115results about How to "Enhance electrostatic interaction" patented technology

The invention discloses a carbon nano-tube / carbon multilevel pore spherical composite and a preparation method thereof. The preparation method comprises the following steps: firstly, pretreating a carbon nano-tube; adding the pretreated carbon nano-tube and a small amount of adhesive into deionized water to obtain a carbon nano-tube suspension; adding the carbon nano-tube suspension in a low-temperature liquid medium dropwise, rapidly solidifying to obtain a composite ice ball, rapidly transferring the composite ice ball into a freeze drier, and vacuum drying to obtain a carbon nano-tube initial composite globule; carrying out carbonization and strengthening on the carbon nano-tube initial composite globule to obtain a carbon nano-tube / carbon composite globule; and further carrying out activation on the carbon nano-tube / carbon composite globule to obtain the carbon nano-tube / carbon multilevel pore spherical composite. The carbon nano-tube / carbon multilevel pore spherical composite is provided with mesopores and micropores and is also provided with a macropore which penetrates through the surface and the spherical center and is high in specific surface area, large in pore volume and good in adsorption property.

The present invention relates to siRNA hydrogel and a method for manufacturing the same, and more particularly, to siRNA hydrogel for targeted gene silencing, which is nano-structured for targeted gene silencing, and a method for manufacturing the same.

The invention provides a conductive photo-thermal self-healing composite hydrogel dressing as well as a preparation method and application thereof.The preparation method comprises the following steps:grafting acrylic acid on chitosan to obtain an N-carboxyethyl chitosan polymer; the preparation method comprises the following steps: grafting p-hydroxybenzaldehyde on a triblock copolymer to obtainan aldehyde-terminated polymer (PF127-CHO); the preparation method comprises the following steps: preparing an aldehyde-terminated polymer into a solution, adding carbon nanotubes into the polymer solution, and carrying out ultrasonic treatment in an ice bath to obtain an aldehyde-terminated / carbon nanotube dispersion liquid; the preparation method comprises the following steps: preparing an N-carboxyethyl chitosan polymer into a solution, mixing the solution with an aldehyde group-terminated / carbon nanotube dispersion liquid, and carrying out mutual crosslinking at 20-45 DEG C for 5-400 seconds to obtain the conductive, adhesive, self-healing, photo-thermal and nano composite hydrogel. The hydrogel has excellent adhesion, self-healing, pH response, biocompatibility and hemostatic performance, can show a photo-thermal behavior after being exposed to a near-infrared (NIR) region, causes physical damage to bacteria, and has huge potential for treating infected wounds.

The invention belongs to the technical field of water treatment and particularly relates to a preparation method of a composite modified fluoride-removing adsorbent. The method comprises the steps of crushing and calcining an animal bone as a raw material and then washing to prepare hydroxyapatite powder with a porous structure; preparing an aluminum-based sol by using aluminum sulfate, loading the aluminum-based sol on the hydroxyapatite powder, wherein the specific surface area of the natural porous hydroxyapatite powder is further improved and the adsorption capacity is improved and can reach 120-130mg / g through the synergistic effect of the aluminum-based sol and organic carbon among pores of the hydroxyapatite powder; preparing a solution from a rare-earth salt and a metal salt, and compounding rare-earth ions and metal ions through the synergistic effect of an aluminum base and hydroxyapatite under an alkaline condition, thereby further strengthening the electrostatic effect and strengthening the effects of lewis acid and base and the complexing action with fluoride ions and reducing the concentration of the fluoride ions in underground effluent to 0.9mg / L. The preparation method has the characteristics of being high in adsorption rate, easy to regenerate and stable in performance.

A method of cleaning thin glass substrates comprises applying a sequence of chemical washing steps as the thin glass substrate is being conveyed in a conveyance direction. In addition, surfaces of the glass substrate may be treated to enhance electrostatic discharge properties of the glass substrates.

