Solar photovoltaic panel cleaning equipment with cleaning brushes capable of being adjusted in a self-adaptation mode is composed of the four parts comprising a vehicle body, an automatic cleaning brush adjustment device, a cleaning brush self-adaptation adjustment device and a cleaning brush body. The vehicle body is composed of a driving vehicle (1) and a rack (2). The cleaning brush body is composed of a brush body supporting beam (30), a conical guide wheel (31), brush rollers (32), separating plates (33), supporting wheels (34), a photovoltaic panel (35), a brush driving motor (37) and an air guide pipe (38), wherein the conical guide wheel (31) is fixed to the uppermost end of the brush body supporting beam (30), the three to five separating plates (33) are evenly distributed on the brush body supporting beam (30), the lower end of each separating plate is provided with one set of supporting wheels (34), two cleaning brushes (32) are installed between every two adjacent separating plates (33) in parallel, the cleaning brushes (32) are integrally connected in series through bearings on the separating plates (33), the lowermost end of each row of cleaning brushes is connected with the brush driving motor (37), and the air guide pipe (38) is installed in a cavity of the brush body supporting beam (30).