs (prepared by referring to the methods described in the aforementioned literature 1 a...

Embodiment 2

[0031] 1. Preparation of cellulose nanofibril membrane:

[0032] Take an appropriate amount of TEMPO oxidized cellulose nanofibrils and add them to water, stir rapidly at 40°C until they are completely dissolved, then add glycerin and continue to stir rapidly at 40°C until the solution is uniform and transparent, then the solution is subjected to centrifugal defoaming and ultrasonic defoaming treatment, degassing The soaked solution was dried in an oven at 55° C. for 10 h to obtain a cellulose nanofibril film.

[0033] The mass parts of each raw material added in the reaction system are: 2 parts of TEMPO oxidized cellulose nanofibrils, 7 parts of glycerin, and the balance of water.

[0034] 2. Preparation of water-soluble cationic β-CD polymer:

[0035] (1) Add an appropriate amount of β-CD into NaOH solution with a concentration of 220g / L, stir at 60°C until completely dissolved, then add 2,3-epoxypropyltrimethylammonium chloride solution with a concentration of 900g / L, Epi...

Embodiment 3

[0044] 1. Preparation of cellulose nanofibril membrane:

[0045] Take an appropriate amount of TEMPO oxidized cellulose nanofibrils and add them to water, stir rapidly at 40°C until they are completely dissolved, then add glycerin and continue to stir rapidly at 40°C until the solution is uniform and transparent, then the solution is subjected to centrifugal defoaming and ultrasonic defoaming treatment, degassing The soaked solution was dried in an oven at 55° C. for 10 h to obtain a cellulose nanofibril film.

[0046] The mass parts of each raw material added in the reaction system are: 1 part of TEMPO oxidized cellulose nanofibrils, 5 parts of glycerin, and the balance of water.

[0047] 2. Preparation of water-soluble cationic β-CD polymer: the method is the same as in Example 2.

[0048] 3. Preparation of hydrogel:

[0049] Dissolve the water-soluble cationic β-CD polymer prepared in step 2 in water to prepare a solution with a concentration of 30%, and then take an appr...

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Abstract

The invention discloses a preparation method of hydrogel. The preparation method has the advantages that the electrostatic interaction between TEMPO oxidized cellulose nano fibrils and water-soluble positive ion beta-CD polymer is used as the basis, the electrostatic interaction is further enhanced through the synergic effect of aminated nano-silver particles and the positive ion beta-CD polymer to double the content of the water-soluble positive ion beta-CD polymer, and the adsorption and drug loading performance of the water-soluble positive ion beta-CD polymer are increased greatly; meanwhile, the nano silver particles and the cellulose nano fibrils can also be used as the enhancement phase to increase the mechanical strength and viscoelasticity of the hydrogel; the use of toxic crosslinking agents during hydrogel assembling is avoided, the preparation conditions are mild, high crosslinking speed is achieved, the prepared hydrogel is good in biocompatibility and biodegradability andhas certain antibacterial performance, the identification and inclusion properties of cyclodextrin to hydrophobic molecules are kept, and the hydrogel has excellent hydrophobic drug loading capacityand excellent sustained release ability under different pH conditions.

Description

Technical field: [0001] The invention relates to the field of gel material synthesis, in particular to a preparation method of hydrogel. Background technique: [0002] Smart hydrogels have gradually become one of the research hotspots in the field of chemistry and pharmacy due to their unique stimulus-response mechanism and the diversity of reversible systems. Hydrogels are playing an increasingly important role in controlling the release rate and location of drugs, improving the bioavailability of drugs in vivo, and reducing toxic and side effects. [0003] Cellulose nanofibrils (CNF) are microfibers with a special network structure and a nanoscale diameter. Hydrogels prepared based on CNF natural polymer materials have better biocompatibility, biodegradability and similarity to living tissues, and are more suitable as carriers for drug delivery. However, in terms of controlled release of cellulose-based hydrogel drugs, due to the inherent incompatibility between hydropho...

Claims

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Application Information

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IPC IPC(8): C08J3/075D06M11/83D06M15/03C08B37/16A61K9/06A61K47/38A61K47/40A61K47/02D06M101/06
CPCA61K9/06A61K47/02A61K47/38A61K47/40C08B37/0012C08J3/075C08J2301/04D06M11/83D06M15/03D06M2101/06
Inventor 刘泽华徐力张佳音
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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