The invention is directed to an electrophotographic photoreceptor, and an electrophotographic cartridge and an electrophotographic imaging apparatus including the electrophotographic photoreceptor. The electrophotographic photoreceptor includes: an electrically conductive substrate; a charge generating layer formed on the electrically conductive substrate and comprising μ-oxo-gallium phthalocyanine dimer as a charge generating material dispersed in a binder resin; and a charge transporting layer formed on the charge generating layer. The charge transporting layer includes a charge transporting material and a binder resin. The charge transporting material is a combination of (1) a butadiene-based amine compound and a hydrazone compound and (2) a combination of a first benzidine compound and a second benzidine compound. The amount of the charge transporting material is 5-200 parts by weight based on 100 parts by weight of the binder resin of the charge transporting layer. The electrophotographic photoreceptor has an excellent electrostatic property and a high interlayer adhesive force and resistance to abrasion and can be manufactured at a low cost.

The invention relates to a modified semi-aromatic polyamide membrane and a preparation method thereof. The modified semi-aromatic polyamide membrane includes the steps: (1) placing graphene oxide intowater, ultrasonically dispersing the graphene oxide in the water to obtain graphene oxide stock solution, and adding the graphene oxide stock solution into piperazine aqueous solution to obtain piperazine aqueous phase solution containing the graphene oxide; (2) soaking a polysulfone ultrafiltration membrane into the piperazine aqueous phase solution containing the graphene oxide, taking out thepolysulfone ultrafiltration membrane without excessive piperazine aqueous phase solution containing the graphene oxide on the surface of the polysulfone ultrafiltration membrane, soaking the taken outpolysulfone ultrafiltration membrane into normal hexane solution of trimesoyl chloride, and reacting mixture to form a semi-aromatic polyamide active layer to obtain an initial membrane; (3) flushingthe initial membrane, soaking the initial membrane into sodium carbonate solution, and taking out and drying the initial membrane to obtain the modified semi-aromatic polyamide membrane. Compared with the prior art, a prepared product has the advantages of high salt intercepting ability and selectivity and good pollution resistance.

The invention discloses an application of magnetic nanoparticles in nucleic acid extraction, wherein the magnetic nanoparticles are magnetic Fe3O4 nanoparticles with surfaces coated with a polydopamine coating. The magnetic nanoparticles provided by the invention have superparamagnetism, high environmental stability and monodispersity, the polydopamine coating coating on the surfaces of the nanoparticles is rich in amino group and hydroxyl group, can realize high-efficiency adsorption for nucleic acid, improves the efficiency and quality for adsorbing nucleic acid of existing magnetic nanoparticles, can realize high-efficiency rapid extraction of nucleic acid, does not need blood processing when being applied to human whole blood extraction, and thus is applicable to clinical disease genediagnosis and treatment. The preparation method of the magnetic nanoparticles disclosed by the invention effectively simplifies the preparation process of the magnetic nanoparticles used as a nucleicacid adsorbent, lowers the preparation process and is suitable for preparation and application of magnetic nanoparticles.

The invention relates to a hollow-structured transition metal cobalt and nitrogen co-doped carbon oxygen reduction catalyst as well as a preparation method and application thereof. A zeolite imidazatemetal organic framework material grows on the surface of a template by utilizing electrostatic interaction between sulfonic acid groups on the surfaces of microspheres and metal cobalt ions, and thenthe zeolite imidazate metal organic framework material is prepared by pyrolysis and carbonization in an inert atmosphere. According to the method provided by the invention, the active site utilization rate of the transition metal cobalt and nitrogen co-doped carbon catalyst can be effectively improved, the prepared catalyst can efficiently catalyze the oxygen reduction reaction of the cathode ofthe fuel cell, and the oxygen reduction catalytic activity is superior to that of commercial Pt / C.

The invention relates to a tri-hydroxy containing hexaquaternary phosphonium cation antibacterial agent and a preparation method thereof and belongs to the technical field of quaternary phosphonate compounds. The structure of the antibacterial agent is as shown as follows, wherein a is a unsubstituted C1-8 fatty group, b is a C1-10 fatty group, and X is a halogen family compound and is selected from Cl, Br and I. The antibacterial unit of the antibacterial agent has a high unit positive charge amount to enhance the electrostatic interaction with a bacterial plasma membrane, so that the excellent antibacterial performance is shown. According to the tri-hydroxy hexaquaternary phosphonium, a material is functionally modified by embedding chemical bonds into a main chain of the material aftera phenolic hydroxyl group is reacted with other compounds, so that the problem of loss of a small molecular antibacterial agent can be avoided, and the application range of the antibacterial agent isexpanded.

The invention discloses an automobile interior trim material capable of removing formaldehyde. The automobile interior trim material is prepared from, by weight, 30-35 parts of bamboo fiber, 2-3 parts of antimonous oxide, 5-7 parts of shell powder, 10-12 parts of waterborne polyurethane, 0.2-0.4 part of a silane coupling agent kh570, 1-2 parts of polyethylene wax, 10-13 parts of polyvinyl alcohol, 100-105 parts of polylactic acid, 60-68 parts of dimethylacetamide, 30-35 parts of dimethyl sulfoxide, 9.6-10.7 parts of carbonized scindapsus aureus, 9.5-10.5 parts of microlite powder, 6-7 parts of poly(butylene succinate), 10-12 parts of acrylic emulsion and an appropriate amount of deionized water. According to the automobile interior trim material, operation is easy, the raw material sources are wide, the biodegradability is good, toxic substances such as formaldehyde in an automobile can be removed, air can be purified, and a healthy and comfortable environment can be built.

The invention relates to an MXene-based three-dimensional porous flexible self-supporting membrane, a preparation method thereof and an application of the membrane in electrochemical adsorption of dyes. The preparation method of the self-supporting membrane comprises the following steps that an MXene nanosheet suspension, a polystyrene microsphere suspension and a single-walled carbon nanotube suspension are mixed and stirred to be uniform, an obtained mixed solution is subjected to ultrasonic treatment, then vacuum filtration is conducted, so that an MXene / PS / SWCNTs composite film is obtained, and then, the polystyrene microsphere template is removed, so that the MXene-based three-dimensional porous flexible self-supporting membrane can be obtained. The self-supporting membrane obtained in the invention has a large pore volume and a high specific surface area, and can expose more active sites. The prepared self-supporting membrane is used for removing dye through electrochemical adsorption and has the advantages of being high in removal efficiency, easy to recycle, low in cost, easy to control and the like.

The invention discloses a preparation method of hydrogel. The preparation method has the advantages that the electrostatic interaction between TEMPO oxidized cellulose nano fibrils and water-soluble positive ion beta-CD polymer is used as the basis, the electrostatic interaction is further enhanced through the synergic effect of aminated nano-silver particles and the positive ion beta-CD polymer to double the content of the water-soluble positive ion beta-CD polymer, and the adsorption and drug loading performance of the water-soluble positive ion beta-CD polymer are increased greatly; meanwhile, the nano silver particles and the cellulose nano fibrils can also be used as the enhancement phase to increase the mechanical strength and viscoelasticity of the hydrogel; the use of toxic crosslinking agents during hydrogel assembling is avoided, the preparation conditions are mild, high crosslinking speed is achieved, the prepared hydrogel is good in biocompatibility and biodegradability andhas certain antibacterial performance, the identification and inclusion properties of cyclodextrin to hydrophobic molecules are kept, and the hydrogel has excellent hydrophobic drug loading capacityand excellent sustained release ability under different pH conditions.

The invention provides reduction-responsive hyperbranched poly-beta-amino ester with efficient gene delivery capability and a preparation method and application thereof. The polymer is polymerized byan A2 + B3 + C2 Michael addition method so that the polymer has a hyperbranched structure. Compared with a linear structure, the branched structure can enhance the interaction between the polymer andnucleic acid molecules, significantly improve the gene condensation ability of the polymer, and increase cellular uptake by enhancing the interaction with cell membranes. The main chain of the polymerhas a reduction-responsive group (disulfide bond), and under the action of GSH in damaged vascular endothelial cells, poly-beta-amino ester can be quickly degraded in cytoplasm to release an entrapped gene drug (ICAM-1 siRNA) so that efficient transfection of genes is realized, and meanwhile, the toxicity of the material is reduced. Due to the properties of the poly-beta-amino ester, the poly-beta-amino ester has a huge development prospect in biomedical materials, especially in the field of gene delivery.

The invention belongs to the field of organic electret materials, and particularly relates to a fluorine-containing organic electret agent, a preparation method thereof and application of the fluorine-containing organic electret agent in electret master batch. The fluorine-containing organic electret agent is core-shell structure particles formed by particle core parts and particle shell parts, the average particle size of the core-shell structure particles is 10-100 [mu]m, the particle core parts are electret silica particles, and the particle shell parts are fluorine-silicon modified resin.The organic fluorine-containing electret agent disclosed by the invention has the technical advantages that the organic fluorine-containing electret agent has good compatibility with polypropylene, and the excellent filtering performance of a polypropylene melt-blown electret material can be well maintained. The electret master batch has high electrostatic capacity, under the action of an externalelectric field, space charge injection and polarization charge generation can be achieved, the PP electrostatic adsorption capacity can be improved, the electret stability of the melt-blown electretmaterial can be improved, charge storage can be effectively prolonged, and the electret master batch is suitable for producing melt-blown cloth with the filtering efficiency of 95 or 99.

The invention designs and synthesizes a class of symmetric short-sequence antibacterial peptide analogues. The symmetric short-sequence antibacterial peptide analogues are obtained by taking tryptophan ''WWW'' as a mirror symmetry center by introducing arginine and hydrophobic amino acid of positive charges to two sides respectively, and then, carrying out C terminal amidation, and structural formulas of the symmetric short-sequence antibacterial peptide analogues are XYWWWYX-NH 2, XWYWWWYWX-NH 2 and XYYWWWYYX-NH2 respectively, wherein X is equal to G, I, L, F, W, V, A, and Y is equal to R. The antibacterial peptide analogues are simple in structural design, and low in manufacturing cost. In vitro bacteriostasis experiments, hemolysis experiments and induced resistance experiments show that the symmetric short-sequence antimicrobial peptide analogues have high antibacterial activity on strains of common gram-positive bacteria and gram negative bacteria, and have low hemolytic toxicity,cannot easily induce bacteria to produce drug resistance, and have good application prospects in the preparation of clinical antibacterial drugs.

Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycoside antibiotic may exhibit antimicrobial activities against Gram-positive and / or Gram-negative strains and display significantly enhanced activity against multi-drug resistant MRSA and MRSE when compared to their unconjugated aminoglycoside antibiotic counterparts.

The invention relates to natural-plant-pigment hair dye and a preparation method thereof and belongs to fine chemical engineering. The natural-plant-pigment hair dye has the advantages that sulfydrylis connected to high-safety natural-plant-pigment dye to form active dye; during hair dyeing, disulfide bonds in hair are opened, and the sulfydryl in the active dye and sulfydryl in the hair disulfide bonds connecting together so as to achieve permanent dyeing; meanwhile, the synergic effect of rabbit hair keratin and soybean protein is utilized to fold protein molecules, hydrophobic groups and sulfydryl embedded inside the protein are exposed to enhance biological adhesion, the hydrophobic film of hair epicuticle is promoted to absorb nutritional substances, and a thin film is formed on thesurface of the hair to protect the hair; the natural-plant-pigment hair dye is nontoxic plant-source hair dye free of carcinogenicit and is good in hair dyeing effect and good in washing fastness andlight fastness.

The invention discloses a lipopolysaccharide amine cationic polymer, which is synthesized with hydrophilic polyaldehyde-based sodium alginate is adopted as a main chain, hydrophobic cholesterol capped polyethylene imine of low molecular weight as a side chain. The physical and chemical structure, buffering capacity, transfection efficiency and cytotoxicity of the lipopolysaccharide amine cationic polymer are characterized. According to exploration of the feasibility of use as a gene carrier and the effects on improvement of the gene transfection efficiency and reduction of the cytotoxicity, the polymer has advantages of good biocompatibility, controllable degradation performance, low cytotoxicity, high safety and practicality and low cost, and the transfection efficiency of GFP (green fluorescent protein) in MSCs (mesenchymal stem cells) is higher than 95 percent regardless of the presence or absence of serum. Moreover, the polymer can be used as a gene carrier and other drug carriers such as anticancer drugs, RNA (ribose nucleic acid) carriers and the like. The invention also discloses a preparation method and application of the polymer.

The present invention relates to cryopreserved cell cultures, methods for cryopreserving cells and methods for conducting cellular assays on such cells. A cryopreserved cell culture of the invention comprises a container having at least a surface which is coated with poly-lysine and frozen cells supported on the surface.

The invention provides UV photoresponsive hyperbranched poly(belta-amino esters) with the efficient gene delivery capability, and a preparation method and application thereof. The polymer is polymerized by an 'A2+B3+C2' Michael addition method, and thus the polymer is provided with a hyperbranched structure. Compared with a linear structure, the branched structure can enhance the interaction between the polymer and nucleic acid molecules, significantly improves the gene condensation capability, and meanwhile can increase cell uptake by enhancing the interaction with a cell membrane. A main chain of the polymer is provided with a UV responsive group, and under UV light irradiation, the poly(belta-amino esters) can be rapidly degraded after cell endocytosis to release an entrapment gene; andefficient gene transfection is realized, and material toxicity is lowered. The properties of the poly(belta-amino esters) enable the poly(belta-amino esters) to have great development prospects in the field of biomedical materials, especially the field of gene delivery.

The invention discloses a method for improving the stability of an inverse emulsion system. The method comprises the following steps: (1) uniformly mixing oily liquid with an emulsifier to obtain an oil phase; (2) mixing a monomer and two amphiphilic cationic polymers with water to obtain an aqueous phase; and (3) mixing the aqueous phase with an initiator and the oil phase to form pre-emulsion, and performing inverse emulsion polymerization. According to the method disclosed by the invention, the two amphiphilic cationic polymers with hydrophobic and hydrophilic groups are introduced in the inverse emulsion system to increase the interaction of the two phases of the system so as to improve the stability of the W / O emulsion, and meanwhile the two amphiphilic cationic polymers introduced in the system also have the functions of cationic water-soluble polymers, which also have a positive effect on the application of the product.

The invention relates to the technical field of flocculating agent preparation, and solves problems of low polysaccharide yield and low polysaccharide flocculation activity in an existing microorganism. The invention discloses a method for preparing a flocculating agent by using Bacillus marinus. The method for preparing the flocculating agent by using the Bacillus marinus comprises the followingsteps: firstly, inoculating a Bacillus marinus strain into a solid culture medium and adding sterile water to the solid culture medium to prepare a strain liquid; secondly, inoculating the strain liquid into a liquid culture medium according to an inoculating quantity to ferment and culture the strain liquid so as to obtain a fermentation liquor; thirdly, adding a flocculation carrier to the fermentation liquor to continue to ferment the fermentation liquor so as to obtain a raw material liquor; and centrifugally separating and drying the raw material liquor to obtain an active polysaccharideflocculating agent. The method for preparing the flocculating agent by using the Bacillus marinus, disclosed by thei nvention, has the advantages that the yield of the active polysaccharide produced by using the Bacillus marinus strains is higher, and the flocculation activity of the active polysaccharide produced by using the Bacillus marinus strains is also higher.

The invention relates to a production process of high-strength corrugated paper. The production process comprises the following steps of: (1) obtaining waste paper pulp from waste paper; (2) obtainingbamboo pulp from bamboo stalks; (3) mixing the waste paper pulp with the bamboo pulp, and adding cationic starch and cellulose powder to obtain papermaking primary pulp; (4) adding a reinforcing agent and an auxiliary agent into the papermaking primary pulp, and uniformly stirring to obtain papermaking pulp; and (5) sequentially carrying out papermaking forming, dehydration, drying, surface sizing and secondary drying on the papermaking pulp to obtain a corrugated paper finished product. According to the invention, dual pulping is carried out on the bamboo stalks; the bamboo fibers can be separated to the greatest extent; the utilization rate of bamboo stalk raw materials is improved; the corrugated paper is more energy-saving and environment-friendly, the gram weight of the corrugated paper can be reduced and the strength of the corrugated paper can be ensured by adding the reinforcing fiber powder into the mixed pulp, and the electrostatic interaction between the pulp can be enhanced by adding the reinforcing agent formed by polymerizing cationic polyacrylamide, hydroxypropyl chitosan and epoxy chloropropane resin, so that the strength of the corrugated paper is further improved.

The invention discloses a microbial fuel cell based on a trimethylamine oxide medium, and belongs to the field of biological fuel cells. The microbial fuel cell based on the trimethylamine oxide medium comprises a reactor, a cell positive electrode and a cell negative electrode, wherein the reactor is arranged in a shell, the cell positive electrode and the cell negative electrode are arranged outside the shell, the bottom of the cell positive electrode is connected to one end of the reactor, and the bottom of the cell negative electrode is connected to the other end of the reactor. The microbial fuel cell based on the trimethylamine oxide medium has the advantages that the electrode surface activation area is large, the electrostatic interaction between microorganisms and the electrode surfaces is enhanced, microorganism adsorption performance is improved, catalysis performance is good, and therefore the cell yield is increased and the production cost is reduced.

The invention discloses a VO2 / S-AC nickel foam air cathode and belongs to the field of electrodes. The preparation method of the VO2 / S-AC nickel foam air cathode includes the three steps of preparing a catalytic layer raw material, preparing nickel foam coated with a catalytic layer and preparing the VO2 / S-AC nickel foam air cathode. The VO2 / S-AC nickel foam air cathode has the advantages that the VO2 / S-AC nickel foam air cathode is larger in electrode surface activation area, the electrostatic effect between microbes and the electrode surface is improved, the microbial adsorptivity is improved, the catalytic performance is good, accordingly the power output is improved, and the production cost is reduced.

The invention discloses a modified-sisal-fiber-polylactic-acid composite environment-friendly automobile internal decorating material. A sisal fiber is prepared from, by weight, 30-35 parts of sisal fibers, 2-3 parts of antimony trioxide, 5-7 parts of shell powder, 10-12 parts of waterborne polyurethane, 0.2-0.4 part of silane coupling agent kh570, 1-2 parts of polyethylene wax, 10-13 parts of polyvinyl alcohol, 100-105 parts of polylactic acid, 60-68 parts of dimethylacetamide, 30-35 parts of dimethyl sulfoxide, 8-9 parts of ceramic microbeads, 6-7 parts of polybenzimidazole, 7-8 parts of aedelforsite and a proper amount of deionized water. According to the modified-sisal-fiber-polylactic-acid composite environment-friendly automobile internal decorating material, a preparing method is simple, and the performance of the composite material is greatly improved through the natural sisal fibers; the composite material is natural, degradable, free of environment pollution and worthy of popularization.

This invention provides methods and compositions for localized delivery of IL-12 to a desired site. The composition comprises liposomes carrying IL-12. The liposomes comprise phosphatidyl choline, phosphatidyl glycerol and cholesterol. The size and composition of the liposomes is such that there is minimal leakage into the systemic circulation. These compositions can be used for delivery of IL-12 to selected sites such as tumors.